Dose-dependent pancreatotrophic effect of cholecystokinin-octapeptide in the rat: The influence of starvation

Pharmacological Research

Volumn 37, Issue 4, 1998, Pages 309-319

  Nagy, István ^a   Lászik, Zoltán ^a   Mohácsi, Gábor ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Cholecystokinin octapeptide; Islets of Langerhans; Pancreatic hypertrophy; Pancreatic secretory trypsin inhibitor; Pancreatitis; Trypsinogen

Indexed keywords

AMYLASE; CHOLECYSTOKININ OCTAPEPTIDE; DNA; PANCREAS ENZYME; PANCREAS HORMONE; PROTEIN; SERINE PROTEINASE; TRYPSIN INHIBITOR;

ACINAR CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL VACUOLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; HISTOLOGY; INFLAMMATION; MALE; NONHUMAN; ORGAN WEIGHT; PANCREAS FUNCTION; PRIORITY JOURNAL; RAT; STARVATION; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0032055927     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.1998.0304     Document Type: Article

References (37)

1. 1. Solomon TE. Regulation of exocrine pancreatic cell proliferation and enzyme synthesis. In: Johnson LR, ed. Physiology of the Gastrointestinal Tract. New York: Raven Press, 1981: pp. 873-92.
2. 2. Elsässer H-P, Adler G, Kern HF. Replication and regeneration of the pancreas. In: Go VLW, DiMagno EP, Gardner JD, Lebenthal E, Reber HA, Scheele GA, eds. The Exocrine Pancreas: Biology, Pathology and Diseases, 2nd ed. New York: Raven Press, 1993: pp. 407-21.
3. 3. Niederau C, Luthen R, Heintges T. Effects of CCK on pancreatic function and morphology. Ann NY Acad Sci, 1994; 713: 180-98.
4. 4. Solcia E, Capella C, Chieli T, Bellini O, Bertazzoli C. Effect of chronic caerulein overdosage on the pancreas and gastrointestinal tract. In: Demling L, ed. Gastrointestinal Hormones. Stuttgart: Thieme, 1972: pp. 103-13.
5. 5. Lampel M, Kern HF. Acute interstitial pancreatitis in the rat induced by excessive doses of a pancreatic secretagogue. Virchows Arch A 1977; 373: 97-117.
6. 6. Gorelick FS, Adler G, Kern FH. Cerulein-induced pancreatitis. In: Go VLW, DiMagno EP, Gardner JD, Lebenthal E, Reber HA, Scheele GA, eds. The Exocrine Pancreas: Biology, Pathology and Diseases, 2nd ed. New York: Raven Press, 1993: pp. 501-26.
7. 7. Solomon TE, Petersen H, Elashoff J, Grossman MI. Interaction of caerulein and secretin on pancreatic size and composition in rat. Am J Physiol 1978; 236: E714-19.
8. 8. Varga G, Papp M, Solomon TE, Scarpignato C, Tóth IE, Szabó D. Caerulein in supramaximal doses fails to stimulate pancreatic growth, but it forces secretory granulopoiesis. Acta Physiol Hung 1988; 71: 99-106.
9. 9. Mansi C, Mela GS, Ceppa P, Sciaba L, Barreca A, Pasini D, Grosso M, Celle G. Trophic response and morphological changes in pancreas of caerulein treated rats: dose and time dependent effects. Ital J Gastroenterol 1990; 22: 59-63.
10. 10. Nagy I, Pap Á, Varró V. Time-course of changes in pancreatic size and enzyme composition in rats during starvation. Int J Pancreatol 1989; 5: 35-45.
11. 11. Tóth GK, Penke B, Zarándi M, Kovács K. Comparison and optimization of synthetic methods for preparing cholecystokinin peptides. Int J Peptide Protein Res 1985; 26: 630-8.
12. 12. Ceska M, Brown B, Birath K. A new rapid method for the clinical determination of α-amylase activities in human serum and urine. Optimal conditions. Clin Chim Acta 1969; 26: 437-44.
13. 13. Nagy I, Hajnal F, Mohácsi G, Németh J, Lászik Z, Pap Á. Pancreatic trophism in experimental liver cirrhosis. Int J Pancreatol 1993; 14: 157-66.
14. 14. Nagy I, Takács T, Mohácsi G. One-year treatment with cholecystokinin-octapeptide and secretin. Effects on pancreatic trophism in the rat. Pharm Res 1997; 36: 77-85.
15. 15. Wisner JR, Renner IG, Grendell JH, Niederau C, Ferrell LD. Gabexate mesilate (FOY) protects against ceruletide-induced acute pancreatitis in the rat. Pancreas 1987; 2: 181-6.
16. 16. Grimm H. Analysis of variance. In: Delaunois AL, ed. Biostatistics in Pharmacology. Oxford: Pergamon Press, 1973: 2: pp. 675-716.
