Investigation into the effect of 5-hydroxytryptamine on fluid transport in the rat small intestine

General Pharmacology

Volumn 30, Issue 2, 1998, Pages 227-231

  McLean, Peter G ^a   Coupar, Ian M ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

5 HT4 receptors; DAU 6236; GR 113808; Rat intestine; SC 53116; Serotonin

Indexed keywords

1 METHYL 3 INDOLECARBOXYLIC ACID [1 [2 (METHYLSULFONYLAMINO)ETHYL] 4 PIPERIDINYLMETHYL] ESTER; 4 AMINO 5 CHLORO N [(HEXAHYDRO 1H PYRROLIZIN 1 YL)METHYL] 2 METHOXYBENZAMIDE; DAU 6236; PENTOBARBITAL; SEROTONIN; SEROTONIN 1 RECEPTOR; SEROTONIN 4 AGONIST; SEROTONIN 4 RECEPTOR; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FLUID TRANSPORT; INTESTINE FLUID; INTESTINE SECRETION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BENZAMIDES; BENZIMIDAZOLES; BICYCLO COMPOUNDS, HETEROCYCLIC; BODY FLUIDS; INDOLES; INTESTINAL ABSORPTION; INTESTINE, SMALL; MALE; PYRROLES; RATS; RATS, WISTAR; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SULFONAMIDES;

EID: 0032008182     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(97)00095-5     Document Type: Article

References (41)

