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Volumn 101, Issue 5, 1998, Pages 921-926

HLA transgenic mice as humanized mouse models of disease and immunity

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN CLASS 2; HLA DQ ANTIGEN; HLA DR ANTIGEN;

EID: 0032032959     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI2860     Document Type: Review
Times cited : (59)

References (40)
  • 1
    • 0025633436 scopus 로고
    • Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human βm: An animal model of HLA-B27 associated human disorders
    • Hammer, R.E., S.D. Maika, J.A. Richardson, J.P. Tang, and J.D. Taurog. 1990. Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human βm: an animal model of HLA-B27 associated human disorders. Cell. 63:1099-1112.
    • (1990) Cell. , vol.63 , pp. 1099-1112
    • Hammer, R.E.1    Maika, S.D.2    Richardson, J.A.3    Tang, J.P.4    Taurog, J.D.5
  • 2
    • 0029083655 scopus 로고
    • Spontaneous inflammatory arthritis in HLA-B27 transgenic mice lacking β2-microglobulin. A model of human spondyloarthropathies
    • Khare, S.D., H.S. Luthra, and C.S. David. 1995. Spontaneous inflammatory arthritis in HLA-B27 transgenic mice lacking β2-microglobulin. A model of human spondyloarthropathies. J. Exp. Med. 182:1153-1158.
    • (1995) J. Exp. Med. , vol.182 , pp. 1153-1158
    • Khare, S.D.1    Luthra, H.S.2    David, C.S.3
  • 3
    • 0030482194 scopus 로고
    • HLA-B27 heavy chains contribute to spontaneous inflammatory disease in B27/human β2-microglobulin (β2m) double transgenic mice with disrupted mouse β2m
    • Khare, S.D., J. Hansen, H.S. Luthra, and C.S. David. 1990. HLA-B27 heavy chains contribute to spontaneous inflammatory disease in B27/human β2-microglobulin (β2m) double transgenic mice with disrupted mouse β2m. J. Clin. Invest. 98:2746-2755.
    • (1990) J. Clin. Invest. , vol.98 , pp. 2746-2755
    • Khare, S.D.1    Hansen, J.2    Luthra, H.S.3    David, C.S.4
  • 4
    • 0024324870 scopus 로고
    • Transgenic HLA-DRα faithfully reconstitutes IE-controlled immune functions and induces cross-tolerance to Eα in Eα○ mutant mice
    • Lawrance, S.K., L. Karlsson, J. Price, V. Quaranta, Y. Ron, J. Sprent,and P.A. Peterson. 1989. Transgenic HLA-DRα faithfully reconstitutes IE-controlled immune functions and induces cross-tolerance to Eα in Eα○ mutant mice. Cell. 58:583-594.
    • (1989) Cell. , vol.58 , pp. 583-594
    • Lawrance, S.K.1    Karlsson, L.2    Price, J.3    Quaranta, V.4    Ron, Y.5    Sprent, J.6    Peterson, P.A.7
  • 5
    • 0026065897 scopus 로고
    • Thymic deletion of Vb11+ and Vb5+ T cells in H-2E negative HLA-DQb+ single transgenic mouse
    • Zhou, P., G.D. Andersen, S. Savarirayan, H. Inoko, and C.S. David. 1991. Thymic deletion of Vb11+ and Vb5+ T cells in H-2E negative HLA-DQb+ single transgenic mouse. J. Immunol. 146:854-859.
    • (1991) J. Immunol. , vol.146 , pp. 854-859
    • Zhou, P.1    Andersen, G.D.2    Savarirayan, S.3    Inoko, H.4    David, C.S.5
  • 6
    • 0026516678 scopus 로고
    • HLA-DQb chain can present mouse endogenous provirus MTV-9 product and clonally delete Tcr Vb5+ and Vb11 + T cells in transgenic mice
    • Zhou, P., M.K. Smart, S. Cheng, S. Savarirayan, H. Inoko, and C.S. David. 1992. HLA-DQb chain can present mouse endogenous provirus MTV-9 product and clonally delete Tcr Vb5+ and Vb11 + T cells in transgenic mice. Immunogenetics. 35:219-223.
