Novel diversity in Th1, Th2 type differentiation of hemagglutinin- specific T cell clones elicited by natural influenza virus infection in three major haplotypes (H-2(b,d,k))

Journal of Immunology

Volumn 161, Issue 3, 1998, Pages 1094-1103

  Graham, Christine M ^a   Smith, Claire A ^a   Thomas, D Brian ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; INFLUENZA VIRUS HEMAGGLUTININ; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 5; LYMPHOKINE; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN RECOGNITION; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GENE REARRANGEMENT; HAPLOTYPE; HELPER CELL; IMMUNOSTIMULATION; INFLUENZA VIRUS; LYMPHOCYTE CLONE; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE RECEPTOR GENE; VIRUS INFECTION;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; CELLS, CULTURED; CLONE CELLS; FEMALE; H-2 ANTIGENS; HAPLOTYPES; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNOPHENOTYPING; INFLUENZA A VIRUS; INTERFERON TYPE II; INTERLEUKIN-5; LYMPHOKINES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED CBA; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; TH1 CELLS; TH2 CELLS;

EID: 0032146226     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Mosmann, T. R., H. Cherwinski, M. W. Bond, M. A. Giedlin, and R. L. Coffman. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted peptides. J. Immunol. 136:2348.
2. Cher, D. J., and T. R. Mosmann. 1987. Two types of murine helper T cell clone. II. Delayed type hypersensitivity is mediated by Th1 clones. J. Immunol. 138:3688.
3. Kim, J., A. Woods, E. Becker-Dunn, and K. Bottomly. 1985. Distinct functional phenotypes of cloned Ia-restricted helper T cells. J. Exp. Med. 162:188.
4. Abbas, A. K., K. M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature 383:787.
5. + T cells. Annu. Rev. Immunol. 12:635.
6. Howard, J. G., C. Hale, and W. L. Chan-Liew. 1980. Immunological regulation of experimental cutaneous leishmaniasis. 1. Immunogenetic aspects of susceptibility to Leishmania tropica in mice. Parasite Immunol. 2:303.
7. Liew, F. Y., and C. A. O' Donnell. 1993. Immunology of leishmaniasis. Adv. Parasitol. 32:161.
8. Reiner, S. L., and R. M. Locksley. 1995. The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 13:151.
9. Roberts, M., B. A. Mock, and J. M. Blackwell. 1993. Mapping of genes controlling Leishmania major infection in CXS recombinant inbred mice. Eur. J. Immunogenet. 20:349.
10. Demant, P., M. Lipoldova, and M. Svobodova. 1996. Resistance to Leishmania major in mice. Science 274:1392.
11. Gorham, J. D., M. L. Guler, R. G. Steen, A. J. Mackey, M. J. Daly, K. Frederick, W. F. Dietrich, and K. M. Murphy. 1996. Genetic mapping of a murine locus controlling development of T helper 1/T helper 2 type responses. Proc. Natl. Acad. Sci. USA 93:12467.
12. Marsh, D. G., J. D. Neely, D. R. Breazeale, B. Ghosh, L. R. Freidhoff, E. Ehrlich-Kautzky, C. Schou, G. Krishnaswamy, and T. H. Beaty. 1994. Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science 264:1152.
13. Postma, D. S., E. R. Bleecker, P. J. Amelung, K. J. Holroyd, J. Xu, C. I. M. Panhuysen, D. A. Meyers, and R. C. Levitt. 1995. Genetic susceptibility to asthma: bronchial hyperresponsiveness coinherited with a major gene for atopy. N. Engl. J. Med. 333:894.
14. + T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol. Today 16: 34.
15. Conboy, I. M., R. H. De Kruyff, K. M. Tate, Z. A. Cao, T. A. Moore, D. T. Umetsu, and P. P. Jones. 1997. Novel genetic regulation of T helper 1 (Th1)/Th2 cytokine production and encephalitogenicity in inbred mouse strains. J. Exp. Med. 185:439.
16. Swain, S. L., A. D. Weinburg, M. English, and G. Huston. 1990. IL-4 directs the development of Th2-like helper effectors. J. Immunol. 145:3796.
17. Hsieh, C.-S., A. B. Heimberger, J. S. Gold, A. O'Garra, and K. M. Murphy. 1992. Differential regulation of T helper phenotype development by interleukins 4 and 10 in αβ T-cell receptor transgenic system. Proc. Natl. Acad. Sci. USA 89:6065.
18. + T cells from TCR transgenic mice. J. Exp. Med. 176:1091.
19. Paul, W. E., and R. A. Seder. 1994. Lymphocyte responses and cytokines. Cell 76:241.
