Livestock Odors: Implications for Human Health and Well-Being

Journal of Animal Science

Volumn 76, Issue 5, 1998, Pages 1343-1355

  Schiffman, Susan S ^a  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Health; Livestock; Odors; Pigs; Senses

Indexed keywords

AIR POLLUTION; ANIMAL; ATTITUDE; BRAIN; DOMESTIC ANIMAL; EYE DISEASE; HEADACHE; HEALTH; HUMAN; HYPERSENSITIVITY; MEMORY DISORDER; MOOD DISORDER; NOSE DISEASE; ODOR; PERCEPTION; PHARYNX DISEASE; PHYSIOLOGY; QUALITY OF LIFE; REVIEW; SLEEP STAGE; STRESS; SWINE;

AIR POLLUTION; ANIMALS; ANIMALS, DOMESTIC; ATTITUDE; BRAIN; EYE DISEASES; HEADACHE; HEALTH; HUMANS; HYPERSENSITIVITY; MEMORY DISORDERS; MOOD DISORDERS; NOSE DISEASES; ODORS; PERCEPTION; PHARYNGEAL DISEASES; QUALITY OF LIFE; SLEEP STAGES; STRESS; SWINE;

EID: 0032062936     PISSN: 00218812     EISSN: None     Source Type: Journal    
DOI: 10.2527/1998.7651343x     Document Type: Article

References (146)

1. Abraham, M. H., J. Andonian-Haftvan, J. E. Cometto-Muniz, and W. S. Cain. 1996. An analysis of nasal irritation thresholds using a new solvation equation. Fundam. Appl. Toxicol. 31:71-76.
2. Abraham, M. H., G. S. Whiting, Y. Alarie, J. J. Morris, P. J. Taylor, R. M. Doherty, R. W. Taft, and G. D. Nielsen. 1990. Hydrogen bonding 12. A new QSAR for upper respiratory tract irritation by airborne chemicals in mice. Quant. Struct-Act. Relat. 9:6-10.
3. Aggleton, J. P. (Ed.). 1992. The Amygdala: Neurobiological Aspects of Emotion, Memory and Mental Dysfunction. Wiley-Liss, New York.
4. Alarie, Y. 1966. Irritating properties of airborne materials to the upper respiratory tract. Arch. Environ. Health 13:433-449.
5. Alarie, Y. 1973. Sensory irritation of the upper airways by airborne chemicals. Toxicol. Appl. Pharmacol. 24:279-297.
6. Alarie, Y. 1981. Dose-response analysis in animal studies: prediction of human responses. Environ. Health Perspect. 42:9-13.
7. Alarie, Y., G. D. Nielsen, J. Andonian-Haftvan, and M. H. Abraham. 1995. Physicochemical properties of nonreactive volatile organic chemicals to estimate RD50: alternatives to animal studies. Toxicol. Appl. Pharmacol. 134:92-99.
8. Ayer, H. E., and D. W. Yeager. 1982. Irritants in cigarette smoke plumes. Am. J. Public Health 72:1283-1285.
9. Badia, P., M. R. Boecker, and K. P. Wright, Jr. 1995. Some effects of fragrances on sleep. In: A. N. Gilbert (Ed.) Compendium of Olfactory Research. pp 31-37. Kendall/Hunt, Dubuque, IA.
10. Badia, P., N. Wesensten, W. Lammers, J. Culpepper, and J. Harsh. 1990. Responsiveness to olfactory stimuli presented in sleep. Physiol. Behav. 48:87-90.
11. Baltrusch, H. J., W. Stangel, and I. Titze. 1991. Stress, cancer and immunity. New developments in biopsychosocial and psychoneuroimmunologic research. Acta Neurol. (Naples) 13: 315-327.
12. Baringer, J. R. 1976. The biology of herpes simplex virus infection in humans. Surv. Ophthalmol. 21:171-174.
13. Barnett, E. M., G. Jacobsen, G. Evans, M. Cassell, and S. Perlman. 1994. Herpes simplex encephalitis in the temporal cortex and limbic system after trigeminal nerve inoculation. J. Infect. Dis. 169:782-786.
14. Bascom, R., J. Kesavanathan, T. K. Fitzgerald, K. H. Cheng, and D. L. Swift. 1995. Sidestream tobacco smoke exposure acutely alters human nasal mucociliary clearance. Environ. Health Perspect. 103:1026-1030.