17. 17. Varga G, Dobronyi I, Papp M. Time-specific development of pancreatic hypersecretory capacity during chronic caerulein treatment in rats. Scand J Gastroenterol 1989; 24: 565-70.
18. 18. Lee PC, Brooks S, Lebenthal E. Effect of fasting and refeeding on pancreatic enzymes and secretagogue responsiveness in rats. Am J Physiol 1982; 242: G215-21.
19. 19. Nagy I, Pap Á, Varró V, Tóth GK. Trophic effect of CCK-8, secretin and their combination on rat pancreas during starvation. In: Penke B, Török A, eds. Peptides. Berlin, New York: Walter de Gruyter, 1988: pp. 361-4.
20. 20. Lászik Z, Berger Z, Pap Á, Tóth GK, Varró V. Course and regression of acute interstitial pancreatitis induced in rats by repeated serial subcutaneous cholecystokinin-octapeptide injections. Int J Pancreatol, 1989; 5: 347-58.
21. 21. Shorrock K, Austen BM, Hermon-Taylor J. Hyperstimulation pancreatitis in mice induced by cholecystokinin octapeptide, caerulein, and novel analogues: effect of molecular structure on potency. Pancreas, 1991; 6: 404-6.
22. 22. Oates PS, Morgan RGH. Short-term effects of feeding raw soya flour on pancreatic cell turnover in the rat. Am J Physiol 1984; 247: G667-73.
23. 23. Sarraf CE, Watanapa P, Emons VE, Williamson RCN, Alison MR. Severe subcellular damage in the rat exocrine pancreas after pancreatobiliary diversion. Pancreas 1993; 8: 338-45.
24. 24. Nevalainen TJ, Janigan DT. Degeneration of mouse pancreatic acinar cells during fasting. Virchows Arch B 1974; 15: 107-18.
25. 25. Otsuki M, Tani S, Okabayashi Y, Fuji M, Nakamura T, Fujisawa T, Koide M, Itoh H. Fasting prevents acute pancreatitis induced by caerulein in rats. Dig Dis Sci 1990; 35: 840-8.
26. 26. Goodman MN, Ruderman NB. Starvation in the rat. I. Effect of age and obesity on organ weights, RNA, DNA, and protein. Am J Physiol 1980; 239: E269-76.
27. 27. Goodman MN, Larsen PR, Kaplan MM, Aoki TT, Young VR, Ruderman NB. Starvation in the rat. II. Effect of age and obesity on protein sparing and fuel metabolism. Am J Physiol 1980; 239: E277-86.
28. 28. Bockman DE. Microvasculature of the pancreas. Relation to pancreatitis. Int J Pancreatol 1992; 12: 11-21.
29. 29. Williams JA, Goldfine ID. The insulin-acinar relationship. In: Go VLW, DiMagno EP, Gardner JD, Lebenthal E, Reber HA, Scheele GA, eds. The Exocrine Pancreas: Biology, Pathology and Diseases, 2nd ed. New York: Raven Press, 1993: pp. 789-802.
30. 30. v Schönfeld J, Goebell H, Müller MK. The islet acinar axis of the pancreas. Int J Pancreatol 1994; 16: 131-40.
31. 31. Nakagawa A, Stagner JI, Samols E. In situ binding of islet hormones in the isolated perfused rat pancreas: evidence for local high concentrations of islet hormones via the islet-acinar axis. Diabetologia 1995; 38: 262-8.
32. 32. Kramer MF, Tan HT. The peri-insular acini of the pancreas of the rat. Z Zellforsch 1968; 86: 163-70.
33. 33. Sergeyeva MA. Microscopic changes in the pancreatic gland of the cat produced by sympathetic and parasympathetic stimulation. Anat Rec 1938; 71: 319-36.
34. 34. Nagy I. Coordinated regulation of pancreatic secretory trypsin inhibitor (PSTI) and trypsinogen (TG) contents in the rat [abstract]. Z Gastroenterol 1991; 29: 196.
35. 35. Fukuoka S-I, Scheele GA. Rapid and selective cloning of monitor peptide, a novel cholecystokinin-releasing peptide, using minimal amino acid sequence and the polymerase chain reaction. Pancreas 1990; 5: 1-7.
36. 36. Miyasaka K, Funakoshi A, Nakamura E, Teraoka H. Regulation of gene expression of pancreatic secretory trypsin inhibitor-61 and -56 by bile and pancreatic juice in rats. Pancreas 1995; 11: 246-55.
37. 37. Scheele GA. Regulation of pancreatic gene expression in response to hormones and nutritional substrates. In: Go VLW, DiMagno EP, Gardner JD, Lebenthal E, Reber HA, Scheele GA, eds. The Exocrine Pancreas: Biology, Pathology and Diseases, 2nd ed. New York: Raven Press, 1993: pp. 103-20.