Stereospecific synthesis of 9-substituted benzolactam-V8 from L- tyrosine via regioselective aromatic nitration

Tetrahedron Letters

Volumn 39, Issue 40, 1998, Pages 7369-7372

  Ma, Dawei ^a   Tang, Wenjun ^a  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

Aromatic nitration; Benzolactam V8; Protein kinase C

Indexed keywords

BENZOLACTAM DERIVATIVE; LACTAM DERIVATIVE; PROTEIN KINASE C ACTIVATOR; TYROSINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CHINA; DRUG SYNTHESIS; NITRATION; STEREOCHEMISTRY;

EID: 0032191523     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)01598-6     Document Type: Article

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14. 3) δ 7.01 (d, J= 1.3 Hz, 1H), 6.95 (d, J = 7.8 Hz, 1H), 6.89 (dd, J=7.8, 1.3 Hz, 1H), 6.51 (m, 1H), 3.95 (brs, 1H), 3.71 (dd, J = 10.6, 3.9 Hz, 1H), 3.53 (dd, J= 10.6, 9.1 Hz, 1H), 3.09 (dd, J= 17.0 Hz, 7.8 Hz, 1H), 2.79 (s, 3H), 2.74 (m, 1H), 2.51 (m, 1H), 2.38 (t, J= 7.1 Hz, 2H), 1.60 (m, 2H), 1.45 (m, 2H), 1.29 (m, 8H), 1.05 (d, J= 6.4 Hz, 3H), 0.89 (d, J= 6.4 Hz, 3H), 0.87 (t J= 7.0 Hz, 3H).