Determination of function in the isolated working mouse heart: Issues in experimental design

Journal of Molecular and Cellular Cardiology

Volumn 30, Issue 3, 1998, Pages 453-461

  Gauthier, Naomi S ^b   Matherne, G Paul ^a   Morrison, R Ray ^b   Headrick, John P ^b  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b NONE

Author keywords

Afterload; Mouse heart; Preload; Working heart

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA PRESSURE; ARTICLE; CANNULA; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; HEART AFTERLOAD; HEART FUNCTION; HEART HEMODYNAMICS; HEART LEFT VENTRICLE PRESSURE; HEART VOLUME; ISOLATED HEART; METHODOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0032031553     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.1997.0610     Document Type: Article

References (18)

1. BERNE RM, LEVY MN, (eds), 1997. Cardiovascular Physiology, 7th edit. St Louis: Mosby-Year Book, Inc., 120.
2. BITTNER HB, CHEN EP, PETERSEIM DS, VAN TRIGT P, 1996. A work-performing heart preparation for myocardial performance analysis in murine hearts. J Surg Res 64: 57-62.
3. BUNGER R, MALLET RT, HARTMAN DA, 1989. Pyruvate-enhanced phosphorylation potential and inotropism in normoxic and post-ischemic isolated working heart. Eur J Biochem 180: 221-233.
4. CHEN EP, BITTNER HB, DAVIS RD, FOLZ RJ, VAN TRIGT P, 1996. Extracellular superoxide dismutase transgene overexpression preserves post-ischemic myocardial function in isolated murine hearts. Circulation 94 (Suppl. II): II412-II417.
5. CHU G, LUO W, SLACK JP, TILGMANN C, SWEET WE, SPINDLER M, SAUPE KW, BOIVIN GP, MORAVEC CS, MATLIB MA, GRUPP IL, INGWALL JS, KRANIAS EG, 1996. Compensatory mechanisms associated with the hyperdynamic function of phospholamban-deficient mouse hearts. Circ Res 78: 1064-1076.
6. 2 consumption and contractility are based on different mechanisms. Am J Physiol 271: H984-H989.
7. DOBSON GP, HEADRICK JP, 1995. Bioenergetic scaling: metabolic design and body size constraints in mammals. Proc Natl Acad Sci USA 92: 7317-7321.
8. GRUPP IL, SUBRAMANIAM A, HEWETT TE, ROBBINS J, GRUPP G, 1993. Comparison of normal, hypodynamic, and hyperdynamic mouse hearts using isolated work-performing heart preparations. Am J Physiol 265: H1401-H1410.
9. KATZ AM, 1986. In: Physiology of the Heart. New York: Raven Press, 209-227.
10. DE LEIRIS J, HARDING DP, PESTRE S, 1984. The isolated perfused rat heart: a model for studying myocardial hypoxia or ischaemia. Basic Res Cardiol 79: 313-321.
11. LUO W, GRUPP IL, HARRER J, PONNIAH S, GRUPP G, DUFFY JJ, DOETSCHMAN T, KRANIAS EG, 1994. Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of β-agonist stimulation. Circ Res 75: 401-409.
12. MARBER MS, MESTRIL R, CHI S-H, SAYEN MR, YELLON DM, DILLMAN WH, 1995. Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury. J Clin Invest 95: 1446-1456.
13. 1 adenosine receptor overexpression increases myocardial resistance to ischemia. Proc Natl Acad Sci USA 94: 6541-6546.
14. NEELY JR, LIEBERMEISTER H, BATTERSBY EJ, MORGAN HE, 1967. Effect of pressure development on oxygen consumption by isolated rat heart. Am J Physiol 212: 804-814.
15. NG WA, GRUPP IL, SUBRAMANIAM A, ROBBINS J, 1991. Cardiac myosin heavy chain mRNA expression and myocardial function in the mouse heart. Circ Res 68: 1742-1750.
16. PATTERSON SW, STARLING EH, 1914. On the mechanical factors which determine the output of the ventricles. J Physiol (Lond) 48: 347-379.
17. PLUMIER J-CL, ROSS BM, CURRIE RW, ANGELIDIS CE, KAZLARIS H, KOLLIAS G, PAGOULATOS GN, 1995. Transgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery. J Clin Invest 95: 1854-1860.
18. RADFORD NB, FINA M, BENJAMIN IJ, MOREADITH RW, GRAVES KH, ZHAO P, GAVVA S, WIETHOFF A, SHERRY AD, MALLOY CR, 1996. Cardioprotective effects of 70-kDa heat shock protein in transgenic mice. Proc Natl Acad Sci USA 93: 2339-2342.