H+-Coupled Uphill Transport of the Dipeptide Glycylsarcosine by Bovine Intestinal Brush-Border Membrane Vesicles

Journal of Dairy Science

Volumn 81, Issue 10, 1998, Pages 2595-2603

  Wolffram, S ^a   Grenacher, B ^b   Scharrer, E ^b  

^a UNIVERSITY OF KIEL   (Germany)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Brush border membrane; Glycylsarcosine; Intestine; Peptide absorption

Indexed keywords

CEFALEXIN; CEPHALOSPORIN DERIVATIVE; DIPEPTIDE; GLYCYLSARCOSINE; PROTON;

ANIMAL; ARTICLE; CATTLE; CELL MEMBRANE POTENTIAL; FEMALE; ILEUM; INTESTINE; JEJUNUM; KINETICS; METABOLISM; MICROVILLUS; TRANSPORT AT THE CELLULAR LEVEL; ULTRASTRUCTURE;

ANIMALS; BIOLOGICAL TRANSPORT; CATTLE; CEPHALEXIN; CEPHALOSPORINS; DIPEPTIDES; FEMALE; ILEUM; INTESTINES; JEJUNUM; KINETICS; MEMBRANE POTENTIALS; MICROVILLI; PROTONS;

EID: 0032176689     PISSN: 00220302     EISSN: None     Source Type: Journal    
DOI: 10.3168/jds.S0022-0302(98)75817-5     Document Type: Article

References (43)

