-
1
-
-
0026730489
-
Structure-based strategies for drug design and discovery
-
I.D. Kuntz, Structure-based strategies for drug design and discovery (Review), Science 257 (1992) 1078.
-
(1992)
Science
, vol.257
, pp. 1078
-
-
Kuntz, I.D.1
-
2
-
-
0000577984
-
The one-bead-one-compound combinatorial library method
-
K.S. Lam, M. Lebl, V. Krchnak, The one-bead-one-compound combinatorial library method, Chemical Reviews 97 (1997) 411.
-
(1997)
Chemical Reviews
, vol.97
, pp. 411
-
-
Lam, K.S.1
Lebl, M.2
Krchnak, V.3
-
3
-
-
0027533514
-
Molecular recognition analyzed by docking simulations: The aspartate receptor and isocitrate dehydrogenase from Escherichia coli
-
B.L. Stoddard, D. Koshland Jr., Molecular recognition analyzed by docking simulations: The aspartate receptor and isocitrate dehydrogenase from Escherichia coli, Proc. Natl. Acad. Sci. USA 90 (1993) 1146.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 1146
-
-
Stoddard, B.L.1
Koshland D., Jr.2
-
4
-
-
0025675821
-
Acetylcholine binding by a synthetic receptor: Implications for biological recognition
-
D.A. Dougherty, D.A. Stauffer, Acetylcholine binding by a synthetic receptor: Implications for biological recognition, Science 250 (1990) 1558.
-
(1990)
Science
, vol.250
, pp. 1558
-
-
Dougherty, D.A.1
Stauffer, D.A.2
-
5
-
-
0022419375
-
Aromatic-aromatic interaction: A mechanism of protein structure stabilization
-
S.K. Burley, G.A. Petsko, Aromatic-aromatic interaction: A mechanism of protein structure stabilization (Review) (41 Refs.), Science 229 (1985) 23.
-
(1985)
Science
, vol.229
, pp. 23
-
-
Burley, S.K.1
Petsko, G.A.2
-
7
-
-
0028693767
-
Prediction of the binding sites of huperzine a in acetylcholinesterase by docking studies
-
Y.-P. Pang, A.P. Kozikowski, Prediction of the binding sites of huperzine a in acetylcholinesterase by docking studies, J. Comput. Aided Mol. Design 8 (1994) 669.
-
(1994)
J. Comput. Aided Mol. Design
, vol.8
, pp. 669
-
-
Pang, Y.-P.1
Kozikowski, A.P.2
-
8
-
-
0028710014
-
Prediction of the binding site of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine in acetylcholinesterase by docking studies with the sysdoc program
-
Y.-P. Pang, A.P. Kozikowski, Prediction of the binding site of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine in acetylcholinesterase by docking studies with the sysdoc program, J. Comput. Aided Mol. Design 8 (1994) 683.
-
(1994)
J. Comput. Aided Mol. Design
, vol.8
, pp. 683
-
-
Pang, Y.-P.1
Kozikowski, A.P.2
-
11
-
-
0031015343
-
Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine a
-
M.L. Raves, M. Harel, Y.-P. Pang, I. Silman, A.P. Kozikowski, J.L. Sussman, Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine a, Nature Structural Biology 4 (1997) 57.