    • (1992) Immunogenetics. , vol.35 , pp. 219-223
    • Zhou, P.1    Smart, M.K.2    Cheng, S.3    Savarirayan, S.4    Inoko, H.5    David, C.S.6
  • 7
    • 0028261110 scopus 로고
    • Negative and positive selection by HLA-DR3 (Drw17) molecules in transgenic mice
    • Straub, G., D.A.A. Vignali, G. Schonrich, and G.J. Hammerling. 1994. Negative and positive selection by HLA-DR3 (Drw17) molecules in transgenic mice. Immunogenetics. 40:104-108.
    • (1994) Immunogenetics , vol.40 , pp. 104-108
    • Straub, G.1    Vignali, D.A.A.2    Schonrich, G.3    Hammerling, G.J.4
  • 10
    • 0026535396 scopus 로고
    • Species specific binding of CD4 to the β2 domain of major histocompatibility complex class II molecules
    • Vignali, D.A.A., J. Moreno, D. Schiller, and G.J. Hammerling. 1992. Species specific binding of CD4 to the β2 domain of major histocompatibility complex class II molecules. J. Exp. Med. 175:925-932.
    • (1992) J. Exp. Med. , vol.175 , pp. 925-932
    • Vignali, D.A.A.1    Moreno, J.2    Schiller, D.3    Hammerling, G.J.4
  • 11
    • 0028931032 scopus 로고
    • The T cell response of HLA-DR transgenic mice to human myelin basic protein and other antigens in the presence and absence of human CD4
    • Altmann, D.M., D.C. Douek, A.J. Frater, C.M. Hetherington. H. Inoko. and J.I. Elliot. 1994. The T cell response of HLA-DR transgenic mice to human myelin basic protein and other antigens in the presence and absence of human CD4. J. Exp. Med. 181:867-875.
    • (1994) J. Exp. Med. , vol.181 , pp. 867-875
    • Altmann, D.M.1    Douek, D.C.2    Frater, A.J.3    Hetherington, C.M.4    Inoko, H.5    Elliot, J.I.6
  • 12
    • 0028352051 scopus 로고
    • Functional interaction between human histocompatibility leukocyte antigen (HLA) class II and mouse CD4 molecule in antigen recognition by T cells in HLA-DR and DQ transgenic mice
    • Yammaoto, K., Y. Fukui, Y. Esaki. T. Inamitsu. T. Sudo, K. Yamane, N. Kamikawaji, A, Kimura, and T. Sasazuki. 1994. Functional interaction between human histocompatibility leukocyte antigen (HLA) class II and mouse CD4 molecule in antigen recognition by T cells in HLA-DR and DQ transgenic mice. J. Exp. Med. 180:165-171.
    • (1994) J. Exp. Med. , vol.180 , pp. 165-171
    • Yammaoto, K.1    Fukui, Y.2    Esaki, Y.3    Inamitsu, T.4    Sudo, T.5    Yamane, K.6    Kamikawaji, N.7    Kimura, A.8    Sasazuki, T.9
  • 13
    • 0028306138 scopus 로고
    • Expression of HLA-DR4 and human CD4 transgenes in mice determines the variable region beta-chain T cell repertoire and mediates an HLA-DR restricted immune response
    • Fugger, L., S.A. Michie, I. Rulifson, C.B. Lock, and G.S. McDevitt. 1994. Expression of HLA-DR4 and human CD4 transgenes in mice determines the variable region beta-chain T cell repertoire and mediates an HLA-DR restricted immune response. Proc. Natl. Acad. Sci. USA. 91:6151-6155.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 6151-6155
    • Fugger, L.1    Michie, S.A.2    Rulifson, I.3    Lock, C.B.4    McDevitt, G.S.5
  • 14
    • 0028080015 scopus 로고
    • Human CD4-major histocompatibility complex class H (DQW6) transgenic mice in an endogenous CD4/CD8-deticient background: Reconstitution of phenotype and human-restricted function
    • Yeung, R.S.M., J.M. Penninger, T.M. Kundig, Y. Law, K. Yammamoto, N. Kamikawaji, L. Burkly. T. Sasazuki, R. Flavell, P.S. Ohashi, and T. W. Mak. 1994. Human CD4-major histocompatibility complex class H (DQW6) transgenic mice in an endogenous CD4/CD8-deticient background: reconstitution of phenotype and human-restricted function. J. Exp. Med. 180:1911-1920.
