Protective effect of vitamin E in a rat model of focal cerebral ischemia

Zeitschrift fur Naturforschung - Section C Journal of Biosciences

Volumn 53, Issue 3-4, 1998, Pages 273-278

  Stohrer, M ^a   Eichinger, Andrea ^a   Schlachter, M ^b   Stangassinger, M ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHERYLACETATE; ANIMAL MODEL; BRAIN ISCHEMIA; DISEASE MODEL; REDOX REACTION; WEIGHT GAIN;

ANIMALIA;

EID: 0032031995     PISSN: 09395075     EISSN: None     Source Type: Journal    
DOI: 10.1515/znc-1998-3-418     Document Type: Article

References (31)

1. Armstead W. M., Mirro R., Busija D. W. and Leffler C. W. (1988), Postischemic generation of superoxide anion by newborn pig brain. Am. J. Physiol. 255, H401-H403.
2. Armstead W. M., Mirro R., Leffler C. W. and Busija D. W. (1989), Cerebral superoxide anion generations during seizures in newborn pigs. J. Cereb. Blood Flow Metab. 9, 175-179.
3. Belayev L., Busto R., Zhao W. and Ginsberg M. D. (1995), HU-211, a novel noncompetetive N-methyl-D-aspartate antagonist, improves neurological deficit and reduces infarct volume after reversible focal cerebral ischemia in the rat. Stroke 26 (12), 2313-2320.
4. Clément M., Dinh L. and Bourre J.-M. (1995), Uptake of dietary RRR-α-tocopherol and RRR-γ-tocopherol by nervous tissues, liver and muscle in vitamin-E-deficient rats. Biochim. Biophys. Acta 1256, 175-180.
5. Dietrich W. D. (1994), Morphological manifestations of reperfusion injury in brain. In: Cellular, biochemical, and Molecular Aspects of Reperfusion Injury (DAS D. K. ed.). New York Acad Sciences, New York. Ann. N. Y.Acad. Sci. 723, 15-24.
6. Fisher M., Meadows M. E., Do T., Weise J., Trubetskoy V., Charette M. and Finklestein S. P. (1995), Delayed treatment with intravenous basic fibroblast growth factor reduces infarct size following permanent focal cerebral ischemia in rats. J. Cereb. Blood Flow Metab. 15 (6), 953-959.
7. Goettsch M. and Pappenheimer A. M. (1931), Nutritional muscular dystrophy in the guinea pig and rabbit J. Exp. Med. 54, 145-165.
8. Goss-Sampson M. A. and Muller D. P. R. (1988), Studies on the neurochemistry and neurophysiology of experimental vitamin E deficiency. Biochem. Soc. Trans. 16, 466-467.
9. Hall N. C., Carney J. M., Cheng M. S. and Butterfield D. A. (1995), Ischemia / reperfusion-induced changes in membrane proteins and lipids of gerbil cortical synaptosomes. Neuroscience 64, 81-89.
10. Halliwell B. and Gutteridge J. M. C. (1986), Oxygen free radicals and iron in relation to biology and medicine: some problems and concepts. Arch. Biochem. Biophys. 246 (2), 501-514.
11. Iadecola C., Zhang F. and Xu X. (1995), Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage. Am. J. Physiol. 268, R286-292.
12. Kawai H., Nakai H., Suga M., Yuki S., Watanabe T. and Saito K.-I. (1997), Effects of a novel free radical scavenger, MCI-186, on ischemic brain damage in the rat distal middle cerebral artery occlusion model. J. Pharmacol. Exp. Ther. 281 (2), 921-927.
13. Kiyota Y., Pahlmark K., Memezawa H., Smith M.-L. and Siesjö B. K. (1993), Free radicals and brain damage due to transient middle cerebral artery occlusion: the effect of dimethylthiourea. Exp. Brain Res. 95, 388-396.
14. Kontos H. A., Wei E. P., Dietrich W. D., Navari R. M., Povlishock J. T., Ghatak N. R., Ellis E. F. and Patterson Jr. J. L. (1981), Mechanism of cerebral arteriolar abnormalities after acute hypertension. Am. J. Physiol. 240, H511-H527.
15. Machlin L. J. and Gabriel E. (1982), Kinetics of tissue α-tocopherol uptake and depletion following administration of high levels of vitamin E. Ann. N. Y. Acad. Sci. 393, 48-59.
16. Machlin L. J. and Bendich A. (1987), Free radical tissue damage: protective role of antioxidant nutrients. FASEB J. 1, 441-445.
17. Memezawa H., Minamisawa H., Smith M.-L. and Siesjö B. K. (1992), Ischemic penumbra in a model of reversible middle cerebral artery occlusion in the rat. Exp. Brain Res. 89, 67-78.
18. Minamisawa H., Smith M.-L. and Siesjö B. K. (1990), The effect of mild hyperthermia and hypothermia on brain damage following 5, 10, and 15 minutes of forebrain ischemia. Ann. Neurol. 28, 26-33.
19. Mufti S. I., Eskelson C. D., Odeley O. E. and Nachiappan V. (1993), Alcohol-associated generation of oxygen free radicals and tumor promotion. Alcohol Alcoholism 28 (6), 621-638.
20. Pappenheimer A. M. and Goettsch M. (1931), A cerebellar disorder in chicks, apparently of nutritional origin. J. Exp. Med. 53, 11-16.
21. Pourcyrous M., Leffler C. W., Mirro R. and Busija D. W. (1990), Brain superoxide anion generation during asphyxia and reventilation in newborn pigs. Fed. Res. 28, 618-621.
22. Robinson K. L. and Coey W. E. (1951), A brown discoloration of pig fat and vitamin E deficiency. Nature (London) 168, 997-998.
23. Schäbitz W. R., Schwab S., Spranger M. and Hacke W. (1997), Intraventricular brain-derived neurotrophic factor reduces infarct size after focal cerebral ischemia in rats. J. Cereb. Blood Flow Metab. 17, 500-506.
24. Scott M. L. (1978), in: Handbook of Lipid Research (DeLuca, H. F., ed.), Vol. 2. Plenum Press, New York, 133.
25. Shivakumar B. R., Anandatheerthavarada H. K. and Ravindranath V. (1991), Free radical scavenging systems in developing rat brain. Int. J. Dev. Neurosci. 9 (2), 181-185.
26. Siesjö B. K. (1993), A new perspective on ischemic brain damage? Progress in Brain Res. 96, 1-9.
27. Sokol R. J. (1988), Vitamin E deficiency and neurologic disease. Ann. Rev. Nutr. 8, 351-373.
28. Stowe H. D. and Whitehair C. K. (1963), Gross and microscopic pathology of tocopherol-deficient mink. J. Nutr. 81, 287-300.
29. Vuilleumier J. P., Keller H. E., Gysel D., and Hunziker F. (1983), Clinical chemical methods for the routine assessment of the vitamin status in human populations. Int. J. Vit. Nutr. Res. 53, 265-272.
30. Wei E. P., Dietrich W. D., Povlishock J. T., Navari K. M. and Kontos H. A. (1989), Functional, morphological, and metabolic abnormalities of the cerebral microcirculation after concussive brain injury in cats. Circ. Res. 46, 37-47.
31. Westerberg E., Friberg M. and Akeson B. (1981), Assay of brain tocopherols using high performance liquid chromatography. J. Liq. Chromatogr. 4 (1), 109-121.