Polymorphism at the HLA-DQ locus determines susceptibility to experimental autoimmune myasthenia gravis

Journal of Immunology

Volumn 160, Issue 9, 1998, Pages 4169-4174

  Raju, Raghavan ^a   Zhan, Wen Zhi ^b   Karachunski, Peter ^c   Conti Fine, Bianca ^c   Sieck, Gary C ^b   David, Chella ^a  

^a MAYO GRADUATE SCHOOL   (United States)

^b MAYO CLINIC   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; HLA ANTIGEN CLASS 2; HLA DQ ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA POLYMORPHISM; ELECTROPHYSIOLOGY; GENE LOCUS; MOUSE; MYASTHENIA GRAVIS; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ANIMALS; GENETIC PREDISPOSITION TO DISEASE; HLA-DQ ANTIGENS; HUMANS; MICE; MICE, TRANSGENIC; MYASTHENIA GRAVIS; POLYMORPHISM, GENETIC;

EID: 0032080382     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Lindstrom, J., D. Shelton, and Y. Fuji. 1988. Myasthenia gravis. Adv. Immunol. 42:233.
2. Conti-Tronconi, B. M., K. E. Mclane, M. A. Raftery, S. A. Grando, and M. P. Protti. 1994. The nicotinic acetylcholine receptor: structure and autoimmune pathology. Crit. Rev. Biochem. Mol. Biol. 29:69.
3. Oshima, M., T. Ashizawa, M. S. Pollack, and M. Z. Atassi. 1990. Autoimmune T cell recognition of human acetylcholine receptor: the sites of T cell recognition in myasthenia gravis on the extracellular pan of the α subunit. Eur. J. Immunol. 20:2563.
4. Protti, M. P., A. A. Manfredi, R. M. Horton, M. Bellone, and B. M. Conti-Tronconi. 1993. Myasthenia gravis: recognition of a human autoantigen at the molecular level. Immunol. Today 14:363.
5. Brocke, S., C. Brautbar, L. Steinman, O. Abramsky, J. Rothbard, D. Neuman, S. Fuchs, and E. Mozes. 1988. In vitro proliferative responses and antibody titers specific to human acetylcholine receptor synthetic peptides in patients with myasthenia gravis and relation to HLA class II genes. J. Clin. Invest. 82:1894.
6. Protti, M. P., A. A. Manfredi, C. Straub, J. F. Howard, Jr., and B. M. Conti-Tronconi. 1990. Immunodominant regions fro T helper-cell sensitization on the human nicotinic receptor a subunit in myasthenia gravis. Proc. Natl. Acad. Sci. USA 87:7792.
7. + cells of myasthenia gravis patients and healthy subjects. J. Immunol. 93:1020.
8. + epitopes on the embryonic γ subunit of human muscle acetylcholine receptor. J. Clin. Invest. 90:1558.
9. Hawke, S., H. Matsuo, M. Nocolle, G. Malcherek, A. Melms, and N. Willcox. 1996. Autoimmune T cells in myasthenia gravis: heterogeneity and potential for specific immunotargeting. Immunol. Today 17:307.
10. Protti, M. P., A. A. Manfredi, X. D. Wu, L. Moiola, J. F. Howard, Jr., and B. M. Conti-Tronconi. 1991. Myasthenia gravis: T epitopes on the δ subunit of human muscle acetylcholine receptor. J. Immunol. 146:2253.
11. Drachman, D. B. 1994. Myasthenia gravis. N. Engl. J. Med. 330:1797.
12. Lennon, V., J. Lindstrom, and M. Seybold. 1976. Experimental autoimmune myasthenia gravis, cellular and humoral immune responses. Ann. NY Acad. Sci. 1976:283.
13. Krolick, K., and O. Urso. 1987. Analysis of helper T cell function by AChR-reactive cell lines of defined supernatant subunit specificity. Cell. Immunol. 105: 75.
14. Asthana, D., Y. Fuji, G. E. Huston, and J. Lindstrom. 1993. Regulation of antibody production by helper T cell clones in experimental autoimmune myasthenia gravis is mediated by IL-4 and antigen-specific T cell factors. Clin. Immunol. Immunopathol. 67:2408.
15. Nepom, G. T. 1991. MHC class II molecules and autoimmunity. Annu. Rev. Immunol. 9:493.
