A genetic deficiency that spans the flightin gene of Drosophila melanogaster affects the ultrastructure and function of the flight muscles

Journal of Experimental Biology

Volumn 201, Issue 13, 1998, Pages 2033-2044

  Vigoreaux, Jim O ^a   Hernandez, Carmen ^a   Moore, Jeff ^a   Ayer, Gretchen ^a   Maughan, David ^a  

^a UNIVERSITY OF VERMONT   (United States)

Author keywords

Drosophila melanogaster; Flight muscle; Flightin; Muscle mutant; Mutation; Stretch activation

Indexed keywords

DROSOPHILA MELANOGASTER;

EID: 0032125909     PISSN: 00220949     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. AN, H. AND MOGAMI, K. (1996). Isolation of 88F actin mutants of Drosophila melanogaster and possible alterations in the mutant actin structures. J. molec. Biol. 260, 492-505.
2. ASHBURNER, M. (1989). Drosophila, A Laboratory Manual. New York: Cold Spring Harbor Laboratory.
3. BAINBRIDGE, S. P. AND BOWNES, M. (1981). Staging the metamorphosis of Drosophila melanogaster. J. Embryol. exp. Morph. 66, 57-80.
4. BEALL, C. J. AND FYRBERG, E. (1991). Muscle abnormalities in Drosophila melanogaster heldup mutants are caused by missing or aberrant troponin-I isoforms. J. Cell Biol. 114, 941-951.
5. BEALL, C. J., SEPANSKI, M. A. AND FYRBERG, E. A. (1989). Genetic dissection of Drosophila myofibril formation: effects of actin and myosin heavy chain null alleles. Genes & Dev. 3, 131-140.
6. BERNSTEIN, S. I., O'DONNELL, P. T. AND CRIPPS, R. M. (1993). Molecular genetic analysis of muscle development, structure and function in Drosophila. Int. Rev. Cytol. 143, 63-152.
7. CRIPPS, R. M., BALL, E., STARK, M., LAWN, A. AND SPARROW, J. C. (1994). Recovery of dominant, autosomal flightless mutants of Drosophila melanogaster and identification of a new gene required for normal muscle structure and function. Genetics 137, 151-164.
8. DEAK, I. L., BELLAMY, P. R., BIENZ, M., DUBUIS, Y., FENNER, E., GOLLIN, M., RAHMI, A., RAMP, T., REINHARDT, C. A. AND COTTON, B. (1982). Mutations affecting the indirect flight muscles of Drosophila melanogaster. J. Embryol. exp. Morph. 69, 61-81.
9. DE FRUTOS, R., KIMURA, K. AND PETERSON, K. (1990). In situ hybridization of Drosophila polytene chromosomes with digoxigenin-dUTP labeled probes. Methods molec. Cell Biol. 2, 32-36.
10. DICKINSON, M. H., HYATT, C. J., LEHMANN, F.-O., MOORE, J. R., REEDY, M. C., SIMCOX, A., TOHTONG, R., VIGOREAUX, J. O., YAMASHITA, H. AND MAUGHAN, D. W. (1997). Phosphorylation-dependent power output of transgenic flies: an integrated study. Biophys. J. 73, 3122-3134.
11. DRUMMOND, D. R., HENNESSEY, E. S. AND SPARROW, J. C. (1991). Characterisation of missense mutations in the Act88F gene of Drosophila melanogaster. Molec. gen. Genet. 226, 70-80.
12. DRUMMOND, D. R., PECKHAM, M., SPARROW, J. C. AND WHITE, D. C. S. (1990). Alteration in crossbridge kinetics caused by mutations in actin. Nature 348, 440-442.
13. EPSTEIN, H. F. AND FISCHMAN, D. A. (1991). Molecular analysis of protein assembly in muscle development. Science 251, 1039-1044.
14. FYRBERG, E. C., FYRBERG, C., BEALL, C. AND SAVILLE, D. L. (1990a). Drosophila melanogaster troponin-T mutations engender three distinct syndromes of myofibrillar abnormalities. J. molec. Biol. 216, 657-675.
15. FYRBERG, E., KELLY, M., BALL, E., FYRBERG, C. AND REEDY, M. C. (1990b). Molecular genetics of Drosophila alpha-actinin: Mutant alleles disrupt Z disc integrity and muscle insertions. J. Cell Biol. 110, 1999-2011.
16. HOMYK, T. AND EMERSON, C. P. (1988). Functional interactions between unlinked muscle genes within haploinsufficient regions of the Drosophila genome. Genetics 119, 105-121.
17. HYATT, C. J. AND MAUGHAN, D. W. (1994). Fourier analysis of wing beat signals: Assessing the effects of genetic alterations of flight muscle structure in Diptera. Biophys. J. 67, 1149-1154.
18. INGBER, D. E., DIKE, L., HANSEN, L., KARP, S., LILEY, H., MANIOTIS, A., MCNAMEE, H., MOONEY, D., PLOPPER, G., SIMS, J. AND WANG, N. (1994). Cellular tensegrity: Exploring how mechanical changes in the cytoskeleton regulate cell growth, migration and tissue pattern during morphogenesis. Int. Rev. Cytol. 150, 173-224.