1. Ahlman H., Bhargava H. N., Dahlstrom A., Larsson I., Newson B. and Pettersson G. (1981) On the presence of serotonin in the gut lumen and possible release mechanisms. Acta. Physiol. Scand, 112(3), 263-269.
2. 4 receptors mediate relaxation of the rat oesophageal tunica muscularis mucosae. Naunyn-Schmiedeberg's Arch. Pharmac. 343, 439-446.
3. Beubler E., Bukhave K. and Rask-Madsen J. (1986) Significance of calcium for the prostaglandin E2-mediated secretory response to 5-hydroxytryptamine in the small intestine of the rat in vivo. Gastroenterology 90(6), 1972-1977.
4. Beubler E., Coupar I. M., Hardcastle J. and Hardcastle P. T. (1990) Stimulatory effects of 5-hydroxyttyptamine on fluid secretion and transmural potential difference in rat small intestine are mediated by different receptor subtypes. J. Pharm. Pharmac. 42(1), 35-39.
5. Beubler E. and Horina G. (1990) 5-HT2 and 5-HT3 receptor subtypes mediate cholera toxin-induced intestinal fluid secretion in the rat. Gastroenterology 99(1), 83-89.
6. Beubler E., Schirgi-Degen A. and Gamse R. ( 1993) Inhibition of 5-hydroxytryptamine- and enterotoxin-induced fluid secretion of 5-HT receptor antagonists in the rat jejunum. Eur. J. Pharmac. 248, 157-162.
7. 4 receptor: a place in the sun. Trends Pharmac. Sci. 13, 141-145.
8. 4 receptor in the secretory response of human small intestine to 5-HT. Br. J. Pharmac. 110, 927-928.
9. Branchek T. A. and Gershon M. D. (1987) Development of neural receptors for serotonin in the murine bowel. J. Comp. Neurol. 258(4), 597-610.
10. 4 receptor mediates 5-hydroxytryptamine-induced rise in short circuit current in the human jejunum in vitro. Surgery 116(2), 396-400.
11. Cassuto J., Jodal M., Tuttle R. and Lundgren O. (1982) 5-Hydroxytryptamine and cholera secretion: physiological and pharmacological studies in cats and rats. Scand J. Gastroenterol. 17(5), 695-703.
12. Cooke H. J., Montakhab M., Wade P. R. and Wood J. D. (1983) Transmural fluxes of 5-hydroxytryptamine in guinea pig ileum. Am. J. Physiol. 244(4), G421-425.
13. Coupar I. M. (1985) Choice of anaesthetic for intestinal absorption and secretion experiments using rats. J. Pharmac. Methods 13, 331-338.
14. 4) positively coupled to adenylate cyclase in neurons. Naunyn-Schmiedeberg s Arch. Pharmac. 340, 403-410.
15. 4 receptors in guinea-pig ascending colon. Eur. J. Pharmac. 196, 149-155.
16. Erspamer V. (1954) Pharmacology of indolealkylamines. Pharmac. Rev. 6, 425-487.
17. 4 receptor subtype. J. Med. Chem. 35, 1486-1489.
18. Gaginella T. S. and Galligan J. J. (1995) Serotonin and Gastrointestinal Function. CRC Press, New York.
19. 4 receptor. Br. J. Pharmac. 111, 332-338.
20. 4 receptor: use of a novel antagonist. Br. J. Pharmac. 108, 106.
21. Hansen M. B. and Jaffe B. M. (1994) 5-HT receptor subtypes involved in luminal serotonin-induced secretion in rat intestine in vivo. J. Surg. Res. 56(3), 277-287.
22. Hansen M. B., Thorboll J. E., Beubler E. and Skadhauge E. (1994) Effect of indomethacin, renzapride, methysergide, ketanserin, and citalopram on serotonin-induced fluid accumulation in pig jejunum. Physiol. Res. 43(2), 83-93.
23. Hoyer D., Clarke D. E., Fozard J. R., Hartig P. R., Martin G. R., Mylecharane E. J., Saxena P. R. and Humphrey P. P. A. (1994) International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmac. Rev. 46, 157-204.
24. Hubel K. A., Renquist K. S. and Varley G. (1991) Secretory reflexes in ileum and jejunum: absence of remote effects. J. Auton. Nerv. Syst. 35, 53-62.
25. Jaffe B. M., Ferrara A. and Sherlock D. J. (1986) Comparative effects of ketanserin, atropine and methysergide on the gastrointestinal effects of hyperserotoninemia in the awake dog. J. Pharmac. Exp. Ther. 238(2), 536-541.
26. 4 receptor. Am. J. Physiol. 267(3, Part 1), G357-363.
27. Leung E., Blissard D., Jett M. F. and Eglen R. M. (1995) Investigation of the 5-hydroxytryptamine receptor mediating the "transient" short-circuit current response in guinea-pig ileal mucosa. Naunyn-Schmiedeberg's Arch. Pharmac. 351(6), 596-602.
28. McFadden D, Jaffe B. M. and Zinner M. J. ( 1986) Effect of luminally administered serotonin and substance P on jejunal handling of water and electrolytes. Am. J. Surg. 51(1), 81-86.
29. 4 receptor antagonist affinities of SB207710, SB205008, and SB203186 in the human colon, rat oesophagus, and guinea-pig ileum peristaltic reflex. Naunyn-Schmiedeberg's Arch. Pharmac. 352, 132-140.
30. 4-like receptor in the circular smooth muscle of human colon. Br. J. Pharmac. 118, 1058-1064.
31. 4 receptors in human colon, rat oesophagus and rat ileum. Br. J. Pharmac. 115, 47-56.
32. 14C and effects of perfusion techniques. Gastroenterology 62, 48-55.
33. Mourre C., Calas A. and Gonella J. (1981) Radioautographic study of uptake and storage of indoleamines in the rabbit enterochromaffin cells. Neurosci. Lett. 23(3), 251-256.
34. Oosterbosch L., von der Ohe M., Valdovinos M. A., Kost L. J., Phillips S. F. and Camilleri M. Effects of serotonin on rat ileocolonic transit and fluid transfer in vivo: possible mechanisms of action. Gut 34(6), 794-800.
35. 4 receptor agonists with prokinetic and acetylcholine releasing properties in the guinea-pig ileum. J. Pharmac. Exp. Ther. 261, 412-419.
36. Schultz B. D., Homaidan F., Donowitz M. and Sharp G. W. G. (1988) Pharmacological characterization of the effect of 5-hydroxytryptamine on rabbit ileal electrolyte transport. FASEB J. 2, A1722.
37. Sladen G. E. G. ( 1975) Absorption of fluid and electrolyte in health and disease. In Intestinal Absorption in Man (Edited by Sladen G. E. G. and McColl I.), pp-51-98. Academic Press, London.
38. Tam F. S.-F., Hillier K. and Bunce K. T. (1994) Characterization of the 5-hydroxytryptamine receptor type involved in inhibition of spontaneous activity of human isolated colonic circular muscle. Br. J. Pharmac. 113, 143-150.
39. Thompson J. H. (1971) Serotonin and the alimentary tract. Res. Commun. Chem. Pathol. Pharmac. 2, 687-781.
40. Tonini M., Messori E., Franceschetti G. P., Rizzi C. A., Castoldi A. F., Coccini T. and Candura S. M. (1994) Characterization of the 5-HT receptor potentiating neuromuscular cholinergic transmission in strips of human isolated detrusor muscle. Br. J. Pharmac. 113(1), 1-2.
41. Wade P. R. Chen J., Jaffe B., Kassem I. S., Blakely R. D. and Gershon M. D. (1996) Localization and function of a 5-HT transporter in crypt epithelia of the gastrointestinal tract. J. Neurosci. 16(7), 2352-2364.