Exercise and interstitial lung disease

Current Opinion in Pulmonary Medicine

Volumn 4, Issue 5, 1998, Pages 272-280

  Markovitz, Gerald H ^a   Cooper, Christopher B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRONCHODILATING AGENT; NITRIC OXIDE;

BREATHING MECHANICS; COMPUTER ASSISTED TOMOGRAPHY; EXERCISE; EXERCISE TEST; EXERCISE TOLERANCE; HUMAN; INHALATION; INTERSTITIAL LUNG DISEASE; LUNG; LUNG CIRCULATION; LUNG VENTILATION PERFUSION RATIO; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW;

BRONCHODILATOR AGENTS; EXERCISE; EXERCISE TEST; EXERCISE TOLERANCE; HUMANS; INHALATION; LUNG; LUNG DISEASES, INTERSTITIAL; NITRIC OXIDE; PULMONARY CIRCULATION; RESPIRATORY MECHANICS; TOMOGRAPHY, X-RAY COMPUTED; VENTILATION-PERFUSION RATIO;

EID: 0032148866     PISSN: 10705287     EISSN: None     Source Type: Journal    
DOI: 10.1097/00063198-199809000-00006     Document Type: Article

References (59)

1. Coultas DB, Aumwalt RE, Black WE, Sobonya RE: The epidemiology of interstitial lung diseases. Am J Respir Crit Care Med 1994, 150:967-972.
2. Cooper CB: Determining the role of exercise in patients with chronic pulmonary disease. Med Sci Sports Exerc 1995, 27:147-157.
3. Anderson DS, Bye PT: Exercise testing in the evaluation of diffuse interstitial lung disease. Aust N Z J Med 1984, 14(suppl 3):762-768.
4. Burdon JGW, Killian KJ, Jones NL: Pattern of breathing during exercise in patients with interstitial lung disease. Thorax 1983, 38:778-784.
5. Hansen JE, Wasserman K: Pathophysiology of activity limitation in patients with interstitial lung disease. Chest 1996, 109:1566-1576.
6. Epler GR, McLoud TC, Gaensler EA, Mikus JP, Carrinton CB: Normal chest roentgenograms in chronic diffuse infiltrative lung disease. N Engl J Med 1978, 298:934-939.
7. Bye PTP, Anderson SD, Woolcock AJ, Young IH, Alison JA: Bicycle endurance performance of patients with interstitial lung disease breathing air and oxygen. Am Rev Respir Dis 1982, 126:1005-1012.
8. Cotes JE, Zejda J, King B: Lung function impairment as a guide to exercise limitation in work-related lung disorders. Am Rev Respir Dis 1988, 137:1089-1093.
9. Baydur A: Pulmonary physiology in interstitial lung disease: recent developments in diagnostic and prognostic implications. Curr Opin Pulm Med 1996, 2:370-375.
10. Robertson TH: Clinical application of pulmonary function and exercise tests in the management of patients with interstitial lung disease. Semin Respir Crit Care Med 1994, 15:1-9.
11. Marciniuk DD, Gallagher CG: Clinical exercise testing in interstitial lung disease. Clin Chest Med 1994, 15:287-303.
12. Murphy DMG, Hall DR, Petersen MR, Lapp NL: The effect of diffuse pulmonary fibrosis on lung mechanics. Bull Eur Physiolpathol Respir 1981, 17:27-41.
13. Todisco T, Matthys H, Cegla UH: Clinical determination of airway closure, comparison of three methods in patients with lung fibrosis. Respiration 1977, 34:197-204.
14. Lahdensuo A, Korpela M: Pulmonary findings in patients with primary Sjogren's syndrome. Chest 1995, 108:316-319.
15. Dayton CS, Schwartz DA, Sprince NL, Yagla SJ, Davis CS, Koechnke RK, et al.: Low-dose methotrexate may cause air trapping in patients with rheumatoid arthritis. Am J Respir Crit Care Med 1995, 151:1189-1193.
16. Koulouris NG, Valta P, Lavoie A, Corbeil C, Chasse M, Brady J, Milic-Emili J: A simple method to detect expiratory flow limitation during spontaneous breathing. Eur Respir J 1995, 8:306-313.
17. Koulouris NG, Dimopoulou I, Valta P, Finkelstein R, Cosio MG, Milic-Emili J: Detection of expiratory flow limitation during exercise in COPD patients. J Appl Physiol 1997, 82:723-731.
18. Baydur A, Milic-Emili J: Expiratory flow limitation during spontaneous breathing: comparison of patients with restrictive and obstructive respiratory disorders. Chest 1997, 112:1017-1023. To our knowledge, this study is the first describing the findings related to the application of the NEP technique to patients with ILD. The authors compare 19 subjects with a variety of restrictive lung disorders (including 5 with various types of ILD) and 20 subjects with chronic obstructive airway disease. Nine subjects with chronic obstructive airway disease and only one subject with restrictive disease (scoliosis) demonstrated evidence of airflow limitation. Of all the subjects with expiratory flow limitation, inspection of the tidal V-V curve was not a reliable means of detecting the limitation.