-
(1997)
Nature Structural Biology
, vol.4
, pp. 57
-
-
Raves, M.L.1
Harel, M.2
Pang, Y.-P.3
Silman, I.4
Kozikowski, A.P.5
Sussman, J.L.6
-
12
-
-
0029817834
-
Highly potent, selective, and low-cost bistetrahydroaminacrine inhibitors of acetylcholinesterase: Steps toward novel drugs for treating Alzheimer's disease
-
Y.-P. Pang, P. Quiram, T. Jelacic, F. Hong, S. Brimijoin, Highly potent, selective, and low-cost bistetrahydroaminacrine inhibitors of acetylcholinesterase: Steps toward novel drugs for treating Alzheimer's disease, J. Biol. Chem. 271 (1996) 23646.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 23646
-
-
Pang, Y.-P.1
Quiram, P.2
Jelacic, T.3
Hong, F.4
Brimijoin, S.5
-
13
-
-
84922342912
-
The structures of huperzine A and B, two new alkaloids exhibiting marked anticholinesterase activity
-
J.-S. Liu, Y.-L. Zhu, C.-M. Yu, Y.-Z. Zhou, Y.-F. Han, F.-W. Wu, B.-F. Qi, The structures of huperzine A and B, two new alkaloids exhibiting marked anticholinesterase activity, Can. J. Chem. 64 (1986) 837.
-
(1986)
Can. J. Chem.
, vol.64
, pp. 837
-
-
Liu, J.-S.1
Zhu, Y.-L.2
Yu, C.-M.3
Zhou, Y.-Z.4
Han, Y.-F.5
Wu, F.-W.6
Qi, B.-F.7
-
14
-
-
0346757562
-
-
C.-G. Wermuth, (Ed.), Escom, Leiden
-
Y.-P. Pang, A.P. Kozikowski, in: C.-G. Wermuth, (Ed.), Trends in QSAR and Molecular Modelling 92, Escom, Leiden, 1993, p. 422.
-
(1993)
Trends in QSAR and Molecular Modelling
, vol.92
, pp. 422
-
-
Pang, Y.-P.1
Kozikowski, A.P.2
-
15
-
-
0027999470
-
Identification of amino acid residues involved in the binding of huperzine a to cholinesterases
-
A. Saxena, N.F. Qian, I.M. Kovach, A.P. Kozikowski, Y.-P. Pang, D.C. Vellom, Z. Radic, D. Quinn, P. Taylor, B.P. Doctor, Identification of amino acid residues involved in the binding of huperzine a to cholinesterases, Protein. Sci 3 (1994) 1770.
-
(1994)
Protein. Sci
, vol.3
, pp. 1770
-
-
Saxena, A.1
Qian, N.F.2
Kovach, I.M.3
Kozikowski, A.P.4
Pang, Y.-P.5
Vellom, D.C.6
Radic, Z.7
Quinn, D.8
Taylor, P.9
Doctor, B.P.10
-
16
-
-
0027517144
-
Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors
-
Z. Radic, N.A. Pickering, D.C. Vellom, S. Camp, P. Taylor, Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors, Biochemistry 32 (1993) 12074.
-
(1993)
Biochemistry
, vol.32
, pp. 12074
-
-
Radic, Z.1
Pickering, N.A.2
Vellom, D.C.3
Camp, S.4
Taylor, P.5
-
17
-
-
0028177161
-
Differential effects of peripheral site ligands on Torpedo and chicken acetylcholinesterase
-
J. Eichler, A. Anselment, J.L. Sussman, I. Massoulie, U. Silman, Differential effects of peripheral site ligands on Torpedo and chicken acetylcholinesterase, Mol. Pharmacol 45 (1994) 335.
-
(1994)
Mol. Pharmacol
, vol.45
, pp. 335
-
-
Eichler, J.1
Anselment, A.2
Sussman, J.L.3
Massoulie, I.4
Silman, U.5
-
18
-
-
0027368530
-
Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase
-
M. Harel, I. Schalk, L. Ehretsabatier, F. Bouet, M. Goeldner, C. Hirth, P.H. Axelsen, I. Silman, J.L. Sussman, Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase, Proc. Natl. Acad. Sci. USA 90 (1993) 9031.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 9031
-
-
Harel, M.1
Schalk, I.2
Ehretsabatier, L.3
Bouet, F.4
Goeldner, M.5
Hirth, C.6
Axelsen, P.H.7
Silman, I.8
Sussman, J.L.9
-
19
-
-
0013472170
-
Physostigmines and tetrahydroaminoacridine analogs as alternative drugs for the treatment of Alzheimer's disease
-
M. Pomponi, B. Giardina, F. Gatta, M. Marta, Physostigmines and tetrahydroaminoacridine analogs as alternative drugs for the treatment of Alzheimer's disease, Med. Chem. Res. 2 (1992) 306.
