Antioxidant activity of lazaroid (U-75412E) and its protective effects against crystalline silica-induced cytotoxicity

Free Radical Biology and Medicine

Volumn 24, Issue 4, 1998, Pages 529-536

  Huang, S H ^a   Leonard, S ^a   Shi, X ^a   Goins, M R ^a   Vallyathan, V ^a  

^a Pathology and Physiology Research Branch   (United States)

Author keywords

Free radical injury; Inhibition of cytotoxicity; Lazaroid protection; Lipid peroxidation; Silica induced cytotoxicity prevention

Indexed keywords

GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; LACTATE DEHYDROGENASE; LAZAROID; N ACETYL BETA GLUCOSAMINIDASE; SILICON DIOXIDE; SUPEROXIDE DISMUTASE; U 75412E; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROTECTION; CHEMICAL REACTION KINETICS; CYTOTOXICITY; ELECTRON SPIN RESONANCE; LIPID PEROXIDATION; LUNG ALVEOLUS MACROPHAGE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIOXIDANTS; CRYSTALLIZATION; CYCLIC N-OXIDES; ELECTRON SPIN RESONANCE SPECTROSCOPY; FREE RADICAL SCAVENGERS; HYDROGEN PEROXIDE; HYDROXYL RADICAL; KINETICS; LIPID PEROXIDATION; MACROPHAGES, ALVEOLAR; MALE; RATS; RATS, SPRAGUE-DAWLEY; SILICON DIOXIDE; SPIN LABELS; STEROIDS; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

ANIMALIA; LETHRINIDAE;

EID: 0032030987     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(97)00285-2     Document Type: Article

References (36)