19. Marciniuk DD, Sridhar G, Clemens RE, Zintel TA, Gallagher CG: Lung volumes and expiratory flow limitation during exercise in interstitial lung disease. J Appl Physiol 1994, 77:963-973.
20. Goldin JG, Aberle DR: Functional imaging of the airways. J Thorac Imaging 1997, 12:29-37. These authors review the technical considerations behind helical HRCT, published experience with functional imaging of small airways, and potential clinical applications of this new technology in exploring the relationships between regional pulmonary function and structure.
21. Goldin JG, McNitt-Gray MF, Johnson T, Lim R, Kleerup EB, Aberle DR: Functional helical high-resolution CT: sensitive test for detecting air trapping due to reversible airway hyperreactivity. Radiology 1995, 197:437.
22. Jones NL, Rebuck AS: Tidal volume during exercise in patients with diffuse fibrosing alveolitis. Bull Eur Physiolpathol Respir 1979, 15:321-327.
23. Harris-Eze AO, Sridhar G, Clemens RE, Zintel TA, Gallagher CG, Marciniuk DD: Role of hypoxemia and pulmonary mechanics in exercise limitation in interstitial lung disease. Am J Respir Crit Care Med 1996, 154:994-1001.
24. Austrian R, McClement JH, Renzetti AD, Donald Aw, Riley RL, Cournand A: Clinical and physiologic features of some types of pulmonary diseases with impairment of alveolar-capillary diffusion: the syndrome of "alveolar-capillary block." Am J Med 1951, 11:667-685.
25. Agusti AGN, Roca J, Gea J, Wagner PD, Xaubet A, Rodriguez-Roisin R: Mechanisms of gas-exchange impairment in idiopathic pulmonary fibrosis. Am Rev Respir Dis 1991, 143:219-225.
26. Jernudd-Wilhelmsson Y, Hornblad Y, Hedenstierna G: Ventilation-perfusion relationships in interstitial lung disease. Eur J Respir Dis 1986, 68:39-49.
27. Gaensler EA, Carrington CB, Coutu RE, Fitzgerald MX: Radiographic-physiologic-pathologic correlations in interstitial pneumonias. Prog Respir Res 1975, 8:223-241.
28. Fulmer JD, Roberts WC, von Gal ER, Crystal RG: Morphologic-physiologic correlates of the severity of fibrosis and degree of cellularity in idiopathic pulmonary fibrosis. J Clin Invest 1979, 63:665-676.
29. Risk C, Epler GR, Gaensler EA: Exercise alveolar-arterial oxygen pressure difference in interstitial lung disease. Chest 1984, 85:69-74.
30. Crystal RG, Fulmer JD, Roberts WC, Moss ML, Line BR, Reynolds HY: Idiopathic pulmonary fibrosis: clinical, histologic, radiographic, physiologic, scintigraphic, cytologic, and biochemical aspects. Ann Intern Med 1976, 85:769-788.
31. Crausman RS, Jennings CA, Tuder RM, Ackerson LM, Irvin CG, King TE Jr: Pulmonary histiocytosis X: pulmonary function and exercise pathophysiology. Am J Respir Crit Care Med 1996, 153:426-435.
32. Agusti C, Xaubet A, Agusti AG, Roca J, Ramirez J, Rodriguez-Roisin R: Clinical and functional assessment of patients with idiopathic pulmonary fibrosis: results of a 3 year follow-up. Eur Respir J 1994, 7:643-650.
33. Tukiainen P, Taskinen E, Holsti P, Korhola O, Valle M: Prognosis of cryptogenic fibrosing alveolitis. Thorax 1983, 38:349-355.
34. Hawrylkiewicz I, Izdebska-Makosa A, Grebska E, Zielinski J: Pulmonary haemodynamics at rest and on exercise in patients with idiopathic pulmonary fibrosis. Bull Eur Physiolpathol Respir 1982, 18:403-410.
35. Enson Y, Thomas HM 3d, Bosken CH, Wood JA, Leroy EC, Blanc WA, et al.: Pulmonary hypertension in interstitial lung disease: relation of vascular resistance to abnormal lung structure. Trans Assoc Am Physicians 1975, 88:248-255.
36. Widimsky J, Riedel M, Stanek V: Central haemodynamics during exercise in patients with restrictive pulmonary disease. Bull Eur Physiolpathol Respir 1977, 13:369-379.
37. Weitzenblum E, Ehrhart M, Rasaholinjanahary J, Hirth C: Pulmonary hemodynamics in idiopathic pulmonary fibrosis and other interstitial pulmonary disease. Respiration 1983, 44:118-127.
