Origin DNA-binding proteins

Current Opinion in Structural Biology

Volumn 8, Issue 1, 1998, Pages 49-53

  Edwards, Aled M ^a   Bochkarev, Alexey ^b   Frappier, Lori ^b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DNA BINDING PROTEIN; EPSTEIN BARR VIRUS ANTIGEN;

DIMERIZATION; DNA REPLICATION; DNA REPLICATION ORIGIN; DNA SEQUENCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DNA BINDING; PROTEIN DOMAIN; REVIEW;

EID: 0032006676     PISSN: 0959440X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-440X(98)80009-2     Document Type: Article

References (40)

1. Kelman Z, O'Donnell M. DNA replication: enzymology and mechanisms. Curr Opin Genet Dev. 4:1994;185-195.
2. Echols H. Nucleoprotein structures initiating DNA replication, transcription, and site-specific recombination. J Biol Chem. 265:1990;14697-146700.
3. Boroweic JA, Dean FB, Bullock PA, Hurwitz J. Binding and unwinding - how T antigen engages the SV40 origin of DNA replication. Cell. 60:1990;181-184.
4. DePamphilis M. DNA Replication in Eukaryotic Cells. 1996;Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
5. Yates JL. Epstein-Barr virus DNA replication. DePamphilis M. DNA Replication in Eukaryotic Cells. 1996;751-773 Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
6. Rowley A, Dowell SJ, Diffley JFX. Recent developments in the initiation of chromosomal DNA replication: a complex picture emerges. Biochim Biophys Acta. 1217:1994;239-256.
7. Stenlund A. Papillomavirus DNA replication. DePamphilis M. DNA Replication in Eukaryotic Cells. 1996;679-697 Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
8. Bochkarev A, Barwell J, Pfuetzner R, Furey W, Edwards AM, Frappier L. Crystal structure of the DNA binding domain of the Epstein-Barr virus origin binding protein EBNA1. Cell. 83:1995;39-46.
9. of outstanding interest Bochkarev A, Barwell J, Pfuetzner R, Bochkareva E, Frappier L, Edwards AM. Crystal structure of the DNA-binding domain of the Epstein-Barr virus origin binding protein, EBNA1, bound to DNA. Cell. 84:1996;791-800 The authors determined the co-crystal structure of the EBNA1 DNA binding and dimerization domains bound to DNA. The structure reveals a new mechanism for DNA binding that has mechanistic implications for origin activation.
10. Hegde RS, Grossman SR, Laimins LA, Sigler PB. Crystal structure at 1.7 Å of the bovine papillomavirus-1 E2 DNA-binding protein bound to its DNA target. Nature. 359:1992;505-512.
11. of special interest Liang H, Petros AM, Meadows RP, Yoon HS, Egan DA, Walter K, Holzman TF, Robbins T, Fesik SW. Solution structure of the DNA-binding domain of a human papillomavirus E2 protein: evidence for flexible DNA-binding regions. Biochemistry. 335:1996;2095-2103 This paper describes the solution structure of the DNA binding and dimerization domain of the E2 protein from human papillomavirus as determined by NMR spectroscopy. The structure was very similar to that of the co-crystal structure of the E2 protein from bovine papillomavirus [10] but slight differences in the demerization interface were observed.
12. of outstanding interest Luo X, Sanford DG, Bullock PA, Bachovchin WW. Solution structure of the origin DNA-binding domain of SV40 T-antigen. Nat Struct Biol. 3:1996;1034-1039 In this paper the solution structure determination by NMR of the DNA-binding domain of SV40 T antigen was described. The SV40 T antigen has long served as a paradigm for origin-binding proteins and the structure of its DNA binding domain had been long awaited. The overall fold of this domain is novel but structural similarities to E2, EBNA1 and U1A are discussed.
13. Adams A. Replication of latent Epstein-Barr virus genomes. J Virol. 61:1987;1743-1746.
14. Yates JL, Guan N. Epstein-Barr virus-derived plasmids replicate only once per cell cycle and are not amplified after entry into cells. J Virol. 65:1991;483-488.
15. Rawlins DR, Milman G, Hayward SD, Hayward GS. Sequence-specific DNA binding of the Epstein-Barr virus nuclear antigen (EBNA1) to clustered sites in the plasmid maintenance region. Cell. 42:1985;859-868.
16. Yates JL, Warren N, Sugden B. Stable replication of plasmids derived from Epstein-Barr virus in various mammalian cells. Nature. 313:1985;812-815.
17. Lupton S, Levine AJ. Mapping of genetic elements of Epstein-Barr virus that facilitate extrachromosomal persistence of Epstein-Barr virus-derived plasmids in human cells. Mol Cell Biol. 5:1985;2533-2542.
