Glucagon and insulin metabolism in cirrhotic patients

Hepato-Gastroenterology

Volumn 45, Issue 20, 1998, Pages 468-471

  Yoshida, Takanori ^a   Ninomiya, Koichi ^a   Matsumoto, Toshifumi ^a   Baatar, Dolgor ^a   Bandoh, Toshio ^a   Kitano, Seigo ^a  

^a OITA UNIVERSITY   (Japan)

Author keywords

Cirrhosis; Glucagon; Insulin; Metabolic clearance rate; Splanchnic output

Indexed keywords

GLUCAGON; INSULIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLUCAGON BLOOD LEVEL; HUMAN; HYPERGLUCAGONEMIA; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INSULIN CLEARANCE; INSULIN METABOLISM; LIVER CIRRHOSIS; MALE; METABOLIC CLEARANCE RATE; PANCREAS FUNCTION; PORTAL VEIN; PORTAL VEIN BLOOD FLOW; PRIORITY JOURNAL; SPLANCHNIC BLOOD FLOW; THERMODILUTION;

CASE-CONTROL STUDIES; FEMALE; GLUCAGON; HUMANS; HYPERINSULINISM; INSULIN; ISLETS OF LANGERHANS; LIVER CIRRHOSIS; MALE; MIDDLE AGED; PORTAL SYSTEM; RADIOIMMUNOASSAY;

EID: 0031982143     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Sherwin RS, Fisher M, Bessoff J, Snyder N, Hendler R, Conn Ho, Feiig P. Hyperglucagonemia in cirrhosis: Altered secretion and sensitivity to glucagon. Gastroenterology 1978; 74:1224-8.
2. Greco AV, Crucitti F, Ghirlanda G, Manna R, Altomonte L, Rebuzzi AG, Bertoli A. Insulin and glucagon concentrations in portal and peripheral veins in patients with hepatic cirrhosis. Diabetologia 1979; 17:23-8.
3. Smith-Laing G, Orskov H, Gore MBR, Sherlock S. Hyperglucagonemia in cirrhosis: Relationship to hepatocellular damage. Diabetologia 1980; 19:103-8.
4. Lewis FW, Adair O, Hossack KF, Everson GT, White JC, Rector WG Jr. Plasma glucagon concentration in cirrhosis is related to liver function but not to portal-systemic shunting, systemic vascular resistance, or urinary sodium excretion. J Lab Clin Med 1991; 117:67-75.
5. Lin H-C, Yang MC-M, Hou M-C, Lee F-Y, Huang Y-T, Lin L-F, Li S-M, Hwang S-J, Wang S-S, Tsai Y-T, Lee S-D. Hyperglucagonaemia in cirrhotic patients and its relationship to the severity of cirrhosis and haemodynamic values. J Gastroenterol Hepatol 1996; 11:422-8.
6. Johnston DG, Alberti KGMM, Faber OK, Binder C, Wright R. Hyperinsulinemia of hepatic cirrhosis: Diminished degradation or hypersecretion? Lancet 1977; 1:10-1.
7. Smith-Laing G, Sherlock S, Faber OK. Effects of spontaneous portal-systemic shunting on insulin metabolism. Gastroenterology 1979; 76:685-90.
8. Sirinek KR, O'Dorisio TM, Levine BA. Glucose intolerance and hyperinsulinemia of cirrhosis are not results of spontaneous or surgical portosystemic shunting. Am J Surg 1991; 161:149-53.
9. Bosch J, Gomis R, Kravetz D, Casamitjana R, Teres J, Rivera F, Rodes J. Role of spontaneous portal-systemic shunting in hyperinsulinism of cirrhosis. Am J Physiol 1984; 247:G206-12.
10. Ganz W, Tamura K, Marcus HS, Donoso R, Yoshida S, Swan HJC. Measurement of coronary sinus blood flow by continuous thermodilution in man. Circulation 1971; 44:181-95.
11. Yamazaki O, Sakai K, Kinoshita H, Hirohashi K, Tsuji Y, Igawa S, Suzuki N, Lee T, Nagata E, Inoue T, Matsuoka S. Measurement of the portal blood flow in man by continuous local thermodilution method: Preliminary report (in Japanese with English abstract). Nippon Syokakibyo Gakkai Zasshi (Jpn J Gastroenterology) 1984; 81:2951-9.
12. Sikuler E, Polio J, Groszmann RJ, Hendler R. Glucagon and insulin metabolism in a portal-hypertensive rat model. Am J Physiol 1987; 253:G110-5.
13. Unger RH, Eisentraut AM, McCall MS, Lenoard L. Glucagon antibodies and an immunoassay for glucagon. J Clin Invest 1961; 42:1280-9.
14. Nishino T, Kodaira T, Shin S, Imagawa K, Shima K, Kumahara Y, Yanaihara C, Yanaihara N. Glucagon radioimmunoassay with use of antiserum to glucagon C-terminal fragment. Clin Chem 1981; 27:1690-7.
15. Yoshida T, Mitarai Y, Nagamine K, Kobayashi M. The implication of hyper-glucagonemia and -insulinemia in liver cirrhotics (in Japanese with English abstract). Nippon Syokakibyo Gakkai Zasshi (Jpn J Gastroenterology) 1989; 86:1273-80.
16. Mukai J, Tanaka A, Ohta Y. Effect of ammonia on glucagon secretion from the perfused pancreas of cirrhotic rats. Diabetes Res Clin Pract 1986; 2:145-55.
17. Yoshida T, Kitano S, Kobayashi M, Mitarai Y, Bandoh T, Shuto K. The role of glucagon in the gastric hyperdynamic circulation of cirrhotic portal hypertensive rats. Surg Today 1995; 25:906-10.
18. Bachmann W, Haslbeck M, Bottger I, Hepp KD, Mehnert H. Reduced insulin binding to hepatic plasma membranes in D-galactosamine-treated rats. Diabetologia 1979; 17:101-9.
19. Cavallo-Perin P, Cassader M, Bozzo C, Bruno A, Nuccio P, Dall'Omo AM, Marucci M, Pagano G. Mechanism of insulin resistance in human liver cirrhosis: Evidence of a combined receptor and postreceptor defect. J Clin Invest 1985; 75:1659-65.