15. Bates, D. V. 1995. Observations on asthma. Environ. Health Perspect. 103(Suppl. 6):243-247.
16. Becker, Y. 1995. HSV-1 brain infection by the olfactory nerve route and virus latency and reactivation may cause learning and behavioral deficiencies and violence in children and adults: A point of view. Virus Genes 10:217-226.
17. Bell, I. R. 1994. White paper: Neuropsychiatric aspects of sensitivity to low-level chemicals: A neural sensitization model. Toxicol. Ind. Health 10:277-312.
18. Bell, I. R., E. E. Hardin, C. M. Baldwin, and G. E. Schwartz. 1995. Increased limbic system symptomatology and sensitizability of young adults with chemical and noise sensitivities. Environ. Res. 70:84-97.
19. Bell, I. R., C. S. Miller, G. E. Schwartz, J. M. Peterson, and D. Amend. 1996. Neuropsychiatric and somatic characteristics of young adults with and without self-reported chemical odor intolerance and chemical sensitivity. Arch. Environ. Health 51: 9-21.
20. Bell, I. R., G. E. Schwartz, J. M. Peterson, and D. Amend. 1993a. Self-reported illness from chemical odors in young adults without clinical syndromes or occupational exposures. Arch. Environ. Health. 48:6-13.
21. Bell, I. R., G. E. Schwartz, J. M. Peterson, D. Amend, and W. A. Stini. 1993b. Possible time-dependent sensitization to xenobiotics: Self-reported illness from chemical odors, foods, and opiate drugs in an older adult population. Arch. Environ. Health 48: 315-327.
22. Benignus, V. A., K. E. Muller, J. A. Graham, and C. N. Barton. 1984. Toluene levels in blood and brain of rats as a function of toluene level in inspired air. Environ. Res. 33:39-46.
23. Bloomberg, G. R., and R. C. Strunk. 1992. Crisis in asthma care. Pediatr. Clin. North Am. 39:1225-1241.
24. Bolla-Wilson, K., R. J. Wilson, and M. L. Bleecker. 1988. Conditioning of physical symptoms after neurotoxic exposure. J. Occup. Med. 30:684-686.
25. Bundy, D. S. 1992. Odor issues with wastes. In: National Livestock, Poultry and Aquaculture Waste Management. ASAE Publ. 03-92. pp 288-292. American Society of Agricultural Engineers, St. Joseph, Michigan.
26. Burge, P. S. 1992. New developments in occupational asthma. Br. Med. Bull. 48:221-230.
27. Cann, A., and D. Ross. 1989. Olfactory stimuli as context cues in human memory. Am. J. Psychol. 102:91-102.
28. Carey, J. 1996. Building a "canary on a chip." Business Week December: 130.
29. Carlson, C. R., and R. H. Hoyle. 1993. Efficacy of abbreviated progressive muscle relaxation training: A quantitative review of behavioral medicine research. J. Consult. Clin. Psychol. 61: 1059-1067.
30. Cometto-Muniz, J. E., and W. S. Cain. 1991. Nasal pungency, odor, and eye irritation thresholds for homologous acetates. Pharmacol. Biochem. Behav. 39:983-989.
31. Cometto-Muniz, J. E., and W. S. Cain. 1992. Sensory irritation. Relation to indoor air pollution. Ann. N.Y. Acad. Sci. 641: 137-151.
32. Cometto-Muniz, J. E., and W. S. Cain. 1993. Efficacy of volatile organic compounds in evoking nasal pungency and odor. Arch. Environ. Health 48:309-314.
33. Cometto-Muniz, J. E., and W. S. Cain. 1994. Sensory reactions of nasal pungency and odor to volatile organic compounds: The alkylbenzenes. Am. Ind. Hyg. Assoc. J. 55:811-817.
34. Cottraux, J. 1993. Behavioral psychotherapy applications in the medically ill. Psychother. Psychosom. 60:116-128.
35. Crockett, A. J., J. M. Cranston, and J. H. Alpers. 1995. The changing prevalence of asthma-like respiratory symptoms in South Australian rural schoolchildren. J Paediatr. Child Health 31: 213-217.
36. Dalton, P. 1996. Odor perception and beliefs about risk. Chem. Senses 21:447-458.
37. Dalton, P. 1997. Cognitive influence on odor perception. Aroma-Chol. Rev. 6:2-9.
38. Dalton, P., and C. J. Wysocki. 1996. The nature and duration of adaptation following long-term odor exposure. Percept. Psychophys. 58:781-792.
