Manipulating flux through plant metabolic pathways

Current Opinion in Plant Biology

Volumn 1, Issue 2, 1998, Pages 173-178

  Kinney, Anthony J ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MODEL; METABOLISM; PLANT; REVIEW;

MODELS, BIOLOGICAL; PLANTS;

EID: 0032035335     PISSN: 13695266     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1369-5266(98)80021-6     Document Type: Article

References (9)

1. Kinney AJ: Improving soybean seed quality. In Induced Mutations and Molecular Techniques for Crop Improvement. Vienna: International Atomic Energy Agency: 1995:101-113.
2. Herbers K, Sonnewald U: Manipulating metabolic partitioning in plants. Trends Biotech 1996, 14:198-205.
3. John ME, Keller G: Metabolic pathway engineering in cotton: biosynthesis of polyhydroxybutyrate in fiber cells. Proc Natl Acad Sci USA 1996, 93:1268-1277.
4. Kinney AJ: Genetic engineering of oilseeds for desired traits. In Genetic Engineering. Edited by Setlow JK. New York: Plenum Press 1997, 19:149-166. Comprehensive review of the metabolic engineering of fatty acid biosynthetic pathways in plants.
5. Hezari M, Croteau R: Taxol biosynthesis: an update. Planta Medica 1997, 63:291-295. An update on the biosynthesis of taxol, a diterpenoid chemotherapeutic agent, with useful discussion on target for pathway engineering to increase production. A good example of the potential for engineering secondary metabolism to produce a pharmaceutically important chemical.
6. Dixon RA, Lamb CJ, Masoud S, Sewalt VJH, Paiva NL: Metabolic engineering: prospects for crop improvement through the genetic manipulation of polypropanoid biosynthesis and defense responses. Gene 1996, 179:61-71.
7. Thomas S, Mooney PJF, Burrell MM, Fell DA: Finite change analysis of glycolytic intermediates in tuber tissue of lines of transgenic potato overexpressing phosphofructokinase. Biochem J 1997, 322:111-117. Using transgenic plant lines for metabolic control analysis. With its companion paper (see [8]) postulates novel view of flux generating steps in metabolic pathways. A different and interesting view of metabolism.
8. Thomas S, Mooney PJF, Burrell MM, Fell DA: Metabolic control analysis of glycolysis in tuber tissue of potato (Solanum tuberosum): explanation for the low control coefficient of phosphofructokinase over respiratory flux Biochem J 1997, 322:111-117. With its companion paper [7] expands on a novel view of flux-generating steps in metabolic pathways with the postulation that flux-generating steps may not be ideal targets for pathway flux manipulation.
9. Nagiec MM, Wells GB, Lester RL, Dickson RC: A suppressor gene that enables Saccharomyces cerevisiae to grow without making sphingolipids encodes a protein that resembles an E. coli fatty acyltransferase. J Biol Chem 1993, 268:22156-22163.