Characterization of the interactions between MHC class I subunits: A systematic approach for the engineering of higher affinity variants of β2- microglobulin

Journal of Immunology

Volumn 160, Issue 5, 1998, Pages 2297-2307

  Shields, Michael J ^a   Assefi, Nassim ^a   Hodgson, Wesley ^a   Kim, Ellen J ^a   Ribaudo, Randall K ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ANIMAL CELL; ANTIGEN ANTIBODY COMPLEX; ANTIGEN BINDING; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; HUMAN; HUMAN CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION;

ANIMALS; BETA 2-MICROGLOBULIN; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; L CELLS (CELL LINE); MICE; PEPTIDE FRAGMENTS; POINT MUTATION; PROTEIN BIOSYNTHESIS; PROTEIN CONFORMATION; PROTEIN ENGINEERING; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES;

EID: 0032030642     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Restifo, N. P., F. Esquivel, Y. Kawakami, J. W. Yewdell, J. J. Mule, S. A. Rosenberg, and J. R. Bennink. 1993. Identification of human cancers deficient in antigen processing. J. Exp. Med. 177:265.
2. Proffitt, J. L., E. Sharma, and G. E. Blair. 1994. Adenovirus 12-mediated down-regulation of the major histocompatibility complex (MHC) class I promoter: identification of a negative regulatory element responsive to Ad12 E1A. Nucleic Acids Res. 22:4779.
3. Korner, H., and H. G. Burgert. 1994. Down-regulation of HLA antigens by the adenovirus type 2 E3/19K protein in a T-lymphoma cell line. J. Virol. 68:1442.
4. + T lymphocytes. Cell 77:525.
5. Ye, X., A. Kralli, R. Ge, R. P. Ricciardi, and B. B. Knowles. 1994. Down-regulation of MHC class I antigen in insulinoma cells controlled by the R1 element of the H-2 enhancer. Oncogene 9:1195.
6. + T cell line, CEM-E5, after HIV-1 infection. J. Immunol. 143:2858.
7. Paabo, S., L. Severinsson, M. Andersson, I. Martens, T. Nilsson, and P. A. Peterson. 1989. Adenovirus proteins and MHC expression. Adv. Cancer Res. 52:151.
8. Campbell, A. E., and J. S. Slater. 1994. Down-regulation of major histocompatibility complex class I synthesis by murine cytomegalovirus early gene expression. J. Virol. 68:1805.
9. Cromme, F. V., J. Airey, M. T. Heemels, H. L. Ploegh, P. J. Keating, P. L. Stern, C. J. Meijer, and J. M. Walboomers. 1994. Loss of transporter protein, encoded by the TAP-1 gene, is highly correlated with loss of HLA expression in cervical carcinomas. J. Exp. Med. 179:335.
10. Germain, R. N., and D. H. Margulies. 1993. The biochemistry and cell biology of antigen processing and presentation. In Annual Review of Immunology. Vol. 11. W. P. Paul, C. G. Fathman, and H. Metzger, eds. Annual Reviews, Inc., Palo Alto, p. 402.
11. W. P. Paul, C. G. Fathman, and H. Metzger, eds. Annual Reviews, Inc., Palo Alto, p. 402.
12. Ljunggren, H. G., N. J. Stam, C. Ohlen, J. J. Neefjes, P. Hoglund, M. T. Heemels, J. Bastin, T. N. Schumacher, A. Townsend, K. Karre, and H. L. Ploegh. 1990. Empty MHC class I molecules come out in the cold. Nature 346:476.
13. 2-microglobulin regulation of cell surface MHC class I conformation and expression. J. Immunol. 148:3723.
14. 2-microglobulin and presentation of a viral peptide. J. Immunol. 155:3481.
15. Smith, J. D., W. R. Lie, J. Gorka, N. B. Myers, and T. H. Hansen. 1992. Extensive peptide ligand exchange by surface class I major histocompatibilily complex molecules independent exogenous beta 2-microglobulin. Proc. Natl. Acad. Sci. USA 89:7767.
16. 2m) and purified class-1 major histocompatibility (MHC) antigen. Scand. J. Immunol. 39:64.
17. 2-Microglobulin from serum associates with several class I antigens expressed on the surface of mouse L-cells. Mol. Immunol. 22:955.
18. b molecules are noncooperative. J. Immunol. 157:2256.
19. 2-microglobulin is necessary for Kb class I major histocompatibility complex binding of exogenous peptides. Proc. Natl. Acad. Sci. USA 87:7517.
20. 2-microglobulin is required for antigenic peptide binding to isolated class I major histocompatibility complex molecules. Eur. J. Immunol. 21:2289.
21. 2-microglobulin is necessary for Db class 1 major histocompatibility complex binding of an exogenous influenza peptide. Proc. Natl. Acad. Sci. USA 88:301.
22. 2-microglobulin leads to the accumulation of a substantial pool of inactive class I MHC heavy chains on the cell surface. Cell 65:611.
23. 2m. Eur. J. Immunol. 25: 1609.
24. 2-microglobulins on the conformation of HLA-B27 detected by antibody and by CTL. J. Immunol. 153:3543.
25. Horton, R. M., H. D. Hunt, S. N. Ho, J. K. Pullen, and L. R. Pease. 1989. Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension. Gene 77:61.
