Comparative mitogenic potencies of EGF and TGFα and their dependence on receptor-limitation versus ligand-limitation

Medical and Biological Engineering and Computing

Volumn 36, Issue 4, 1998, Pages 499-507

  Reddy, Cartikey C ^a,c,e,f   Wells, Alans ^a,b,c,g,h   Lauffenburger, Douglas A ^a,d,i  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b Baptist Health   (United States)

^c BIRMINGHAM VA MEDICAL CENTER   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e BAYER CORPORATION   (United States)

^f INDIAN INSTITUTE OF TECHNOLOGY MADRAS   (India)

^g KAROLINSKA INSTITUTE   (Sweden)

^h UNIVERSITY OF CALIFORNIA   (United States)

ⁱ UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Epidermal growth factor; Mitogenic potency; Transforming growth factor

Indexed keywords

CELLS; DISSOCIATION; POLYPEPTIDES;

EPIDERMAL GROWTH FACTOR; LIGANDS; MITOGENIC POTENCY; TRANSFORMING GROWTH FACTOR;

BIOMEDICAL ENGINEERING;

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; LIGAND; MITOGENIC AGENT; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL STRAIN 3T3; FIBROBLAST; HORMONE RESPONSE; MITOGENESIS; MOUSE; NONHUMAN;

ANIMALS; CELL CULTURE TECHNIQUES; DOWN-REGULATION; EPIDERMAL GROWTH FACTOR; HUMANS; MICE; MITOSIS; RECEPTOR, EPIDERMAL GROWTH FACTOR; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 0032128152     PISSN: 01400118     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02523222     Document Type: Article

References (21)

1. AARONSON, S. A. (1991): 'Growth factors and cancer, Science, 254, pp. 1146-1153
2. CAMPBELL, I. D., BARON, M., COOKE, R. M., DUDGEON, T. J., FALLON, A., HARVEY, T. S. and TAPPIN, M. J. (1990): 'Structure-function relationships in epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-α), Biochem. Pharmacol., 40, pp. 35-40
3. CARPENTER, G. and WAHL, M. I. (1990): 'The epidermal growth factor family' in SPORN, M. B. and ROBERTS, A. B. (Eds.): Peptide growth factors and their receptors (Springer-Verlag, Berlin, Heidelberg), pp. 69-171
4. CHEN, P., GUPTA, K. and WELLS, A. (1994): 'Cell movement elicited by the epidermal growth factor receptor requires kinase and autophosphorylation but is separable from mitogenesis, J. Cell Biol., 124, pp. 547-555
5. DECKER, S. J. (1990): 'Epidermal growth factor and transforming growth factor-alpha induce differential processing of the epidermal growth factor receptor,' Biochem. Biophys. Res. Comm., 166, pp. 615-621
6. EBNER, R. and DERYNCK, R. (1991): 'Epidermal growth factor and transforming growth factor-α: differential intracellular routing and processing of ligand receptor complexes, Cell Regul., 2, pp. 599-612
7. FRENCH, A. R., SUDLOW, G. P., WILEY, H. S. and LAUFFENBURGER, D. A. (1994): 'Postendocytic trafficking of epidermal growth factor-receptor complexes is mediated through saturable and specific endosomal interactions,' J. Biol. Chem., 269, pp. 15749-15755
8. FRENCH, A. R., TADAKI, D. K., NIYOGI, S. K. and LAUFFENBURGER, D. A. (1995): 'Intracellular trafficking of epidermal growth factor family ligands is directly influenced by the pH sensitivity of the receptor/ligand interaction,' J. Biol. Chem., 270, pp. 4334-4340
9. HERBST, J. J., OPRESKO, L. K., WALSH, B. J., LAUFFENBURGER, D. A. and WILEY, H. S. (1994): 'Regulation of postendocytic trafficking of the epidermal growth factor through endosomoal retention,' J. Biol. Chem., 269, pp. 12865-12873
10. KORC, M. and FINMAN, J. E. (1989): 'Attenuated processing of epidermal growth factor in the face of marked degradation of transforming growth factor-α, J. Biol. Chem., 264, pp. 14990-14999
11. KURTEN, R. C., CADENA, D. L. and GILL, G. N. (1996): 'Enhanced degradation of EGF receptors by a sorting nexin, SNX1, Science, 272, pp. 1008-1010
12. LAUFFENBURGER, D. A., CHU, L., FRENCH, A., OEHRTMAN, G., REDDY, C., WELLS, A., NIYOGI, S. and WILEY, H. S. (1996): 'Engineering dynamics of growth factor and other therapeutic ligands,' Biotech. Bioneng., 52, pp. 61-80
13. LAX, I., JOHNSON, A., HOWK, R., SAP, J., BELLOT, F., WINKLER, M., ULLRICH, A., VENNSTROM, B., SCHLESSINGER, J. and GIVOL, D. (1988): 'Chicken epidermal growth factor (EGF) receptor: cDNA cloning, expression in mouse cells and differential binding of EGF and transforming growth factor alpha,' Mol. Cell. Biol., 8, pp. 1970-1978
14. MASSAGUE, J. (1983): 'Epidermal growth factor-like transforming growth factor. II. Interaction with epidermal growth factor receptors in human placenta membranes and A431 cells, J. Biol. Chem., 258, pp. 13614-13620
15. 1H NMR assignments and identification of two antiparallel β-sheets in the solution structure of recombinant hTGF-α,' Proc. Natl. Acad. Sci. USA, 86, pp. 1519-1523
16. PRUSS, R. M. and HERSCHMAN, H. R. (1977): 'Variants of 3T3 cells lacking mitogenic response to epidermal growth factor,' Proc. Natl. Acad. Sci. USA, 74, pp. 3918-3921
17. REDDY, C. C., WELLS, A. and LAUFFENBURGER, D. A. (1994): 'Proliferative response of fibroblasts expressing internalization-deficient epidermal growth factor (EGF) receptors is altered via differential EGF depletion effect,' Biotechnol. Prog., 10, pp. 377-384
18. REDDY, C. C., WELLS, A. and LAUFFENBURGER, D. A. (1996a): 'Receptor-mediated effects on ligand availability influence relative mitogenic potencies of epidermal growth factor and transforming growth factor α,' J. Cell. Physiol., 166, pp. 512-522
19. REDDY, C. C., NIYOGI, S. K., WELLS, A., WILEY, H. S. and LAUFFENBURGER, D. A. (1996b): 'Engineering epidermal growth factor for enhanced mitogenic potency,' Nature Biotech., 14, pp. 1696-1699
20. WELLS, A., WELSH, J. B., LAZAR, C. S., WILEY, H. S., GILL, G. N. and ROSENFELD, M. G. (1990): 'Ligand-induced transformation by a non-internalizing epidermal growth factor receptor? Science, 247, pp. 962-964
21. WILEY, H. S., HERBST, J. J., WALSH, J. B., LAUFFENBURGER, D. A., ROSENFELD, M. G. and GILL, G. N. (1991): 'The role of tyrosine kinase activity in endocytosis, compartmentation and down-regulation of the epidermal growth factor receptor,' J. Biol. Chem., 266, pp. 11083-11094