Abnormal numbers of cytokine producing cells in patients with polymyositis and dermatomyositis

Clinical and Experimental Rheumatology

Volumn 14, Issue 5, 1996, Pages 485-491

  Hagiwara, E ^a   Adams, E M ^b   Plotz, P H ^b   Klinman, D M ^a,c  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^b NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

cytokines; dermatomyositis; polymyositis

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 6;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DERMATOMYOSITIS; FEMALE; HUMAN; HUMAN CELL; MALE; MONOCYTE; POLYMYOSITIS; PRIORITY JOURNAL;

ADULT; CELL COUNT; CYTOKINES; DERMATOMYOSITIS; HUMANS; LEUKOCYTES, MONONUCLEAR; MIDDLE AGED; POLYMYOSITIS;

EID: 0029812789     PISSN: 0392856X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. PLOTZ PH, DALAKAS M, LEFF RL, LOVE LA, MILLER FW, CRONIN ME: Current concepts in the idiopathic inflammatory myopathies: Polymyositis, dermatomyositis, and related disorders. Ann Intern Med 1989; 111: 143-57.
2. ENGEL AG, HOHLFELD R, BANKER BQ: Inflammatory myopathies. In: ENGEL AG, C FRANZINI-ARMSTRONG C (Eds.): Myology: Basic and Clinical, 2nd ed. New York, McGraw Hill Inc., 1993; 1335-83
3. KISSEL JT, MENDELL JR, RAMMOHAN KW: Microvascular deposition of complement membrane attack complex in dermatomyositis. N Eng J Med 1986; 314: 329-34.
4. HOHLFELD R, ENGEL AG: The immunobiology of muscle. Immunol Today 1994; 15: 269-74.
5. MANTEGAZZA R, ANDREETTA F, BERNASCONI P, BAGGI F, OKSENBERG JR, SIMONCINI O, MORA M, CORNELIO F, STEINMAN L: Analysis of T cell receptor repertoire of muscle-infiltrating T lymphocytes in polymyositis. J Clin Invest 1993; 91: 2880-6.
6. O'HANLON TP, DALAKAS MC, PLOTZ PH, MILLER FW: Predominant TCR-alpha beta variable and joining gene expression by muscle-infiltrating lymphocytes in the idiopathic myopathies. J Immunol 1994; 152: 2569-76.
7. KATSIKIS P, CHU C, BRENNAN F, MAINI R, FELDMANN M: Immunoregulatory role of interleukin 10 in rheumatoid arthritis. J Exp Med 1994; 179: 1517-27.
8. SAWADA T, HIROHATA S, INOUE T, ITO K: Correlation between rheumatoid factor and IL-6 activity in synovial fluids from patients with rheumatoid arthritis. Clin Exp Rheumatol 1991; 9: 363-8.
9. LINKER-ISRAELI M, DEANS R, WALLACE D, PREHN J, OZERI-CHEN T, KLINENBERG J: Elevated levels of endogenous IL-6 in systemic lupus erythematosus. J Immunol 1991; 147: 117-23.
10. AL-JANADI M, AL-BALLA S, AL-DALAAN A, RAZIUDDIN S: Cytokine profile in systemic lupus erythematosus, rheumatoid arthritis, and other rheumatic diseases. J Clin Immunol 1993; 13: 58-67.
11. HAGIW ARA E, KLINMAN DM: Abnormalities in cytokine production and responsiveness in autoimmune diseases. In: SNAPPER CM (Ed.): Cytokine Regulation of Immunoglobulin Synthesis and Class Switching. New York, John Wiley and Sons, Ltd., 1996; 419-30.
12. HAGIWARA E, GOURLEY MF, LEE S, KLINMAN DM: Disease severity in patients with SLE correlates with an increased ratio of IL-10 : IFNγ secreting cells in the peripheral blood. Arthritis Rheum 1996; 39: 379-85.
13. ROMAGNAMI S: Induction of Th 1 and T2 responses: a key role for the 'natural' immune response? Immunol Today 1992; 13: 379-81.
14. BONETTI B, ZANUSSO GL, MONACO S, KALEHUA N, RIZZUTO G, TOMELLERI G, KREUTZERG W: Cytokine-mediated inflammation in polymyositis. Third International Conference on Cytokines 1994; 154 (abstract).
15. GABAY C, GAY-CROSIER F, ROUX-LOMBARD P, MEYER O, MAINETI C, GUERNE P, VISCHER T, DAYER J: Elevated serum levels of IL-IR antagonist in polymyositis/dermatomyositis. Arthritis Rheum 1994; 37: 1744-51.
16. WOLF RE, BAETHGE BA: IL-I, IL-2 and soluble IL-2R in polymyositis. Arthritis Rheum 1990; 33: 1007-14.
17. MANTEGAZZA R, BERNASCONI P: Cellular aspects of myositis. Curr Opin Rheumatol 1994; 6: 568-74.
18. MARCHANT A, DEVIERE J, BYL B, DE GROOTE D, VINCENT J, GOLDMAN M: Interleukin-10 production during septicaemia. Lancet 1994; 343: 707-8.
