Significance of cell proliferation measurement in gastric cancer

European Journal of Cancer

Volumn 34, Issue 6, 1998, Pages 781-790

  Schipper, D L ^a   Wagenmans, M J M ^a   Peters, W H M ^a   Wagener, D J T ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Cell proliferation; Gastric cancer; Labelling index

Indexed keywords

CELL CYCLE; CELL KINETICS; CELL PROLIFERATION; DIAGNOSTIC VALUE; HUMAN; PRIORITY JOURNAL; REVIEW; STOMACH CANCER;

ANTIGENS, NUCLEAR; CELL DIVISION; FLOW CYTOMETRY; HUMANS; KI-67 ANTIGEN; MITOTIC INDEX; NUCLEAR PROTEINS; PROGNOSIS; PROLIFERATING CELL NUCLEAR ANTIGEN; STOMACH NEOPLASMS; THYMIDINE;

EID: 0032078924     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(97)10073-9     Document Type: Review

References (79)

1. Lajhta LG. On the concept of the cell cycle. J Cell Comp Physiol 1963, 62 (Suppl. 1), 143-145.
2. Mendelsohn ML. The growth fraction: a new concept applied to tumours. Science 1963, 132, 1496.
3. Quinn CM, Wright NA. The clinical assessment of proliferation and growth in human tumours: evaluation of methods and applications as prognostic variables. J Pathol 1990, 160, 93-102.
4. Sadler DW, Coghill SB. Histopathologists, malignancies and undefined high power fields. Lancet 1989, 1, 785-786.
5. Akerman M, Brandt L, Johnson A, Olsson H. Mitotic activity in non-Hodgkin's lymphoma. Relation to the Kiel classification and to prognosis. Br J Cancer 1987, 55, 219-223.
6. Donhuijsen K. Mitosis counts. Reproducibility and significance in grading of malignancy. Hum Pathol 1986, 17, 1122-1125.
7. Ellis PSJ, Whitehead R. Mitosis counting - a need for reappraisal. Hum Pathol 1981, 12, 3-4.
8. Silverberg SG. Reproducibility of the mitosis count in the histologic diagnosis of smooth muscle tumors of the uterus. Hum Pathol 1976, 7, 451-454.
9. Holt S, Croton R, Leinster SJ, et al. In vitro thymidine labelling index in primary operable breast cancer. Eur J Surg Oncol 1986, 12, 53-57.
10. Smallwood JA, Cooper A, Taylor I. The errors of thymidine labelling in breast cancer. Clin Oncol 1983, 9, 331-335.
11. Malaise EP, Chavaudra N, Tubiana M. The relationship between growth rate, labelling index and histological type of human solid tumours. Eur J Cancer 1973, 9, 305-312.
12. Camplejohn RS, Macartney JC. Flow cytometry. In Hall PA, Levison DA, Wright NA, eds. Assessment of Cell Proliferation in Clinical Practice. London, Springer, 1992, 95-111.
13. Hedley DW, Friedlander ML, Taylor IW, Rugg CA, Musgrove EA. Method for analysis of cellular DNA content of paraffin embedded pathological material using flow cytometry. J Histochem Cytochem 1983, 31, 1333-1335.
14. Gratzner HG. Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: a new reagent for detection of DNA replication. Science 1982, 218, 474-475.
15. Vanderlaan M, Watkins B, Thomas C, Dolbaere F, Stanker L. Improved high-affinity monoclonal antibody to iododeoxyuridine. Cytometry 1986, 7, 499-507.
16. Schutte B, Reynders MMJ, Van Assche CLMVJ, Hupperets PSGJ, Bosman FT, Blijham GH. An improved method for the immunocytochemical detection of bromodeoxyuridine labelled nuclei using flow cytometry. Cytometry 1987, 8, 372-376.
17. Wilson GD, McNally NJ. Measurement of cell proliferation using bromodeoxyuridine. In Hall PA, Levison DA, Wright NA, eds. Assessment of Cell Proliferation in Clinical Practice. London, Springer, 1992, 113-139.
18. Tan CK, Castillo C, So AG, Downey KM. An auxiliary protein for DNA polymerase-δ from foetal calf thymus. J Biol Chem 1986, 261, 12310-12316.
19. Prelich G, Tan CK, Kostura M, et al. Functional identity of proliferating cell nuclear antigen and DNA polymerase S auxiliary protein. Nature 1987, 326, 517-520.
