Targeted overexpression of phospholamban to mouse atrium depresses Ca2+ transport and contractility

Journal of Molecular and Cellular Cardiology

Volumn 30, Issue 10, 1998, Pages 1991-2002

  Neumann, Joachim ^a   Boknik, Peter ^a   DePaoli Roach, Anna A ^b   Field, Loren J ^b   Rockman, Howard A ^d   Kobayashi, Yvonne M ^c   Kelley, Jeffrey S ^c   Jones, Larry R ^c  

^a Inst fur Pharmakol/Toxikologie   (Germany)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Ca uptake; Contractility; Phospholamban; Transgenic mice

Indexed keywords

CALCIUM ION; CYCLIC AMP; ISOPRENALINE; MONOCLONAL ANTIBODY; PHOSPHOLAMBAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPHOSPHORYLATION; GENE FUSION; HEART ATRIUM; HEART MUSCLE CONTRACTILITY; INOTROPISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SARCOPLASMIC RETICULUM; TRANSGENIC MOUSE;

ANIMALIA; MAMMALIA; MUS MUSCULUS;

EID: 0032192291     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.1998.0760     Document Type: Article

References (26)

1. 2+ ATPase. J Biol Chem 267: 26056-26061.
2. 2+ pump. J Biol Chem 264: 18561-18568.
3. 2+. J Biol Chem 268: 17018-17025.
4. GAO WD, PEREZ NG, MARBAN E, 1998. Calcium cycling and contractile activation in intact mouse cardiac muscle. J Physiol 507: 175-184.
5. GULICK J, SUBRAMANIAM A, NEUMANN J, ROBBINS J, 1991. Isolation and characterization of the mouse cardiac myosin heavy chain genes. J Biol Chem 266: 9180-9185.
6. HOGAN B, 1994. Manipulating the mouse embryo. Plainview, NY: Cold Spring Harbor Laboratory Press.
7. HOIT BD, KHOURY SF, KRANIAS EG, BALL N, WALSH RA, 1995. In vivo echocardiographic detection of enhanced left ventricular function in gene-targeted mice with phospholamban deficiency. Circ Res 77: 632-637.
8. 2+ transport ATPase of cardiac sarcoplasmic reticulum. J Biol Chem 259: 1834-1841.
9. KADAMBI VJ, PONNIAH S, HARRER JM, HOLT BD, DORN II GW, WALSH RA, KRANIAS EG, 1996. Cardiac-specific overexpression of phospholamban alters calcium kinetics and resultant cardiomyocyte mechanics in transgenic mice. J Clin Invest 97: 533-539.
10. KOSS KL, KRANIAS EG, 1996. Phospholamban: a prominent regulator of myocardial contractility. Circ Res 79: 1059-1063.
11. KOSS KL, PONNIAH S, JONES WK, GRUPP IL, KRANIAS EG, 1995. Differential phospholamban gene expression in murin cardiac compartments. Molecular and physiological analyses. Circ Res 77: 342-353.
12. KRANIAS EG, GARVEY JL, SRIVASTAVA RD, SOLEARO RJ, 1985. Phosphorylation and functional modifications of sarcoplasmic reticulum and myofibrils in isolated rabbit hearts stimulated with isoprenaline. Biochem J 226: 113-121.
13. 2+-calmodulin-dependent mechanisms. J Biol Chem 260: 4516-4525.
14. 2+-ATPase activity in guinea pig ventricles. J Biol Chem 258: 464-471.
15. LOWRY OH, ROSEBROUGH NJ, FARR AL, RANDALL RJ, 1951. Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275.
16. LUO W, GRUPP IL, HARRER J, PONNIAH S, GRUPP G, DUFFY JJ, DOETSCHMAN T, KRANIAS EG, 1994, Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of β-agonist stimulation. Circ Res 75: 401-409.
17. LUO W, WOLSKA BM, GRUPP IL, HARRER JM, HAGHIGHI K, FERGUSON DG, SLACK JP, GRUPP G, DOETSCHMAN T, SOLARO RJ, KRANIAS EG, 1996. Phospholamban gene dosage effects in the mammalian heart. Circ Res 78: 839-847.
18. 2+ transporting ATPase, phospholamban and calsequestrin levels in failing and nonfailing hearts. Circulation 90: 653-657.
19. SAMBROOK J, FRITSCH EF, MANIATIS T, 1989. Molecular cloning. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
20. 2+ uptake in mammalian ventricular myocytes. Am J Physiol 261: H1344-H1349.
21. SUBRAMANIAM A, KEITH JONES W, GULICK J, WERT S, NEUMANN J, ROBBINS J, 1991. Tissue-specific regulation of the α-myosin heavy chain gene promoter in transgenic mice. J Biol Chem 36: 24613-24620.
22. TADA M, KIRCHBERGER MA, REPKE DI, KATZ AM, 1974. The stimulation of calcium transport in cardiac sarcoplasmic reticulum by adenosine 3′-5′-mono-phosphate-dependent protein kinase. J Biol Chem 249: 6174-6180.
23. WEGENER AD, LINDEMANN JP, SIMMERMAN HKB, JONES LR, 1989. Phospholamban phosphorylation in intact ventricles. J Biol Chem 264: 11468-11474.
24. 2+. Am J Physiol 271: C391-C397.
25. ZHANG Z, BAI G, DEANS-ZIRATTU S, BROWNER MF, LEE EYC, 1992. Expression of the catalytic subunit of phosphorylase phosphatases (protein phosphatase-1) in Escherichia coli. J Biol Chem 267: 1484-1490.
26. ZIMMERMANN N, BOKNIK P, GAMS E, HERZIG JW, NEUMANN J, SCHMITZ W, SCHOLZ H, WENZLAFF H, 1996. Positive inotropic effects of the calcium sensitizer CGP 48506 in guinea pig myocardium. J Pharmacol Exp Ther 277: 1-7.