39. Dalton, P., C. J. Wysocki, M. J. Brody, and H. J. Lawley. 1997. Perceived odor, irritation, and health symptoms following short-term exposure to acetone. Am. J. Ind. Med. 31:558-569.
40. Dember, W. N., J. S. Warm, and R. Parasuraman. 1995. Olfactory stimulation and sustained attention. In: A. N. Gilbert (Ed.) Compendium of Olfactory Research. pp 39-46. Kendall/Hunt Publ. Co., Dubuque, IA.
41. Dick, R. B. 1988. Short duration exposures to organic solvents: the relationship between neurobehavioral test results and other indicators. Neurotoxicol. Teratol. 10:39-50.
42. Donham, K. J., J. A. Merchant, D. Lassise, W. J. Popendorf, and L. F. Burmeister. 1990. Preventing respiratory disease in swine confinement workers: Intervention through applied epidemiology, education, and consultation. Am. J. Ind. Med. 18:241-261.
43. Doty, R. L., D. A. Deems, R. E. Frye, R. Pelberg, and A. Shapiro. 1988. Olfactory sensitivity, nasal resistance, and autonomic function in patients with multiple chemical sensitivities. Arch. Otolaryngol. Head Neck Surg. 114:1422-1427.
44. Durand-Lagarde, M., and G. Kobal. 1991. P300: A new technique of recording a cognitive component in olfactory evoked potential. Chem. Senses 16:379.
45. Eccles, R. 1995. Rhinitis as a mechanism of respiratory defense. Eur. Arch. Oto-Rhino-Laryngol. Suppl. 1:S2-S7.
46. Ehrlichman, H. 1995. Influence of odors on mood-related behavior. In: A. N. Gilbert (Ed.) Compendium of Olfactory Research. pp 91-96. Kendall/Hunt, Dubuque, IA.
47. Eisen, E. A., D. H. Wegman, D. Kriebel, S. R. Woskie, and X. Hu. 1991. An epidemiologic approach to the study of acute reversible health effects in the workplace. Epidemiology 2:263-270.
48. Emmelkamp, P. M., and P. van Oppen. 1993. Cognitive interventions in behavioral medicine. Psychother. Psychosom. 59: 116-130.
49. Engel, G. L. 1977. The need for a new medical model: A challenge for biomedicine. Science (Wash., DC) 196:129-136.
50. EPA. The Environmental Exposures and Health Questionnaire. Obtained from Dr. Howard Kerhl at the Environmental Protection Agency, U.S. EPA Chapel Hill, NC.
51. Feron, V. J., and A. Kruysse. 1978. Til HP. Immel HR. Repeated exposure to acrolein vapour: subacute studies in hamsters, rats and rabbits. Toxicology 9:47-57.
52. Fishwick, D., A. M. Fletcher, C. A. Pickering, R. M. Niven, and E. B. Faragher. 1994. Ocular and nasal irritation in operatives in Lancashire cotton and synthetic fibre mills. Occup. Environ. Med. 51:744-748.
53. Friedman, R., D. Sobel, P. Myers, M. Caudill, and H. Benson. 1995. Behavioral medicine, clinical health psychology, and cost offset. Health Psychol. 14:509-518.
54. Gagnaire, F., S. Azim, P. Bonnet, P. Simon, J. P. Guenier, and J. de Ceaurriz. 1989. Nasal irritation and pulmonary toxicity of aliphatic amines in mice. J. Appl. Toxicol. 9:301-304.
55. Gilbert, M. E. 1992. Neurotoxicants and limbic kindling. In: R. L. Isaacson and K. F. Jensen (Ed.) The Vulnerable Brain and Environmental Risks. Vol. 1. Malnutrition and Hazard Assessment. Plenum Press, New York.
56. Goldstein, B. D. (Workshop Chair). 1993. Research Priorities for Mobile Air Toxics. Health Effects Institute, Cambridge, MA.
57. Gomez, S. R., R. A. Parker, J. A. Dosman, and H. H. McDuffie. 1992. Respiratory health effects of alkali dust in residents near desiccated Old Wives Lake. Arch. Environ. Health 47:364-369.