20. Bravo R, Frank R, Blundell PA, MacDonald-Bravo H. Cyclin/ PCNA is the auxiliary protein of DNA polymerase-δ. Nature 1987, 326, 515-517.
21. Fairman MP. DNA polymerase delta/PCNA: actions and interactions. J Cell Sei 1990, 95, 1-4.
22. Hall PA, Levison DA. Review: Assessment of cell proliferation in histological material. J Clin Pathol 1990, 43, 184-192.
23. McCormick D, Hall PA. The complexities of proliferating cell nuclear antigen. Histopathology 1992, 21, 591-594.
24. Bravo R, MacDonald-Bravo H. Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: association with DNA replication sites. J Cell Biol 1987, 105, 1549-1554.
25. Roos G, Landberg G, Huff JP, Houghten R, Takasaki Y, Tan EM. Analysis of the epitopes of proliferating cell nuclear antigen recognized by monoclonal antibodies. Lab Invest 1993, 68, 204-210.
26. Hall LA, Levison DA, Woods EL, et al. Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: an index of cell proliferation with evidence of deregulated expression in some neoplasms. J Pathol 1990, 162, 285-294.
27. Gerdes J, Schwab U, Lemke H, Stein H. Production of a monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. IntJ Cancer 1983, 31, 13-20.
28. Gerdes J, Lemke H, Wacker HH, Schwab J, Stein H. Cell cycle analysis of a cell proliferation associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 1984, 133, 1710-1715.
29. Key G, Becker MHG, Baron B, et al. New Ki-67-equivalent murine monoclonal antibodies (MIB 1-3) generated against bacterially expressed parts of the Ki-67 cDNA containing three 62 base pair repetitive elements encoding for the Ki-67 epitope. Lab Invest 1993, 68, 629-636.
30. Cattoretti G, Becker MHG, Key G, et al. Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections. J Pathol 1992, 168, 357-363.
31. Gerdes J, Becker MHG, Key G, Cattorretti G. Immunohistological detection of tumour growth fraction (Ki-67 antigen) in formalin-fixed and routinely processed tissues. J Pathol 1992, 168, 85-86.
32. Underwood JCE. Nucleolar organizer regions. In Hall PA, Levison DA, Wright NA, eds. Assessment of Cell Proliferation in Clinical Practice. London, Springer, 1992, 161-175.
33. Roncucci L, Pedroni M, Scalmati A, et al. Cell kinetics evaluation of colorectal tumors after in vivo administration of bromodeoxyuridine. Int J Cancer 1992, 52, 856-861.
34. Yonemura Y, Sugiyama K, Fujimura T, De Aretxabala X, Kamata T, Kosaka T. Correlation of DNA ploidy and proliferative activity in human gastric cancer. Cancer 1988, 62, 1497-1502.
35. Onda K, Davis RL, Shibuya M, Wilson CB, Hoshino T. Correlation between the bromodeoxyuridine labeling index and the MIB-1 and Ki-67 proliferating cell indices in cerebral gliomas. Cancer 1994, 74, 1921-1926.
36. Onda K, Davis RL, Wilson CB, Hoshino T. Regional differences in bromodeoxyuridine uptake, expression of Ki-67 protein, and nuclear organizer region counts in glioblastoma multiforme. Acta Neuropathol 1994, 87, 586-593.
37. Shibuya M, Ito S, Miwa T, Davis RL, Wilson CB, Hoshino T. Proliferative potential of brain tumors. Analyses with Ki-67 and anti-DNA polymerase alpha monoclonal antibodies, bromodeoxyuridine labelling, and nucleolar organizer region counts. Cancer 1993, 71, 199-206.
38. Yonemura Y, Kimura H, Fushida S, et al. Analysis of proliferative activity using anti-proliferating cell nuclear antigen antibody in gastric cancer tissue specimens obtained by endoscopic biopsy. Cancer 1993, 71, 2448-2453.
39. Yonemura Y, Fushida S, Tsugawa K, et al. Correlation of p53 expression and proliferative activity in gastric cancer. Anal Cell Pathol 1993, 5, 277-288.
40. Yonemura Y, Fonseca L, Tsugawa K, et al. Prediction of lymph node metastasis and prognosis from the assay of the expression of proliferating cell nuclear antigen and DNA ploidy in gastric cancer. Oncology 1994, 51, 251-257.
