Effect of N-[(trans-4-isopropylcyclohexyl)- carbonyl]-d-phenylalanine on nutrient catabolism in rat pancreatic islets

General Pharmacology

Volumn 31, Issue 3, 1998, Pages 451-454

  Malaisse, Willy J ^a   Sener, Abdullah ^a  

^a FREE UNIVERSITY OF BRUSSELS   (Belgium)

Author keywords

Meglitinide analogs; Nutrient metabolism; Pancreatic islets

Indexed keywords

NATEGLINIDE;

AMINO ACID METABOLISM; ANIMAL TISSUE; ARTICLE; DRUG EFFECT; FEMALE; GLUCOSE METABOLISM; INSULIN RELEASE; ISOLATED PANCREAS ISLET; METABOLISM; NONHUMAN; NUTRIENT; PRIORITY JOURNAL; RAT;

ANIMALS; BENZAMIDES; CYCLOHEXANES; FEMALE; GLUCOSE; HYPOGLYCEMIC AGENTS; ISLETS OF LANGERHANS; LEUCINE; OXIDATION-REDUCTION; PHENYLALANINE; RATS; RATS, WISTAR;

EID: 0032167478     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(98)00014-7     Document Type: Article

References (24)

1. Bakkali Nadi A., Malaisse-Lagae F., Malaisse W.J. Insulinotropic action of meglitinide analogs. concentration-response relationship and nutrient dependency Diabetes Res. 27:1994;81-87.
2. Bakkali Nadi A., Malaisse-Lagae F., Malaisse W.J. Ionophoretic properties of the non-sulphonylurea hypoglycaemic agents A-4166 and KAD-1229. Res. Commun. Mol. Pathol. Pharmac. 88:1995;339-347.
3. Bakkali Nadi A., Zhang T.-M., Malaisse W.J. Effects of the methyl esters of pyruvate, succinate and glutamate on the secretory response to meglitinide analogues in rat pancreatic islets. Pharmac. Res. 33:1996;191-194.
4. Garcia-Martinez J.A., Viñambres C., Villanueva-Peñacarrillo M.L., Valverde I., Malaisse W.J. Comparison and synergism between the insulinotropic action of succinic acid monomethyl ester and N-[(trans-4-isopropylcyclohexyl)-carbonyl]-D-phenylalanine. Med. Sci. Res. 23:1995;777-778.
5. Jijakli H., Ulusoy S., Malaisse W.J. Dynamics of the cationic and secretory responses to A-4166 in perifused pancreatic islets. Fund. Clin. Pharm. 11:1997;300-304.
6. Kawazu S., Sener A., Couturier E., Malaisse W.J. Metabolic, cationic and secretory effects of hypoglycemic sulfonylureas in pancreatic islets. Naunyn-Schmiedeberg's Arch. Pharmac. 312:1980;277-283.
7. Levy J., Malaisse W.J. The stimulus-secretion coupling of glucose-induced insulin release XVII. effects of sulfonylurea and diazoxide on insular biosynthetic activity Biochem. Pharmac. 24:1975;235-239.
8. Lins L., Brasseur R., Malaisse W.J. Conformational analysis of non-sulfonylurea hypoglycemic agents of the meglitinide family. Biochem. Pharmac. 50:1995;1879-1884. a.
9. Lins L., Brasseur R., Malaisse W.J. Conformation analysis of the calcium complexes formed by meglitinide analogs. Res. Commun. Mol. Pathol. Pharmac. 90:1995;153-164. b.
10. Malaisse W.J. Stimulation of insulin release by non-sulfonylurea hypoglycemic agents. the meglitinide family Horm. Metab. Res. 27:1995;263-266. a.
11. + concentrations Pharmac. Res. 32:1995;111-114. b.
12. 14C-labelled A-4166 in pancreatic islets. Acta Diabetol. 33:1996;298-300.
13. Malaisse W.J., Sener A. Hexose metabolism in pancreatic islets. Feedback control of D-glucose oxidation by functional events. Biochim. Biophys. Acta. 971:1988;246-254.
14. Malaisse W.J., Sener A., Malaisse-Lagae F., Hutton J.C., Christophe J. The stimulus-secretion coupling of amino acid-induced insulin release VI. metabolic interaction of L-glutamine and 2-ketoisocaproate in pancreatic islets Biochim. Biophys. Acta. 677:1981;39-49.
15. Malaisse W.J., Best L., Kawazu S., Malaisse-Lagae F., Sener A. The stimulus-secretion coupling of glucose-induced insulin release LV. fuel metabolism in islets deprived of exogenous nutrient Arch. Biochem. Biophys. 224:1983;102-110.
16. Malaisse W.J., Giroix M.-H., Malaisse-Lagae F., Sener A. 3-O-Methyl-D-glucose transport in tumoral insulin-producing cells. Am. J. Physiol. 251:1986;C841-C846.
17. Malaisse W.J., Lebrun P., Sener A. Modulation of the insulinotropic action of glibenclamide and glimepiride by nutrient secretagogues in pancreatic islets from normoglycemic and hyperglycemic rats. Biochem. Pharmac. 45:1993;1845-1849.
18. Panten U., Zünkler B.J., Scheit S., Kirchhoff K., Lenzen S. Regulation of energy metabolism in pancreatic islets by glucose and tolbutamide. Diabetologia. 29:1986;648-654.
19. Sato Y., Nishikawa M., Shinkai H., Sukegawa E. Possibility of ideal blood glucose control by a new oral hypoglycemic agent, N-[(trans-4-isopropylcyclohexyl)-carbonyl]-D-phenylalanine (A-4166), and its stimulatory effect on insulin secretion in animals. Diabetes Res. Clin. Pract. 12:1991;53-60.
20. Sener A., Malaisse W.J. Stimulation by D-glucose of mitochondrial oxidative events in islet cells. Biochem. J. 246:1987;89-95.
21. Sener A., Kawazu S., Hutton J.C., Boschero A.C., Devis G., Somers G., Herchuelz A., Malaisse W.J. The stimulus-secretion coupling of glucose-induced insulin release XXXIII. effect of exogenous pyruvate on islet function Biochem. J. 176:1978;217-232.
22. Sener A., Malaisse-Lagae F., Ulusoy S., Leclercq-Meyer V., Malaisse W.J. Contrasting secretory behaviour of pancreatic islets from old rats in two models of non-insulin-dependent diabetes. Diabetes Res. 31:1996;67-76. a.
23. Sener A., Reusens B., Remacle C., Hoet J.J., Malaisse W.J. Nutrient metabolism in pancreatic islets from protein malnourished rats. Biochem. Mol. Med. 59:1996;62-67. b.
24. Viñambres C., Garcia-Martinez J.A., Villanueva-Peñacarrillo M.L., Valverde I., Malaisse W.J. Preservation of nutrient-stimulated biosynthetic activity in pancreatic islets exposed to a meglitinide analogue. Med. Sci. Res. 23:1995;779-780.