One-year treatment with cholecystokinin-octapeptide and secretin: Effects on pancreatic trophism in the rat

Pharmacological Research

Volumn 36, Issue 1, 1997, Pages 77-85

  Nagy, István ^a   Takács, Tamás ^a   Mohácsi, Gábor ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Cholecystokinin; Neoplasia; Pancreas; Rat; Secretin

Indexed keywords

AMYLASE; CHOLECYSTOKININ OCTAPEPTIDE; CHYMOTRYPSINOGEN; DNA; PANCREATIC ELASTASE; PROTEIN; SECRETIN; TRIACYLGLYCEROL LIPASE; TRYPSIN INHIBITOR; TRYPSINOGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; DNA CONTENT; HISTOLOGY; HYPERPLASIA; HYPERTROPHY; LONG TERM CARE; MALE; NONHUMAN; ORGAN WEIGHT; PANCREAS; PANCREAS SECRETION; PRIORITY JOURNAL; PROTEIN CONTENT; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0031193271     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.1997.0210     Document Type: Article

References (40)

1. 1. Solomon TE. Regulation of exocrine pancreatic cell proliferation and enzyme synthesis. In: Johnson LR. ed. Physiology of the Gastrointestinal Tract. New York: Raven Press, 1981: pp. 873-92.
2. 2. Longnecker DS, Jamieson JD, Asch HL. Regulation of growth and differentiation in pancreatic cancer. Pancreas 1989; 4: 256-75.
3. 3. Longnecker DS. Hormones and pancreatic cancer. Int J Pancreatol 1991; 9: 81-6.
4. 4. Baldwin GS. The role of gastrin and cholecystokinin in normal and neoplastic gastrointestinal growth. J Gastroenterol Hepatol 1995; 10: 215-32.
5. 5. Wormsley KG. Adaptive mutagenesis - cause of alimentary cancer? Scand J Gastroenterol 1992; 27:(suppl 193): 68-75.
6. 6. Stace NH, Palmer TJ, Vaja S, Dowling RH (1987). Longterm pancreaticobiliary diversion stimulates hyperplastic and adenomatous nodules in the rat pancreas: a new model for spontaneous tumour formation. Gut 1987; 28:(suppl 1): 265-8.
7. 7. Miazza BM, Widgren S, Chayvialle JA, Nicolet T, Loizeau E. Exocrine pancreatic nodules after longterm pancreaticobiliary diversion in rats. An effect of raised CCK plasma concentrations. Gut 1987; 28:(suppl 1): 269-73.
8. 8. Watanapa P, Williamson RCN. Experimental pancreatic hyperplasia and neoplasia: effects of dietary and surgical manipulation. Br J Cancer 1993; 67: 877-84.
9. 9. Pap A, Berger Z, Varró V. Trophic effect of cholecystokinin-octapeptide in man. A new way in the treatment of chronic pancreatitis? Digestion 1981; 21: 163-8.
10. 10. Pap Á, Varró V. Effect of ceruletide treatment on exocrine pancreatic function in chronic pancreatitis. Digestion 1984; 30: 118.
11. 11. Henry J, Steinberg W, Roberts I, Lambiotte M, Nochomowitz L. The pancreas self regulates its growth despite longterm (6 months) CCK-8 administration. Pancreas 1988; 3: 600.
12. 12. Solcia E, Capella C, Chieli T, Bellini O, Bertazzoli C. Effect of chronic caerulein overdosage on the pancreas and gastrointestinal tract. In: Demling L. ed. Gastrointestinal Hormones. Stuttgart: G Thieme, 1972: pp. 103-13.
13. 13. Tóth GK, Penke B, Zarándi M, Kovács K. Comparison and optimization of synthetic methods for preparing cholecystokinin peptides. Int J Pept Protein Res 1985; 26: 630-8.
14. 14. Giles KW, Myers A. An improved diphenylamine method for the estimation of deoxyribonucleic acid. Nature (London) 1965; 206: 93.
15. 15. Fritz H, Trautschold I, Werle E. Protease inhibitors. In: Bergmeyer HU. ed. Methods of Enzymatic Analysis. 2nd edn. Weinheim: Verlag Chemie, New York: Academic, 1974: vol. 2, pp. 1064-80.
16. 16. Ceska M, Brown B, Birath K. A new rapid method for the clinical determination of α-amylase activities in human serum and urine. Optimal conditions. Clin Chim Acta 1969; 26: 437-44.
17. 17. Erlanger BF, Kokowsky W, Cohen W. The preparation and properties of two new chromogenic substrates of trypsin. Arch Biochem Biophys 1961; 95: 271-8.
