Thyroid Hormone Receptor Does Not Heterodimerize with the Vitamin D Receptor but Represses Vitamin D Receptor-Mediated Transactivation

Molecular Endocrinology

Volumn 12, Issue 9, 1998, Pages 1367-1379

  Raval Pandya, Mihali ^a   Freedman, Leonard P ^b   Li, Hui ^a   Christakos, Sylvia ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIA; MINK CELL FOCUS-FORMING VIRUS;

CALBINDIN; CALCITRIOL; CALCITRIOL RECEPTOR; DNA; LIOTHYRONINE; NERVE PROTEIN; REPRESSOR PROTEIN; RETINOIC ACID RECEPTOR; RETINOID X RECEPTOR; THYROID HORMONE RECEPTOR; TRANSCRIPTION FACTOR;

ANIMAL; ARTICLE; CELL CULTURE; CELL LINE; DIMERIZATION; DROSOPHILA; FEMALE; GENETICS; HUMAN; METABOLISM; MOUSE; PROMOTER REGION; RAT; TRANSACTIVATION;

ANIMALS; CALCITRIOL; CALCIUM-BINDING PROTEIN, VITAMIN D-DEPENDENT; CELL LINE; DIMERIZATION; DNA; DROSOPHILA; FEMALE; HUMANS; MICE; NERVE TISSUE PROTEINS; PROMOTER REGIONS (GENETICS); RATS; RECEPTORS, CALCITRIOL; RECEPTORS, RETINOIC ACID; RECEPTORS, THYROID HORMONE; REPRESSOR PROTEINS; RETINOID X RECEPTORS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRIIODOTHYRONINE; TUMOR CELLS, CULTURED;

EID: 0032159214     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.12.9.0165     Document Type: Article

References (79)

