Expression of cholera toxin subunits in plants

Annals of the New York Academy of Sciences

Volumn 792, Issue , 1996, Pages 50-56

  Hein, Mich B ^a   Yeo, Tiong Chia ^a,b   Wang, Fei ^a   Sturtevant, Ann ^a,c  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c NORTHERN ARIZONA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLERA TOXIN; CHOLERA TOXIN B SUBUNIT; CHOLERA VACCINE; PROTEIN SUBUNIT;

CONFERENCE PAPER; DNA TRANSFECTION; NONHUMAN; PROTEIN EXPRESSION; TOBACCO; TRANSGENIC PLANT;

EID: 0029815722     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1996.tb32490.x     Document Type: Conference Paper

References (19)

1. MASON, H. S., D. M.-K. LAM & C. J. ARNTZEN. 1992. Expression of hepatitis B surface antigen in transgenic plants. Proc. Natl. Acad. Sci. USA 89: 11745-11749.
2. HAQ, T. A., H. S. MASON, J. D. CLEMENTS & C. J. ARNTZEN. 1995. Oral immunization with a recombinant bacterial antigen produced in transgenic plants. Science 268: 714-716.
3. FITCHEN, J., R. N. BEACHY & M. B. HEIN. 1995. Plant virus expressing hybrid coat protein with added murine epitope elicits autoantibody response. Vaccine 13: 1051-1057.
4. ELSON, C. O. & W. EALDING. 1984. Generalized systemic and mucosal immunity in mice after mucosal stimulation with cholera toxin. J. Immunol. 132: 2736-2741.
5. ELSON, C. O. & W. EALDING. 1984. Cholera toxin feeding did not induce oral tolerance in mice and abrogated oral tolerance to an unrelated protein antigen. J. Immunol. 133: 2892-2897.
6. DERTZBAUGH, M. T. & C. O. ELSON. 1993. Comparative effectiveness of cholera toxin B subunit and alkaline phosphatase as carriers for oral vaccines. Infect. Immun. 61: 48-55.
7. JOBLING, M. G. & R. K. HOLMES. 1992. Fusion proteins containing the A2 domain of cholera toxin assemble with B polypeptides of cholera toxin to form immunoreactive and functional holotoxin-like chimeras. Infect. Immun. 60: 4915-4924.
8. HAJISHENGALLIS, G., S. K. HOLLINGSHEAD, T. KOGA & M. W. RUSSELL. 1995. Mucosal immunization with a bacterial protein antigen genetically coupled to cholera toxin A2/B subunits. J. Immunol. 154: 4322-4332.
9. MEKALANOS, J. J., D. J. SWARTZ, G. D. N. PEARSON, N. HARFORD, F. GROYNE & M. DE WILDE. 1983. Cholera toxin genes: Nucleotide sequence, deletion analysis and vaccine development. Nature 306: 551-557.
10. CARRINGTON, J. C. & D. D. FREED. 1990. Cap-independent enhancement of translation by a plant potyvirus 5′ nontranslated region. J. Virol. 4: 1590-1597.
11. CARRINGTON, J. C., D. D. FREED & C.-S. OH. 1990. Expression of potyviral polyproteins in transgenic plants reveals three proteolytic activities required for complete processing. EMBO J. 9: 1347-1353.
12. HASE, C. C., L. S. THAI, M. BOESMAN-FINKELSTEIN, V. L. MAR, W. N. BURNETTE, H. R. KASLOW, L. A. STEVENS, J. MOSS & R. A. FINKELSTEIN. 1994. Construction and characterization of recombinant Vibrio cholerae strains producing inactive cholera toxin analogs. Infect. Immun. 62: 3051-3057.
13. AN, G. 1986. Development of plant promoter expression vectors and their use for analysis of differential activity of nopaline synthase promoter in transformed tobacco cells. Plant Physiol. 81: 86-91.
14. HORSCH, R. B., J. E. FRY, N. L. HOFFMANN, D. EICHHOLTZ, S. G. RODGERS & R. T. FRALEY. 1985. A simple and general method for transferring genes into plants. Science 227: 1229-1231.
15. SPANGLER, B. D. 1992. Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin. Microbiol. Rev. 56: 622-647.
16. SUN, J. B., J. HOLMGREN & C. CZERKINSKY. 1994. Cholera toxin B subunit, an efficient transmucosal carrier-delivery system for induction of peripheral immunological tolerance. Proc. Natl. Acad. Sci. USA 91: 10795-10799.
17. LENCER, W. I., J. B. DE ALMEIDA, S. MOE, J. L. STOW, D. A. AUSIELLO & J. L. MADARA. 1993. Entry of cholera toxin into polarized human intestinal epithelial cells. J. Clin. Invest. 92: 2941-2951.
18. JERTBORN, M., A.-M. SVENNERHOLM & J. HOLMGREN. 1992. Safety and immunogenicity of an oral recombinant cholera B subunit-whole cell vaccine in Swedish volunteers. Vaccine 10: 130-132.
19. PIERCE, N. F., W. C. CRAY & J. B. SACCI. 1982. Oral immunization of dogs with purified cholera toxin, crude cholera, or B subunit: evidence of synergistic protection by antitoxic and antibacterial mechanisms. Infect. Immun. 37: 687-694.