26. Silverman, T., A. Rein, B. Orrison, J. Langloss, G. Bratthauer, J. Miyazaki, and K. Ozato. 1988. Establishment of cell lines from somite stage mouse embryos and expression of major histocompatibility class I genes in these cells. J. Immunol. 140:4378.
27. Evans, G. A., D. H. Margulies, R. D. Camerini-Otero, K. Ozato, and J. G. Seidman. 1982. Structure and expression of a mouse major histocompatibility antigen gene, H-2Ld. Proc. Natl. Acad. Sci. USA 79:1994.
28. Kozlowski, S., M. Corr, T. Takeshita, L. F. Boyd, C. D. Pendleton, R. N. Germain, J. A. Berzofsky, and D. H. Margulies. 1992. Serum angiotensin-1 converting enzyme activity processes a human immunodeficiency virus 1 gp160 peptide for presentation by major histocompatibility complex class I molecules. J. Exp. Med. 175:1417.
29. Kozlowski, S., M. Corr, M. Shirai, L. F. Boyd, C. D. Pendleton, J. A. Berzofsky, and D. H. Margulies. 1993. Multiple pathways are involved in the extracellular processing of MHC class I-restricted peptides. J. Immunol. 151:4033.
30. 2-microglobulin, and peptides on class I MHC folding and assembly in an in vitro translation system. J. Immunol. 149:2935.
31. Ashwell, J. D., R. E. Cunningham, P. D. Noguchi, and D. Hernandez. 1987. Cell growth cycle block of T cell hybridomas upon activation with antigen. J. Exp. Med. 165:173.
32. d antigen, the products of a third polymorphic locus of the mouse major histocompatibility complex. J. Immunol. 125: 2473.
33. d are influenced by its amino terminus. J. Immunol. 137:916.
34. 2m facilitate the folding of the α1 and α2 domains during de novo synthesis. J. Immunol. 140:3522.
35. d class I MHC molecule. Nature 344:439.
36. Townsend, A., C. Öhlen, J. Bastin, H. G. Ljunggren, L. Foster, and K. Kärre. 1989. Association of class I major histocompatibility heavy and light chains induced by viral peptides. Nature 340:443.
37. Townsend, A., T. Elliott, V. Cerundolo, L. Foster, B. Barber, and A. Tse. 1990. Assembly of MHC class I molecules analyzed in vitro. Cell 62:285.
38. Anderson, K. S., J. Alexander, M. Wei, and P. Cresswell. 1993. Intracellular transport of class I MHC molecules in antigen processing mutant cell lines. J. Immunol. 151:3407.
39. Bikoff, E. K., L. Jaffe, R. K. Ribaudo, G. R. Otten, R. N. Germain, and E. J. Robertson. 1991. MHC class I surface expression in embryo-derived cell lines inducible with peptide or interferon. Nature 354:235.
40. b. Science 257:919.
41. Oldstone, M. B., A. Tishon, R. Geckeler, H. Lewicki, and J. L. Whitton. 1992. A common antiviral cytotoxic T-lymphocyte epitope for diverse major histocompatibility complex haplotypes: implications for vaccination. Proc. Natl. Acad. Sci. USA 89:2752.
42. Balendiran, G. K., J. C. Solheim, A. C. Young, T. H. Hansen, S. G. Nathenson, and J. C. Sacchettini. 1997. The three-dimensional structure of an H-2Ld-peptide complex explains the unique interaction of Ld with β-2 microglobulin and peptide. Proc. Natl. Acad. Sci. USA 94:6880.
43. Nieto, M. C., E. S. Song, D. McKinney, M. McMillan, and R. S. Goodenow. 1989. The association of H-2Ld with human β-2 microglobulin induces localized conformational changes in the α-1 and -2 superdomain. Immunogenetics 30:361.
44. 2-microglobulin. Mol. Immunol. 29:481.
45. Smith, M. J., T. Basora, J. E. Kieran, and M. C. Nieto. 1993. Alteration within a discrete region of the H-2Ld α1 helix upon association with human beta 2 microglobulin. Immunol. Cell. Biol. 71:145.
46. Wang, H., G. G. Capps, B. E. Robinson, and M. C. Zuniga. 1994. Ab initio association with beta 2-microglobulin during biosynthesis of the H-2Ld class I major histocompatibility complex heavy chain promotes proper disulfide bond formation and stable peptide binding. J. Biol. Chem. 269:22276.
47. Orihuela, M., D. H. Marulies, and W. M. Yokoyama. 1996. The natural killer cell receptor Ly-49A recognizes a peptide-induced conformational determinant on its major histocompatibility complex class I ligand. Proc. Natl. Acad. Sci. USA 93: 11792.
48. + cytolytic T cell responses. J. Exp. Med. 182:1663.
49. Paglia, P., C. Chiodoni, M. Rodolfo, and M. P. Colombo. 1996. Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo. J. Exp. Med. 183:317.
50. Zitvogel, L., J. I. Mayordomo, T. Tjandrawan, A. B. DeLeo, M. R. Clarke, M. T. Lotze and W. J. Storkus. 1996. Therapy of murine tumors with tumor peptide-pulsed dendritic cells, dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines. J. Exp. Med. 183:87.
51. 2-microglobulin as an adjuvant. J. Immunol. 150:1244.
52. 2-microglobulin. J. Exp. Med. 138:1608.
53. Sabin, C. A., A. N. Phillips, C. A. Lee, J. Elford, A. Timms, M. Bofill, and G. Janossy. 1994. β-2 microglobulin as a predictor of prognosis in HIV-infected men with haemophilia: a proposed strategy for use in clinical care. Br. J. Haematol. 86:366.