58. Green, D. J., R. Bascom, E. M. Healey, J. R. Hebel, L. R. Sauder, and T. J. Kulle. 1989. Acute pulmonary response in healthy, nonsmoking adults to inhalation of formaldehyde and carbon. J. Toxicol. Environ. Health 28:261-275.
59. Herz, R. S., and T. Engen. 1996. Odor memory: Review and analysis. Psycho. Bull. Rev. 3:300-313.
60. Horesh, A. J. 1966. The role of odors and vapors in allergic disease. J. Asthma Res. 4:125-136.
61. Hudnell, H. K., D. A. Otto, D. E. House, and L. Molhave. 1992. Exposure of humans to a volatile organic mixture. II. Sensory. Arch. Environ. Health. 47:31-38.
62. Hughes, J. R., and O. J. Andy. 1979. The human amygdala. I. Electrophysiological responses to odorants. Electroencephalogr. Clin. Neurophysiol. 46:428-443.
63. Jackson, R. T., J. Tigges, and W. Arnold. 1979. Subarachnoid space of the CNS, nasal mucosa, and lymphatic system. Arch. Otolaryngol. 105:180-184.
64. Jenkins, C. D. 1990. An integrated behavioral medicine approach to improving care of patients with diabetes mellitus. Behav. Med. 21:53-68.
65. Kaplan, R. M. 1990. Behavior as the central outcome in health care. Am. Psychol. 45:1211-1220.
66. Kawai, T., T. Yasugi, K. Mizunuma, S. Horiguchi, Y. Hirase, Y. Uchida, and M. Ikeda. 1991. Methanol in urine as a biological indicator of occupational exposure to methanol vapor. Int. Arch. Occup. Environ. Health 63:311-318.
67. Kelly, J. A., and D. A. Murphy. 1992. Psychological interventions with AIDS and HIV: prevention and treatment. J. Consult. Clin. Psychol. 60:576-585.
68. King, D. S. 1981. Can allergic exposure provoke psychological symptoms? A double-blind test. Biol. Psychiatry 16:3-19.
69. Kishi, R., I. Itoh, S. Ishizu, I. Harabuchi, and H. Miyake. 1991. Symptoms among workers with long-term exposure to methyl bromide. An epidemiological study. Sangyo Igaku 33:241-250.
70. Knasko, S. C., A. N. Gilbert, and J. Sabini. 1990. Emotional state, physical well-being, and performance in the presence of feigned ambient odor. J. Appl. Soc. Psychol. 20:1345-1357.
71. Kobal, G., and T. Hummel. 1991. Human electro-olfactograms and brain responses to olfactory stimulation. In: D. F. Laing, R. L. Doty, and W. Breipohl (Ed.) The Human Sense of Smell. pp 199-215. Springer, Berlin.
72. Koren, H. S. 1995. Associations between criteria air pollutants and asthma. Environ. Health Perspect. 103(Suppl. 6):235-242.
73. Koren, H. S., and R. B. Devlin. 1992. Human upper respiratory tract responses to inhaled pollutants with emphasis on nasal lavage. Ann. NY Acad. Sci. 641:215-224.
74. Koren, H. S., D. E. Graham, and R. B. Devlin. 1992. Exposure of humans to a volatile organic mixture. III. Inflammatory response. Arch. Environ. Health 47:39-44.
75. Kruysse, A., V. J. Feron, and H. P. Til. 1975. Repeated exposure to acetaldehyde vapor. Studies in Syrian golden hamsters. Arch. Environ. Health 30:449-452.
76. Lach, B., and E. Atack. 1988. Disseminated hemorrhagic leukoencephalomyelitis with localized herpes simplex brain stem infection. Acta Neuropathol. (Berl.). 75:354-361.
77. Leikauf, G. D. 1992. Formaldehyde and other aldehydes. In: M. Lippmann (Ed.) Environmental Toxicants: Human Exposures and Their Health Effects. pp 299-330. Van Nostrand Reinhold, New York.
78. Leikauf, G. D., S. Kline, R. E. Albert, C. S. Baxter, D. I. Bernstein, and C. R. Buncher. 1995. Evaluation of a possible association of urban air toxics and asthma. Environ. Health Perspect. 103(Suppl. 6):253-271.
79. Levin, A. S., and V. S. Byers. 1987. Environmental illness: A disorder of immune regulation. Occup. Med. 2:669-681.
80. Lindberg, E., and G. Hedenstierna. 1983. Chrome plating: Symptoms, findings in the upper airways, and effects on lung function. Arch. Environ. Health. 38:367-374.
