Hemodynamic effects of repeated doses of epinephrine after prolonged cardiac arrest and CPR: Preliminary observations in an animal model

Resuscitation

Volumn 36, Issue 3, 1998, Pages 181-185

  Cairns, Charles B ^a   Niemann, James T ^b  

^a HARBOR UCLA MEDICAL CENTER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Cardiac arrest; Catecholamines; Epinephrine; Ventricular fibrillationl

Indexed keywords

ADRENALIN; CATECHOLAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA PRESSURE; ARTICLE; CARDIOVERSION; COMPRESSION; DOG; FEMALE; HEART ARREST; HEART HEMODYNAMICS; HEART RIGHT ATRIUM PRESSURE; HEART VENTRICLE FIBRILLATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RESUSCITATION; TIME;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; CARDIOPULMONARY RESUSCITATION; DOGS; ELECTRIC COUNTERSHOCK; EPINEPHRINE; FEMALE; HEART ARREST; HEMODYNAMIC PROCESSES; MALE; TIME FACTORS; VENTRICULAR FIBRILLATION;

EID: 0032031927     PISSN: 03009572     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-9572(98)00018-5     Document Type: Article

References (18)

1. [1] Brown CG, Werman HA. Adrenergic agonists during cardiopulmonary resuscitation. Resuscitation 1990;19:1-16.
2. [2] Paradis NA, Koscove EM. Epinephrine in cardiac arrest: a critical review. Ann Emerg Med 1990;19:1288-301.
3. [3] Michael JR, Guerci AD, Koehler RC, et al. Mechanisms by which epinephrine augments cerebral and myocardial perfusion during cardiopulmonary resuscitation in dogs. Circulation 1984;69:822-35.
4. [4] Ditchey RV, Lindenfeld J. Failure of epinephrine to improve the balance between myocardial oxygen supply and demand during closed-chest resuscitation in dogs. Circulation 1988;78:382-9.
5. [5] Guidelines for cardiopulmonary resuscitation and emergency cardiac care. JAMA 1992;268:2205-2241.
6. [6] Tang W, Weil MH, Sun S, Marko N, Yang L, Gazmuri RJ. Epinephrine increases the severity of postresuscitation myocardial dysfunction. Circulation 1995;92:3089-93.
7. [7] Thandroyen FT, Muntz KH, Buja LM, Willerson JT. Alterations in β-adrenergic receptors, adenylate cyclase, and cyclic AMP concentrations during acute myocardial ischemia and reperfusion. Circulation 1990;82 Suppl 11:11-30-11-37.
8. [8] Wortsman J, Frank S, Cryer PE. Adrenomedullary response to maximal stress in humans. Am J Med 1984;77:779-84.
9. [9] Insel PA. Adrenergic receptors-evolving concepts and clinical implications. N Engl J Med 1996;334:580-5.
10. [10] Strasser RJ, Marquetant R, Kubler W. Adrenergic receptors and sensitization of adenylyl cyclase in acute myocardial ischemia. Circulation 1990;82 Suppl II:II-23-II-29.
11. [11] Wortsman J, Paradis NA, Martin GB, et al. Functional response to extremely high plasma epinephrine concentrations in cardiac arrest. Crit Care Med 1993;21:692-7.
12. [12] Hargarten KM, Stueven HA, Waite EM, et al. Prehospital experience with defibrillation of coarse ventricular fibrillation: a 10-year review. Ann Emerg Med 1990; 19:157-62.
13. [13] Gonzalez ER, Ornato JP, Garnett AR, Levine RL, Young DS, Racht EM. Dose-dependent vasopressor response to epinephrine during CPR in human beings. Ann Emerg Med 1989;18:920-6.
14. [14] Paradis NA, Martin GB, Rosenberg J, et al. The effect of standard-and high-dose epinephrine on coronary perfusion pressure during prolonged cardiopulmonary resuscitation. JAMA 1991;265:1139-44.
15. [15] Karch SB. High-dose epinephrine. Am J Emerg Med 1993; 11:423-426 (editorial).
16. [16] Paradis NA. If one receptor doesn't do it, try another. Acad Emerg Med 1996;3:97-99 (editorial).
17. [17] Weaver WD, Fahrenbruch CE, Johnson DD, Hallstrom AP, Cobb LA, Copass MK. Effect of epinephrine and lidocaine therapy on outcome after cardiac arrest due to ventricular fibrillation. Circulation 1990;82:2027-34.
18. [18] Rivers EP, Wortsman J, Rady MY, Blake HC, McGeorge FT, Buderer NM. The effect of the total cumulative epinephrine dose administered during human CPR on hemodynamic, oxygen transport, and utilization variables in the postresuscitation period. Chest 1994;106:1499-507.