Enhanced Protective Antibody Responses to PspA after Intranasal or Subcutaneous Injections of PspA Genetically Fused to Granulocyte-Macrophage Colony-Stimulating Factor or Interleukin-2

Infection and Immunity

Volumn 66, Issue 4, 1998, Pages 1513-1520

  Wortham, Charles ^a   Grinberg, Luba ^a   Kaslow, David C ^c   Briles, David E ^d   Mcdaniel, Larry S ^e   Lees, Andrew ^a   Flora, Michael ^b   Snapper, Clifford M ^b   Mond, James J ^a,b  

^a Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d University of Alabama at Birmingham   (United States)

^e UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; BACTERIUM ANTIBODY; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEAT SHOCK PROTEIN; HYBRID PROTEIN; IMMUNOGLOBULIN CLASS; INTERLEUKIN 2; PHAGE SHOCK PROTEIN, BACTERIA;

ANIMAL; ARTICLE; BLOOD; C3H MOUSE; CELL LINE; DBA MOUSE; IMMUNIZATION; IMMUNOLOGY; INTRANASAL DRUG ADMINISTRATION; MOUSE; STREPTOCOCCUS PNEUMONIAE; SUBCUTANEOUS DRUG ADMINISTRATION;

ADMINISTRATION, INTRANASAL; ANIMALS; ANTIBODIES, BACTERIAL; BACTERIAL PROTEINS; CELL LINE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HEAT-SHOCK PROTEINS; IMMUNIZATION; IMMUNOGLOBULIN ISOTYPES; INJECTIONS, SUBCUTANEOUS; INTERLEUKIN-2; MICE; MICE, INBRED C3H; MICE, INBRED DBA; RECOMBINANT FUSION PROTEINS; STREPTOCOCCUS PNEUMONIAE;

EID: 0032037720     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.66.4.1513-1520.1998     Document Type: Article

References (34)

