Peripheral serotonin measures in prepubertal psychiatric inpatients and normal children: Associations with suicidal behavior and its risk factors

Biological Psychiatry

Volumn 44, Issue 7, 1998, Pages 568-577

  Pfeffer, Cynthia R ^a,d   McBride, P Anne ^a   Anderson, George M ^b   Kakuma, Tatsuyuki ^a   Fensterheim, Leonard ^c   Khait, Vadim ^c  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NEW YORK PRESBYTERIAN HOSPITAL   (United States)

^d WEILL CORNELL MEDICAL CENTER   (United States)

Author keywords

Prepubertal suicidal behavior; Serotonin measures

Indexed keywords

SEROTONIN; TRYPTOPHAN;

ARTICLE; CHILD; CHILD PSYCHIATRY; CONTROLLED STUDY; DISEASE ASSOCIATION; ETHNIC DIFFERENCE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PREPUBERTY; PRIORITY JOURNAL; RACE DIFFERENCE; RISK ASSESSMENT; RISK FACTOR; SEROTONINERGIC SYSTEM; SUICIDE;

ATTENTION DEFICIT AND DISRUPTIVE BEHAVIOR DISORDERS; BLOOD PLATELETS; CHILD; FEMALE; HUMANS; INPATIENTS; MALE; MENTAL DISORDERS; MOOD DISORDERS; PLATELET AGGREGATION; PSYCHIATRIC STATUS RATING SCALES; RECEPTORS, SEROTONIN; RISK FACTORS; SEROTONIN; SUICIDE; SUICIDE, ATTEMPTED; TRYPTOPHAN;

EID: 0032191671     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(98)00020-1     Document Type: Article

References (53)