16. Bell, J., L. Rassenti, S. Smoot, K. Smith, C. Newby, R. Hohlfeld, K. Toyka, H. McDevitt, and L. Steinman. 1986. HLA-DQ β-chain polymorphism linked to myasthenia gravis. Lancet 1:1058.
17. Kaul, R., M. Shenoy, and P. Christadoss. 1994. The role of major histocompatibility complex genes in myasthenia gravis and experimental autoimmune myasthenia gravis pathogenesis. Adv. Neuroimmunol. 4:387.
18. Pirskanen, R., A. Tilikainen, and E. Hokkanen. 1972. Histocompatibility (HLA) antigens associated with myasthenia gravis: a preliminary report. Annu. Clin. Res. 4:304.
19. Feltkamp, T. E. W., P. M. van den Berg-Loonen, L. E. Nijenhuis, C. P. Engelfreit, A. L. van Rossum, J. J. van Loghem, and H. J. Oosterhuis. 1974. Myasthenia gravis, autoantibodies, and HLA antigens. Br. Med. J. 1:131.
20. Naeim, F., J. C. Keesey, C. Herrmann, Jr., J. Lindstrom, E. Zeller, and R. L. Walford. 1978. Association of HLA-B8, DRw3, and anti-acetylcholine receptor antibodies in myasthenia gravis. Tissue Antigens 12:381.
21. Compstom, D. A. S., A. Vincent, J. Newsom-Davis, and J. R. Batchelor. 1980. Clinical, pathological, HLA antigen and immunological evidence for disease heterogeneity in myasthenia gravis. Brain 103:579.
22. Tola, M. R., L. M. Caniatti, I. Casetta, E. Granieri, C. Conighi, R. Quatrale, V. C. Monetti, E. Paolino, V. Govoni, R. Pascarella, and M. Carreras. 1994. Immunogenetic heterogeneity and associated autoimmune disorders in myasthenia gravis: a population-based survey in the province of Ferrara, northern Italy. Acta Neurol. Scand. 90:318.
23. Vieira, M. L., S. Caillat-Zucman, P. Gajdos, S. Cohen-Kaminsky, A. Casteur, and J.-F. Bach. 1993. Identification by genomic typing of non-DR3 HLA class II genes associated with myasthenia gravis. J. Neuroimmunol. 47:115.
24. Horiki, T., H. Inoko, J. Moriuchi, Y. Ichikawa, and S. Anmori. 1994. Combinations of HLA-DPB1 and HLA-DQB1 alleles determine susceptibility to early-onset myasthenia gravis in Japan. Autoimmunity 19:49.
25. Barton, E. N., M. Smikle, and O. S. Morgan. 1992. Myasthenia gravis and HLA phenotypes in Jamaicans. South. Med. J. 85:904.
26. Hjelmstrom, P., R. Giscombe, A. K. Lefvert, R. Pirskanen, I. Kochum, M. Landin-Olsson, and C. B. Sanjeevi. 1995. Different HLA-DQ are positively and negatively associated in Swedish patients with myasthenia gravis. Autoimmunity 22:59.
27. Carlsson, B., J. Wallin, R. Pirskanen, G. Matell, and C. I. E. Smith. 1990. Different HLA DR-DQ associations in subgroups of idiopathic myasthenia gravis. Immunogenetics 31:285.
28. Hjelmstrom, P., R. Giscombe, A. K. Lefvert, R. Pirskanen, I. Kochum, M. Landin-Olsson, and C. B. Sanjeevi. Polymorphic amino acid domains of the HLA-DQ molecule are associated with disease heterogeneity in myasthenia gravis. J. Neuroimmunol. 65:125.
29. Christadoss, P. 1989. Immunogenetics of experimental autoimmune myasthenia gravis. Ann. NY Acad. Sci. 9:247.
30. + cells sensitized to nicotinic acetylcholine receptor. J. Immunol. 147:1484.
31. Infante, A. J., P. A. Thompson, K. A. Krolick, and K. A. Wall. 1991. Determinant selection in murine experimental autoimmune myasthenia gravis: effect of the bm12 mutation on T cell recognition of acetylcholine receptor epitopes. J. Immunol. 146:2977.
32. Kaul, R., M. Shenoy, E. Goluszko, and P. Christadoss. 1994. Major histocompatibility complex class II gene disruption prevents experimental autoimmune myasthenia gravis. J. Immunol. 152:3152.