81. Lorig, T. S. 1994. EEG and ERP studies of low-level odor exposure in normal subjects. Toxicol. Ind. Health 10:579-586.
82. Lorig, T. S., K. B. Herman, G. E.Schwartz, and W. S. Cain. 1990. EEG activity during administration of low-concentration odors. Bull. Psychonom. Soc. 28:405-408.
83. Lorig, T. S., E. Huffman, A. DeMartino, and J. DeMarco. 1991. The effects of low concentration odors on EEG activity and behavior. J. Psychophysiol. 5:69-77.
84. Lorig, T. S., and M. Roberts. 1990. Odor and cognitive alteration of the contingent negative variation. Chem. Senses 15:537-545.
85. Lundblad, L., and J. M. Lundberg. 1984. Capsaicin sensitive sensory neurons mediate the response to nasal irritation induced by the vapour phase of cigarette smoke. Toxicology 33:1-7.
86. Marnett, L. J. 1988. Health effects of aldehydes and alcohols in mobile source emissions. In: A. Y. Watson, R. R. Bates, and D. Kennedy (Ed.) Air Pollution, The Automobile, and Public Health. National Academy Press, Washington, DC.
87. Marshall, J. S., and J. Bienenstock. 1994. The role of mast cells in inflammatory reactions of the airways, skin and intestine. Curr. Opin. Immunol. 6:853-859.
88. Maruniak, J. A., W. L. Silver, and D. G. Moulton. 1983. Olfactory receptors respond to blood-borne odorants. Brain Res. 265: 312-316.
89. Meggs, W. J. 1993. Neurogenic inflammation and sensitivity to environmental chemicals. Environ. Health Perspect. 101: 234-238.
90. Morse, D. 1995. Environmental considerations of livestock producers. J. Anim. Sci. 73:2733-2740.
91. Nolte, D., and D. Berger. 1983. On vagal bronchoconstriction in asthmatic patients by nasal irritation. Eur. J. Respir. Dis. Suppl. 128:110-115.
92. Powell, C. V. 1993. Asthma in childhood. Br. J. Hosp. Med. 49: 127-130.
93. Price, J. L. 1991. The olfactory system. In: G. Paxinos (Ed.) The Human Nervous System. pp 979-998. Academic Press, San Diego, CA.
94. Redd, W. H., and S. Manne. 1995. Using aroma to reduce distress during magnetic resonance imaging. In: A. N. Gilbert (Ed.) Compendium of Olfactory Research. pp 47-52. Kendall/Hunt, Dubuque, IA.
95. Reynolds, S. J., K. J. Donham, P. Whitten, J. A. Merchant, L. F. Burmeister, and W. J. Popendorf. 1996. Longitudinal evaluation of dose-response relationships for environmental exposures and pulmonary function in swine production workers. Am. J. Ind. Med. 29:33-40.
96. Riechelmann, H., K. Kienast, J. Schellenberg, and W. J. Mann. 1994. An in vitro model to study effects of airborne pollutants on human ciliary activity. Rhinology 32:105-108.
97. Roberts, E. 1986. Alzheimer's disease may begin in the nose and may be caused by aluminosilicates. Neurobiol. Aging 7: 561-567.
98. Rudell, B., T. Sandstrom, U. Hammarstrom, M. L. Ledin, P. Horstedt, and N. Stjernberg. 1994. Evaluation of an exposure setup for studying effects of diesel exhaust in humans. Int. Arch. Occup. Environ. Health. 66:77-83.
99. Russell, M., K. A. Dark, R. W. Cummins, G. Ellman, E. Callaway, and H. V. Peeke. 1984. Learned histamine release. Science (Wash., DC) 225:733-734.
100. Rusznak, C., J. L. Devalia, and R. J. Davies. 1994. The impact of pollution on allergic disease. Allergy 49(Suppl. 18):21-27.
101. Samet, J. M. 1995. Asthma and the environment: do environmental factors affect the incidence and prognosis of asthma? Toxicol. Lett. 82-83:33-38.
102. Sanderson, W. C., R. M. Rapee, and D. H. Barlow. 1989. The influence of an illusion of control on panic attacks induced via inhalation of 5.5% carbon dioxide-enriched air. Arch. Gen. Psychiatry 46:157-162.