-
(1992)
Med. Chem. Res.
, vol.2
, pp. 306
-
-
Pomponi, M.1
Giardina, B.2
Gatta, F.3
Marta, M.4
-
20
-
-
0026504115
-
Interaction of tetrahydroaminoacridine with acetylcholinesterase and butyrylcholinesterase
-
H.A. Berman, K. Leonard, Interaction of tetrahydroaminoacridine with acetylcholinesterase and butyrylcholinesterase, Mol. Pharmacol. 41 (1992) 412.
-
(1992)
Mol. Pharmacol.
, vol.41
, pp. 412
-
-
Berman, H.A.1
Leonard, K.2
-
21
-
-
0028047375
-
Conformers of acetylcholinesterase: A mechanism of allosteric control
-
J.L. Taylor, R.T. Mayer, C.M. Himel, Conformers of acetylcholinesterase: A mechanism of allosteric control, Mol. Pharmacol. 45 (1994) 74.
-
(1994)
Mol. Pharmacol.
, vol.45
, pp. 74
-
-
Taylor, J.L.1
Mayer, R.T.2
Himel, C.M.3
-
22
-
-
0025778840
-
Atomic structure of acetylcholinesterase from Torpedo californica: A prototypic acetylcholine-binding protein
-
J.L. Sussman, M. Harel, F. Frolow, C. Oefner, A. Goldman, L. Toker, I. Silman, Atomic structure of acetylcholinesterase from Torpedo californica: A prototypic acetylcholine-binding protein, Science 253 (1991) 872.
-
(1991)
Science
, vol.253
, pp. 872
-
-
Sussman, J.L.1
Harel, M.2
Frolow, F.3
Oefner, C.4
Goldman, A.5
Toker, L.6
Silman, I.7
-
23
-
-
0346757558
-
Synthesis and evaluation of glucose-ADP hybrids as inhibitors of hexokinase
-
K.S. Akerfeldt, P.A. Bartlett, Synthesis and evaluation of glucose-ADP hybrids as inhibitors of hexokinase, J. Org. Chem. 56 (1991) 7133.
-
(1991)
J. Org. Chem.
, vol.56
, pp. 7133
-
-
Akerfeldt, K.S.1
Bartlett, P.A.2
-
24
-
-
0001781266
-
The comparison of non-enzymic and enzymic reaction velocities
-
D.E. Koshland, The comparison of non-enzymic and enzymic reaction velocities, J. Theor. Biol. 2 (1962) 75.
-
(1962)
J. Theor. Biol.
, vol.2
, pp. 75
-
-
Koshland, D.E.1
-
25
-
-
0026454813
-
Conversion of acetylcholinesterase to butyrylcholinesterase: Modeling and mutagenesis
-
M. Harel, J.L. Sussman, E. Krejci, S. Bon, P. Chanal, J. Massoulie, I. Silman, Conversion of acetylcholinesterase to butyrylcholinesterase: Modeling and mutagenesis, Proc. Natl. Acad. Sci. USA 89 (1992) 10827.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 10827
-
-
Harel, M.1
Sussman, J.L.2
Krejci, E.3
Bon, S.4
Chanal, P.5
Massoulie, J.6
Silman, I.7
-
26
-
-
0029099970
-
5,7-dihydro-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-6h-pyrrolo[3 2-f]-1,2-benzisoxazol-6-one - A potent and centrally-selective inhibitor of acetylcholinesterase with an improved margin of safety
-
A. Villalobos, T.W. Butler, D.S. Chapin, Y.L. Chen, S.B. Demattos, J.L. Ives, S.B. Jones, D.R. Listen, A.A. Nagel, D.M. Nason, J.A. Nielsen, A.D. Ramirez, I.A. Shalaby, W.F. White, 5,7-dihydro-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-6h-pyrrolo[3 2-f]-1,2-benzisoxazol-6-one - a potent and centrally-selective inhibitor of acetylcholinesterase with an improved margin of safety, J. Med. Chem. 38 (1995) 2802.