    • (1994) J. Exp. Med. , vol.180 , pp. 1911-1920
    • Yeung, R.S.M.1    Penninger, J.M.2    Kundig, T.M.3    Law, Y.4    Yammamoto, K.5    Kamikawaji, N.6    Burkly, L.7    Sasazuki, T.8    Flavell, R.9    Ohashi, P.S.10    Mak, T.W.11
  • 15
    • 0028333939 scopus 로고
    • Human major histocompatibility complex class II-restricted T cell responses in transgenic mice
    • Woods, A., H.Y. Chen, M.E. Trumbauer, A. Sirotina, R. Cummings, and D.M. Zaller. 1994. Human major histocompatibility complex class II-restricted T cell responses in transgenic mice. J. Exp. Med. 180:173-181.
    • (1994) J. Exp. Med. , vol.180 , pp. 173-181
    • Woods, A.1    Chen, H.Y.2    Trumbauer, M.E.3    Sirotina, A.4    Cummings, R.5    Zaller, D.M.6
  • 18
    • 0030058644 scopus 로고    scopus 로고
    • HLA-DQ8 transgenic mice are highly susceptible to collagen induced arthritis. A novel model for human polyarthritis
    • Nabozny, G.H., J.M. Baisch, S. Cheng, D. Cossgrove. M.M. Griffiths, H.S. Luthra, and C.S. David. 1996. HLA-DQ8 transgenic mice are highly susceptible to collagen induced arthritis. A novel model for human polyarthritis. J. Exp. Med. 183:27-37.
    • (1996) J. Exp. Med. , vol.183 , pp. 27-37
    • Nabozny, G.H.1    Baisch, J.M.2    Cheng, S.3    Cossgrove, D.4    Griffiths, M.M.5    Luthra, H.S.6    David, C.S.7
  • 21
    • 0028997241 scopus 로고
    • Could HLA-DRB1 be the protective locus in rheumatoid arthritis?
    • Zanelli, E., M.A. Gonzalez-Gay, and C.S. David. 1995. Could HLA-DRB1 be the protective locus in rheumatoid arthritis? Immumol. Today. 16: 274-278.
    • (1995) Immumol. Today , vol.16 , pp. 274-278
    • Zanelli, E.1    Gonzalez-Gay, M.A.2    David, C.S.3
  • 22
    • 0029987134 scopus 로고    scopus 로고
    • Immune response of HLA-DQ8 transgenic mice to peptides from the third hyper-variable region of HLA-DRB1 correlates with predisposition to rheumatoid arthritis
    • Zanelli, E., C.J. Krco, J.M. Baisch, S. Cheng, and C.S. David. 1996. Immune response of HLA-DQ8 transgenic mice to peptides from the third hyper-variable region of HLA-DRB1 correlates with predisposition to rheumatoid arthritis. Proc. Natl. Aacd. Sci. USA. 93:1814-1819.
    • (1996) Proc. Natl. Aacd. Sci. USA , vol.93 , pp. 1814-1819
    • Zanelli, E.1    Krco, C.J.2    Baisch, J.M.3    Cheng, S.4    David, C.S.5
  • 23
    • 0029980659 scopus 로고    scopus 로고
    • HLA-DQ binding motifs. Comparative analysis of type II collagen-derived peptides to DR and DQ molecules of rheumatoid arthritis-susceptible and non-susceptible haplotypes
    • Matsushita, S., T. Nishi, M. Oiso, K. Yamaoka, K. Yone, T. Kanai, and Y. Nishimura. 1996. HLA-DQ binding motifs. Comparative analysis of type II collagen-derived peptides to DR and DQ molecules of rheumatoid arthritis-susceptible and non-susceptible haplotypes. Int. Immunol. 8:757-764.
    • (1996) Int. Immunol. , vol.8 , pp. 757-764
    • Matsushita, S.1    Nishi, T.2    Oiso, M.3    Yamaoka, K.4    Yone, K.5    Kanai, T.6    Nishimura, Y.7
  • 24
    • 0031112358 scopus 로고    scopus 로고
    • Critical residues on HLA-DRB1*0402 HV3 peptide for HLA-DQ8-restricted immunogenicity: Implications for rheumatoid arthritis predisposition
    • Zanelli, E., C.J. Krco, and C.S. David. 1997. Critical residues on HLA-DRB1*0402 HV3 peptide for HLA-DQ8-restricted immunogenicity: implications for rheumatoid arthritis predisposition. J. Immunol. 158:3545-3551.