1. Altman K, Greengard O (1966): Correlation of kynurenine excretion with liver tryptophan pyrrolase levels in disease and after hydrocortisone induction. J Clin Invest 45:1527-1534.
2. Anderson GM, Feibel FC, Cohen DJ (1987): Determination of serotonin in whole blood, platelet-rich plasma, platelet-poor plasma and plasma ultrafiltrate. Life Sci 40:1063-1070.
3. Banki CM (1978): 5-Hydroxytryptamine content of the whole blood in psychiatric illness and alcoholism. Acta Psychiatr Scand 57:232-238.
4. Brent DA, Perper JA, Moritz G, Allman C, Friend A, Roth C, et al (1993): Psychiatric risk factors for adolescent suicide: A case-control study. J Am Acad Child Adolesc Psychiatry 32:521-529.
5. Brewerton TD (1989): Seasonal variations of serotonin function in humans: Research and clinical implications. Ann Clin Psychiatry 1:153-164.
6. Brusov OS, Beliaev BS, Katasonav AB, Zlobina GP, Factor MI, Liderman RR (1989): Does platelet serotonin receptor supersensitivity accompany endogenous depression? Biol Psychiatry 25:375-381.
7. Butler J, Leonard BE (1988): The platelet serotonergic system in depression and following sertraline treatment. Int Clin Psychopharmacol 3:343-347.
8. Chambers JM, Hastie TJ, editors (1993): Statistical Models in S., New York: Chapma and Hall.
9. Coccaro EF, Siever LJ, Klar HM, Mauer G, Cochrane K, Cooper TB, et al (1989): Serotonergic studies in patients with affective and personality disorders. Arch Gen Psychiatry 46:587-599.
10. Coccaro EF, Silverman JM, Klar HM, Horvath TB, Siever LJ (1994): Family correlates of reduced central serotonergic system function in patients with personality disorders. Arch Gen Psychiatry 51:318-324.
11. Cohen J (1960): A coefficient of agreement for nominal scales. Educ Psychol Measures 20:37-46.
12. Cook EH, Fletcher KE, Wainwright M, Marks N, Yan SY, Leventhal B (1994): Primary structure of the human platelet serotonin 5-HT-2A receptor: Identity with frontal cortex serotonin 5-HT-2A receptor. J Neurochem 63:465-469.
13. Cook E Jr, Stein MA, Ellison T, Unis AS, Leventhal BL (1995): Attention deficit hyperactivity disorder and whole blood serotonin levels: Effects of comorbidity. Psychiatry Res 57:13-20.
14. Corona GL, Cucchi ML, Santagostino G, Frattini P, Zerbi F, Fenoglio L, et al (1982): Blood noradrenaline and 5-HT levels in depressed women during amitriptyline or lithium treatment. Psychopharmacology (Berlin) 77:236-241.
15. Ellis PM, Salmond C (1994): Is platelet imipramine binding reduced in depression? A meta-analysis. Biol Psychiatry 36:292-299.
16. Entwisle DR, Astone NM (1994): Some practical guidelines for measuring youth's race/ethnicity and socioeconomic status. Child Dev 65:1521-1540.
17. Ernouf D, Compagnon P, Lothion P, Narcisse G, Benard JY, Daoust M (1993): Platelet 3H 5-HT uptake in descendants from alcoholic patients: A potential risk factor for alcohol dependence? Life Sci 52:989-995.
18. Green AR, Sourkes TL, Young SN (1975): Liver and brain tryptophan metabolism following hydrocortisone administration to rats and gerbils. Br J Pharmacol 53:287-292.
19. Greenhill L, Waslick B, Parides M, Fan B, Shaffer D, Mann J (1995): Biological studies in suicidal adolescent inpatients. In: Leventhal B, Schwab-Stone M, editors. Scientific Proceedings of the Annual Meeting of the American Academy of Child and Adolescent Psychiatry, Washington, D.C.: American Academy of Child and Adolescent Psychiatry, vol 11. p 124.
20. Halperin JM, Sharma V, Siever LJ, Schwartz SD, Matier K, Wornell G, et al (1994): Serotonergic function in aggressive and nonaggressive boys with attention deficit hyperactivity disorder. Am J Psychiatry 151:243-248.
21. Halperin JM, Newcorn JH, Schwartz ST, Sharma V, Siever LJ, Koda VH, et al (1997): Age-related changes in the association between serotonergic function and aggression in boys with ADHD. Biol Psychiatry 41:682-689.
22. Healy D, Carney PA, O'Halloran A, Leonard BE (1985): Peripheral adrenoceptors and serotonin receptors in depression: Changes associated with response to treatment with trazodone or amitriptyline. J Affect Disord 9:285-296.
23. Hollingshead AB, Redlich P (1958): Social Class and Mental Illness. New York: Wiley.
24. Kochanek KD, Hudson BL (1995): Advance report of final mortality statistics, 1992. Monthly vital statistics report, vol 43, no 6, suppl. Hyattsville, MD: Medical Center for Health Statistics.
25. Lesch KP, Aengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, et al (1996): Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527-1531.
26. Maes M, Cosyns P, Meltzer HY, De Meyer F, Peeters D (1993): Seasonality in violent suicide but not in nonviolent suicide or homicide. Am J Psychiatry 150:1380-1385.
