Platelet count, anti-heparin/platelet factor 4 antibodies and tissue factor pathway inhibitor plasma antigen level in chronic dialysis

Thrombosis Research

Volumn 89, Issue 3, 1998, Pages 115-122

  Luzzatto, Guido ^a,b   Bertoli, Massimo ^a   Cella, Giuseppe ^a   Fabris, Fabrizio ^a   Zaia, Barbara ^a   Girolami, Antonio ^a  

^a UNIVERSITY HOSPITAL OF PADOVA   (Italy)

^b Patologia Medica 2 ^*  (Italy)

Author keywords

Chronic kidney failure; Dialysis; Heparin; Platelet count; Protease inhibitors; Thrombocytopenia

Indexed keywords

AUTOANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; THROMBOCYTE FACTOR 4; TISSUE FACTOR PATHWAY INHIBITOR;

ADULT; AGED; ANTIBODY DETECTION; ARTICLE; CHRONIC KIDNEY FAILURE; CLINICAL ARTICLE; CONTROLLED STUDY; DIALYSIS MEMBRANE; FEMALE; HEMODIALYSIS; HEMOSTASIS; HUMAN; MALE; PRIORITY JOURNAL; THROMBOCYTE COUNT; THROMBOCYTOPENIA;

ADULT; AGED; AGED, 80 AND OVER; ANTICOAGULANTS; FEMALE; HEPARIN; HUMANS; KIDNEY FAILURE, CHRONIC; LIPOPROTEINS; MALE; MIDDLE AGED; PLATELET COUNT; PLATELET FACTOR 4; RENAL DIALYSIS;

EID: 0032004346     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(97)00301-0     Document Type: Article

References (30)

