No self-injurious behavior was found in HPRT-deficient mice treated with 9-Ethyladenine

Pharmacology Biochemistry and Behavior

Volumn 61, Issue 2, 1998, Pages 175-179

  Edamura, K ^a   Sasai, H ^a  

^a JAPAN TOBACCO INC   (Japan)

Author keywords

9 Ethyladenine; APRT; HPRT deficient mouse; Lesch Nyhan Syndrome; Self injurious behavior

Indexed keywords

9 ETHYLADENINE; ADENINE PHOSPHORIBOSYLTRANSFERASE; DOPAMINE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOMUTILATION; BRAIN CELL; COMPETITIVE INHIBITION; CONTROLLED STUDY; ENZYME DEFICIENCY; ENZYME INHIBITION; LESCH NYHAN SYNDROME; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADENINE; ANIMALS; CELL EXTRACTS; DISEASE MODELS, ANIMAL; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LESCH-NYHAN SYNDROME; MICE; MICE, INBRED C57BL; SELF-INJURIOUS BEHAVIOR;

ANIMALIA;

EID: 0032190001     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(98)00095-1     Document Type: Article

References (18)

1. Breese G.R., Criswell H.E., Duncan G.E., Mueller R.A. A dopamine deficiency model of Lesch-Nyhan disease - the neonatal-6-OHDA-lesioned rat. Brain Res. Bull. 25:1990;477-484.
2. Engle S.J., Stockelman M.G., Chen J., Goivin G., Yum M.N., Davies P.M., Ying M.Y., Sahota A., Simmonds H.A., Stambrook P.J., Tischfield J.A. Adenine phosphoribosyltransferase-deficient mice develop 2,8-dihydroxyadenine nephrolithiasis. Proc. Natl. Acad. Sci. USA. 93:1996;5307-5312.
3. Engle S.J., Womer D.E., Davies P.M., Boivin G., Sahota A., Simmonds H.A., Stambrook P.J., Tischfield J.A. HPRT-APRT-deficient mice are not a model for Lesch-Nyhan syndrome. Hum. Mol. Genet. 5:1996;1607-1610.
4. Ernst M., Zametkin A.J., Matochik J.A., Pascualvaca D., Jons P.H., Hardy K., Hankerson J.G., Doudet D.J., Cohen R.M. Presynaptic dopaminergic deficits in Lesch-Nyhan disease. N. Engl. J. Med. 334:1996;1568-1572.
5. Hirohisa T., Catherina E.M., Laura H.R., Takayuki Y., Koji E., Nobuyo M., Oliver S., Aya J.L. Inactivation of the mouse HPRT locus by a 203-bp retroposon insertion and a 55-kb gene-targeted deletion. Establishment of new HPRT-deficient mouse embryonic stem cell lines Genomics. 42:1997;413-421.
6. Hooper M., Hardy K., Handyside A., Hunter S., Monk M. HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells. Nature. 326:1987;292-295.
7. Jinnah H.A., Wojcik B.E., Hunt M., Narang N., Lee K.T., Goldstein M., Wamsley J.K., Langlais P.J., Friedmann T.J. Dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease. Neurol. Sci. 14:1994;1164-1175.
8. Jinnah H.A., Gage F.H., Friedmann T. Animal models of Lesch-Nyhan syndrome. Brain Res. Bull. 25:1990;467-475.
9. Jinnah H.A., Gage F.H., Friedmann T. Amphetamine-induced behavioral phenotype in hypoxanthine-guanine phosphoribosyltransferase-deficient mouse model of Lesch-Nyhan syndrome. Behav. Neurosci. 105:1991;1004-1012.
10. Kuehn M.R., Bradley A., Robertson E.J., Evans M.J. A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice. Nature. 326:1987;295-298.
11. Kühn R., Rajewsky K., Müller W. Generation and analysis of Interleukin-4 deficient mice. Science. 254:1991;707-710.
12. Lesch M., Nyhan W.L. A familial disorder of uric acid metabolism and central nervous system function. Am. J. Med. 36:1964;561-570.
13. Lloyd K.G., Hornykiewicz O., Davidson L., Shannak K., Farley I., Goldstein M., Shibuya M., Kelly W.N., Fox I.H. Biochemical evidence of dysfunction of brain neurotransmitters in the Lesch-Nyhan syndrome. N. Engl. J. Med. 305:1981;1106-1111.
14. Meuth M., Harwood J. Selection of cells defective in pyrimidine (TK-) and Purine (APRT- and HPRT-) salvage. Murray E.J. Methods in molecular biology. Gene transfer and expression protocols:1991;257-267 Humana Press Inc, Clifton, NJ.
15. Mueller K., Saboda S., Palmour R., Nyhan W.L. Self-injurious behavior produced in rats by daily caffeine and continuous amphetamine. Pharmacol. Biochem. Behav. 17:1982;613-617.
16. Sege-Peterson K., Nyhan W.L., Page T. Lesch-Nyhan disease and HPRT deficiency. Rosenberg R.N., Prusiner S.B., DiMauro S., Barchi R.L., Kunkel L.M. The molecular and genetic basis of neurological disease. 1992;241-260 Butterworth-Heinemann, Boston.
17. Wong D.F., Harris J., Yung G., Dannals R.F., Ravert H.T., Chen C., Yaster M., Neumeyer J., Carpenter R., Nyhan W., Wagner H.N. Jr., Kuhar M.J., Breese G.R. Dopamine transporters are markedly reduced in Lesch-Nyhan disease in vivo. Proc. Natl. Acad. Sci. USA. 93:1996;5539-5543.
18. Wu C.-L., Melton D.W. Production of a model for Lesch-Nyhan syndrome in hypoxanthine phosphoribosyltransferase-deficient mice. Nat. Genet. 3:1993;235-240.