1. Suda T, Shinki T, Takahashi N 1990 The role of vitamin D in bone and intestinal differentiation. Annu Rev Nutr 10:195-211
2. 3. Biochem J 316:361-371
3. Darwish H, DeLuca HF 1993 Vitamin D regulated gene expression. Crit Rev Eukaryot Gene Expr 3:89-116
4. McDonald PN, Dowd DR, Haussler MR 1994 New insight into the structure and functions of the vitamin D receptor. Semin Nephrol 14:101-118
5. Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schutz G, Umesono K, Blumberg, B, Kastner P, Mark M, Chambon P, Evans RM 1995 The nuclear receptor superfamily: the second decade. Cell 83:835-839
6. Whitfield GK, Hsieh J-C, Nakajima S, MacDonald PN, Thompson PD, Jurutka PW, Haussler CA, Haussler MR 1995 A highly conserved region in the hormone binding domain of the human vitamin D receptor contains residues vital for heterodimerization with retinoid × receptor and for transcriptional activation. Mol Endocrinol 9:1166-1179
7. Jin CH, Kemer SA, Hong MH, Pike JW 1996 Transcriptional activation and dimerization functions in the human vitamin D receptor. Mol Endocrinol 10:945-957
8. Blanco JCG, Wang I-M, Tsai SY, Tsai, M-J, O'Malley BW, Jurutka PW, Haussier MP, Ozato K 1995 Transcription factor IIB and the vitamin D receptor cooperatively activate ligand-dependent transcription. Proc Natl Acad Sci USA 92:1535-1539
9. Masuyama H, Jefcoat SC, MacDonald PN 1997 The N-terminal domain of transcription factor IIB is required for direct interaction with the vitamin D receptor and participates in vitamin D mediated transcription. Mol Endocrinol 11:218-228
10. Ing NH, Beekman JM, Tsai, SY, Tsai M-J, O'Malley BW 1992 Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II). J Biol Chem 267:17617-17623
11. 3-dependent cell free transcription. Mol Cell Biol 17:1923-1937
12. 3 and thyroid hormone receptors in mammalian cells. Genes Dev 11:1381-1395
13. Masuyama H, Brownfield, CM, St Arnaud R, MacDonald PN 1997 Evidence for ligand-dependent intramolecular folding of the AF-2 domain in vitamin D receptor-activated transcription and coactivator interaction. Mol Endocrinol 11:1507-1517
14. Onate SA, Tsai SY, Tsai M-J, O'Malley BW 1995 Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 270:1354-1357
15. Chen H, Lin RJ, Schiltz L, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y, Evans RM 1997 Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell 90:569-580
16. Hong H, Kohli K, Trivedi A, Johnson DL, Stallcup MR 1996 GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for hormone binding domains of steroid receptors. Proc Natl Acad Sci USA 93:4948-4952
17. Williams GR, Harney JW, Moore DD, Larsen PR, Brent GA 1992 Differential capacity of wild-type promoter elements for binding and transactivation by retinoic acid and thyroid hormone receptors. Mol Endocrinol 6:1527-1537
18. Parker MG 1993 Steroid and related receptors. Curr Opin Cell Biol 5:499-504
19. Scott REM, Wu-Peng XS, Yen PM, Chin WW, Pfaff DW 1997 Interactions of estrogen and thyroid hormone receptors on a progesterone receptor estrogen response element (ERE) sequence: a comparison with the vitellogenin A2 consensus ERE. Mol Endocrinol 11:1581-1592
20. 3 24-hydroxylase (CYP24) promoter. J Biol Chem 271:29715-29721
21. 3 24-hydroxylase gene promoter and identification of two vitamin D responsive elements. Biochim Biophys Acta 1263:1-9
22. 9k gene. Proc Natl Acad Sci USA 89:603-607
23. 3 and butyrate inducible responses. Proc Natl Acad Sci USA 90:2984-2988
24. 3-thyroid hormone receptor heterodimer polarity directs ligand sensitivity of transactivation. Nature 370:382-386
25. Forrest D, Sjoberg M, Vennstrom B 1990 Contrasting developmental and tissue-specific expression of α and β thyroid hormone receptor genes. EMBO J 9:1519-1528
26. 3 and retinoid signaling. Endocrinology 135:2375-2385
27. 3 in pituitary cells. Endocrinology 124:930-936
28. 3. Kidney Int 45:95-102
29. Giuliano AR, Franceschi RT, Wood RJ 1991 Characterization of the vitamin D receptor from Caco-2 human colon carcinoma cell line: effect of cellular differentiation. Arch Biochem Biophys 285:261-269
30. 9k gene in rat uterus. J Biol Chem 266:551-558
31. Schräder M, Müller K, Carlberg C 1994 Specificity and flexibility of vitamin D signaling. J Biol Chem 269:5501-5504
32. Nishikawa J, Matsumoto M, Sakoda K, Kitaura M, Imagawa M, Nishihara T 1993 Vitamin D receptor zinc finger region binds to a direct repeat as a dimer and discriminates the spacing number between each half-site. J Biol Chem 268:19739-19743
33. 3 receptor in the absence of the retinoid × receptor. Mol Endocrinol 8:265-273
34. Forman BM, Yang CR, Au M, Casanova J, Ghysdael J, Samuels HH 1989 A domain containing leucine-zipper like motifs mediate novel in vivo interactions between the thyroid hormone and retinoic acid receptors. Mol Endocrinol 3:1610-1626
35. Yen PM, Liu Y, Sugawara A, Chin WW 1996 Vitamin D receptors repress basal transcription and exert dominant negative activity on triidothyronine-mediated transcriptional activity. J Biol Chem 271:10910-10916
36. Graupner G, Wills KN, Tzukerman M, Zhang X-k, Pfahl M 1989 Dual regulatory role for thyroid-hormone receptors allows control of retinoic-acid receptor activity. Nature 340:653-656
37. Damm K, Thompson CC, Evans RM 1989 Protein encoded by v-erb A functions as a thyroid hormone receptor antagonist. Nature 339:593-597
38. 3R but not its oncogenic variant, v-erb A, suppresses RAR-dependent transactivation by titrating out RXR. EMBO J 12:1343-1354
39. Hollenbeck PL, Phyillaier M, Nikodem VM 1993 Divergent effects of 9-cis-retinoic acid receptor on positive and negative thyroid hormone receptor-dependent gene expression. J Biol Chem 268:3825-3828
