Decline in total T cell count is associated with onset of AIDS, independent of CD4+ lymphocyte count: Implications for AIDS pathogenesis

Clinical Immunology and Immunopathology

Volumn 88, Issue 3, 1998, Pages 256-263

  Margolick, Joseph B ^a   Donnenberg, Albert D ^b   Chu, Clara ^a   O'Gorman, Maurice R G ^c   Giorgi, Janis V ^d   Muñoz, Alvaro ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; DISEASE ASSOCIATION; DISEASE COURSE; HELPER CELL; HOMEOSTASIS; HOMOSEXUALITY; HUMAN; HUMAN CELL; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

EID: 0032169878     PISSN: 00901229     EISSN: None     Source Type: Journal    
DOI: 10.1006/clin.1998.4577     Document Type: Article

References (22)

1. Zolla-Pazner S., Des Jarlais D. C., Friedman S. R., Spira T. J., Marmor M., Holzman R., Mildvan D., Yancovitz S., Mathur-Wagh U., Garber J., El-Sadr W., Cohen H., Smith D., Kalyanaraman V. S., Kaplan J. E., Fishbein D. B. Nonrandom development of immunologic abnormalities after infection with human immunodeficiency virus: Implications for immunologic classification of the disease. Proc. Natl. Acad. Sci. USA. 84:1987;5404-5408.
2. Margolick J. B., Muñoz A., Donnenberg A., Park L. P., Galai N., Giorgi J. V., O'Gorman M. R. G., Ferbas J. Failure of T-cell homeostasis preceeding AIDS in HIV-1 infection. Nat. Med. 1:1995;674-680.
3. Galai N., Margolick J. B., Astemborski J., Vlahov D. Existence and failure of T-cell homeostasis prior to AIDS onset in HIV-infected injection drug users. Clin. Immunol. Immunopathol. 79:1996;134-141.
4. +-. J. Acquired Immune Defic. Syndr. 6:1993;153-161.
5. Adleman L. M., Wofsy D. T-cell homeostasis: Implications in HIV infection. J. Acquired Immune Defic. Syndr. 6:1993;144-152.
6. Adleman L. M., Wofsy D. Blind T-cell homeostasis in CD4-deficient mice. J. AIDS Human Retrovirol. 11:1996;334-340.
7. Gange, S. J. Muñoz, A. Chmiel, J. S. Donnenberg, A. D. Kirstein, L. M. Detels, R. Margolick, J. B. Identification of inflections in T-cell counts among HIV-1 infected individuals and relationship with progression to clinical AIDS, Proc. Natl. Acad. Sci. (USA).
8. +. Ann. Intern. Med. 126:1997;946-954.
9. +. JAMA. 279:1998;35-40.
10. Kirby A. J., Muñoz A., Detels R., Armstrong J. A., Saah A. J., Phair J. P. Thrush and fever as measures of immunocompetence in HIV-1 infected men. J. Acquired Immune Defic. Syndr. 7:1994;1242-1249.
11. Kaslow R. A., Ostrow D. G., Detels R., Phair J. P., Polk B. F., Rinaldo C. R. The Multicenter AIDS cohort study: Rationale, organization, and selected characteristics of the participants. Am. J. Epidemiol. 126:1987;310-318.
12. Giorgi J. V., Cheng H-L., Margolick J. B., Bauer K. D., Ferbas J., Waxdal M., Schmid I., Hultin L. E., Jackson A. L., Park L., Taylor J. M. G. Quality control in the flow cytometric measurement of T-lymphocyte subsets: The Multicenter Aids Cohort study (MACS) experience. Clin. Immunol. Immunopathol. 55:1990;173-186.
13. Schenker E. L., Hultin L. E., Bauer K. D., Ferbas J., Margolick J. B., Giorgi J. V. Evaluation of a dual-color flow cytometry immunophenotyping panel in a multicenter quality assurance program. Cytometry. 14:1993;307-317.
14. MMWR. 36:1987;3S-15S.
15. Diggle, T. J. Liang, K-Y. Zeger, S. L. Analysis of Longitudinal Data, Oxford Univ. Press, Oxford, 1994.
16. Wei L. J., Lin D. Y., Weissfeld L. Regression analysis of multivariate incomplete failure time data by modeling marginal distributions. J. Am. Stat. Assoc. 84:1989;1065-1073.
17. Muñoz A., Sabin C. A., Phillips A. N. The incubation period of AIDS. AIDS. 11:1997;S69-S76.
18. +. Ann. Intern. Med. 118:1993;681-688.
19. +, AIDS Res. Human. Retrovir.
20. Embretson J., Zupancic M., Bencke J., Wolinsky S., Burke A., Haase A. Analysis of HIV-infected tissues by amplification and in situ hybridization. Proc. Natl. Acad. Sci. USA. 90:1993;357-361.
21. Galai N., Muñoz A., Carey V. J., Chen K., Chmiel J., Zhou S. Y. J. Tracking of markers and onset of disease among HIV-1 seroconverters. Stat. Med. 12:1993;2133-2145.
22. Saah A. J., Muñoz A., Kuo V., Fox R., Kaslow R. A., Phair J. P., Rinaldo C. R. Jr., Detels R., Polk B. F. Predictors of the risk of development of acquired immunodeficiency syndrome within 24 months among gay men seropositive for human immunodeficiency virus type 1: A report from the Multicenter AIDS Cohort Study. Am. J. Epidemiol. 135:1994;1147-1155.