Immunocytochemical localization of immunoglobulins in disc herniations

Spine

Volumn 21, Issue 16, 1996, Pages 1864-1869

  Habtemariam, Aklilu ^a   Grönblad, Mats ^a   Virri, Johanna ^a   Seitsalo, Seppo ^a   Ruuskanen, Martti ^a   Karaharju, Erkki ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

disc herniation; immune complexes; immunoglobulin G; immunoglobulin M; inflammation

Indexed keywords

IMMUNOGLOBULIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; PHOSPHOLIPASE A;

ADULT; ANTIGEN ANTIBODY COMPLEX; CONFERENCE PAPER; FEMALE; HUMAN; HUMAN TISSUE; IMMUNITY; IMMUNOCYTOCHEMISTRY; IMMUNOGLOBULIN DEPOSITION; INFLAMMATION; INFLAMMATORY CELL; INTERVERTEBRAL DISK HERNIA; ISCHIALGIA; LOW BACK PAIN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

ADULT; ANTIBODIES, MONOCLONAL; FEMALE; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DISPLACEMENT; MALE; MIDDLE AGED;

EID: 0029762872     PISSN: 03622436     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007632-199608150-00005     Document Type: Conference Paper

References (23)

1. Bishop SA, Stockes CR, Lucke VM. Experimental proliferative glomerulonephritis in the cat. J Comp Pathol 1992; 106:49-60.
2. Blagodatskii MD, Solodun IuV. Autoimmune component of inflammatory reactions in the radicular syndromes of lumbar osteochondrosis. Zhurnal Nevropatologii i Psikhiatrii Imeni SS Korsakova 1988;88:48-51.
3. Gertzbein SD, Tile M, Gross A, Falk R. Autoimmunity of the degenerative disc disease of the lumbar spine. Orthop Clin North Am 1975;6:67-73.
4. Gertzbein SD. Degenerative disc disease of the lumbar spine: Immunological implication. Clin Orthop 1977;129: 68-71.
5. Gherardi RK, Mhiri C, Baudrimont M, et al. Iron pigment deposits, small vessel vasculitis, and erythrophagocytosis in the muscle of human immunodeficiency virus infected patients. Human Pathol 1991;22:1187-94.
6. Grönblad M, Virri J, Tolonen J, et al. A controlled immunohistochemical study of inflammatory cells in disc herniation tissue. Spine 1994;19:2744-51.
7. Grönblad M, Virri J. Nerves, neuropeptides and inflammation in spinal tissues: Mechanisms of back pain. In: Giles LGF and Singer KP, eds. Clinical Anatomy and Management of Low Back Pain. Oxford: Butterworth Heinemann, 1995. In press.
8. Hsu SM, Raine L, Fanger H. Use of avidin-biotin peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 1981;29:577-80.
9. Jaffray D, O'Brien JP. Isolated intervertebral disc resorption: A source of mechanical and inflammatory back pain. Spine 1986;11:397-401.
10. Marshall LL, Trethewie ER, Curtain CC. Chemical radiculitis: A clinical physiological and immunological study. Clin Orthop 1977;129:61-7.
11. McCarron RF, Wimpee MW, Hudkins PG, Laros GS. The inflammatory effect of nucleus pulposus: A possible element in the pathogenesis of low back pain. Spine 1987;12:760-4.
12. Miller VE, Rogers K, Muirden KD. Detection of tumour necrosis factor alpha and interleukin-1 beta in the rheumatoid osteoarthritic cartilage-pannus junction by immunohistochemical methods. Rheumatol Int 1993;13:77-82.
13. Minkus G, Breuer W, Wanke R, et al. Familial nephropathy in Bernese mountain dogs. Vet Pathol 1994;31:421-8.
14. Olmarker K, Rydevik B, Nordberg C. Autologous nucleus pulposus induces neurophysiologic and histologic changes in porcine cauda equina nerve roots. Spine 1993;18:1425-32.
15. Olmarker K, Byröd G, Cornefjord M, Nordborg C, Rydevik B. Effects of methylprednisolone on nucleus pulposus induced nerve root injury. Spine 1994;19:1803-8.
16. Pennington JB, McCarron RF, Laros GS. Identification of IgG in the canine intervertebral disc. Spine 1988;13:909-12.
17. Prior R, Schober R, Scharffetter K, Wechsler W. Occlusive microangiopathy by immunoglobulin (IgM-kappa) precipitation: Pathogenetic relevance in paraneoplastic cryoglobulinemic neuropathy. Acta Neuropathol 1992;83:423-6.
18. 2 activity in lumbar disc herniations. Spine 1990;15:674-8.
19. Sehested M, Hou-Jensen K. Factor VIII related antigen as an endothelial cell marker in benign and malignant diseases. Virchows Arch Pathol 1981;391:217-25.
20. Spiliopoulou I, Korvessis P, Konstantinou D, Dimitracopoulos G. IgG and IgM concentration in the prolapsed human intervertebral disc and sciatica etiology. Spine 1994;19: 1320-3.
21. Tolonen J, Grönblad M, Virri J, Seitsalo S, Rytömaa T, Karaharju EO. Basic fibroblast growth factor immunoreactivity in blood vessels and cells of disc herniations. Spine 1995; 20:271-6.
22. Virri J, Sikk S, Grönblad M, et al. Concomitant immunocytochemical study of macrophage cells and blood vessels in disc herniation tissue. Eur Spine J 1994;3:336-41.
23. Virri J, Grönblad M, Tolonen J, Seitsalo S, Ruuskanen M, Karaharju EO. Immunocytochemical analysis of lymphocytes in disc herniation. Presented at the Annual Meeting of the International Society for the Study of the Lumbar Spine, June 18-22, 1995, Helsinki, Finland.