40. 3 response: hormonal crosstalk by ligand induced squelching. Mol Cell Biol 13:7698-7707
41. Graupner G, Zhang X-k, Tzukerman M, Wills K, Hermann T, Pfahl M 1991 Thyroid hormone receptors repress estrogen receptor activation of a TRE. Mol Endocrinol 5:365-372
42. Spanjaard RA, Nguyen VYP, Chin WW 1995 Repression of glucocorticoid receptor-mediated transcriptional activation by unliganded thyroid hormone receptor(TR) is TR isoform-specific. Endocrinology 136:5084-5092
43. Don Chen, J, Evans RM 1995 A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 377:454-457
44. Horlein, AJ, Naar, AM, Heinzel T, Torchia J, Gloss B, Kurokawa R, Ryan A, Kamei Y, Soderstrom M, Glass CK, Rosenfeld MG 1995 Ugand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 377:397-404
45. Fondell JD, Roy AL, Roeder RG 1993 Unliganded thyroid hormone receptor inhibits formation of a functional preinitiation complex: implications for active repression. Genes Dev 7:1400-1410
46. Baniahmad A, Ha I, Reinberg D, Tsai S, Tsai M-J, O'Malley BW 1993 Interaction of human thyroid hormone receptor β with transcription factor TFIIB may mediate target gene depression and activation by thyroid hormone. Proc Natl Acad Sci USA 90:8832-8836
47. Dupret J-M, Brun P, Perret C, Lomri N, Thomasset M, Cuisinier-Gleizes P 1987 Transcriptional and post transcriptional regulation of vitamin D-dependent calcium binding protein in rat duodenum by 1,25-dihydroxycholecalciferol. J Biol Chem 262:16553-16557
48. 28k gene. Mol Endocrinol 3:495-502
49. 9k fusion genes in transgenic mice. J Biol Chem 271:16820-16826
50. 3 using transgenic mice In: Norman AW, Bouillon R and Thomasset M (eds) Vitamin D: Chemistry, Biology and Clinical Applications of the Steroid Hormone. Printing and Reprographics, University of California, Riverside, CA, pp 312-313
51. Walters MR 1992 Newly identified actions of the vitamin D endocrine system. Endocr Rev 13:1-46
52. 3 receptors in hyperthyroid and hypothyroid rats. Biochem Biophys Res Commun 131:122-128
53. Oppenheimer JH 1979 Thyroid hormone action at the cellular level. Science 203:971-979
54. Allain TJ, McGregor AM 1993 Thyroid hormones and bone. J Endocrinol 139:9-18
55. Stern PH 1996 Thyroid hormone and bone. In: Bilezikian JP, Raisz LG, Rodan GA (eds) Principles of Bone Biology. Academic Press, New York, pp 521-531
56. DeLuca HF 1984 The metabolism, physiology and function of vitamin D. In: Kumar R (ed) Vitamin D: Basic and Clinical Aspects. Martinus Nijhoff, Boston, pp 1-10
57. Refetoff S, Weiss RE, Usala SJ 1993 The syndromes of resistance to thyroid hormone. Endocr Rev 14:348-399
58. Krieger NS, Stappenbeck TS, Stern PH 1988 Characterization of specific thyroid hormone receptors in bone. J Bone Miner Res 3:473-478
59. Rizzoli R, Poser J, Burgi U 1986 Nuclear thyroid hormone receptors in cultured bone cells. Metabolism 35:71-74
60. 3 and thyroid hormone in three osteosarcoma cell lines. Endocrinology 136:4304-4314
61. 9k cDNA from mouse placenta. In: Norman AW, Schaefer K, Grigoleit HG, Herrath DV (eds). Vitamin D: Molecular, Cellular and Clinical Endocrinology. Walter de Gruyter, Berlin, pp 507-508
62. Krisinger J, Darwish H, Maeda N, DeLuca HF 1988 Structure and nucleotide sequence of the rat intestinal vitamin D-dependent calcium binding protein gene. Proc Natl Acad Sci USA 85:8988-8992
63. Sanger F, Nicklen S, Coulson AR 1977 DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 74:5463-5467
64. Matkovits T, Christakos S 1995 Ligand occupancy is not required for vitamin D receptor and retinoid receptor mediated transcriptional activation. Mol Endocrinol 9:232-242
65. 3 enhancement of mouse secreted phosphoprotein 1 (Spp-1 or osteopontin) gene expression. Proc Natl Acad Sci USA 87:9995-9999
66. 3. Proc Natl Acad Sci USA 87:9751-9755
67. Forman BM, Casanova J, Raaka BM, Ghysdael J, Samuels HH 1992 Half-site spacing and orientation determines whether thyroid hormone and retinoic acid receptors and related factors bind to DNA response elements as monomers, homodimers or heterodimers. Mol Endocrinol 6:429-442
68. Forman B, Samuels HH 1991 pEXPRESS: a family of expression vectors containing a single transcription unit active in prokaryotes, eukaryotes and in vitro. Gene 105:9-15
69. 3 in Caco-2 cells. Arch Biochem Biophys 308:171-174
70. Gorman C, Padamanbhan R, Howard B 1983 High efficiency DNA-mediated transformation of primate cells. Science 221:551-553
71. Gorman CM, Moffat LF, Howard BH 1982 Recombinant genomes which express chloramphenicol acetyl transferase in mammalian cells. Mol Cell Biol 2:1044-1051
72. Liu M, Freedman LP 1994 Transcriptional synergism between the vitamin D receptor and other nonreceptor transcription factors. Mol Endocrinol 8:1593-1604
73. 3 receptor zinc finger region. Mol Endocrinol 5:1815-1826
74. 3 receptor (VDR) homodimers into VDR-retinoid × receptor homodimers. Mol Cell Biol 14:3329-3338
75. 3 receptor: mechanism of dimer binding to an asymmetric repeat element. Proc Natl Acad Sci USA 90:6310-6314
76. MacDonald PN, Sherman DR, Dowd DR, Jefcoat SC, DeLisle RK 1995 The vitamin D receptor interacts with general transcription factor IIB. J Biol Chem 270:4748-4752
77. Geitz D, Jean AS, Woods RA, Schiestl RH 1991 Improved method for high efficiency transformation of intact yeast cells. Nucleic Acids Res 20:1425
78. Hannon GJ, Demetrick D, Beach D 1993 Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins. Genes Dev 7:2378-2391
79. Estojak J, Brent R, Golemis EA 1995 Correlation of two-hybrid affinity data with in vitro measurements. Mol Cell Biol 15:5820-5829