27. Maes M, Scharpe S, Verkerk R, D'Hondt P, Peeters D, Cosyns P, et al (1995): Seasonal variation in plasma L-tryptophan availability in healthy volunteers. Arch Gen Psychiatry 52: 937-946.
28. Mann JJ, McBride PA, Anderson GM, Mieczkowski TA (1992a): Platelet and whole blood serotonin content in depressed inpatients: Correlations with acute and life-time psychopathology. Biol Psychiatry 32:243-257.
29. Mann JJ, McBride PA, Brown RP, Linnoila M, Leon AC, DeLeo M, et al (1992b): Relationship between central and peripheral serotonin indexes in depressed and suicidal psychiatric inpatients. Arch Gen Psychiatry 49:442-446.
30. McBride PA, Brown RP, DeMeo M, Keilp J, Mieczkowski T, Mann JJ (1994): The relationship of platelet 5-HT-2 receptor indices to major depressive disorder, personality traits, and suicidal behavior. Biol Psychiatry 35:295-308.
31. McBride PA, Mann JJ, Polley MJ, Wiley AJ, Sweeney JA (1987): Assessment of binding indices and physiological responsiveness of the 5-HT-2 receptor in human platelets. Life Sci 40:1799-1809.
32. McBride PA, Anderson GM, Hertzig ME, Snow ME, Thompson SM, Khait VD, et al (in press): Effects of diagnosis, race, and pubertal status on platelet serotonin levels in autism and mental retardation. J Am Acad Child Adolesc Psychiatry.
33. Meltzer HY, Arora RC (1986): Platelet markers of suicidality. Ann NY Acad Sci 487:271-280.
34. Owen MJ, Nemeroff CD (1994): Role of serotonin in the pathophysiology of depression: Focus on the serotonin transporter. Clin Chem 40:288-295.
35. Pfeffer CR (1986): The Suicidal Child. New York: Guilford Press.
36. Pfeffer CR, Klerman GL, Hurt SW, Kakuma T, Peskin JR, Siefker CA (1993): Suicidal children grow up: Rates and psychosocial risk factors for suicide attempts during follow-up. J Am Acad Child Adolesc Psychiatry 32:106-113.
37. 3H]imipramine binding in adolescents who attempted suicide. Am J Psychiatry 152:923-925.
38. 2A) receptor characteristics and parenting factors for boys at risk for delinquency: A preliminary report. Am J Psychiatry 153: 538-544.
39. Pine DS, Wasserman G, Coplan J, Fried J, Sloan R, Myers M, et al (1996b): Serotonergic and cardiac correlates of aggression in children. Ann NY Acad Sci 794:391-393.
40. Pliszka SR, Rogeness GA, Renner P, Sherman J, Broussard T (1988): Plasma neurochemistry in juvenile offenders. J Am Acad Child Adolesc Psychiatry 27:588-594.
41. Quintana J (1992): Platelet serotonin and plasma tryptophan decreases in endogenous depression: Clinical, therapeutic, and biological correlations. J Affect Disord 24:55-62.
42. Ramamoorthy S, Bauman AL, Moore KR, Han H, Yang-Feng T, Chang AS, et al (1993): Antidepressant-and cocaine-sensitive human serotonin transporter: Molecular cloning, expression, and chromosomal localization. Proc Natl Acad Sci USA 90:2542-2567.
43. Rogeness GA, Mitchell EL, Custer GJM, Harris WR (1985): Comparison of whole blood serotonin and platelet MAO in children with schizophrenia and major depressive disorder. Biol Psychiatry 20:270-275.
44. Sarrias MJ, Artagas F, Martinez E, Gelpi E (1989): Seasonal changes of plasma serotonin and related parameters: Correlation with environmental measures. Biol Psychiatry 26:695-706.
45. Shaffer D (1988): The epidemiology of teen suicide: An examination of risk factors. J Clin Psychiatry 49:36-41.
46. Sitaramam V, Ramasarma T (1975): Nature of induction of tryptophan pyrrolase in cold exposure. J Appl Physiol 38: 245-249.
47. Sneddon JM (1973): Blood platelet as a model for monoamine-containing neurons. Prog Neurobiol 1:151-198.
48. Souetre E, Salvati E, Belugou JL, Douillet P, Braccini T, Darcourt G (1987): Seasonally of suicides: Environmental, sociological and biological covariations. J Affect Disord 13:215-225.
49. Stoff DM, Pasatiempo AP, Yeung J, Cooper TC, Bridger WH, Rabinovich H (1992): Neuroendocrine responses to challenges with dl-fenfluramine and aggression in disruptive behavior disorders of children and adolescents. Psychiatry Res 43:263-276.
50. Swade C, Coppen A (1980): Seasonal variations in biochemical factors related to depressive illness. J Affect Disord 2:249-255.
51. Wirz-Justice A, Puhringer W (1978): Seasonal incidence of an altered diurnal rhythm of platelet serotonin in unipolar depression. J Neural Transm 42:45-53.
52. Wood K, Swade C, Abou-Saleh M, Coppen A (1984): Peripheral serotonergic receptor sensitivity in depressive illness. J Affect Disord 7:59-65.
53. Young SN (1981): Mechanism of decline in rat brain 5-hydroxytryptamine after induction of liver tryptophan pyrrolase by hydrocortisone: Roles of tryptophan catabolism and kynurenine synthesis. Br J Pharmacol 74:695-700.