Processing of neuropeptide Y and somatostatin in human cerebrospinal fluid as monitored by radioimmunoassay and mass spectrometry

Peptides

Volumn 19, Issue 7, 1998, Pages 1137-1146

  Nilsson, Carol ^a   Westman, Ann ^a   Blennow, Kaj ^a   Ekman, Rolf ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Cerebrospinal fluid; Mass spectrometry; Neuropeptides; Radioimmunoassay

Indexed keywords

NEUROPEPTIDE Y; NEUROPEPTIDE Y [18-36]; SOMATOSTATIN 28; SOMATOSTATIN DERIVATIVE; SOMATOSTATIN[15-28]; UNCLASSIFIED DRUG;

ARTICLE; CEREBROSPINAL FLUID; DISULFIDE BOND; HUMAN; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN STABILITY; RADIOIMMUNOASSAY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

AMINO ACIDS; AMINOPEPTIDASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; MOLECULAR WEIGHT; NEUROPEPTIDE Y; PEPTIDE FRAGMENTS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RADIOIMMUNOASSAY; SOMATOSTATIN; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TIME FACTORS;

EID: 0032122374     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(98)00071-0     Document Type: Article

References (37)

1. Ågren H., Lundqvist G. Low levels of somatostatin in human CSF mark depressive episodes. Psychoneuroendocrinology. 9:1984;233-248.
2. Banki C.M., Karmacsi L., Bissette G., Nemeroff C.B. CSF corticotropin releasing hormone, somatostatin, and thyrotropin releasing hormone in schizophrenia. Psychiatry Res. 43:1992;13-21.
3. Bard J.A., Walker M.W., Branchek T.A., Weinshank R.L. Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. J. Biol. Chem. 45:1995;26762-26765.
4. 18-36. Int. J. Peptide Protein Res. 33:1989;11-15.
5. Corness J.D., Demchyshyn L.L., Seeman P., et al. A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides. FEBS Lett. 321:1993;279-284.
6. Davis K.L., Davidson M., Yang R.-K., et al. CSF somatostatin in Alzheimer's disease, depressed patients, and control subjects. Biol. Psychiatry. 24:1988;710-712.
7. Demchyshyn L.L., Srikant C.B., Sunahara R.K., et al. Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20. Mol. Pharmacol. 43:1993;894-901.
8. Edvinsson L., Minthon L., Ekman R., Gustafson L. Neuropeptides in cerebrospinal fluid of patients with Alzheimer's disease and dementia with frontotemporal lobe degeneration. Dementia. 4:1993;167-171.
9. Ekman R., Juhasz P., Heilig M., Ågren H., Costello C.E. Novel neuropeptide Y processing in human cerebrospinal fluid from depressed patients. Peptides. 17:1996;1107-1111.
10. Gerald C., Walker M.W., Criscione L., et al. A receptor subtype involved in neuropeptide-Y-induced food intake. Nature. 382:1996;168-171.
11. Harajiri S., Wood G., Desiderio D.M. Analysis of proenkephalin A, proopiomelanocortin and protachykinin neuropeptides in human lumbar cerebrospinal fluid by reversed-phase high-performance liquid chromatography (HPLC), radioimmunoassay and enzymolysis. J. Chrom. Biomed. Appl. 575:1992;213-222.
12. Heilig M., Ekman R. Chronic parenteral antidepressant treatment in rats: unaltered levels and processing of neuropeptide Y (NPY) and corticotropin-releasing hormone (CRH). Neurochem. Int. 26:1995;351-355.
13. Heilig M., Sjögren M., Blennow K., Ekman R., Wallin A. Cerebrospinal fluid neuropeptides in Alzheimer's disease and vascular dementia. Biol. Psychiatry. 38:1995;210-216.
14. Hyyppä M.T., Alaranta H., Lahtela K., et al. Neuropeptide converting enzyme activities in CSF of low back pain patients. Pain. 43:1990;163-168.
15. Li Y.-M., Brostedt P., Hjertén S., Nyberg F., Silberring J. Capillary liquid chromatography-fast atom bombardment mass spectrometry using a high-resolving cation exchanger, based on a continuous chromatographic matrix: application to studies on neuropeptide peptidases. J. Chromatogr. B. 664:1995;426-430.
16. Lindh C., Thörnwall M., Hansen A.-C., Post C., Gordh T., Ordeberg;, Nyberg N. Neuropeptide-converting enzymes in cerbrospinal fluid. Acta Orthop. Scand. 67:1996;189-192.
