Formation of 3- amino-2, 6, 8-trimethyl-10-phenyldeca-4E, 6E-dienoic acid from microcystin LR by the treatment with various proteases, and its detection in mouce liver

Chemosphere

Volumn 36, Issue 10, 1998, Pages 2277-2282

  Takenaka, Shigeyuki ^a  

^a FUKUOKA INSTITUTE OF HEALTH AND ENVIRONMENTAL SCIENCES   (Japan)

Author keywords

3 Amino 2, 6, 8 trimethyl 10 phenyideca 4E; 6E dienoic acid; Microcystin LR; Microcystin LR metabolism in mice; Trypsin

Indexed keywords

CHYMOTRYPSIN; CYANOGINOSIN LR; DRINKING WATER; PEPSIN A; PROTEINASE; TRYPSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DEGRADATION; GASTROINTESTINAL TRACT; MALE; MAMMAL; METABOLISM; MOUSE; NONHUMAN; WATER CONTAMINATION;

ANIMALS; BACTERIAL TOXINS; DIGESTIVE SYSTEM; ENDOPEPTIDASES; HUMANS; LINOLEIC ACIDS; LIVER; MALE; MASS SPECTROMETRY; MICE; MICROCYSTINS; PEPTIDES, CYCLIC; SWINE;

ANIMALIA; MAMMALIA; SUIDAE;

EID: 0032054479     PISSN: 00456535     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0045-6535(97)10196-5     Document Type: Article

References (28)

1. (1) M.NAMIKOSHI, K.L.RINEHART, R.SAKAI. R.R.STOTTS, A.M.DAHLEM, V. R.BEASLEY, W.W. CARMICHAELand W.R.EVANS, J. Org. Chem., 57, 866 (1992).
2. (2) M.NAMIKOSHI, K.SIVONEN, W.R.EVANS, W.W.CARMICHAEL, L.ROUHIAINEN, R.LUUKKAINEN and K.L.RINEHART, Chem. Res. Toxicol., 5, 661 (1992).
3. (3) M.NAMIKOSHI, K.SIVONEN, W.R.EVANS, W.W.CARMICHAEL, F.SUN, L.ROUHIAINEN, R.LUUKKAINEN and K.L.RINEHART, Toxicon, 30, 1457 (1992).
4. (4) M.NAMIKOSHI, K.SIVONEN, W.R.EVANS, F.SUN, W.W.CARMICHAEL and K.L.RINEHART, Toxicon, 30, 1473 (1992).
5. (5) K.SIVONEN, W.W.CARMICHAEL, M.NAMIKOSHI, K.L.RINEHART, A.M. DAHLEMand S.I.NIEMELÄ, Appl. Environ. Microbiol., 56, 2650 (1991).
6. (6) K.SIVONEN, K.KONONEN, W.W.CARMICHAEL, A.M.DAHLEM, K.L.RINEHART, J.KIVIRANTA and S.I. NIEMELÄ, Appl. Environ. Microbiol., 55, 1990 (1989).
7. (7) K.SIVONEN, M.NAMIKOSHI, W.R.EVANS, W.W.CARMICHAEL, F.SUN, L.ROUHIAINEN, R.LUUKKAINEN and K.L.RINEHART, Appl. Environ. Microbiol., 58, 2495 (1992).
8. (8) K.SIVONEN, M.NAMIKOSHI, W.R.EVANS, M.FÄRDIG, W.W.CARMICHAEL and K.L.RINEHART, Chem. Res. Toxicol., 5, 464 (1992).
9. (9) K.SIVONEN, M.NAMIKOSHI, W. R.EVANS, B. V.GROMOV, W.W.CARMICHAEL and K.L.RINEHART, Toxicon, 30, 1481 (1992).
10. (10) K.SIVONEN, O.M.SKULBERG, M.NAMIKOSHI, W.R.EVANS, W.W.CARMICHAEL and K.L.RINEHART, Toxicon, 30, 1465 (1992).
11. (11) R.LUUKKAINEN, K.SIVONEN, M.NAMIKOSHI, M.FÄRDIG, K. L.RINEHART and S.I.NIEMELÄ, Appl. Environ. Microbiol., 59, 2204 (1993).
12. (12) C.MACKINTOSH, K.A.BEATTIE, S.KLUMPP, P.COHEN and G.A.CODD, FEBS Lett., 264, 187 (1990).
13. (13) R.MATSUSHIMA, S.YOSHIZAWA, M.F.WATANABE, K.-I.HARADA, M.FURUSAWA, W.W.CARMICHAEL and H.FUJIKI, Biochem. Biophys. Res. Commun., 171, 867 (1990).
14. (14) S.YOSHIZAWA, R.MATSUSHIMA, M.F.WATANABE, K.-I.HARADA, A.ICHIHARA, W.W.CARMICHAEL and H. FUJIKI, J. Cancer Res. Clin. Oncol., 116, 609(1990).
15. (15) I.R.FALCONER and T.H.BUCKLEY, Med. J. Aust., 150, 351 (1989).
16. (16) R.NISHIWAKI-MATSUSHIMA, T.OHTA, S.NISHIWAKI, M.SUGANUMA, K.KOHYAMA, T.ISHIKAWA, W.W.CARMICHAEL and H.FUJIKI, J. Cancer Res. Clin. Oncol., 118, 420 (1992).
17. (17) S.L.KENEFICK, S.E.HRUDEY, H.G.PERTERSON and E.E.PREPAS, Water Sci. Technol., 27, 433 (1993).
18. (18) G.J.JONES and PT.ORR, Water Res., 28, 871 (1994).
19. (19) K.TSUJI, S.NAITO, F.KONDO, N.ISHIKAWA, M.F.WATANABE, M.SUZUKI and K.-I.HARADA, Environ. Sci. Technol., 28, 173 (1994).
20. (20) T.W.LAMBERT, M.P.BOLAND, C.F.B.HOMES andS.E.HRUDEY, Environ. Sci. Technol., 28, 753 (1994).
21. (21) Y.TANAKA, S.TAKENAKA, H.MATSUO, S.KITAMORI and H.TOKIWA, Toxicol. Environ. Chem., 39, 21 (1993).
22. (22) S.TAKENAKA and M.F.WATANABE, Chemosphere, 34, 749 - 757 (1997).
23. (23) S.TAKENAKA and Y.TANAKA, Chemosphere, 30, 1 (1995).
24. (24) M.NAMIKOSHI, K.L.RINEHART AND W.W.CARMICHAEL, Tetrahedron, 30, 4349 (1989).
25. (25) S.TAKENAKA and Y.TANAKA, Chemosphere. 31, 3635 (1995).
26. (26) D.G.BOURNE, G.J.JONES, R.L.BLAKELEY, A.JONES, A.P.NEGRI and P.RIDDLES, Appl. Environ. Microbiol., 62, 4086 (1996).
27. (27) A.Y.MALYAVEUSKA YA, Arch. Hydrobiol., 97, 412 (1983).
28. (28) M.J.PHILLIPS, R.J.ROBERTS, J.A.STEWART AND G.A.CODD, J. Fish Dis., 8, 339 (1985).