Degradation mechanism and kinetic studies of a novel anticancer agent, AG2034

International Journal of Pharmaceutics

Volumn 167, Issue 1-2, 1998, Pages 49-56

  Li, Shihong ^a   Wang, Wen ^a   Chu, James ^a   Zamansky, Irina ^a   Tyle, Praveen ^a   Rowlings, Colin ^a  

^a AGOURON PHARMACEUTICALS INC   (United States)

Author keywords

AG2034; Anticancer agent; Enzymatic degradation; Microbial induced hydrolysis; Oxidation; Stability

Indexed keywords

ANTINEOPLASTIC AGENT; N [[5 [2 (2 AMINO 4,6,7,8 TETRAHYDRO 4 OXO 1H PYRIMIDO[5,4 B][1,4]THIAZIN 6 YL)ETHYL] 2 THIENYL]CARBONYL]GLUTAMIC ACID; UNCLASSIFIED DRUG;

ARTICLE; DEGRADATION; DRUG DECOMPOSITION; DRUG FORMULATION; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROLYSIS; MICROBIAL GROWTH; OXIDATION; PH; PRIORITY JOURNAL; TEMPERATURE;

EID: 0032102799     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(98)00042-8     Document Type: Article

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