A developmental stage-specific promoter directs germline transcription of Dβj̄ gene segments in precursor T lymphocytes

Journal of Immunology

Volumn 161, Issue 3, 1998, Pages 1399-1405

  Sikes, Michael L ^a   Gomez, Key J ^a   Song, Jing ^a   Oltz, Eugene M ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; GENE LOCUS; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; T LYMPHOCYTE; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION;

ANIMALS; BINDING SITES; CELL DIFFERENTIATION; CELL LINE; DNA-BINDING PROTEINS; GATA3 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE REARRANGEMENT, BETA-CHAIN T-CELL ANTIGEN RECEPTOR; GENES, T-CELL RECEPTOR BETA; MICE; MICE, INBRED BALB C; PEPTIDE CHAIN INITIATION, TRANSLATIONAL; PROMOTER REGIONS (GENETICS); RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SP1 TRANSCRIPTION FACTOR; STEM CELLS; T-LYMPHOCYTE SUBSETS; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

EID: 0032145405     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Sleckman, B. P., J. R. Gorman, and F. W. Alt. 1996. Accessibility control of antigen-receptor variable-region gene assembly: role of cis acting elements. Annu. Rev. Immunol. 14:459.
2. Kronenberg, M., G. Siu, L. E. Hood, and N. Shastri. 1986. The molecular genetics of the T-cell antigen receptor and T-cell antigen recognition. Annu. Rev. Immunol. 4:529.
3. Yancopolous, G. D., and F. W. Alt. 1995. Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell 40:271.
4. Lennon, G. G., and R. P. Perry. 1990. The temporal order of appearance of transcripts from unrearranged and rearranged Ig genes in murine fetal liver. J. Immunol. 144:1983.
5. Royer, H. D., D. Ramarli, O. Acuto, T. J. Campen, and E. L. Reinherz. 1985. Genes encoding the T-cell receptor α and β subunits are transcribed in an ordered manner during intrathymic ontogeny. Proc. Natl. Acad. Sci. USA 82:5510.
6. Ferner, P., B. Krippl, T. K. Blackwell, A. J. W. Furley, H. Suh, A. Winoto, W. D. Cook, L. Hood, F. Constantini, and F. W. Alt. 1990. Separate elements control DJ and VDJ rearrangements in a transgenic recombination substrate. EMBO J. 9:117.
7. Oltz, E. M., F. W. Alt, W.-C. Lin, J. Chen, G. Taccioli, S. Desiderio, and G. Rathbun. 1993. A V(D)J recombinase-inducible B-cell line: role of transcriptional enhancer elements in directing V(D)J recombination. Mol. Cell. Biol. 13:6223.
8. Okada, A., M. Mendelsohn, and F. Alt. 1994. Differential activation of transcription vs recombination of transgenic TCR β variable region gene segments in B and T lineage cells. J. Exp. Med. 180:261.
9. Capone, M., F. Watrin, C. Fernex, B. Horvat, B. Krippl, L. Wu, R. Scollay, and P. Ferner. 1993. TCRβ and TCRα gene enhancers confer tissue- and stagespecificity on V(D)J recombination events. EMBO J. 12:4335.
10. Lauzurica, P., and M. S. Krangel. 1994. Temporal and lineage-specific control of TCR α/δ gene rearrangement by TCR α and δ enhancer. J. Exp. Med. 149: 1913.
11. Serwe, M., and F. Sablitzky. 1993. V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer. EMBO J. 12:2321.
12. Bories, J.-C., J. Demengeot, L. Davidson, and F. W. Alt. 1996. Gene-targeted deletion and replacement mutations of the T-cell receptor β-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility. Proc. Natl Acad. Sci. USA 93:7871.
13. Bouvier, G., F. Watrin, M. Naspetti, C. Verthuy, P. Nazuet, and P. Ferrier. 1996. Deletion of the mouse T-cell receptor β gene enhancer blocks αβ T-cell development. Proc. Natl. Acad. Sci USA 93:7877.
14. B. P. Sleckman, C. G. Bardon, R. Ferrini, L. Davidson, and F. W. Alt. 1997. Function of the TCRα enhancer in αβ and γδ T cells. Immunity 7:505.
15. Xu, Y., L. Davidson, F. W. Alt, and D. Baltimore. 1996. Deletion of the Igκ light chain intronic enhancer/matrix attachment region impairs but does not abolish VκJκ rearrangement. Immunity 4:377.
16. Jenuwein, T., W. C. Forrester, L. A. Fernandez-Herrero, G. Laible, M. Dull, and R. Grosschedl. 1997. Extension of chromatin accessibility by nuclear matrix attachment regions. Nature 385:269.
17. Lee, N. E., and M. M. Davis. 1988. TCR β-chain genes in BW5147 and other AKR tumors. J. Immunol. 140:1665.
