Evidence for the stabilisation of the high-affinity state of β-adrenoceptors by an endogenous factor in rat brain

Pharmacological Research

Volumn 37, Issue 5, 1998, Pages 365-373

  Garnier, Vincent ^a   Zini, Roland ^a   Morin, Didier ^a   Tillement, Jean Paul ^a  

^a FACULTÉ DE MÉDECINE   (France)

Author keywords

G protein; Isoproterenol; Rat brain; adrenergic receptors

Indexed keywords

3 [(3 CHOLAMIDOPROPYL)DIMETHYLAMMONIO] 1 PROPANESULFONIC ACID; 4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE; BETA ADRENERGIC RECEPTOR; GUANYLYLIMIDODIPHOSPHATE; ISOPRENALINE;

ARTICLE; BRAIN; BRAIN CORTEX; CEREBELLUM; CONTROLLED STUDY; DRUG COMPETITION; DRUG RECEPTOR BINDING; HUMAN TISSUE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN STABILITY; RAT; RECEPTOR AFFINITY; SYNAPTOSOME; TEMPERATURE;

EID: 0032078413     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.1998.0305     Document Type: Article

References (23)

1. 1. De Lean A, Stadel JM, Lefkowitz RJ. A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled β-adrenergic receptor. J Biol Chem 1980; 225: 7108-17.
2. 2. Chidiac P, Hebert TE, Valiquette M, Dennis M, Bouvier M. Inverse agonist activity of β-adrenergic antagonists. Mol Pharmacol 1993; 45: 490-9.
3. 2-adrenergic receptor. J Biol Chem 1993; 268: 4625-36.
4. 2-adrenergic receptor. Mol Pharmacol 1994; 45: 390-4.
5. 5. Rasenick MM, Watanabe M, Lazarevic MB, Hatta S, Hamm HE. Synthetic peptides as probes for G protein function. J Biol Chem 1994; 269: 21519-25.
6. 2-adrenergic receptor impairs agonist activation of adenylyl cyclase without affecting high affinity agonist binding. J Biol Chem 1990; 265: 1388-93.
7. 2-adrenergic receptors display subtype-selective coupling to Gs. Mol Pharmacol 1993; 41: 889-93.
8. s coupling decreases with age in rat aorta. Mol Pharmacol 1995; 45: 772-8.
9. 9. O'Donnell JM, Wolfe BB, Frazer A. Agonist interactions with β-adrenergic receptors in rat brain. J Pharmacol Exp Ther 1984; 228: 640-7.
10. 1-adenosine receptor G protein coupling in bovine brain membranes: effect of guanine nucleotides, salt and solubilization. J Neurochem 1988; 51: 1592-8.
11. 11. Vickroy TW, Yamamura HI, Roeske WR. Differential regulation of high-affinity agonist binding to muscarinic sites in the rat heart, cerebellum, and cerebral cortex. Biochem Biophys Res Commun 1993; 116: 284-90.
12. 12. Garnier V, Zini R, Sapena R, Tillement J-P. A match between binding to β-adrenoceptors and stimulation of adenylyl cyclase parameters of (-)isoproterenol and salbutamol on rat brain. Pharmacol Res 1997; 35: 303-12.
13. 13. Kenakin T, Morgan P, Lutz M. On the importance of the 'antagonist assumption' to how receptors express themselves. Biochem Pharmacol 1995; 50: 17-26.
14. 3-receptor agonist (BRL 37,344) and a partial agonist (CGP 12,177) in neonatal rat liver plasma membranes. Biochem Pharmacol 1992; 44: 2333-8.
15. 3H] CGP 12177 or [125I] iodocyanopindolol? J Recept Res 1992; 112: 369-87.
16. 1adrenergic receptors. J Recept Signal Transduct Res 1996; 16: 1-23.
17. 17. Cheng Y, Prusoff WH. Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50% inhibition (I50) of an enzymatic reaction. Biochem Pharmacol 1973; 22: 3099-108.
18. 1-adenosine receptor with receptor/G protein complexes in rat brain membranes. Mol Pharmacol 1996; 49: 915-26.
19. 1-adenosine receptor/G protein coupling: identification of a membrane protein that stabilizes the association of the receptor/G protein complex. Mol Pharmacol 1995; 48: 806-17.
20. iα1β1γ2• Cell 1995; 83: 1047-58.
21. 21. Levitski A, Marbach I, Bar-Sinai A. The signal transduction between β-receptors and adenylyl cyclase. Life Sci 1993; 52: 2093-100.
22. 22. Rens-Domanio S, Hamm HE. Structural and functional relationships of heterotrimeric G proteins. FASEB J 1995; 9: 1059-66.
23. 23. Neubig RR. Membrane organization in G-protein mechanisms. FASEB J 1994; 8: 939-46.