1. Frank L., McLaughling G. E. Protection against acute and chronic hyperoxic inhibition of neonatal rat lung development with 21-aminosteroid drug U74389F. Pediatr. Res. 33:1993;632-638.
2. Griffin R. L., Krzesicki R. F., Fidler S. F., Rosenbloom C. L., Auchampach J. A., Manning A. M., Haas J. V., Cammarata S. K., Chin J. E., Richards I. M. Attenuation of oxidant-induced lung injury by 21-aminosteroids (lazaroid) Correlation with the mRNA expression for E-selectin, P-selectin, ICAM-1, and VCAM-1 . Environ. Health Perspect. 102(Suppl. 10):1994;193-200.
3. Dedhia H. V., Banks D. E. Pulmonary response to hyperoxia Effects of magnesium . Environ. Health Perspect (Suppl.). 102:1994;101-105.
4. Cloi M., Ehrlich H.P. U75412E, a lazaroid, prevents progressive burn ischemia in a rat burn model. Am. J. Pathol. 142:1993;519-528.
5. Haynes J. Jr, Seibert A., Bass J. B., Taylor A. E. U74500A inhibition of oxidant-mediated lung injury. Am. J. Physiol. 259:1990;H144-H148.
6. McLaughling G. E., Frank L. In vivo protective effect of the new 21-aminosteroid U74389F against bleomycin induced pulmonary fibrosis in rats. Am. Rev. Respir. Dis. 145:1992;A574.
7. Cammarata S. K., Richards I. M., Miller J. P., Linseman K. L., Hyzy R. C. Effects of antioxidant lazaroid, U-78517F on bleomycin-induced lung injury. Am. Rev. Respir. Dis. 145:1992;A572.
8. Brughler J. M., Pregenzer F. The 21-aminosteroid inhibitors of lipid peroxidation Reactions with lipid peroxyl and phenoxy radicals . Free Radic. Biol. Med. 7:1989;125-130.
9. Braughler J. M., Pregenzer J. F., Chase R. L., Duncan L. A., Jacobsen E. J., McCall J. M. Novel 21-aminosteroids as potent inhibitors of iron-dependent lipid peroxidation. J. Biol. Chem. 262:1987;10438-10440.
10. Fisher M., Levine P. H., C'Ohen R. A. A 21-aminosteroid reduces hydrogen peroxide generation by a chemiluminescence of stimulated human leukocytes. Stroke. 21:1990;1435-1438.
11. Richards I. M., Shields S. K., Griffin R. L., Fidler S. F., Dunn C. J. Novel steroid-based inhibitors of lung inflammation. Clin. Exp. Allergy. 22:1992;432-439.
12. Mossman B. T., Marsh J. P., Sesko A., Hill S., Shatos M. A., D'Oherty J., Petruska J., Adler K. B., Hemenway D., Mickey R. Inhibition of lung injury, inflammation, and interstitial pulmonary fibrosis by polyethylene glycol-conjugated catalase in a rapid inhalation model of asbestosis. Am. Rev. Respir. Dis. 1412:1990;1266-1271.
13. Walther F. J., Nunez F. L., David C. R., Hill K. E. Mitigation of pulmonary oxygen toxicity in rats by intratracheal instillation of polyethylene glycol-conjugated antioxidant enzymes. Pediatr. Res. 33:1993;332-335.
14. Laskin D. L., Pending K., Punjabi C. J., Del Valle M. R., Laskin J. D. Pulmonary and hepatic effects of inhaled ozone in rats. Environ. Health Perpsect. (Suppl). 102:1994;61-64.
15. Vallyathan V., Mega J. F., Shi X., Dalal N. S. Enhanced generation of free radicals from phagocytes induced by mineral dusts. Am. J. Respir. Cell Mol. Biol. 6:1992;404-413.
16. Quinlan T. R., Marsh J. P., Janssen Y. M. W., Born P. A., Mossman B. T. Oxygen radicals and pneumoconioses. Environ. Health Perspect. (Suppl). 102:1994;107-110.
17. Dalal N. S., Newman J., Pack D., Leonard S., Vallyathan V. Hydroxyl Radical generation by coal mine dust Possible implication to coal workers' pneumoconiosis (CWP) . Free Radic. Bio. Med. 18:1995;11-20.
18. Sata T., Kubota E., Misra H. P., Mojarad M., Pakbaz H., Said S. I. Paraquat-induced lung injury Prevention by N-tert-butyl-alpha-phenylnitrone, a free readical spin-trapping agent . Am. J. Physiol. 262:1992;L145-L152.
19. Dedhia H. V., Banks D. E., Castranova V., Vallyathan V., Masri F., Burrell R., Billie M. Alteration in lung lavagate and macrophage function in rats due to acute toluene diisocyanate exposure. Am. Rev. Respir. Crit. Care Med. 150:1995;A768.
20. Wang S., Lantz R. C., Chen G. J., Breceda V., Rider E., Hays A. M., Parliman G., Tollinger B. J., Robledo R. F., Kunke K., Tinajero J., Witten M. L. The prophylactic effects of U75412E-pretreatment in a smoke-induced lung injury rabbit model. Appl. Pharmacol. Toxicol. 79:1996;3231-3237.
21. Vallyathan V., Castranova V., Pack D., Leonard S., Shumaker J., Hubbs A. F., Shoemaker D. A., Ramsey D. M., Pretty J. R., McLaurin J. L., Khan A., Teass A. Freshly fractured quartz inhalation leads to enhanced lung injury and inflammation Potential role of free radicals . Am. J. Respir. Crit. Care Med. 151:1995;1003-1009.
22. Gay R. J., McComb R. D., Bowers G. N. Jr. Optimum reaction conditions from human lactate dehydrogenase isozymes as they affect total lactate dehydrogenase activity. Clin Chem. 14:1968;740-753.
23. Yakada M., Sugita O., Sakai T., Uchiyma K., Wada K. Urinary enzyme determination and its clinical significance C enzyme revived from the kidney tubular eptihtelium-N-acetyl-B-D-glucosaminidase. 4 Preclinical evaluation of the urinary NAG activity and changes in renal disease . Jpn. J. Clin. Pathol. Suppl. 56:1983;90-101.
24. Elstner, E. F.; Youngman, R. J.; Obwald, W. Superoxide dismutase. In: Bergmeyer, H. U., ed. Methods of enzymatic analysis, 3rd ed. Vol. III. Enzymes 1: Oxidoreductases, transferases. Deerfield Beach, FL: Verlag Chemie; 1983:293-302.
25. Flohe, L; Gunzler, W. A. Assays of glutathione peroxidase. In: Packer, L., Methods in enzymology, vol. 105, New York: Academic Press; 1984:114-121.
26. Van Scott M. R., Miles P. R., Castranova V. Direct measurement of hydrogen peroxide release from rat alveolar macrophages Artifactual effect of horseradish peroxidase . Exp. Lung Res. 6:1984;103-114.
27. Hunter F. E. Jr, Gebicki J. M., HOfsten P. E., Weinstein J., Scott A. Swelling and lysis of rat liver mitochondria induced by ferrous ions. J. Biol. Chem. 238:1963;828-832.
28. Morrow J. D., Hill K. E., Burk R. F., Nammour T. M., Badr K. F., Roberts L. J. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cycloxygenase, free radical-catalyzed mechanism. Proc. Natl. Acad. Sci. USA. 87:1990;9383-9387.
29. Buettner G. R. Spin trapping ESR parameters of spin adducts . Free Radic. Biol. Med. 3:1987;259-303.
30. Buettner G. R. The spin trapping of superoxide and hydroxyl radicals. In:L Oberley L. W. Superoxide dismutase. vol. 2:1982;64-81 CRC Press, Boca Raton, FL.
31. + oxidoreductase . J. Biol. Chem. 263:1988;1204-1211.
32. Flinkelstein E., Rosen G. M., Rauckman E. J. Spin trapping Kinetics of reaction of superoxide and hydroxyl radicals with notrones . J. Am. Chem. Soc. 102:1980;4994-4999.
33. Shi X., Dalal N. S., Vallyathan V. ESR evidence for the hydroxyl radical formation in aqueous suspension of quartz particles and its possible significance to lipid peroxidation in silicosis. J. Toxicol. Environ. Health. 25:1988;237-245.
34. Vallyathan V., Shi X., Dalal N. S., Irr W., Castranova V. Generation of free radicals from freshly fractured silica dust Potential role in acute silica-induced lung injury . Am. Rev. Respir. Dis. 138:1988;1213-1219.
35. Richter C. Biophysical consequences of lipid peroxidation in membranes. Chem. Phys. Lipids. 44:1987;175-189.
36. Poli G., Albano E., Dianzani M. U. The role of lipid peroxidation in liver damage. Chem. Phys. Lipids. 45:1987;117-142.