Low plasma ascorbic acid independently predicts the presence of an unstable coronary syndrome

Journal of the American College of Cardiology

Volumn 31, Issue 5, 1998, Pages 980-986

  Vita, Joseph A ^a,c   Keaney Jr , John F ^a   Raby, Khether E ^a   Morrow, Jason D ^b   Freedman, Jane E ^a   Lynch, Sean ^a   Koulouris, Spyridon N ^a   Hankin, Beth R ^a   Frei, Balz ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BOSTON MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID;

ADULT; AGED; ANGINA PECTORIS; ARTICLE; ATHEROSCLEROSIS; DIABETES MELLITUS; DISEASE SEVERITY; FEMALE; HEART CATHETERIZATION; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HUMAN; HYPERCHOLESTEROLEMIA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SEX DIFFERENCE; STATISTICAL ANALYSIS; UNSTABLE ANGINA PECTORIS; VITAMIN BLOOD LEVEL;

AGED; ANGINA PECTORIS; ANGINA, UNSTABLE; ANTIOXIDANTS; ARTERIOSCLEROSIS; ASCORBIC ACID; BIOLOGICAL MARKERS; CORONARY DISEASE; FEMALE; HUMANS; LINEAR MODELS; LIPID PEROXIDATION; LOGISTIC MODELS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION;

EID: 0032054720     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(98)00059-X     Document Type: Article

References (47)