1. Adibi, S. A. 1997. The oligopeptide transporter (Pept-1) in human intestine: biology and function. Gastroenterology 113: 332-340.
2. Backwell, F.R.C., D. Wilson, and A. Schweizer. 1995. Evidence for a glycyl-proline transport system in ovine enterocyte brush-border membrane vesicles. Biochem. Biophys. Res. Commun. 215:561-565.
3. Ben-Ghedalia, D., H. Tagari, and A. Bondi. 1974. Protein digestion in the intestine of sheep. Br. J. Nutr. 31:125-142.
4. Boll, M., D. Markovich, W.-M. Weber, H. Korte, H. Daniel, and H. Murer. 1994. Expression cloning of a cDNA from rabbit small intestine related to proton-coupled transport of peptides, β-lactam antibiotics and ACE-inhibitors. Eur. J. Physiol. 429: 146-149.
5. Chalupa, W., and C. J. Sniffen. 1994. Carbohydrate, protein and amino acid nutrition of lactating dairy cattle. Pages 265-275 in Recent Advances in Animal Nutrition. P. C. Garnsworthy and D.J.A. Cole, ed. Nottingham Press, Loughborough, Leicestershire, England.
6. Daniel, H. 1997. First insights into the operational mode of epithelial peptide transporters. J. Physiol. (Lond.) 498: 561-561.
7. Daniel, H., M. Boll, and U. Wenzel. 1994. Physiological importance and characteristics of peptide transport in intestinal epithelial cells. EAAP Publ. No. 80:1-7. Eur. Assoc. Anim. Prod., Dummerstorf, Germany.
8. Daniel, H., and M. Herget. 1997. Cellular and molecular mechanisms of renal peptide transport. Am. J. Physiol. 42: F1-F8.
9. Daniel, H., B. Neugebauer, A. Kratz, and G. Rehner. 1985. Localization of acid microclimate along intestinal villi of rat jejunum. Am. J. Physiol. 248:G293-G298.
10. Dantzig, A. H. 1997. Oral absorption of β-lactams by intestinal peptide transport proteins. Adv. Drug Delivery Rev. 23:63-76.
11. Erickson, R. H., J. R. Gum, M. M. Lindstrom, D. Mckean, and Y. S. Kim. 1995. Regional expression and dietary regulation of rat small intestinal peptide and amino acid transporter mRNAs. Biochem. Biophys. Res. Commun. 216:249-257.
12. Fei, Y. J., Y. Kanai, S. Nussberger, V. Ganapathy, F. H. Leibach, M. F. Romero, S. K. Singh, W. F. Boron, and M. A. Hediger. 1994. Expression cloning of a mammalian proton-coupled oligopeptide transporter. Nature (Lond.) 368:563-566.
13. +/Di-tripeptide transporter (PepT1) expression in the rabbit intestine. Pflüg. Arch. Eur. J. Physiol. 430: 394-400.
14. Ganapathy, V., G. Burckhardt, and F. H. Leibach. 1984. Characteristics of glycylsarcosine transport in rabbit intestinal brush-border membrane vesicles. J. Biol. Chem. 259:8954-8959.
15. Ganapathy, V., and F. H. Leibach. 1983. Role of pH gradient and membrane potential in dipeptide transport in intestinal and renal brush-border membrane vesicles from the rabbit. Studies with L-carnosine and glycyl-L-proline. J. Biol. Chem. 258:14189-14192.
16. Ganapathy, M. E., P. D. Prasad, B. Mackenzie, V. Ganapathy, and F. H. Leibach. 1997. Interaction of anionic cephalosporins with the intestinal and renal peptide transporters PepT1 and PepT2. Biochim. Biophys. Acta 1324:296-308.
17. GraphPad Software: GraphPad Instat, Version 2.05a; and GraphPad Inplot Version 4.04+. 1994. H. Motulsky, San Diego, CA.
18. Kay, R.N.B., and E. Pfeffer. 1970. Movement of water and electrolytes into and from the intestine of the sheep. Pages 390-402 in Physiology of Digestion and Metabolism in the Ruminant. A. T. Phillipson, ed. Oriel Press Ltd., Newcastle upon Tyne, England.
19. Kessler, M., O. Acuto, C. Storelli, H. Murer, M. Müller, and G. Semenza. 1978. A modified procedure for the rapid preparation of efficiently transporting vesicles from small intestinal brush border membranes. Biochim. Biophys. Acta 506:136-154.
20. Kessler, M., V. Tannenbaum, and C. Tannenbaum. 1978. A simple apparatus for performing short-time (1-2 seconds) uptake measurements in small volumes; its application to D-glucose transport studies in brush border vesicles from rabbit jejunum and ileum. Biochim. Biophys. Acta 509:348-359.
21. Leibach, F. H., and V. Ganapathy. 1996. Peptide transporters in the intestine and the kidney. Annu. Rev. Nutr. 16:99-119.
22. +/peptide cotransporter -cloning, functional expression, and chromosomal localization. J. Biol. Chem. 270:6456-6463.
23. Lister, N., P. D. Bailey, I. D. Collier, C.A.R. Boyd, and J. R. Bronk. 1997. The influence of luminal pH on transport of neutral and charged dipeptides by rat small intestine, in vitro. Biochim. Biophys. Acta 1324:245-250.
24. +-Glycyl-L-proline cotransport in brush-border membrane vesicles of eel (Anguilla Anguilla) intestine. Am. J. Physiol. 41:R217-R225.
25. Matthews, D. M., and S. A. Adibi. 1976. Peptide absorption. Gastroenterology 71:151-161.
26. Matthews, J. C., and K. E. Webb. 1995. Absorption of L-carnosine, L-methionine, and L-methionylglycine by isolated sheep ruminal and omasal epithelial tissue. J. Anim. Sci. 73: 3464-3475.
27. Matthews, J. C., E. A. Wong, P. K. Bender, J. R. Bloomquist, and K. E. Webb. 1996. Demonstration and characterization of dipeptide transport system activity in sheep omasal epithelium by expression of mRNA in Xenopus laevis oocytes. J. Anim. Sci. 74:1720-1727.
28. Miyamoto, Y., J. L. Coone, V. Ganapathy, and F. H. Leibach. 1988. Distribution and properties of the glycylsarcosine-transport system in rabbit renal proximal tubule. Biochem. J. 249:247-253.
29. +/peptide cotransporter in rat digestive tract. Biochem. Biophys. Res. Commun. 220:848-852.
30. Rajendran, V. M., S. A. Ansari, J. M. Hang, M. B. Adams, A. H. Khan, and K. Ramaswamy. 1985. Transport of glycyl-L-proline by human intestinal brush border membrane vesicles. Gastroenterology 89:1298-1304.
31. Rajendran, V. M., A. Berteloot, and K. Ramaswamy. 1985. Transport of glycyl-L-proline by mouse intestinal brush-border membrane vesicles. Am. J. Physiol. 248:G682-G686.
32. Rajendran, V. M., J. M. Harig, and K. Ramaswamy. 1987. Characteristics of glycyl-L-proline transport in intestinal brush-border membrane vesicles. Am. J. Physiol. 252:G281-G286.
33. Sachs, L., ed. 1992. Angewandte Statistik. Springer Verlag, Berlin, Germany.
34. +/peptide cotransporter mediating absorption of β-lactam antibiotics in the intestine and kidney. J. Pharmacol. Exp. Ther. 275:1631-1637.
35. Shiau, Y.-F., P. Fernandez, M. J. Jackson, and S. McMonagle. 1985. Mechanisms maintaining a low-pH microclimate in the intestine. Am. J. Physiol. 248:G608-G617.
36. Steel, A., S. Nussberger, M. F. Romero, W. F. Boron, C.A.R. Boyd, and M. A. Hediger. 1997. Stoichiometry and pH dependence of the rabbit proton-dependent oligopeptide transporter PepT1. J. Physiol. (Lond.) 498:563-569.
37. Thamotharan, M., J. Gomme, G. V. Zonno, M. Maffia, C. Storelli, and G. A. Ahearn. 1996. Electrogenic, proton-coupled, intestinal dipeptide transport in herbivorous and carnivorous teleosts. Am. J. Physiol. 39:R939-R947.
38. Wallace, R. J. 1996. Ruminal microbial metabolism of peptides and amino acids. J. Nutr. 126:S1326-S1334.
39. Webb, K. E., D. B. Dirienzo, and J. C. Matthews. 1993. Recent developments in gastrointestinal absorption and tissue utilization of peptides: a review. J. Dairy Sci. 76:351-361.
40. Webb, K. E., J. C. Matthews, and D. B. Dirienzo. 1992. Peptide absorption - a review of current concepts and future perspectives. J. Anim. Sci. 70:3248-3257.
41. Wolffram, S., C. Hagemann, and E. Scharrer. 1991. Regression of high-affinity carrier-mediated intestinal transport of taurine in adult cats. Am. J. Physiol. 261:R1089-RR1095.
42. +-Dependent L-lactate uptake by bovine small intestinal brush border membrane vesicles. J. Dairy Sci. 71:3267-3273.
43. Yang, C.-M. J., and J. B. Russell. 1992. Resistance of proline-containing peptides to ruminal degradation in vitro. Appl. Environ. Microbiol. 58:3954-3958.