17. Malessa R., Heimbach M., Brockmeyer N.H., Hengge U., Rascher W., Michel M.C. Increased neuropeptide Y-like immunoreactivity in cerebrospinal fluid and plasma of human immunodeficiency virus-infected patients: relation to HIV encephalopathy. J. Neurol. Sci. 136:1996;154-158.
18. Minthon L., Edvinsson L., Ekman R., Gustafson L. Reduced lumbar cerebrospinal fluid somatostatin levels in Alzheimer's disease and dementia with frontotemporal degeneration. Dementia. 2:1991;273-277.
19. Molchan S.E., Hill J.L., Martinez R.A., et al. CSF somatostatin in Alzheimer's disease and major depression relationship to hypothalamic-pituitary-adrenal axis and clinical measures . Psychoneuroendocrinology. 18:1993;509-519.
20. Nilsson, C. L.; Karlsson, G.; Bergquist, J.; Westman, A.; Ekman, R. Mass spectrometry of peptides in neuroscience Peptides 19: 781-789; 1998.
21. O'Carroll A.-M., Raynor K., Lolait S.J., Reisine T. Characterization of cloned human somatostatin receptor SSTR5. Mol. Pharmacol. 46:1994;291-298.
22. Patel Y.C., Greenwood M., Kent G., Panetta R., Srikant C.B. Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation. Biochem. Biophys. Res. Commun. 192:1993;288-294.
23. Persson S., Post C., Alari L., Nyberg F., Terenius L. Increased neuropeptide-converting enzyme activities in cerebrospinal fluid of opiate-tolerant rats. Neurosci. Lett. 107:1989;318-322.
24. Pierotti A.R., Harmar A.J. Multiple forms of somatostatin-like immunoreactivity in the hypothalamus and amygdala of the rat selective localization of somatostatin-28 in the median eminence . J. Endocr. 105:1985;383-389.
25. Raskind M.A., Peskind E.R., Lampe T.H., Risse S.C., Taborsky G.J., Dorsa D. Cerebrospinal fluid vasopressin, oxytocin, somatostatin, and β-endorphin in Alzheimer's disease. Arch. Gen. Psychiatry. 43:1986;382-388.
26. Rissler K., Jost S., Mohadjer M., Mundinger F., Cramer H. Molecular size distribution of somatostatin-like immunoreactivity in the cerebroventricular fluid of neurosurgical patients. Neurosci. Res. 4:1987;343-356.
27. Schwartz J.-C., Bouthenet M.-L., Giros B., Gros C., Llorens-Cortes C., Pollard H. Neuropeptidases and neuropeptide inactivation in the brain. Fuxe K., Agnati F. Volume transmission in the brain Novel mechanisms for neural transmission . 1991;381-394 Raven Press, New York.
28. Shen L.-P., Pictet R.L., Rutter W.J. Human somatostatin I sequence of the cDNA . Proc. Natl. Acad. Sci. USA. 79:1982;4575-4579.
29. Smith D.L., Sun Y. Detection and location of disulfide bonds in proteins by mass spectrometry. Desiderio D.M. Mass spectrometry of peptides. 1991;275-287 CRC Press, Boca Raton.
30. Terenius L., Nyberg F. Neuropeptide-processing, -converting, and -inactivating enzymes in human cerebrospinal fluid. Int. Rev. Neurobiol. 30:1988;101-121.
31. Terenius L., Nyberg F. Peptidases and proteases in cerebrospinal fluid, significance in volume transmission. Fuxe K., Agnati F. Volume transmission in the brain Novel mechanisms for neural transmission . 1991;415-424 Raven Press, New York.
32. Vecsei L., Csala B., Widerlöv E., Ekman R., Czopf J., Palffy G. Lumbar cerebrospinal fluid concentrations of somatostatin and neuropeptide Y in multiple sclerosis. Brain Res. Bull. 25:1990;411-413.
33. Wahlestedt C., Regunathan S., Reis D.J. Identification of cultured cells selectively expressing Y1-, Y2-, or Y3-type receptors for neuropeptide Y/peptide YY. Life Sci. 50:1991;7-12.
34. Wallengren J., Ekman R., Sundler F. Occurrence and distribution of neuropeptides in the human skin. Acta Dermatol. Venereol. 67:1987;551-558.
35. Westman, A.; Karlsson, G; Ekman, R. A comparison of MALDI-MS sample preparation strategies for proteins in complex biological mixtures. Adv. Mass Spectrom., in press, 1998.
36. Wood P.L., Etienne P., Lal S., Gauthier S., Cajal S., Nair N.P.V. Reduced lumbar CSF somatostatin levels in Alzheimer's disease. Life Sci. 31:1982;2037-2079.
37. Yamada Y., Post S.R., Wang K., Tager H.S., Bell G.I., Seino S. Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. Proc. Natl. Acad. Sci. USA. 89:1992;251-255.