1. Rimm EB, Stampfer MJ, Ascherio A, Giovannucci E, Colditz GA, Willett WC. Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med 1993;328:1450-6.
2. Stampfer MJ, Hennekens CH, Manson JE, Colditz GA, Rosner B, Willett WC. Vitamin E consumption and the risk of coronary disease in women. N Engl J Med 1993;328:1444-9.
3. Enstrom JE, Kanim LE, Klein MA. Vitamin C intake and mortality among a sample of the United States population. Epidemiology 1992;3:194-202.
4. Lynch SM, Frei B. Antioxidants as antiatherogens: animal studies. In: Frei B, editor. Natural Antioxidants in Human Health and Disease. San Diego (CA): Academic Press, 1994:353-86.
5. Hodis HN, Mack WJ, LaBree L, et al. Serial coronary angiographic evidence that antioxidant vitamin intake reduces progression of coronary artery atherosclerosis. JAMA 1995;273:1849-54.
6. Walldius G, Erikson U, Olsson AG, et al. The effect of probucol on femoral atherosclerosis: the Probucol Quantitative Regression Swedish Trial (PQRST). Am J Cardiol 1994;74:875-83.
7. Kritchevsky SB, Shimakawa T, Tell GS, et al. Dietary antioxidants and carotid artery wall thickness: the ARIC study. Circulation 1995;92:2142-50.
8. Diaz MN, Frei B, Vita JA, Keaney JF Jr. Antioxidants and atherosclerotic heart disease. N Engl J Med 1997;337:408-17.
9. Levine GN, Frei B, Koulouris SN, Gerhard MD, Keaney JF Jr, Vita JA. Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation 1996;96:1107-13.
10. Anderson TJ, Meredith IT, Yeung AC, Frei B, Selwyn A, Ganz P. The effect of cholesterol lowering and antioxidant therapy on endothelium-dependent coronary vasomotion. N Engl J Med 1995;332:488-93.
11. Freedman JE, Farhat J, Lock JM, Loscalzo J, Keaney JF Jr. Alpha tocopherol inhibits aggregation of human platelets by a protein kinase C-dependent mechanism. Circulation 1996;94:2434-40.
12. Berliner JA, Navab M, Fogelman AM, et al. Atherosclerosis: basic mechanisms; oxidation, inflammation, and genetics. Circulation 1995;91:2488-96.
13. Stephens NG, Parsons A, Schofield PM, Kelly F, Cheeseman K, Mitchinson MJ. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). Lancet 1996;347: 781-6.
14. Regnström J, Nilsson J, Tornvall P, Landou C, Hamsten A. Susceptibility to low-density lipoprotein oxidation and coronary atherosclerosis in man. Lancet 1992;339:1183-6.
15. Regnström J, Nilsson J, Moldeus P, et al. Inverse relation between the concentration of low-density-lipoprotein vitamin E and severity of coronary artery disease. Am J Clin Nutr 1996;63:377-85.
16. Ramirez J, Flowers NC. Leukocyte ascorbic acid and its relationship to coronary artery disease in man. Am J Clin Nutr 1980;33:2079-87.
17. Riemersma RA, Wood DA, Macintyre CCH, Elton RA, Gey KF, Oliver MF. Risk of angina pectoris and plasma concentrations of vitamins A, C, E, and carotene. Lancet 1991;337:1-5.
18. Nyyssönen K, Parviainen MT, Salonen R, Tuomilehto J, Salonen JT. Vitamin C deficiency and risk of myocardial infarction: prospective population study of men from eastern Finland. BMJ 1997;314:634-8.
19. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502.
20. Hamsten A, Walldius G, Szamosi A, Dahlen G, deFaire U. Relationship of angiographically defined coronary artery disease to serum lipoproteins and apolipoproteins in young survivors of myocardial infarction. Circulation 1986;73:1097-110.
21. Braunwald E. Unstable angina: a classification. Circulation 1989;80:410-14.
22. Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes (part 1). N Engl J Med 1992;326:242-50.
23. Frei B, Gaziano JM. Content of antioxidants, preformed lipid hydroperoxides, and cholesterol as predictors of the susceptibility of human LDL to metal ion-dependent and -independent oxidation. J Lipid Res 1993;34:2135-45.
24. Hess D, Keller HE, Oberlin B, Bonfanti R, Schuep W. Simultaneous determination of retinol, tocopherols, carotenes and lycopene in plasma by means of high-performance liquid chromatography on reversed phase. Int J Vit Res 1991;61:232-8.
25. Frei B, England L, Ames BN. Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci USA 1989;86:6377-81.
26. Ellman GL. Tissue sulphhydryl groups. Arch Biochem Biophys 1959;82:70-77.
27. Morrow JD, Roberts LJ. Mass spectrometry of prostanoids: F2-isoprostanes produced by noncyclooxygenase free radical-catalyzed mechanism. Methods Enzymol 1994;233:163-74.
28. Schosinsky KH, Lehmann HP, Beeler MF. Measurement of ceruloplasmin from its oxidase activity in serum by use of o-dianisidine dihydrochloride. Clin Chem 1974;20:1556-63.
29. Lynch SM, Strain JJ. Effects of copper deficiency on hepatic and cardiac antioxidant enzyme activities in lactose- and sucrose-fed rats. Br J Nutr 1989;61:345-54.
30. Andrews TC, Goldman L, Creager MA, et al. Identification and treatment of myocardial ischemia in patients undergoing peripheral vascular surgery. J Vase Med Biol 1994;5:8-15.
31. Mickey RM, Greenland S. The impact of confounder selection criteria on effect estimation. Am J Epidemiol 1989;129:125-37.
32. Labadarios D, Brink PA, Weich HFH, et al. Plasma vitamin A, E, C and B6 levels in myocardial infarction. S Afr Med J 1987;71:561-3.
33. Vallance BD, Hume R, Weyers E. Reassessment of changes in leukocyte and serum ascorbic acid after acute myocardial infarction. Br Heart J 1978;40: 64-8.
34. Machtey I, Syrkis I, Fried M. Studies of blood ascorbic acid levels in acute myocardial infarction. Clinica Chimica Acta 1975;62:149-51.
35. Ylä-Herttuala S, Palinski W, Rosenfeld ME, et al. Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. J Clin Invest 1989;84:1086-95.
36. Salonen JT, Ylä-Herttuala S, Yamamoto R, et al. Autoantibody against oxidised LDL and progression of carotid atherosclerosis. Lancet 1992;339: 883-7.
37. Keaney JF Jr, Frei B. Antioxidant protection of low-density lipoprotein and its role in the prevention of atherosclerotic vascular disease. In: Frei B, editor. Natural Antioxidants in Human Health and Disease. San Diego (CA): Academic Press, 1994:303-52.
38. McMurray J, Chopra M, Abdullah I, Smith WE, Dargie HJ. Evidence of oxidative stress in unstable angina. Br Heart J 1992;68:454-7.
39. Levine M, Conry-Cantilena C, Wang Y, et al. Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc Natl Acad Sci USA 1996;93:3704-9.
40. Meister A. Glutathione-ascorbic acid antioxidant system in animals. J Biol Chem 1994;269:9397-400.
41. Levine GN, Keaney JF Jr, Vita JA. Cholesterol reduction in cardiovascular disease: clinical benefits and possible mechanisms. N Engl J Med 1995;332: 512-21.
42. Libby P. Molecular basis of the acute coronary syndromes. Circulation 1995;91:2844-50.
43. Keaney JF, Vita JA. Atherosclerosis, oxidative stress and antioxidant protection in endothelium-derived relaxing factor action. Prog Cardiovasc Dis 1995;38:129-54.
44. Weber C, Erl W, Weber K, Weber PC. Increased adhesiveness of isolated monocytes to endothelium is prevented by vitamin C intake in smokers. Circulation 1996;93:1488-92.
45. Beetens JR, Herman AG. Vitamin C increases the formation of prostacyclin by aortic rings from various species and neutralizes the inhibitory effect of 15-hydroperoxy-arachidonic acid. Br J Pharmacol 1983;80:249-54.
46. Moran JP, Cohen L, Greene JM, et al. Plasma ascorbic acid concentrations relate inversely to blood pressure in human subjects. Am J Clin Nutr 1993;57:213-7.
47. Ghigo D, Alessio P, Foco A, et al. Nitric oxide synthesis is impaired in glutathione-depleted human umbilical vein endothelial cells. Am J Physiol 1993;265:C728-32.