18. 18. Bundy HF. Chymotrypsin-catalyzed hydrolysis of N-acetyl- and N-benzoyl-L-tyrosine p-nitroanilides. Arch Biochem Biophys 1963; 102: 416-22.
19. 19. Bieth J, Spiess B, Wermuth CG. The synthesis and analytical use of a highly sensitive and convenient substrate of elastase. Biochem Med 1974; 11: 350-7.
20. 20. Goa J. Micro biuret method for protein determination; determination of total protein in cerebrospinal fluid. Scand J Clin Lab Med 1953; 5: 218-22.
21. 21. Honegger J, Hadorn B. The determination of lipase activity in human duodenal juice. Biol Gastroenterol 1973; 6: 217-23.
22. 22. Nagy I, Pap Á, Varró V. Time-course of changes in pancreatic size and enzyme composition in rats during starvation. Int J Pancreatol 1989; 5: 35-45.
23. 23. Nagy I, Hajnal F, Mohácsi G, Németh J, Lászik Z, Pap Á. Pancreatic trophism in experimental liver cirrhosis. Int J Pancreatol 1993; 14: 157-66.
24. 24. Takács T, Nagy I, Pap Á, Varró V. The anti-CCK effect of glutaramic acid derivatives in anesthetized and conscious rats. Pancreas 1988; 3: 465-70.
25. 25. Grimm H. Analysis of variance. In: Delaunois AL. ed. Biostatistics in Pharmacology. Vol. 2. Oxford: Pergamon Press, 1973: pp. 675-716.
26. 26. Pap Á, Nagy I, Takács T, Hajnal F, Tóth GK, Varró V. Mechanism of action of alcohol administration on the trophic effect of soybean trypsin inhibitor and cholecystokinin octapeptide in rat. Int J Pancreatol 1989; 5: 263-72.
27. 27. Niederau C, Lüthen R, Niederau M, Strohmeyer G, Ferrell LD, Grendell JH. Effects of long-term CCK stimulation and CCK blockade on pancreatic and intestinal growth, morphology and function. Digestion 1990; 66:(suppl 2): 217-25.
28. 28. Greenberg RE, McCann PP, Holt PR. Trophic responses of the pancreas differ in aging rats. Pancreas 1988; 3: 311-16.
29. 29. Williams JA. Role of receptors in mediating trophic stimuli in the pancreas. Gut 1987; 28:(suppl 1): 45-9.
30. 30. Petersen H, Solomon TE, Grossman MI. Pancreatic secretion in rats after chronic treatment with secretin plus cerulein. Gastroenterology 1979; 76: 790-4.
31. 31. Varga G, Dobronyi I, Papp M. Time-specific development of pancreatic hypersecretory capacity during chronic caerulein treatment in rats. Scand J Gastroenterol 1989; 24: 565-70.
32. 32. Papp M, Fodor I, Varga G, Folly G. Pancreatic edema: its effect on the function and morphology of the pancreas in dogs and rats. Mt Sinai J Med 1982; 49: 456-64.
33. 33. Papp M, Fodor I, Varga G. Development of intraductal protein plugs in rats fed with ethanol for 18 months. Acta Morphol Hung 1984; 32: 31-5.
34. 34. Sperti C, Militello C, Rovati L, Behboo R, Khajeturian E, Perasole A, Alaggio R, Pedrazzoli S. Effect of cholecystokinin analogue caerulein and cholecystokinin antagonist lorglumide on pancreatic carcinogenesis in the rat. J Surg Oncol 1994; 57: 11-16.
35. 35. McGuinnes EE, Morgan RGH, Wormsley KG. Fate of pancreatic nodules induced by raw soy flour in rats. Gut 1987; 28:(suppl 1): 207-12.
36. 36. Pour PM, Lawson T, Helgeson S, Donelly T, Stepan K. Effect of cholecystokinin on pancreatic carcinogenesis in the hamster model. Carcinogenesis 1988; 9: 597-602.
37. 37. Meijers M, Van Garderen-Hoetmer A, Lamers CBHW, Rovati LC, Jansen JBMJ, Woutersen RA. Role of cholecystokinin in the development of BOP-induced pancreatic lesion in hamsters. Carcinogenesis 1990; 11: 2223-6.
38. 38. Herrington MK, Permert J, Kazakoff KR, Zucker KA, Bilchik AJ, Pour PM, Adrian TE. Effects of raw soya diet and cholecystokinin receptor blockade on pancreatic growth and tumor initiation in the hamster. Cancer Lett 1994; 82: 7-16.
39. 39. Pour PM. The role of Langerhans islets in exocrine pancreatic cancer. Int J Pancreatol 1995; 17: 217-23.
40. 40. Bell RH Jr, Kuhlmann ET, Jensen RT, Longnecker DS. Overexpression of cholecystokinin receptors in azaserine-induced neoplasms of the rat pancreas. Cancer Res 1992; 52: 3295-9.