38. Campbell EJ, Harris B: Idiopathic pulmonary fibrosis (clinical conference). Arch Intern Med 1981, 141:771-774.
39. Whitelaw WA, Derenne JP, Milic-Emili J: Occlusion pressure as a measure of respiratory center output in conscious man. Respir Physiol 1975, 23:181-199.
40. Hussain SNA, Pardy RL, Dempsey JA: Mechanical impedance as determinant of inspiratory neural drive during exercise in humans. J Appl Physiol 1985, 59:365-375.
41. DiMarco AF, Kelsen SC, Cherniack NS, Gothe B: Occlusion pressure and breathing pattern in patients with interstitial lung disease. Am Rev Respir Dis 1983, 127:425-430.
42. Van Meerhaeghe A, Scano G, Sergysels R, Bran M, De Coster A: Respiratory drive and ventilatory pattern during exercise in interstitial lung disease. Bull Eur Physiolpathol Respir 1981, 17:15-26.
43. Renzi G, Milic-Emili J, Grasino AE: The pattern of breathing in diffuse lung fibrosis. Bull Eur Physiolpathol Respir 1982, 18:461-472.
44. Read DJC: A clinical method for assessing the ventilatory response to carbon dioxide. Australas Ann Med 1967, 16:20-32.
45. 2 rebreathing in patients with chronic interstitial lung disease. Chest 1989, 96:824-830.
46. Bauerle O, Chrusch CA, Younes M: Mechanisms by which COPD affects exercise tolerance. Am Rev Respir Crit Care Med 1998, 157:57-68.
47. O'Donnell DE, Webb KA: Exertional breathlessness in patients with chronic airflow limitation. Am Rev Respir Dis 1993, 148:1351-1357.
48. Make BJ: Pulmonary rehabilitation: myth or reality? Clin Chest Med 1986, 7:519-540.
49. Foster S, Thomas HM: Pulmonary rehabilitation in lung disease other than chronic obstructive pulmonary disease. Am Rev Respir Dis 1990, 141:601-604.
50. Bush A, Busst CM: Cardiovascular function at rest and on exercise in patients with cryptogenic fibrosing alveolitis. Thorax 1988, 43:276-283.
51. Harris-Eze AO, Sridhar G, Clemens RE, Gallagher CG, Marciniuk DD: Oxygen improves maximal exercise performance in interstitial lung disease. Am J Respir Crit Care Med 1994, 150:1616-1622.
52. Morrison DA, Stovall JR: Increased exercise capacity in hypoxemic patients after long-term oxygen therapy. Chest 1992, 102:542-550.
53. Polonski L, Krzywiecki A, Polonska A, Tendera M, Cwiertka P, Oklek K, Wodniecki J: Effects of long-term oxygen therapy in patients with idiopathic pulmonary fibrosis: I. Effect on the course of the primary disease and on pulmonary circulation. Pol Arch Med Wewn 1995, 94:331-336.
54. Polonski L, Kusnierz B, Krzywiecki A, Polonska A, Tendera M, Oklek K, Wodniecki J: Effects of long term oxygen in patients with idiopathic pulmonary fibrosis: II. Effect of oxygen therapy on function of heart ventricles. Pol Arch Med Wewn 1995, 94:337-341.
55. Harris-Eze AO, Sridhar G, Clemens RE, Zintel TA, Gallagher CG, Marciniuk DD: Low-dose nebulized morphine does not improve exercise in interstitial lung disease. Am J Respir Crit Care Med 1995, 152(6 Pt 1):1940-1945.
56. Winning AJ, Hamilton RD, Guz A: Ventilation and breathlessness on maximal exercise patients with interstitial lung disease after local anaesthetic aerosol inhalation. Clin Sci 1988, 74:275-281.
57. Channick RN, Hoch RC, Newhart JW, Johnson FW, Smith CM: Improvement in pulmonary hypertension and hypoxemia during nitric oxide inhalation in a patient with end-stage pulmonary fibrosis. Am J Respir Crit Care Med 1994, 149:811-814.
58. 2 alone.
59. Riley MS, Porszasz J, Miranda J, Engelen MPKJ, Brundage B, Wasserman K: Exhaled nitric oxide during exercise in primary pulmonary hypertension and pulmonary fibrosis. Chest 1997, 111:44-50. The authors prospectively studied nine patients with primary pulmonary hypertension, six patients with pulmonary fibrosis, and 20 normal volunteers. All subjects were studies at rest and during continuous incremental (ramp) cycle ergometry exercise and VNO was measured. In the pulmonary fibrosis group, VNO was significantly lower at rest and failed to rise in patients compared to normal controls. The authors suggest that the low resting VNO in pulmonary fibrosis may be due to loss of normal functional pulmonary capillary bed. The failure to increase VNO during exercise may reflect an inability to recruit the capillary bed.