1. 1. Warkentin TE, Kelton JG. Heparin and platelets. Hematol Oncol Clin North Am 1990;4: 243-64.
2. 2. Patrassi GM, Luzzatto G. Heparin-induced thrombocytopenia with thrombosis of the aorta, iliac arteries and right axillary vein successfully treated by low-molecular weight heparin. Acta Haematol 1994;91:55-6.
3. 3. Amiral J, Bridey F, Dreyfus M, Vissac AM, Fressinaud E, Wolf M, Meyer, D. Platelet factor 4 complexed to heparin is the target of the antibodies generated in heparin-induced thrombocytopenia. Thromb Haemost 1992;68: 95-6.
4. 4. Horne MK III, Alkins BR. Platelet binding of IgG from patients with heparin-induced thrombocytopenia. J Lab Clin Med 1996;127:435-42.
5. 5. Aster RH. Heparin-induced thrombocytopenia: Understanding improves but questions remain. J Lab Clin Med 1996;127:418-9.
6. 6. Greinacher A, Amiral J, Dummel V, Vissac A, Kiefel V, Mueller-Eckhardt C. Laboratory diagnosis of heparin-associated thrombocytopenia and comparison of platelet aggregation test, heparin-induced platelet activation test, and platelet factor 4/heparin enzyme-linked immunosorbent assay. Transfusion 1994;34:381-5.
7. 7. Stead RB, Schafer AI, Rosenberg RD, Handin RI, Josa M, Khuri SF. Heterogeneity of heparin lots associated with thrombocytopenia and thromboembolism. Am J Med 1984;77:185-8.
8. 8. Greinacher A, Alban S, Dummel V, Franz G, Mueller-Eckhardt C. Characterization of the structural requirements of a carbohydrate based anticoagulant therapy with a reduced risk of inducing the immunologic type of heparin-associated thrombocytopenia. Thromb Haemost 1995;74:886-92.
9. 9. Hall AV, Clark WF, Parbtani A. Heparin-induced thrombocytopenia in renal failure. Clin Nephrol 1992;38:86-9.
10. 10. Pham PT, Miller JM, Demetrion G, Lew SQ. Clotting by heparin hemoaccess for hemodialysis in an end-stage renal disease patient. Am J Kidney Dis 1995;25:642-7.
11. 11. De Sancho M, Lema MG, Amiral J, Rand J. Frequency of antibodies direct against heparin-platelet factor 4 in patients exposed to heparin through chronic hemodialysis. Thromb Haemost 1996;75:695-6.
12. 12. Boon DMS, Van Vliet HHDM, Zietse R, Kappers-Klunne MC. The presence of antibodies against a PF4/heparin complex in patients on haemodialysis. Thromb Haemost 1996;76:480.
13. 13. Yamamoto S, Koide M, Matsuo M, Suzuki S, Ohtaka M, Saika S, Matsuo T. Heparin-induced thrombocytopenia in hemodialysis patients. Am J Kidney Dis 1996;28:82-5.
14. 14. Quijada WE, Lindsay RM, Winchester JF. Organ and metabolic complications: Bleeding disorders in renal failure. In: Jacobs C, Kjellstrand CM, Koch KM, Winchester JF, editors. Replacement of Renal Function by Dialysis (4th Revised Edition). Dordrecht: Kluwer Academic Publishers; 1996. p. 1077-9.
15. 15. Descamps-Latscha B, Herbelin A, Nguyen AT, Zingraff J, Jungers P, Chatenoud L. Immune system dysregulation in uremia. Semin Nephrol 1994;14:253-60.
16. 16. Novotny WF. Tissue factor pathway inhibitor. Semin Thromb Haemost 1994;20:101-8.
17. 17. Broze GJ. Tissue factor pathway inhibitor. Thromb Haemost 1995;4:90-3.
18. 18. Kario K, Matsuo T, Yamada T, Matsuo M. Increased tissue factor pathway inhibitor levels in uremic patients on regular hemodialysis. Thromb Haemost 1994;71:275-9.
19. 19. Hubbard AR, Weller LJ, Gray E. Measurement of tissue factor pathway inhibitor in normal and post-heparin plasma. Blood Coag Fibrinol 1994;5:819-23.
20. 20. Cella G, Cipriani A, Tommasini A, Rampin E, Sbarai A, Rocconi R, Mazzaro G, Luzzatto G. Tissue factor pathway inhibitor (TFPI) antigen plasma level in patients with interstitial lung disease before and after heparin administration. Semin Thromb Haemost 1997;23:45-9.
21. 21. Keber R. On the use of different correction factors for hemoconcentrations. Thromb Haemostas 1983;49:238.
22. 22. Visentin GP, Ford SE, Scott PJ, Aster RH. Antibodies from patients with heparin-induced thrombocytopenia-thrombosis are specific for platelet factor 4 complexed with heparin or bound to endothelial cells. J Clin Invest 1994; 93:81-8.
23. 23. Fabris F, Cordiano I, Salvan F, Saggin L, Cella G, Luzzatto G, Girolami A. Heparin-induced thrombocytopenia: Prevalence in a large cohort of patients and confirmed role of PF4/heparin complex as the main antigen for antibodies. Clin App Thromb Hemost 1997;3:203-9.
24. 24. Cella G, Vertolli U, Naso A, Vianello A, Rampin E, Sbarai A, Boeri G, Strauss WE. Tissue factor pathway inhibitor (TFPI) activity in uremic patients during hemodialysis. Thromb Res 1996;81:671-7.
25. 25. Gasparotto ML, Bertoli M, Vertolli U, Ruffatti A, Stoppa, ML, Di Landro D, Romagnoli GF. Biocompatibility of various dialysis membranes as assessed by coagulation assay. Contr Nephrol 1984;37:96-100.
26. 26. Kelton JG, Warkentin TE. Heparin-induced thrombocytopenia: What the serologist have taught us. J Lab Clin Med 1996;128:346-8.
27. 27. Luzzatto G, Cordiano I, Patrassi G, Fabris F. Heparin induced thrombocytopenia: Discrepancy between the presence of IgG cross-reacting in vitro with fraxiparine and its successful clinical use. Thromb Haemost 1995;74: 1607-8.
28. 28. Amiral J, Bridey F, Wolf M. Antibodies to macromolecular platelet factor 4 heparin complexes in heparin-induced-thrombocytopenia: A study of 44 cases. Thromb Haemost 1995;73:21-8.
29. 14C serotonin release assay in the diagnosis of heparin-induced thrombocytopenia. Am J Clin Pathol 1995;104: 648-54.
30. 30. Visentin GP, Malik M, Cyganiak KA, Aster RH. Patients treated with unfractioned heparin during open heart surgery are at high risk to form antibodies reactive with heparin:Platelet factor 4 complexes. J Lab Clin Med 1996; 128:376-383.