Percutaneous absorption and model membrane variations of melatonin in aqueous-based propylene glycol and 2-hydroxypropyl-β-cyclodextrin vehicles

Archives of Pharmacal Research

Volumn 21, Issue 5, 1998, Pages 503-507

  Lee, Beom Jin ^a   Cui, Jing Hao ^a   Parrott, Keith A ^b   Ayres, James W ^b   Sack, Robert L ^c  

^a Kangwon National University   (South Korea)

^b OREGON STATE UNIVERSITY   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

2 Hydroxypropyl cyclodextrin; Aqueous based vehicles; Melatonin; Model membrane variations; Percutaneous absorption; Propylene glycol

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN; ANTIOXIDANT; BETA CYCLODEXTRIN DERIVATIVE; CYCLODEXTRIN; DRUG VEHICLE; EXCIPIENT; MELATONIN; PROPYLENE GLYCOL;

ANIMAL; ARTICLE; CHEMISTRY; DIFFUSION; HAIRLESS MOUSE; MALE; MOUSE; PERMEABILITY; SKIN ABSORPTION; SOLUBILITY; TOPICAL DRUG ADMINISTRATION; VEHICLES;

ADMINISTRATION, TOPICAL; ANIMALS; ANTIOXIDANTS; BETA-CYCLODEXTRINS; CYCLODEXTRINS; DIFFUSION; EXCIPIENTS; MALE; MELATONIN; MICE; MICE, INBRED HRS; PERMEABILITY; PROPYLENE GLYCOL; SKIN ABSORPTION; SOLUBILITY; VEHICLES;

EID: 0032175995     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02975365     Document Type: Article

References (17)

1. Benes, L., Brun, J., Claustrat, B., Degrande, G., Ducloux, N., Geoffriau, M., Horriere, F., Karsenty, H. and Lagain, D., Plasma melatonin (M) and Sulfatoxymelatonin (aMT6s) kinetics after transmucosal administration to humans. Melatonin and the pineal gland-from basic science to clinical application. Proceedings from the congress on pineal gland. Paris France March, 347-350 (1993).
2. Chang, S. and Banga, A. K., Iontophoretic delivery of hydrocortisone from cyclodextrin solutions. Pharm. Res. 13, 5364 (1996).
3. Garfinkel, D., Laudon, M., Dof, D. and Zisapel, N., Improvement of sleep quality in elderly people by controlled-release melatonin. Lancet, 346, 541-544 (1995).
4. Hadgraft, J. and Guy, R. H., Transdermal drug delivery. Developmental issues and research initiatives. Marcel Dekker Inc., New York, 1989.
5. Haimov, I., Lavie, P., Laudon, M., Herer, P., Vigder, C. and Zisapel, N., Melatonin replacement therapy of elderly insomniacs. Sleep, 18, 598-603 (1995).
6. Konsil, J., Parrott, K. A., Ayres, J. W. and Sack, R. L. Development of a transdermal delivery device for melatonin in vitro study. Drug Dev. Ind. Pharm., 21, 1377-1387 (1995).
7. Kydonieus, A. F. and Berner B., Transdermal delivery of drugs. Vol. I, II, & III. CRC Press, Inc., Boca Raton, FL, 1987.
8. Lee, B.-J., Choe J.-S. and Kim C.-K., Preparation and characterization of melatonin-loaded steary alcohol microspheres, J. Microencapsulation, in press.
9. Lee, B.-J., Choi, H.-G., Kim, C. K., Parrott, K. A., Ayres, J. W. and Sack, R. L., Solubility and stability of melatonin in propylene glycol and 2-hydroxpropyl-β-cyclodextrin. Arch. Pharm. Res. 20, 560-565 (1997).
10. Lee, B.-J. and Min, G.-H., Oral controlled release of melatonin using polymer-reinforced and coated alginate beads. Int. J. Pharm., 144, 37-46 (1996).
11. Lee, B.-J., Parrott, K. A., Ayres, J. W. and Sack R. L., Preliminary evaluation of transdermal delivery of melatonin in human subjects. Res. comm. Mol. Pathol. & Pharmacol. 85, 337-344 (1994).
12. Lee, B.-J., Parrott, K. A., Ayres, J. W. and Sack, R.L., Design and evaluation of an oral controlled release delivery system for melatonin in human subjects. Int. J. Pharm., 124, 119-127 (1995).
13. Lee, B.-J., Parrott, K. A., Ayres, J. W. and Sack R. L., Development and characterization of an oral controlled release delivery system for melatonin. Drug Dev. Ind. Pharm. 22, 269-274 (1996).
14. Loftsson, T. and Border, N., Effects of 2-hydroxypropyl-β-cyclodextrin on the aqueous solubility of drugs and transdermal delivery of 17β-estradiol. Acta Pharm. Nordica. 1, 185-194 (1989).
15. Roy, S. D., Gutierrez, M., Flynn, G. L. and Cleary G. W. Controlled transdermal delivery of fentanyl: Characterization of pressure-sensitive adhesives for matrix patch design. J. Pharm. Sci., 85, 491-495 (1996).
16. Shao, Z. Krishnamoorthy, R. and Mitra, A. K. Cyclodextrins as nasal absorption promoters of insulin. Pharm. Res. 9, 1157-1163 (1992).
17. Waldhauser, F. and Dietzel, M. Daily and annual rhythms in human melatonin secretion: role in puberty. Ann. NY. Acad. Sci. 453, 205-214 (1985).