103. Sapolsky, R. M., H. Uno, C. S. Rebert, and C. E. Finch. 1990. Hippocampal damage associated with prolonged glucocorticoid exposure in primates. J. Neurosci. 10:2897-2902.
104. Saunders, R. L, Jr., G. M. Halpern, and M. E. Gershwin. 1995. Odor-associated idiopathic anaphylaxis. A case report. Allergol. Immunopathol. (Madr.) 23:35-37.
105. Schiffman, S. S. 1974. Physicochemical correlates of olfactory quality. Science (Wash., DC) 185:112-117.
106. Schiffman, S. S., and H. T. Nagle. 1992. Effect of environmental pollutants on taste and smell. Otolaryngol. Head Neck Surg. 106:693-700.
107. Schiffman, S. S., E. A. Sattely-Miller, M. S. Suggs, and B. G. Graham. 1995a. The effect of environmental odors emanating from commercial swine operations on the mood of nearby residents. Brain Res. Bull. 37:369-375.
108. Schiffman, S. S., E. A. Sattely-Miller, M. S. Suggs, and B. G. Graham. 1995b. The effect of pleasant odors and hormone status on mood of women at midlife. Brain Res. Bull. 36:19-29.
109. Schiffman, S. S., and J. M. Siebert. 1991. New frontiers in fragrance use. Cosmet. Toiletries 106:39-45.
110. Schiffman, S. S., M. S. Suggs, and E. A. Sattely-Miller. 1995c. Effect of pleasant odors on mood of males at midlife: Comparison of African-American and European-American men. Brain Res. Bull. 36:31-37.
111. Schiffman, S. S., and Z. S. Warwick. 1993. Effect of flavor enhancement of foods for the elderly on nutritional status: Food intake, biochemical indices and anthropometric measures. Physiol. Behav. 53:395-402.
112. Schwartz, G. E. 1982. Testing the biopsychosocial model: The ultimate challenge facing behavioral medicine?. J. Consult. Clin. Psychol. 50:1040-1053.
113. Sekizawa, S. I., and H. Tsubone. 1994. Nasal receptors responding to noxious chemical irritants. Respir. Physiol. 96:37-48.
114. Shah, J. J., and H. B. Singh. 1988. Distribution of volatile organic chemicals in outdoor and indoor air. Environ. Sci. Technol. 22: 1381-1388.
115. Shavit, Y., J. W. Lewis, G. W. Terman, R. P. Gale, and J. C. Liebeskind. 1984. Opioid peptides mediate the suppressive effect of stress on natural killer cell cytotoxicity. Science (Wash., DC) 223:188-190.
116. Shipley, M. T. 1985. Transport of molecules from nose to brain: Transneuronal anterograde and retrograde labeling in the rat olfactory system by wheat germ agglutinin-horseradish peroxidase applied to the nasal epithelium. Brain Res. Bull. 15: 129-142.
117. Shusterman, D. 1992. Critical review: The health significance of environmental odor pollution. Arch. Environ. Health 47:76-87.
118. Shusterman, D., J. Balmes, and J. Cone. 1988. Behavioral sensitization to irritants/odorants after acute overexposures. J. Occup. Med. 30:565-567.
119. Silver, W. L. 1992. Neural and pharmacological basis for nasal irritation. Ann. NY Acad. Sci. 641:152-163.
120. Simon, G. E., W. J. Katon, and P. J. Sparks. 1990. Allergic to life: psychological factors in environmental illness. Am. J. Psychiatry 147:901-906.
121. Singh, I., M. Mehta, J. Singh, and J. Yadav. 1994. Nasal mucus clearance in chronic smokers. Indian J. Chest Dis. Allied Sci. 36:133-136.
122. Smid, T., D. Heederik, R. Houba, and P. H. Quanjer. 1994. Dust- and endotoxin-related acute lung function changes and workrelated symptoms in workers in the animal feed industry. Am. J. Ind. Med. 25:877-888.
123. Sparks, P. J., G. E. Simon, W. J. Katon, L. C. Altman, G. H. Ayars, and R. L. Johnson. 1990. An outbreak of illness among aerospace workers. West. J. Med. 153:28-33.
124. Speer, F. 1976. Allergic headache. Compr. Ther. 2:45-50.
125. Spit, B. J., F. Bretschneider, E. G. Hendriksen, and C. F. Kuper. 1993. Ultrastructure of free nerve endings in respiratory and squamous epithelium on the rat nasal septum. Cell Tissue Res. 274:329-335.