41. Lynch DAF, Clarke AMT, Jackson P, Axon ATR, Dixon MF, Quirke P. Comparison of labelling by bromodeoxyuridine, MIB-1, and proliferating cell nuclear antigen in gastric mucosal biopsy specimens. J Clin Pathol 1994, 47, 122-125.
42. Hagel C, Schwartz P, Laas R, Stavrou DK. Comparison of four proliferation markers and their significance for evaluation of tumor dignity in intracranial tumors. IntJ Oncol 1995, 7, 107-113.
43. Waldman FM, Carroll PR, Cohen MB, Kerschmann R, Chew K, Mayall BH. 5-Bromodeoxyuridine incorporation and PCNA expression as measures of cell proliferation in transitional cell carcinoma of the urinary bladder. Modern Pathol 1993, 6, 20-24.
44. Keshgegian AA, Cnaan A. Proliferation markers in breast carcinoma. Mitotic figure count, S-phase fraction, proliferating cell nuclear antigen, Ki-67 and MIB-1. Am J Clin Pathol 1995, 104, 42-49.
45. Sallinen PK, Haapasalo HK, Visakorpi T, et al. Prognostication of astrocytoma patient survival by Ki-67 (MIB-1), PCNA, and S-phase fraction using archival paraffin-embedded samples. J Pathol 1994, 174, 275-282.
46. Pich A, Ponti R, Valente G, et al. MIB-1, Ki67, and PCNA scores and DNA flow cytometry in intermediate grade malignant lymphomas. J Clin Pathol 1994, 47, 18-22.
47. Jain S, Filipe MI, Hall PA, Waseem N, Lane DP, Levison DA. Prognostic value of proliferating cell nuclear antigen in gastric carcinoma. J Clin Pathol 1991, 44, 655-659.
48. Carey FA, Fabbroni GF, Lamb D. Expression of proliferating cell nuclear antigen in lung cancer: a systematic study and correlation with DNA ploidy. Histapathol 1992, 20, 499-503.
49. Leonardi E, Girlando S, Serio G, et al. PCNA and Ki-67 expression in breast carcinoma: correlations with clinical and biological variables. J Clin Pathol 1992, 45, 416-419.
50. Hepburn PJ, Glynne-Jones E, Goddard L, Gee JMW, Harper ME. Cell proliferation in prostatic carcinoma: comparative analysis of Ki-67, MIB-1 and PCNA. HistochemJ 1995, 27, 196-203.
51. Albers P, Orazi A, Ulbright TM, et al. Prognostic significance of immunohistochemical proliferation markers (Ki-67/MIB-1 and Proliferation-Associated Nuclear Antigen), p53 protein accumulation, and neovascularization in clinical stage A nonseminomatous testicular germ cell tumors. Modern Pathol 1995, 8, 492-497.
52. Budke H, Orazi A, Neiman RS, Cattoretti G, John K, Barberis M. Assessment of cell proliferation in paraffin sections of normal bone marrow by the monoclonal antibodies Ki-67 and PCNA. Modem Pathol 1994, 7, 860-866.
53. Kakeji Y, Maehara Y, Adachi Y, et al. Proliferative activity as a prognostic factor in Borrmann type 4 gastric carcinoma. Br J Cancer 1994, 69, 749-753.
54. Remmele W, Muhlfait V, Keul HG. Estimation of the proliferative activity of human breast cancer tissue by means of the Ki-67 and MIB-1 antibodies - comparative studies on frozen and paraffin sections. Virchows Arch 1995, 426, 435-439.
55. Ostrowski ML, Chakraborty S, Laucirica R, Brown RW, Greenberg SD. Quantitative image analysis of MIB-1 immunoreactivity. A comparison with flow cytometric assessment of proliferative activity in invasive carcinoma of the breast. Anal Quant Cytol Histal 1995, 17, 15-24.
56. Lipkin M, Sherlock P, Bell B. Cell proliferation kinetics in the gastrointestinal tract of man. II. Cell renewal in stomach, ileum, colon and rectum. Gastroenterology 1963, 45, 721-729.
57. Hattori T, Fujita S. Tritiated thymidine autoradiographic study on cellular migration in the gastric gland of the golden hamster. Cell Tissue Res 1976, 172, 171-184.
58. Willems G, Lehy T. Radioautographic and quantitative studies on parietal and peptic cell kinetics in the mouse. Gastroenterology 1975,69,416-426.