18. Chien, Y.-h., D. M. Becker, T. Lindsten, M. Okamura, D. I. Cohen, and M. M. Davis. 1984. A third type of murine TCR gene. Nature 312:31.
19. + thymocyte differentiation. J. Immunol. 160:1256.
20. McDougall, S., C. L. Peterson, and K. Calame. 1988. A transcriptional enhancer 3′ of Cβ2 in the TCR β locus. Science 241:205.
21. Henthorn, P., P. Zervos, M. Raducha, H. Harris, and T. Kadesch. 1988. Expression of a human placental alkaline phosphatase gene in transfected cells: use as a reporter for studies of gene expression. Proc. Natl Acad. Sci. USA 85:8047.
22. Smith, M. 1985. In vitro mutagenesis. Ann. Rev. Genet. 19:423.
23. Mironov, V. N., M. V. Montagu, and D. Inze. 1995. High throughput RNase protection assay. Nucleic Acids Res. 23:3359.
24. Ballard, D. W., W. H. Walker, S. Doerre, P. Sista, J. A. Molitor, E. P. Dixon, N. E. Peffer, M. Hannink, and W. C. Greene. 1990. The v-rel oncogene encodes a κB enhancer-binding protein that inhibits NF-κB function. Cell 63:803.
25. Scherer, D. C., J. A. Brockman, H. H. Bendall, G. M. Zhang, D. W. Ballard, and E. M. Oltz. 1996. Corepression of RelA and c-rel inhibits immunoglobulin κ gene transcription and rearrangement in precursor B lymphocytes. Immunity 5:563.
26. Jones, K. A., J. T. Kadonaga, P. A. Luciw, and R. Tjian. 1986. Activation of the AIDS retrovirus promoter by the cellular transcription factor, Spl. Science 232:755.
27. Henderson, A. J., S. McDougall, J. Leiden, and K. L. Calame. 1994. GATA elements are necessary for the activity and tissue specificity of the T-cell receptor beta-chain transcriptional enhancer. Mol. Cell. Biol. 14:4286.
28. Brockman, J. A., D. C. Scherer, T. A. McKinsey, S. M. Hall, X. Qi, W. U. Lee, and D. W. Ballard. 1995. Coupling of a signal-response domain in IκBα to multiple pathways for NF-κB activation. Mol. Cell Biol 15:2809.
29. β gene segments of the murine T-cell antigen receptor. Nature 311:344.
30. Shinkai, Y., G. Rathbun, K.-P. Lam, E. M. Oltz, V. Stewart, M. Mendelsohn, J. Charron, M. Datta, F. Young, A. M. Stall, and F. W. Alt. 1992. Rag-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68:855.
31. Nelsen, B., G. Tian, B. Erman, J. Gregoire, R. Maki, B. Graves, and R. Sen. 1993. Regulation of lymphoid-specific immunoglobulin μ heavy chain gene enhancer by ETS-domain proteins. Science 261:82.
32. Muthusamy, N., K. Barton, and J. M. Leiden. 1995. Defective activation and survival of T cells lacking the Ets-1 transcription factor. Nature 377:639.
33. Sack, M. N., D. L. Disch, H. A. Rockman, and D. P. Kelly. 1997. A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program. Proc. Natl. Acad. Sci. USA 94:6438.
34. Orkin, S. H. 1992. GATA-binding transcription factors in hematopoietic cells. Blood 80:575.
35. Marine, J., and A. Winoto. 1991. The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements. Proc. Natl. Acad. Sci. USA 88:7284.
36. Ting, C.-N., M. C. Olson, K. P. Barton, and J. M. Leiden. 1996. Transcription factor GATA-3 is required for development of the T-cell lineage. Nature 384:474.
37. Boothby, M., H.-C. Liou, and L. H. Glimcher. 1989. Differences in DNA sequence specificity among MHC class II X box binding proteins. J. Immunol. 142:1005.
38. Ko, L. J., M. Yamamoto, M. W. Leonard, K. M George, P. Ting, and J. D. Engel. 1991. Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor δ gene enhancer. Mol. Cell. Biol 11:2778.
39. Villey, I., P. Quartier, F. Selz, and J.-P. de Villartay. 1997. Germ-line transcription and methylation status of the TCR-Jα locus in its accessible configuration: Eur. J. Immunol. 27:1619.
40. Fulton, R., and B. Van Ness. 1993. κ immunoglobulin promoters and enhancers display developmentally controlled interactions. Nucleic Acids Res. 21:4941.
41. Kottman, A. H., B. Zevnick, M. Welte, P. J. Nielson, and G. Kohler. 1994. A second promoter and enhancer element within the immunoglobulin heavy chain locus. Eur. J. Immunol. 24:817.
42. H gene segment rearrangements in lymphoid cells. Nature 312:418.
43. Clark, S. P., Y. Yoshikai, S. Taylor, G. Siu, L. Hood, and T. W. Mak. 1994. Identification of a diversity segment of human T-cell receptor β-chain, and comparison with the analogous murine element. Nature 311:387.