Inflammatory cells in full-thickness anulus injury in pigs: An experimental disc herniation animal model

Spine

Volumn 23, Issue 5, 1998, Pages 524-529

  Habtemariam, Aklilu ^a   Virri, Johanna ^a,b   Grönblad, Mats ^a,b,d   Holm, Sten ^c   Kaigle, Allison ^c   Karaharju, Erkki ^b  

^a Thermo Fisher Scientific Oy   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^d HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Full thickness anulus injury; Inflammation; Porcine disc

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; IMMUNOPATHOGENESIS; IMMUNOREACTIVITY; INFLAMMATORY CELL; INTERVERTEBRAL DISK HERNIA; LUMBAR DISK HERNIA; MACROPHAGE; NONHUMAN; PATHOPHYSIOLOGY; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; SPINAL CORD INJURY; SWINE; T LYMPHOCYTE;

ANIMALS; BIOLOGICAL MARKERS; DISEASE MODELS, ANIMAL; HUMANS; INTERVERTEBRAL DISK DISPLACEMENT; LEUKOCYTE COUNT; MACROPHAGES; SWINE; T-LYMPHOCYTES;

EID: 0032033675     PISSN: 03622436     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007632-199803010-00002     Document Type: Article

References (24)

1. Cordell JL, Falini B, Erber WN, et al. Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J Histochem Cytochem 1984;32: 219-29.
2. Doita M, Kanatani T, Harada T, Mizuno K. Immunohistologic study of the ruptured intervertebral disc of the lumbar spine. Spine 1996;21:235-41.
3. Franson RC, Saal JS, Saal JA. Human disc phospholipase A2 is inflammatory. Spine 1992;17(Suppl):S129-32.
4. Grönblad M, Tolonen J, Virri J, Karaharju E, Kankare J, Myllynen P. Immunohistochemical characterization of proinflammatory cell types in disc herniation tissue. Presented at the annual meeting of the International Society for the Study of the Lumbar Spine, Marseilles, France, June 15-19, 1993.
5. Grönblad M, Virri J, Tolonen J, et al. A controlled immunohistochemical study of inflammatory cells in disc herniation tissue. Spine 1994;19:2744-51.
6. Grönblad M, Virri J. Nerves, neuropeptides and inflammation in spinal tissues: Mechanisms of back pain. In: Giles LGF, Singer KP, eds. Clinical Anatomy and Management of Low back Pain. Oxford: Butterworth Heinemann, 1996:231-42.
7. Habtemariam A, Grönblad M, Virri J, Seitsalo S, Ruuskanen M, Karaharju E. Immunocytochemical localization of immunoglobulins in disc herniations. Spine 1996;21:1864-9.
8. Horowitz MC, Friedlaender GE, Qian H-Y. The immune response: The efferent arm. Clin Orthop 1996;326:25-34.
9. Ikeda T, Nakamura T, Kikuchi T, Umeda S, Senda H, Takagi K. Pathomechanism of spontaneous regression of the herniated lumbar disc: Histologic and immunohistochemical study. J Spinal Disord 1996;9:136-40.
10. Kang JD, Georgescu HI, McIntyre-Larkin L, Stefanovic-Racic M, Evans CH. Herniated cervical intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2. Spine 1995;20: 2373-8.
11. Komori H, Shinomiya K, Nakai O, Yamaura I, Takeda S, Furuya K. The natural history of herniated nucleus pulposus with radiculopathy. Spine 1996;21:225-9.
12. Maigne JY, Rime B, Deligne B. Computed tomographic follow-up study of forty-eight cases of nonoperatively treated lumbar intervertebral disc herniation. Spine 1992;17:1071-4.
13. Nohara Y, Tohmura T. Fate of epidurally sequestrated disk: An immuno-histological study of herniated nucleus pulposus of the lumbar spine. Presented at the annual meeting of the International Society for the Study of the Lumbar Spine, Marseilles, France, June 15-19, 1993.
14. Saal JS, Sibley R, Dobrow R, et al. Cellular response to lumbar disc herniation: An immunohistologic study. Presented at the annual meeting of the International Society for the Study of the Lumbar Spine, Boston, Massachusetts, June 13-17, 1990.
15. Saal JA, Saal JS. Nonoperative treatment of herniated lumbar intervertebral disc with radiculopathy: An outcome study. Spine 1989;14:431-7.
16. Saal JS, Franson RC, Dobrow R, Saal JA, White AH, Goldthwaite N. High levels of inflammatory phospholipase A2 activity in lumbar disc herniations. Spine 1990;15:674-8.
17. Saal JS. The role of inflammation in lumbar pain. Spine 1995;20:1821-7.
18. Smith JW, Walmsley R. Experimental incision of the intervertebral disc. J Bone Joint Surg [Br] 1951;33:612-25.
19. Takahashi H. A mechanism for sciatic pain caused by lumbar disc herniation: Involvement of inflammatory cytokines with sciatic pain. Journal of the Japanese Orthopedic Association 1995;69:17-29.
20. Takahashi H, Suguro T, Okazima Y, Motegi M, Okada Y, Kakiuchi T. Inflammatory cytokines in the herniated disc of the lumbar spine. Spine 1996;21:218-24.
21. Tolonen J, Grönblad M, Virri J, Seitsalo S, Rytömaa T, Karaharju EO. Platelet-derived growth factor and vascular endothelial growth factor expression in disc herniation tissue: An immunohistochemical study. Eur Spine J 1997;6:63-9.
22. Virri J, Sikk S, Grönblad M, et al. Concomitant immunocytochemical study of macrophage cells and blood vessels in disc herniation tissue. Eur Spine J 1994;3:336-41.
23. Virri J, Grönblad M, Tolonen JP, Seitsalo S, Ruuskanen M, Karaharju EO. Prevalence of T and B lymphocytes in disc herniation tissue. In: Oegema TR, ed. Transactions of the Second Combined Meeting of the Orthopaedic Research Societies of U.S.A., Japan, Canada and Europe, November 5-8, San Diego, California, 1995. Chicago, IL: Rider Dickerson, 1995: 36.
24. Virri J, Grönblad M, Savikko J, et al. Prevalence, morphology, and topography of blood vessels in herniated disc tissue: A comparative immunocytochemical study. Spine 1996;21: 1856-63.