59. Deschner EE, Tamura K, Bralow SP. Early proliferative changes in rat pyloric mucosa induced with N-methyl-N′-nitro-N-nitro-soguanide (MNNG). In Rozen P, Eidelman S, Gilat T, eds. Gastrointestinal Cancer: Advances in Basic Research. Basel, Karger, 1979, 25-31.
60. Lipkin M, Correa P, Mikol YB, et al. Proliferative and antigenic modifications in epithelial cells in chronic atrophic gastritis. J Natl Cancer Inst 1985, 75, 613-619.
61. Hart-Hansen O, Pedersen T, Larsen JK. A method to study cell proliferation kinetics in human gastric mucosa. Gut 1975, 16, 23-27.
62. Cahill RJ, Kilgallen C, Beattie S, Hamilton H, O'Morain C. Gastric epithelial cell kinetics in the progression from normal mucosa to gastric carcinoma. Gut 1996, 38, 177-181.
63. Biasco G, Paganelli GM, Santucci R, Miglioli M, Barbara L. Cell proliferation kinetics as a marker of gastric cancer risk. Ital J Gastroent 1991, 23, 24-28.
64. Lynch DAF, Mapstone NP, Clarke AMT, et al. Cell proliferation in Helicobacter pylori associated gastritis and the effect of eradication therapy. Gut 1995, 36, 346-350.
65. Lynch DAF, Mapstone NP, Clarke AMT, et al. Cell proliferation in the gastric corpus in Helicobacter pylori associated gastritis and after gastric resection. Gut 1995, 36, 351-353.
66. Miracco C, Spina D, Vindigni C, Filipe MI, Tosi P. Cell proliferation patterns and p53 expression in gastric dysplasia. Int J Cancer 1995, 62, 149-154.
67. Amadori D, Bonaguri C, Volpi A, et al. Cell kinetics and prognosis in gastric cancer. Cancer 1993, 71, 1-4.
68. Amadori D, Maltoni M, Volpi A, et al. Gene amplification and proliferative kinetics in relation to prognosis of patients with gastric carcinoma. Cancer 1997, 79, 226-232.
69. Tanigawa N, Masuda Y, Shimomatsuya T, Fujii H, Muraoka R, Tanaka T. Thymidine uptake in vitro as a prognostic indicator for primary gastric cancer. Cancer 1993, 72, 2883-2888.
70. Tosi P, Leoncini L, Cintorino M, et al. Flow cytometric analysis of DNA ploidy pattern from deparaffinized formalin-fixed gastric cancer tissue. Int J Cancer 1988, 42, 868-871.
71. Danova M, Riccardi A, Mazzinni G, et al. Flow cytometric analysis of paraffin-embedded material in human gastric cancer. Anal Quant Cytol Histol 1988, 10, 200-206.
72. Ballantyne KG, James PD, Robins RA, Baldwin RW, Hardcastle JD. Flow cytometric analysis of the DNA content of gastric cancer. Br J Cancer 1987, 56, 52-54.
73. Sasaki K, Takahashi M, Hashimoto T, Kawachnino K. Flow cytometric DNA measurement of gastric cancers. Clinicopathological implication of DNA ploidy. Path Res Pract 1989, 184, 561-566.
74. Ohyama S, Yonemura Y, Miyazaki I. Prognostic value of S-phase fraction and DNA ploidy studied with in vivo administration of bromodeoxyuridine on human gastric cancers. Cancer 1990, 65, 116-121.
75. Yonemura Y, Ooyama S, Sugiyama K, et al. Retrospective analysis of the prognostic significance of DNA ploidy patterns and S-phase fraction in gastric carcinoma. Cancer Res 1990, 50, 509-514.
76. Ohyama S, Yonemura Y, Miyazaki I. Proliferative activity and malignancy in human gastric cancers. Significance of the proliferation rate and its clinical application. Cancer 1992, 69, 314-332.
77. Yonemura Y, Kamata T, Ohoyama S, et al. Relation of proliferative activity to survival in patients with advanced gastric cancer. Anal Cell Pathol 1991, 3, 103-110.
78. Mori M, Kakeji Y, Adachi Y, et al. The prognostic significance of proliferating cell nuclear antigen in clinical gastric cancer. Surgery 1993, 113, 683-690.
79. Mueller W, Schneiders A, Meier S, Hommel G, Gabbert HE. Immunohistochemical study on the prognostic value of MIB-1 in gastric carcinoma. Br J Cancer 1996, 74, 759-765.