33. Wei, B.-Y., J. Martin, S. Savarirayan, R. Little, and C. S. David. 1990. Transgenic mice with MHC class II genes: the use in the study of allelic a/b chain pairing and the production of engineered mice with mutant I-A genes. In Transgenic Mice and Mutants in MHC Research. I. K. Egorov and C. S. David, eds. Springer-Verlag, Berlin, Heidelberg, p. 237.
34. Bradley, D. S., G. H. Nabozny, S. Chen, P. Zhou, M. M. Griffiths, H. S. Luthra, and C. S. David. 1997. HLA DQB1 polymorphism determines incidence, onset and severity of collagen-induced arthritis in transgenic mice: implications in human rheumatoid arthritis. J. Clin. Invest. 100:2227.
35. Okada, K., J. M. Boss, H. Prentice, T. Spies, R. Mengler, C. Auffray, J. Lillie, D. Grossberger, and J. L. Strominger. 1985. Gene organization of DC and DX subregions of the human major histocompatibility complex. Proc. Natl. Acad. Sci. USA 82:3410.
36. Cosgrove, D., D. Gray, A. Dierich, J. Kaufman, M. Lemeur, C. Benoist, and D. Mathis. 1991. Mice lacking MHC class II molecules. Cell 66:1051.
37. Nabozny, G. H., J. M. Baisch, S. Cheng, D. Cosgrove, M. M. Griffiths, H. S. Luthra, and C. S. David. 1996. HLA-DQ8 transgenic mice are highly susceptible to collagen induced arthritis: a novel model for human polyarthritis. J. Exp. Med. 183:27.
38. Lindstrom, J., B. Einarson, and S. Tzartos. 1981. Production and assay of antibodies to acetylcholine receptor. Methods Enzymol. 74:432.
39. Elliot, J., S. M. J. Dunn, S. C. Blanchard, and M. A. Raftery. 1979. Specific binding of perhydrohistrionicotoxin to Torpedo acetylcholine receptor. Proc. Natl. Acad. Sci. USA 76:2576.
40. Laemmli, U. K. 1970. cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680.
41. Schmidt, J., and M. A. Raftery. 1973. A simple assay for the study of solubilized acetylcholine receptors. Anal. Biochem. 52:349.
42. Shenoy, M., R. Kaul, E. Goluszko, C. David, and P. Christadoss. 1994. Effect of MHC class I and CD8 cell deficiency on experimental autoimmune myasthenia gravis pathogenesis. J. Immunol. 152:5330.
43. Sieck, G. C., and M. Fournier. 1990. Changes in diaphragm motor unit EMG during fatigue. J. Appl. Physiol. 68:1917.
44. Kuei, J. H., R. Shadmehr, and G. C. Sieck. 1990. Relative contribution of neurotransmission failure to diaphragm fatigue. J. Appl. Physiol. 68:174.
45. Neeno, T., C. J. Krco, J. Harders, J. Baisch, S. Cheng, and C. S. David. 1996. HLA-DQ8 transgenic mice lacking endogenous class II molecules respond to house dust allergens. J. Immunol. 156:3191.
46. Krco, C. J., S. Chapoval, J. Harders, T. Neeno, and C. S. David. 1996. Identification of HLA-DQ restricted T cell epitopes on dust mite grass, and weed allergens using HLA-DQ6 transgenic mice. Hum. Immunol. 49(Suppl.):16.
47. Shenoy, M., C. David, M. Oshima, M. Z. Atassi, and P. Christadoss. Molecular immunopathogenesis of myasthenia gravis using MHC class II mutant and transgenic mice. Ann. NY Acad. Sci. 329.
48. Karachunski, P. I., N. Ostlie, M. Bellone, A. J. Infante, and B. M. Conti-Fine. 1995. Mechanisms by which the I-bm12 mutation influences susceptibility to experimental myasthenia gravis: a study in homozygous and heterozygous mice. Scand. J. Immunol. 42:215.
49. Christadoss, P., J. M. Lindstrom, R. W. Melvold, and N. Talal. 1985. Mutation at I-A β chain prevents experimental autoimmune myasthenia gravis. Immunogenetics 21:33.
50. Christadoss, P., C. S. David, and S. Keve. 1992. I-Aak transgene pairs with I-Abb gene and protects C57BL10 mice from developing autoimmune myasthenia gravis. Clin. Immunol. Immunopathol. 62:235.
51. + T cells are essential to induce experimental autoimmune myasthenia gravis. J. Exp. Med. 184:349.