126. Stueven, H. A., P. Coogan, and V. Valley. 1993. A hazardous material episode: Sulfur trioxide. Vet. Hum. Toxicol. 35:37-38.
127. Taub, S. J. 1967. The role of odors and vapors in allergic disorders. Eye Ear Nose Throat Mon. 46:779-780.
128. Thu, K., K. Donham, R. Ziegenhorn, S. Reynolds, P. S. Thorne, P. Subramanian, P. Whitten, and J. Stookesberry. 1997. A control study of the physical and mental health of residents living near a large-scale swine operation. J. Agric. Safety Health 3:13-26.
129. Utell, M. J., and R. J. Looney. 1995. Environmentally induced asthma. Toxicol. Lett. 82-83:47-53.
130. van Toller, S., and M. Kendal-Reed. 1995. A possible protocognitive role for odor in human infant development. Brain Cognition 29: 275-293.
131. Verrier, R. L., and M. A. Mittleman. 1996. Life-threatening cardiovascular consequences of anger in patients with coronary heart disease. Cardiol. Clin. 14:289-307.
132. Wachs, M., D. Proud, L. M. Lichtenstein, A. Kagey-Sobotka, P. S. Norman, and R. M. Naclerio. 1989. Observations on the pathogenesis of nasal priming. J. Allergy Clin. Immunol. 84:492-501.
133. Wang, H. W., C. J. Wysocki, and G. H. Gold. 1993. Induction of olfactory receptor sensitivity in mice. Science (Wash., DC) 260: 998-1000.
134. Wardlaw, A. J. 1993. The role of air pollution in asthma. Clin. Exp. Allergy 23:81-96.
135. Ware, J. H., J. D. Spengler, L. M. Neas, J. M. Samet, G. R. Wagner, D. Coultas, H. Ozkaynak, and M. Schwab. 1993. Respiratory and irritant health effects of ambient volatile organic compounds. The Kanawha County Health Study. Am. J. Epidemiol. 137:1287-1301.
136. Warren, D. W., J. C. Walker, A. F. Drake, and R. W. Lutz. 1992. Assessing the effects of odorants on nasal airway size and breathing. Physiol. Behav. 51:425-430.
137. Warren, D. W., J. C. Walker, A. F. Drake, and R. W. Lutz. 1994. Effects of odorants and irritants on respiratory behavior. Laryngoscope 104:623-626.
138. Weeke, E. R. 1992. Epidemiology of allergic diseases in children. Rhinol. Suppl. 13:5-12.
139. Wexler, B. E., R. F. Fulbright, C. Greer, G. M. Shepherd, A. Bowers, C. Lacdie, and J. C. Gore. 1995. An fMRI study of human brain responses to attractant and aversive odors. Chem. Senses 20: 801.
140. Whitehead, W. E. 1992. Behavioral medicine approaches to gastrointestinal disorders. J. Consult. Clin. Psychol. 60:605-612.
141. Wolfe, V., R. Cornell, and C. Palmer. 1991. Acoustic correlates of pathologic voice types. J. Speech Hear. Res. 34:509-516.
142. Wysocki, C. J., P. Dalton, M. J. Brody, and H. J. Lawley. 1997. Acetone odor and irritation thresholds obtained from acetone-exposed factory workers and from control (occupationally unexposed) subjects. Am. Ind. Hyg. Assoc. J. 58:704-712.
143. Wysocki, C. J., K. M. Dorries, and G. K. Beauchamp. 1989. Ability to perceive androstenone can be acquired by ostensibly anosmic people. Proc. Natl. Acad. Sci. USA 86:7976-7978.
144. Yousem, D. M., S. C. Williams, R. O. Howard, C. Andrew, A. Simmons, M. Allin, R. J. Geckle, D. Suskind, E. T. Bullmore, M. J. Brammer, and R. L. Doty 1997. Functional MR imaging during odor stimulation: Preliminary data. Radiology 204: 833-838.
145. Zald, D. H., and J. V. Pardo. 1997. Emotion, olfaction and the human amygdala: Amygdala activation during aversive olfactory stimulation. Proc. Natl. Acad. Sci. USA 94:4119-4124.
146. Ziem, G. E., and L. L. Davidoff. 1992. Illness from chemical "odors": is the health significance understood? Arch. Environ. Health 47:88-91.