1. Boraschi, D., L. Nencioni, L. Villa, S. Censini, P. Bossù, P. Ghiara, R. Presentini, F. Perin, D. Frasca, G. Doria, G. Forni, T. Musso, M. Giovarelli, P. Ghezzi, R. Bertini, H. O. Besedovsky, A. Del Ray, J. D. Sipe, G. Antoni, S. Silvestri, and A. Tagliabue. 1988. In vivo stimulation and restoration of the immune response by the noninflammatory fragment 163-171 of human interleukin 1β. J. Exp. Med. 168:675-686.
2. Briles, D. E., J. D. King, M. A. Gray, L. S. McDaniel, E. Swiatlo, and K. A. Benton. 1996. PspA, a protection-eliciting pneumococcal protein: immunogenicity of isolated native PspA in mice. Vaccine 14:858-867.
3. Briles, D. E., R. C. Tart, H.-Y. Wu, B. A. Ralph, M. W. Russell, and L. S. McDaniel. 1996. Systemic and mucosal protective immunity to pneumococcal surface protein A. N. Y. Acad. Sci. 797:118-126.
4. Chen, T. T., M.-H. Tao, and R. Levy. 1994. Idiotype-cytokine fusion proteins as cancer vaccines. Relative efficacy of IL-2, IL-4, and granulocyte-macrophage colony-stimulating factor. J. Immunol. 153:4775-4787.
5. Constant, S. L., and K. Bottomly. 1997. Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches. Annu. Rev. Immunol. 15:297-322.
6. Dale, J. B., and E. C. Chiang. 1995. Intranasal immunization with recombinant group A streptococcal M protein fragment fused to the B subunit of Escherichia coli labile toxin protects mice against systemic challenge infections. J. Infect. Dis. 171:1038-1041.
7. Debard, N., D. Buzoni-Gatel, and D. Bout. 1996. Intranasal immunization with SAG1 protein of Toxoplasma gondii in association with cholera toxin dramatically reduces development of cerebral cysts after oral infection. Infect. Immun. 64:2158-2166.
8. de Haan, A., J. F. Tomee, J. P. Huchshorn, and J. Wilschut. 1995. Liposomes as an immunoadjuvant system for stimulation of mucosal and systemic antibody responses against inactivated measles virus administered intranasally to mice. Vaccine 13:1320-1324.
9. Disis, M. L., H. Bernhard, F. M. Shiota, S. L. Hand, J. R. Grolow, E. S. Huseby, S. Gillis, and M. A. Cheever. 1996. Granulocyte-macrophage colony-stimulating factor: an effective adjuvant for protein and peptide-based vaccines. Blood 88:202-210.
10. Geissler, M., A. Gesien, K. Tokushige, and J. R. Wands. 1997. Enhancement of cellular and humoral immune responses to hepatitis C virus core protein using DNA-based vaccines augmented with cytokine-expressing plasmids. J. Immunol. 158:1231-1237.
11. Harvill, E. T., J. M. Fleming, and S. L. Morrison. 1996. In vivo properties of an IgG3-IL-2 fusion protein. A general strategy for immune potentiation. J. Immunol. 157:3165-3170.
12. Hazama, M., A. Mayumi-Aono, N. Asakawa, S. Kuroda, S. Hinuma, and Y. Fujisawa. 1993. Adjuvant-independent enhanced immune responses to recombinant herpes simplex virus type 1 glycoprotein D by fusion with biologically active interleukin-2. Vaccine 11:629-637.
13. Hinuma, S., M. Hazama, A. Mayumi, and Y. Fujisawa. 1991. A novel strategy for converting recombinant viral protein into high immunogenic antigen. FEBS Lett. 288:138-142.
14. Lowell, G. H., R. W. Kaminski, S. Grate, R. E. Hunt, C. Charney, S. Zimmer, and C. Colleton. 1996. Intranasal and intramuscular proteosome-staphylococcal enterotoxin B (SEB) toxoid vaccines: immunogenicity and efficacy against lethal SEB intoxication in mice. Infect. Immun. 64:1706-1713.
15. McDaniel, L. S., G. Scott, K. Widenhofer, J. M. Carroll, and D. E. Briles. 1986. Analysis of a surface protein of Streptococcus pneumoniae recognized by protective monoclonal antibodies. Microb. Pathog. 1:519-531.
16. McDaniel, L. S., B. A. Ralph, D. O. McDaniel, and D. E. Briles. 1994. Localization of protection-eliciting epitopes on PspA of Streptococcus pneunionlae between amino acid residues 192 and 260. Microb. Pathog. 17: 323-337.
17. McDaniel, L. S., J. S. Sheffield, P. Delucchi, and D. E. Briles. 1991. PspA, a surface protein of Streptococcus pneumoniae, is capable of eliciting protection against pneumococci of more than one capsular type. Infect. Immun. 59: 222-228.
18. Mond, J. J., A. Lees, and C. M. Snapper. 1995. T cell-independent antigens type 2. Annu. Rev. Immunol. 13:655-692.
19. Morrissey, P. J., L. Bressler, L. S. Park, A. Alpert, and S. Gillis. 1987. Granulocyte-macrophage colony-stimulating factor augments the primary antibody response by enhancing the function of antigen presenting cells. J. Immunol. 139:1113-1119.
20. Mosmann, T. R., and S. Sad. 1996. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today 17:138-146.
21. Nencioni, L., L. Villa, A. Tagliabue, G. Antoni, R. Presentini, F. Perin, S. Silvestri, and D. Boraschi. 1987. In vivo immunostimulating activity of the 163-171 peptide of human IL-1β. J. Immunol. 139:800-804.
22. Rao, K. V. S., and A. R. Nayak. 1990. Enhanced immunogenicity of a sequence derived from hepatitis B virus surface antigen in a composite peptide that includes the immunostimulatory region from human interleukin 1. Proc. Natl. Acad. Sci. USA 87:5519-5522.
23. Reed, S. G., D. L. Pihl, P. J. Conlon, and K. H. Grabstein. 1989. IL-1 as adjuvant: role of T cells in the augmentation of specific antibody production by recombinant human IL-1α. J. Immunol. 142:3129.
24. Russell, M. W., Z. Moldoveanu, P. L. White, G. J. Sibert, J. Mestecky, and S. M. Michalek. 1996. Salivary, nasal, genital, and systemic antibody responses in monkeys immunized intranasally with a bacterial protein antigen and the cholera toxin B subunit. Infect. Immun. 64:1272-1283.
25. Snapper, C. M., and W. E. Paul. 1987. Interferon-γ and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 236:944-947.
26. Snapper, C. M., M. A. Moorman, F. R. Rosas, M. R. Kehry, C. R. Maliszewski, and J. J. Mond. 1995. IL-3 and granulocyte-macrophage colony-stimulating factor strongly induce Ig secretion by sort-purified murine B cells activated through the membrane Ig, but not the CD40, signaling pathway. J. Immunol. 154:5842-5850.
27. Tagliabue, A., and D. Boraschi. 1993. Cytokines as vaccine adjuvants: interleukin 1 and its synthetic peptide 163-171. Vaccine 11:594-595.
28. Talkington, D. F., D. C. Voellinger, L. S. McDaniel, and D. E. Briles. 1992. Analysis of pneumococcal PspA microheterogeneity in SDS polyacrylamide gels and the association of PspA with the cell membrane. Microb. Pathog. 13: 343-355.
29. Tao, M.-H., and R. Levy. 1993. Idiotype/granulocyte-macrophage colony-stimulating factor fusion protein as a vaccine for B-cell lymphoma. Nature 362:755-758.
30. Weinberg, A., and T. C. Merigan. 1988. Recombinant interleukin 2 as an adjuvant for vaccine-induced protection: immunization of guinea pigs with herpes simplex virus subunii vaccines. J. Immunol. 140:294-299.
31. Xiang, Z., and H. C. J. Ertl. 1995. Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines. Immunity 2:129-135.
32. Yother, J., and D. E. Briles. 1992. Structural properties and evolutionary relationships of PspA, a surface protein of Streptococcus pneumoniae, as revealed by sequence analysis. J. Bacteriol. 174:601-609.
33. Yother, J., G. L. Handsome, and D. E. Briles. 1992. Truncated forms of PspA that are secreted from Streptococcus pneumoniae and their use in functional studies and cloning of the PspA gene. J. Bacteriol. 174:610-618.
34. Yother, J., and J. M. White. 1994. Novel surface attachment mechanism for the Streptococcus pneumoniae protein PspA. J. Bacteriol. 176:2976-2985.