    • (1997) J. Immunol. , vol.158 , pp. 3545-3551
    • Zanelli, E.1    Krco, C.J.2    David, C.S.3
  • 25
    • 0030704642 scopus 로고    scopus 로고
    • HLA-DQB1 polymorphism determines incidence, onset, and severity of collagen-induced arthritis in transgenic mice. Implications in human rheumatoid arthritis
    • Bradley, D.S., G.H. Nabozny, S. Cheng, P. Zhou. M.M. Griffiths, H.S. Luthra, and C.S. David. 1997. HLA-DQB1 polymorphism determines incidence, onset, and severity of collagen-induced arthritis in transgenic mice. Implications in human rheumatoid arthritis. J. Clin. Invest. 100:2227-2234.
    • (1997) J. Clin. Invest. , vol.100 , pp. 2227-2234
    • Bradley, D.S.1    Nabozny, G.H.2    Cheng, S.3    Zhou, P.4    Griffiths, M.M.5    Luthra, H.S.6    David, C.S.7
  • 26
    • 0030744097 scopus 로고    scopus 로고
    • Expression of the H2-E molecule mediates protection to collagen-induced arthritis in HLA-DQ8 transgenic mice: Role of cytokines
    • Taneja, V., J. Hanson, M.K. Smart, M.M. Griffiths, H.S. Luthra, and C.S. David. 1997. Expression of the H2-E molecule mediates protection to collagen-induced arthritis in HLA-DQ8 transgenic mice: role of cytokines. Int. Immunol. 9:1213-1219.
    • (1997) Int. Immunol. , vol.9 , pp. 1213-1219
    • Taneja, V.1    Hanson, J.2    Smart, M.K.3    Griffiths, M.M.4    Luthra, H.S.5    David, C.S.6
  • 28
    • 2642647140 scopus 로고    scopus 로고
    • HLA-DRB1 polymorphism mediates protection to collagen induced arthritis: Implications in rheumatoid arthritis
    • Abstr.
    • Taneja, V., J. Hanson, M. Smart, M.M. Griffiths, H. Luthra, and C.S. David. 1996. HLA-DRB1 polymorphism mediates protection to collagen induced arthritis: implications in rheumatoid arthritis. Arthritis Rheum. 39:S31. (Abstr.)
    • (1996) Arthritis Rheum. , vol.39
    • Taneja, V.1    Hanson, J.2    Smart, M.3    Griffiths, M.M.4    Luthra, H.5    David, C.S.6
  • 30
    • 0029830079 scopus 로고    scopus 로고
    • HLA-DRB1 polymorphism delermines susceptibility to autoimmune thyroiditis in transgenic mice: Definitive association with HLA-DRB1*0301 (DR3) gene
    • Kong, Y.M., L.C. Lomo, R.W. Motte. A.A. Giraldo. J. Baisch, S. Gudrun, G.J. Hammerling, and C.S. David. 1996. HLA-DRB1 polymorphism delermines susceptibility to autoimmune thyroiditis in transgenic mice: definitive association with HLA-DRB1*0301 (DR3) gene. J. Exp. Med 184:1167-1172.
    • (1996) J. Exp. Med , vol.184 , pp. 1167-1172
    • Kong, Y.M.1    Lomo, L.C.2    Motte, R.W.3    Giraldo, A.A.4    Baisch, J.5    Gudrun, S.6    Hammerling, G.J.7    David, C.S.8
  • 32
    • 10544223741 scopus 로고    scopus 로고
    • Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401
    • Wicken, L.S., S.L. Chen, G.T. Nepom, J.F. Elliot. D.C. Freed, A. Bansal. S. Zheng, A. Herman, A. Lernmark, D.M. Zaller, et al. 1996. Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401. J. Clin. Invest. 98:2597-2603.