20. + T cells to enhance priming for IFN γ production and diminishes interleukin 4 inhibition of such priming. Proc. Natl. Acad. Sci. USA 90: 10188.
21. + T cells. J. Immunol. 154:5071.
22. Szabo, S. J., N. G. Jacobson, A. S. Dighe, U. Gubler, and K. M. Murphy. 1995. Developmental commitment to the Th2 lineage by extinction of IL-12 signalling. Immunity 2:665.
23. Manetti, R., F. Gerosa, M. G. Giudizi, R. Biagiotti, P. Parronchi, M.-P. Piccinni, S. Sampognaro, E. Maggi, S. Romagnani, and G. Trinchieri. 1994. Interleukin 12 induces stable priming for IFN γ (IFN-γ) production during differentiation of human T helper (Th) cells and transient IFN-γ production in established Th2 cell clones. J. Exp. Med. 179:1273.
24. Magram, J., S. E. Connaughton, R. R. Warrier, D. M. Carvajal, C-y, Wu., J. Ferrante, C. Stewart, U. Sarmiento, D. A. Faherty, and M. K. Gately. 1996. IL-12-deficient mice are defective in IFNγy production and type 1 cytokine responses. Immunity 4:471.
25. Carding, S. R., W. Allan, A. McMickle, and P. C. Doherty. 1993. Activation of cytokine genes in T cells during primary and secondary murine influenza pneumonia. J. Exp. Med. 177:475.
26. Niemialtowski, M. G., and B. T. Rouse. 1992. Predominance of Th1 cells in ocular tissues during herpetic stromal keratitis. J. Immunol. 149:3035.
27. Campbell, I. L., M. V. Hobbs, P. Kemper, and M. B. A. Oldstone. 1994. Cerebral expression of multiple cytokine genes in mice with lymphocytic choriomeningitis. J. Immunol. 152:716.
28. Kanagawa, O., B. A. Vaupel, S. Gayama, G. Koehler, and M. Kopf. 1993. Resistance of mice deficient in IL-4 to retrovirus-induced immunodeficiency syndrome (MAIDS). Science 262:240.
29. Kopf, M., H. Baumann, G. Freer, M. Freudenberg, M. Lamers, T. Kishimoto, R. Zinkernagel, H. Bluethmann, and G. Kohler. 1994. Impaired immune and acute-phase responses in Interleukin-6-deficient mice. Nature 368:339.
30. Smith, C. A., B. C. Barnett, D. B. Thomas, and F. Temoltzin-Palacios. 1991. Structural assignment of novel and immunodominant antigenic sites in the neutralizing antibody response of CBA/Ca mice to influenza hemagglutinin. J. Exp. Med. 173:953.
31. k)-restricted T cell repertoire for influenza hemagglutinin and antigenic drift: six nonoverlapping epitopes on the HA1 subunit are denned by synthetic peptides. J. Exp. Med. 170: 383.
32. d-restricted T cell recognition of influenza hemagglutinin: synthetic peptides identify multiple epitopes corresponding to antibody binding regions of the HA1 subunit. J. Immunol. 143:2663.
33. Smith, C. A., C. M. Graham, and D. B. Thomas. 1994. Immunodominance correlates with TCR (αβ) gene usage in the class II-restricted response to influenza haemagglutinin. Immunology 82:343.
34. Winship, P. R. 1989. An improved method for directly sequencing PCR amplified material using dimethyl sulphoxide. Nucleic Acids Res. 17:1266.
35. Casanova, J.-L., P. Romero, C. Widmann, P. Kourilsky, and J. L. Maryanski. 1991. TCR genes in a series of class I major histocompatibility complex-restricted cytotoxic T lymphocyte clones specific for a Plasmodium berghei non-apeptide: implications for T cell allelic exclusion and antigen specific-repertoire. J. Exp. Med. 174:1371.
36. d haplotype. Immunogenetics 31:333.
37. a-encoded antigens. Nature 332:40.
38. Staerz, U. D., H.-G., Rammensee, D. Benedetto, and M. J. Bevan. 1985. Characterization of a murine mAb specific for an allotypic determinant on T cell antigen receptor. J. Immunol. 134:3994.
39. Roth, M. G., R. W. Compans, L. Giusti, A. R. Davis, D. P. Nayak, M.-J. Gething, and J. Sambrook. 1983. Influenza virus hemagglutinin expression is polarized in cells infected with recombinant SV40 viruses carrying cloned hemagglutinin DNA. Cell 33:435.
40. Stephens, E. B., R. W. Compans, P. Earl, and B. Moss. 1986. Surface expression of viral glycoproteins is polarized in epithelial cells infected with recombinant vaccinia viral vectors. EMBO J. 5:237.
41. Pfeiffer, C., J. Stein, S. Southwood, H. Ketelaar, A. Sette, and K. Bottomly. 1995. Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo. J. Exp. Med. 181:1569.
42. + T cells. J. Exp. Med. 182:1591.