18. Krysan PJ, Haase SB, Calos MP. Isolation of human sequences that replicate autonomously in human cells. Mol Cell Biol. 9:1989;1026-1033.
19. Gahn T, Sugden B. An EBNA1 dependent enhancer acts from a distance of 10 kilobase pairs to increase expression of the Epstein-Barr virus LMP gene. J Virol. 69:1995;2633-2636.
20. Sugden B, Warren N. A promoter of Epstein-Barr virus that can function during latent infection can be transactivated by EBNA1, a viral protein required for viral DNA replication during latent infection. J Virol. 63:1989;2644-2649.
21. Sample J, Henson EBD, Sample C. The Epstein-Barr virus nuclear protein 1 promoter active in type I latency is autoregulated. J Virol. 66:1992;4654-4661.
22. Reisman D, Sugden B. trans Activation of an Epstein-Barr viral transcriptional enhancer by the Epstein-Barr viral nuclear antigen 1. Mol Cell Biol. 6:1986;3838-3846.
23. Ambinder RF, Shah WA, Rawlins DR, Hayward GS, Hayward SD. Definition of the sequence requirements for binding of the EBNA-1 protein to its palindromic target sites in Epstein-Barr virus DNA. J Virol. 64:1990;2369-2379.
24. Jones CH, Hayward SD, Rawlins DR. Interaction of the lymphocyte-derived Epstein-Barr virus nuclear antigen EBNA-1 with its DNA-binding sites. J Virol. 63:1989;101-110.
25. Harrison S, Fisenne K, Hearing J. Sequence requirements of the Epstein-Barr virus latent origin of DNA replication. J Virol. 68:1994;1913-1925.
26. Chen M-R, Middeldorp JM, Hayward SD. Separation of the complex DNA binding domain of EBNA-1 into DNA recognition and dimerization subdomains of novel structure. J Virol. 67:1993;4875-4885.
27. Ambinder RF, Mullen M, Chang Y, Hayward SD, Hayward SD. Functional domains of Epstein-Barr nuclear antigen EBNA-1. J Virol. 65:1991;1466-1478.
28. Chen M-R, Zong J, Hayward SD. Delineation of a 16 amino acid sequence that forms a core DNA recognition motif in the Epstein-Barr virus EBNA-1 protein. Virology. 205:1994;486-495.
29. Yates JL, Camiolo SM, Ali S, Ying A. Comparison of the EBNA1 proteins of the Epstein-Barr virus and herpesvirus papio in sequence and function. Virology. 222:1996;1-13.
30. Summers H, Barwell JA, Pfuetzner RA, Edwards AM, Frappier L. Cooperative assembly of EBNA1 on the Epstein-Barr virus latent origin of replication. J Virol. 70:1996;1228-1231.
31. Ermakova O, Frappier L, Schildkraut CL. Role of the EBNA-1 protein in pausing of replication forks in the Epstein-Barr virus genome. J Biol Chem. 271:1996;33009-33017.
32. Summers H, Fleming A, Frappier L. Requirements for EBNA1-induced permanganate sensitivity of the Epstein-Barr virus latent origin of DNA replication. J Biol Chem. 272:1997;26434-26440.
33. Bhatia K, Raji A, Gutierrez MI, Judde J-G, Spangler G, Venkatesh H, Magrath IT. Variation in the sequence of Epstein-Barr virus nuclear antigen 1 in normal peripheral blood lymphocytes and in Burkitt's lymphomas. Oncogene. 13:1996;177-181.
34. Snudden DK, Smith PR, Lai D, Ng M-H, Griffin BE. Alterations in the structure of the EBV nuclear antigen, EBNA1, in epithelial cell tumours. Oncogene. 10:1995;1545-1552.
35. Mohr I, Clark R, Sun S, Androphy EJ, MacPherson P, Botchan MR. Targeting the E1 replication protein to the papillomavirus origin of replication by complex formation with the E2 transactivator. Science. 250:1990;1694-1699.
36. Seo Y-S, Muller F, Lusky M, Gibbs E, Kim H-Y, Phillips B, Hurwitz J. Bovine papilloma virus (BPV)-encoded E2 protein enhances binding of E1 protein to the BPV replication origin. Proc Natl Acad Sci USA. 90:1993;2865-2869.
37. Oubridge C, Ito N, Evans PR, Teo C-H, Nagal K. Crystal structure at 1.92 Åresolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin. Nature. 372:1994;432-438.
38. Avis JM, Allain FH-T, Howe PWA, Varani G, Nagai K, Neuhaus D. Solution structure of the N-terminal RNP domain of U1A protein: the role of C-terminal residues in structure stability and RNA binding. J Mol Biol. 257:1996;398-411.
39. Shamoo Y, Krueger U, Rice LM, Williams KR, Steitz TA. Crystal structure of the two RNA binding domains of human hnRNP A1 at 1.75 Åresolution. Nat Struct Biol. 4:1997;215-222.
40. Xu R-M, Jokhan L, Cheng X, Mayeda A, Krainer AR. Crystal structure of human UP1, the domain of hnRNP A1 that contains two RNA-recognition motifs. Structure. 5:1997;559-570.