    • (1996) J. Clin. Invest. , vol.98 , pp. 2597-2603
    • Wicken, L.S.1    Chen, S.L.2    Nepom, G.T.3    Elliot, J.F.4    Freed, D.C.5    Bansal, A.6    Zheng, S.7    Herman, A.8    Lernmark, A.9    Zaller, D.M.10
  • 33
    • 0030759825 scopus 로고    scopus 로고
    • Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR (alpha*0101, beta*0401) transgenic mice
    • Patel, S.D., A.P. Cope, M. Congia. T.T. Chen. E. Kim, L. Fugger, D. Wherrett, and G.S. McDevitt. 1997. Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR (alpha*0101, beta*0401) transgenic mice. Proc. Natl. Acad. Sci. USA. 94:8082-8087.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 8082-8087
    • Patel, S.D.1    Cope, A.P.2    Congia, M.3    Chen, T.T.4    Kim, E.5    Fugger, L.6    Wherrett, D.7    McDevitt, G.S.8
  • 34
    • 0031456751 scopus 로고    scopus 로고
    • T cell recognition of human pre-proinsulin peptides depends on the polymorphism at HLa DQ locus: A study using HLa DQ8 and DQ6 transgenic mice
    • RaJu, R., S.R. Munn, and C.S. David. 1997. T cell recognition of human pre-proinsulin peptides depends on the polymorphism at HLA DQ locus: a study using HLA DQ8 and DQ6 transgenic mice. Hum. Immunnol. 88:21-29.
    • (1997) Hum. Immunnol. , vol.88 , pp. 21-29
    • Raju, R.1    Munn, S.R.2    David, C.S.3
  • 35
    • 15844398106 scopus 로고    scopus 로고
    • HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis
    • Ito, K., H.J. Bian, M. Molina, J. Han, J. Magram, E. Saar, C. Belunis, D.R. Bolin, R. Arceo, R. Campbell, et al. 1996. HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis. J. Exp. Med. 183:2635-2644.
    • (1996) J. Exp. Med. , vol.183 , pp. 2635-2644
    • Ito, K.1    Bian, H.J.2    Molina, M.3    Han, J.4    Magram, J.5    Saar, E.6    Belunis, C.7    Bolin, D.R.8    Arceo, R.9    Campbell, R.10
  • 36
    • 0009617846 scopus 로고    scopus 로고
    • HLA transgenic mice as humanized models of multiple sclerosis (MS): Studies on EAE
    • Abstr.
    • Das, P., K. Drescher, D.S. Bradley, C. Reviera-Quinones, M. Rodriguez, and C.S. David. 1997. HLA transgenic mice as humanized models of multiple sclerosis (MS): studies on EAE. Hum. Immunol. 55(SuppI. 1 ):4. (Abstr.)
    • (1997) Hum. Immunol. , vol.55 , Issue.1 SUPPI , pp. 4
    • Das, P.1    Drescher, K.2    Bradley, D.S.3    Reviera-Quinones, C.4    Rodriguez, M.5    David, C.S.6
  • 37
    • 0031045375 scopus 로고    scopus 로고
    • Immunogenicity and contraceptive potential of a human zona pellucida 3 peptide vaccine
    • Bagavant, H., F.M. Fusi, J. Baisch, B. Kurth, C.S. David, and K.S.K. Tung. 1997. Immunogenicity and contraceptive potential of a human zona pellucida 3 peptide vaccine. Biol. Reprod. 56:764-770.
    • (1997) Biol. Reprod. , vol.56 , pp. 764-770
    • Bagavant, H.1    Fusi, F.M.2    Baisch, J.3    Kurth, B.4    David, C.S.5    Tung, K.S.K.6
  • 39
    • 0029945679 scopus 로고    scopus 로고
    • HLA-DQ8 transgenic mice lacking endogenous class II molecules respond to house dust allergens
    • Neeno, T., C.J. Krco, J. Marders, J. Baisch, S. Cheng, and C.S. David. 1996. HLA-DQ8 transgenic mice lacking endogenous class II molecules respond to house dust allergens. J. Immunol. 156:3191-3195.
    • (1996) J. Immunol. , vol.156 , pp. 3191-3195
    • Neeno, T.1    Krco, C.J.2    Marders, J.3    Baisch, J.4    Cheng, S.5    David, C.S.6
  • 40
    • 2642711757 scopus 로고    scopus 로고
    • HLA-DQ6 and HLA-DQ8 transgenic mice respond to Ryegrass allergen and recognize different epitopes on its major antigen
    • Abstr.
    • Svetlana, S.P., C.J. Krco, J. Marders, and C.S. David. 1997. HLA-DQ6 and HLA-DQ8 transgenic mice respond to Ryegrass allergen and recognize different epitopes on its major antigen. Hum. Immunol. 55(Suppl. 1):24. (Abstr.)
    • (1997) Hum. Immunol. , vol.55 , Issue.1 SUPPL. , pp. 24
    • Svetlana, S.P.1    Krco, C.J.2    Marders, J.3    David, C.S.4


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