19. ISING, G. AND BLOCK, K. (1981). Derivation-dependent distribution of insertion sites for a Drosophila transposon. Cold Spring Harbor Symp. quant. Biol. 45, 527-544.
20. ISING, G. AND BLOCK, K. (1984). A transposon as a cytogenetic marker in Drosophila melanogaster. Molec. gen. Genet. 196, 6-16.
21. KAWAI, M. AND BRANDT, P. W. (1980). Sinusoidal analysis: a high resolution method for correlating biochemical reactions with physiological processes in activated skeletal muscles of rabbit, frog and crayfish. J. Muscle Res. Cell Motil. 1, 279-303.
22. KREUZ, A. J., SIMCOX, A. AND MAUGHAN, D. (1996). Alterations in flight muscle ultrastructure and function in Drosophila tropomyosin mutants. J. Cell Biol. 135, 673-687.
23. KRONERT, W. A., O'DONNELL, P. T., FIECK, A., LAWN, A., VIGOREAUX, J. O., SPARROW, J. C. AND BERNSTEIN, S. I. (1995). Defects in the Drosophila myosin rod permit sarcomere assembly but cause flight muscle degeneration. J. molec. Biol. 249, 111-125.
24. LEHMANN, F.-O. AND DICKINSON, M. H. (1997). The changes in power requirements and muscle efficiency during elevated flight force production in the fruit fly Drosophila. J. exp. Biol. 200, 1133-1143.
25. MOGAMI, K. AND HOTTA, Y. (1981). Isolation of Drosophila flightless mutations which affect myofibrillar proteins of indirect flight muscle. Molec. gen. Genet. 183, 409-417.
26. O'BRIEN, S. J. AND MACINTYRE, R. J. (1978). Genetics and biochemistry of enzymes and specific proteins of Drosophila. In The Genetics and Biology of Drosophila, vol. 2a (ed. M. Ashburner and T. R. F. Wright), pp. 395-551. London: Academic Press.
27. PRINGLE, J. W. S. (1978). Stretch activation of muscle: function and mechanism. Proc. R. Soc. Lond. B 201, 107-130.
28. REEDY, M. C. AND BEALL, C. (1993). Ultrastructure of developing flight muscle in Drosophila. I. Assembly of myofibrils. Devl. Biol. 160, 443-465.
29. SAMBROOK, J., FRITSCH, E. F. AND MANIATIS, T. (1989). Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratories.
30. SCHACHAT, F. H., CANINE, A. C., BRIGGS, M. M. AND REEDY, M. C. (1985). The presence of two skeletal muscle α-actinins correlates with troponin-tropomyosin expression and Z-line width. J. Cell Biol. 101, 1001-1008.
31. SQUIRE, J. M. (1986). Muscle: Design, Diversity and Disease. Menlo Park, CA: Benjamin/Cummings Publishing Co. 381pp.
32. TOHTONG, R., RODRIGUEZ, D., MAUGHAN, D. AND SIMCOX, A. (1997). Analysis of cDNAs encoding Drosophila melanogaster myosin light chain kinase. J. Muscle Res. Cell Motil. 18, 43-56.
33. TOHTONG, R., YAMASHITA, H., GRAHAM, M., HAEBERLE, J., SIMCOX, A. AND MAUGHAN, D. (1995). Impairment of muscle function caused by mutations of phosphorylation sites in myosin regulatory light chain. Nature 374, 650-655.
34. VIGOREAUX, J. O. (1994). The muscle Z band: Lessons in stress management. J. Muscle Res. Cell Motil. 15, 237-255.
35. VIGOREAUX, J. O., SAIDE, J. D. AND PARDUE, M. L. (1991). Structurally different Drosophila striated muscles utilize distinct variants of Z band-associated proteins. J. Muscle Res. Cell Motil. 12, 340-354.
36. VIGOREAUX, J. O., SAIDE, J. D., VALGEIRSDOTTIR, K. AND PARDUE, M. L. (1993). Flightin, a novel myofibrillar protein of Drosophila stretch-activated muscles. J. Cell Biol. 121, 587-598.
37. WARMKE, J. W., KREUZ, A. J. AND FALKENTHAL, S. (1989). Colocalization to chromosome bands 99E1-3 of the Drosophila melanogaster myosin light chain-2 gene and a haplo-insufficient locus that affects flight behavior. Genetics 122, 139-151.
38. WARMKE, J., YAMAKAWA, M., MOLLOY, J., FALKENTHAL, S. AND MAUGHAN, D. (1992). Myosin light chain-2 mutation affects flight, wing beat frequency and indirect flight muscle contraction kinetics in Drosophila. J. Cell Biol. 119, 1523-1539.
39. WEBER, K. E. (1988). An apparatus for selection of flying speed. Drosophila Inf. Ser. 67, 92-93.
40. ZHAO, Y. AND KAWAI, M. (1993). The effect of lattice spacing change on cross-bridge kinetics in chemically skinned rabbit psoas muscle fibers. II. Elementary steps affected by the spacing change. Biophys. J. 64, 197-210.