Epithelial aquaporins

Current Opinion in Cell Biology

Volumn 10, Issue 4, 1998, Pages 435-442

  Deen, Peter MT ^a   Van Os, Carel H ^a  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AQUAPORIN; MEMBRANE PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; EPITHELIUM CELL; FLUID BALANCE; HUMAN; HUMAN CELL; KIDNEY CELL; KNOCKOUT MOUSE; NEPHROGENIC DIABETES INSIPIDUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; RAT; REVIEW;

ANIMALIA; MAMMALIA;

EID: 0032145136     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(98)80055-0     Document Type: Article

References (69)

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61. Nielsen S, Terris J, Andersen D, Ecelbarger C, Frokiaer J, Jonassen T, Marples D, Knepper MA, Petersen JS. Congestive heart failure in rats is associated with increased expression and targeting of aquaporin-2 water channel in collecting duct. of outstanding interest Proc Natl Acad Sci USA. 94:1997;5450-5455 In this study, it is shown for the first time that the increased water retention in rats with congestive heart failure coincides with a marked increase in AQP2 expression and that nearly all AQP2 is located in the apical membrane of collecting duct cells (see also Xu 1997 [62]).
62. Xu DL, Martin PY, Ohara M, Stjohn J, Pattison T, Meng XZ, Morris K, Kim JK, Schrier RW. Upregulation of aquaporin-2 water channel expression in chronic heart failure rat. of outstanding interest J Clin Invest. 99:1997;1500-1505 In this study, it is shown for the first time that the increased water retention in rats with congestive heart failure co-incides with a marked increase in AQP2 mRNA and protein expression and that nearly all AQP2 is located in the apical membrane of collecting duct cells. In addition, administration of the V2 vasopressin receptor antagonist OPC31260 to these rats appeared to reverse totally not only the increase and changed subcellular distribution of AQP2, but also the decreased diuresis, increased urine osmolality and fall in plasma osmolality (see also Nielsen 1997 [61]).
63. Ecelbarger CA, Nielsen S, Olson BR, Murase T, Baker EA, Knepper MA, Verbalis JG. Role of renal aquaporins in escape from vasopressin-induced antidiuresis in rat. of outstanding interest J Clin Invest. 99:1997;1852-1863 In this study, it is shown that, in rats, the increase in water excretion after a water load despite sustained administration of vasopressin is associated with a marked reduction of AQP2 protein and mRNA levels. This result suggests that this 'escape' from vasopressin-induced antidiuresis is, at least in part, attributable to a vasopressin-independent decrease in AQP2 expression levels.
64. Knepper MA, Inoue T. Regulation of aquaporin-2 water channel trafficking by vasopressin. Curr Opin Cell Biol. 9:1997;560-564.
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