Optical resolution of 3-(silyloxy)glutaric acid half esters and their utilization for enantioconvergent synthesis of a HMG-CoA reductase inhibitor

Journal of Organic Chemistry

Volumn 63, Issue 9, 1998, Pages 3037-3040

  Konoike, Toshiro ^a   Okada, Tetsuo ^a   Araki, Yoshitaka ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTARIC ACID DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ARTICLE; CHIRALITY; DIASTEREOISOMER; DRUG SYNTHESIS; ENANTIOMER; OPTICAL RESOLUTION; RACEMIC MIXTURE;

EID: 0032080388     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo9722156     Document Type: Article

References (23)

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15. Both enantiomers (99% ee) are now available through the cooperation of Shionogi & Co., Ltd. and Ube Industries, Ltd. For samples of (R)-1 and (S)-1, send inquiries to T. Hashimoto at Ube Industries, Ltd., 2-3-11, Higashi-Shinagawa, Shinagawa-ku, Tokyo 140, Japan.
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19. A part of this work has been published in the patent. Konoike, T.; Araki, Y. PCT Int. Appl., WO 92/22560, 1992; Chem. Abstr. 1993, 119, 95827n.
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23. Enatiomeric excess was determined by HPLC; see ref 8.