-
(1995)
J. Med. Chem.
, vol.38
, pp. 2802
-
-
Villalobos, A.1
Butler, T.W.2
Chapin, D.S.3
Chen, Y.L.4
Demattos, S.B.5
Ives, J.L.6
Jones, S.B.7
Listen, D.R.8
Nagel, A.A.9
Nason, D.M.10
Nielsen, J.A.11
Ramirez, A.D.12
Shalaby, I.A.13
White, W.F.14
-
27
-
-
0024336329
-
9-Amino-1,2,3,4-tetrahydroacridin-1-ols: Synthesis and evaluation as potential Alzheimer's disease therapeutics
-
G.M. Shutske, F.A. Pierrat, K.J. Kapples, M.L. Cornfeldt, M.R. Szewczak, F.P. Huger, G.M. Bores, V. Haroutunian, K.L. Davis, 9-Amino-1,2,3,4-tetrahydroacridin-1-ols: Synthesis and evaluation as potential Alzheimer's disease therapeutics, J. Med. Chem. 32 (1989) 1805.
-
(1989)
J. Med. Chem.
, vol.32
, pp. 1805
-
-
Shutske, G.M.1
Pierrat, F.A.2
Kapples, K.J.3
Cornfeldt, M.L.4
Szewczak, M.R.5
Huger, F.P.6
Bores, G.M.7
Haroutunian, V.8
Davis, K.L.9
-
28
-
-
0026757043
-
Synthesis and anti-acetylcholinesterase activity of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine hydrochloride (E2020) and related compounds
-
H. Sugimoto, Y. Iimura, Y. Yamanishi, K. Yamatsu, Synthesis and anti-acetylcholinesterase activity of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine hydrochloride (E2020) and related compounds, Bioorg. Med. Chem. Lett. 8 (1992) 871.
-
(1992)
Bioorg. Med. Chem. Lett.
, vol.8
, pp. 871
-
-
Sugimoto, H.1
Iimura, Y.2
Yamanishi, Y.3
Yamatsu, K.4
-
30
-
-
0028197477
-
Tacrine alters the secretion of the beta-amyloid precursor protein in cell lines
-
D.K. Lahiri, S. Lewis, M.R. Farlow, Tacrine alters the secretion of the beta-amyloid precursor protein in cell lines, J. Neuroscience Research 37 (1994) 777.
-
(1994)
J. Neuroscience Research
, vol.37
, pp. 777
-
-
Lahiri, D.K.1
Lewis, S.2
Farlow, M.R.3
-
31
-
-
0030092766
-
Differential effect of tacrine and physostigmine on the secretion of the beta-amyloid precursor protein in cell lines
-
D.K. Lahiri, M.R. Farlow, Differential effect of tacrine and physostigmine on the secretion of the beta-amyloid precursor protein in cell lines, J. Molecular Neuroscience 7 (1996) 41.
-
(1996)
J. Molecular Neuroscience
, vol.7
, pp. 41
-
-
Lahiri, D.K.1
Farlow, M.R.2
-
32
-
-
0030729956
-
The effect of tacrine and leupeptin on the secretion of the beta-amyloid precursor protein in hela cells
-
D.K. Lahiri, M.R. Farlow, K. Sambamurti, C. Nail, The effect of tacrine and leupeptin on the secretion of the beta-amyloid precursor protein in hela cells, Life Sci. 61 (1997) 1985.
-
(1997)
Life Sci.
, vol.61
, pp. 1985
-
-
Lahiri, D.K.1
Farlow, M.R.2
Sambamurti, K.3
Nail, C.4
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