19. OLIVER JC, BLAND LA, OETTIGNER CW, ARDUINO MJ, MCALLISTER SK: Cytokine kinetics in an in vitro whole blood model following an endotoxin challange. Lymph Cytokine Res 1993; 12: 115-20.
20. SHIRAI A, HOLMES K, KLINMAN DM: Detection and quantitation of cells secreting IL-6 under physiological conditions in BALB/c mice. J Immunol 1993; 150: 793-9.
21. WAAGE A, BRANDTZAEG P, HALSTENSEN A, KIERULF P, ESPEVIK T: The complex pattern of cytokines in serum from patients with meningococcal septic shock. J Exp Med 1989; 169: 333-8.
22. BENDTZEN K, SVENSON M, JONSSON V, HIPPE E: Autoantibodies to cytokines - friends or foes ? Immunol Today 1990; 5: 167-9.
23. MAY LT, VIGUET H, KENNEY JS, IDA N, ALLISON AC, SEHGAL PB: High levels of "complexed" IL-6 in human blood. J Biol Chem 1992; 267: 19698-704.
24. BOHAN A, PETER JB: Polymyositis and dermatomyositis. N Eng J Med 1975; 292: 344-7.
25. ADAMS EM, CHOW CK, PREMKUMAR AH, PLOTZ PH: The idiopathic inflamatory myopathies: Spectrum of MR imaging findings. Radiograph 1995;15:563-574.
26. BOYUM A: Separation of leukocytes from blood and bone marrow. Scand J Clin Lab Invest 1968; 21: 77-90.
27. KLINMAN DM, NUTMAN TB: ELIspot assay to detect cytokine-secreting murine and human cells. In: COLIGAN JE, KRUISBEEK AM, MARGULIES DH, SHEVACH EM, STROBER W (Eds.): Current Protocols in Immunology. 7th ed., Brooklyn, NY, Greene Publishing Associates, 1994.
28. HAGIWARA E, ABBASI F, MOR G, ISHIGATSUBO Y, KLINMAN DM: Phenotype and frequency of cells secreting IL-2, IL-4, IL-6, IL-10, IFNγ and TNFα in human peripheral blood. Cytokine 1995; 7: 815-22.
29. SHIRAI A, SIERRA V, KELLY CI, KLINMAN DM: Individual cells simultaneously produce both IL-4 and IL-6 under physiologic conditions in vivo. Cytokine 1994; 6: 329-36.
30. HAGIWARA E, SACKS T, LEITMAN SF, KLINMAN DM: Effect of HIV infection on the frequency of cytokine-secreting cells in human peripheral blood. AIDS Res Human Retro 1996; 12: 127-33.
31. MOSMANN TR, CHERWINSKI H, BOND MW, GIEDLIN MA, COFFMAN RL: Two types of murine helper T cell clones. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986; 136: 2348-57.
32. KISHIMOTO T, HIRANO T: Molecular regulation of B lymphocyte response. Annu Rev Immunol 1988; 6: 485-512.
33. AKIRA S, TAGA T, KISHIMOTO T: Interleukin-6 in biology and medicine. Adv Immunol 1993;54:1-78.
34. NAGAFUCHI H, SUZUKI N, MIZUSHIMA Y. SAKANE T: Constitutive expression of IL-6 receptors and their role in the excessive B cell function in patients with systemic lupus crythematosus. J Immunol 1993; 151: 6525-34.
35. KITANI A, HARA M, HIROSE T, NORIOKA K, HARIGAI M, HIROSE W, SUZUKI K, KAWAKAMI M, KAWAGOE M, NAKAMURA H: Heterogeneity of B Cell responsiveness to interleukin 4, interleukin 6 and low molecular weight B cell growth factor in discrete stages of B cell activation in patients with systemic lupus erythematosus. Clin Exp Immunol 1989; 77: 31-6.
36. YOSHIZAKI K, KURITANI T, KISHIMOTO T: Interleukin-6 in autoimmune disorders. Semin Immunol 1992; 4: 155-66.
37. ARAHATA K, ENGEL AG: Monoclonal antibody analysis of mononuclear cells in myopathies. V. Identification and quantitation of T8+ cytotoxic and T8+ suppressor cells. Ann Neural 1988; 23: 493-9.
38. GONZALEZ R, ALCOCER J, ALARCON-SEGOVIA D: Natural killer cell activity in dermatomyositis-polymyositis. J Rheumatol 1987; 14: 307-10.
39. HOHLFELD R, ENGEL AG: Coculture with autologous myotubes of cytotoxic T cells isolated from muscle in inflammatory myopathies. Ann Neurol 1991; 29: 498-507.
40. SHIRAI A, CONOVER J, KLINMAN DM: Increased activation and altered ratio of IFNγ: IL-4 secreting cells in MRL/lpr mice. Cytokine 1995; 7: 799-805.
41. STEINBERG AD, KRIEG AM, GOURLEY MF, KLINMAN DM: Theoretical and experimental approaches to generalized autoimmunity. Immunol Rev 1990; 118: 129-63.