Hyperglucagonaemia in cirrhotic patients and its relationship to the severity of cirrhosis and haemodynamic values

Journal of Gastroenterology and Hepatology (Australia)

Volumn 11, Issue 5, 1996, Pages 422-428

  Lin, Han Chieh ^a   Yang, May C M ^a   Hou, Ming Chih ^a   Lee, Fa Yauh ^a   Huang, Yi Tsau ^b   Lin, Li Fen ^a   Li, Shu Min ^a   Hwang, Shinn Jang ^a   Wang, Sun Sang ^a   Tsai, Yang Te ^a   Lee, Shou Dong ^a  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Cirrhosis; Glucagon; Portal hypertension

Indexed keywords

GLUCAGON;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ESOPHAGUS VARICES; ETIOLOGY; FEMALE; HEMODYNAMICS; HUMAN; HYPERGLUCAGONEMIA; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PORTAL HYPERTENSION; PRIORITY JOURNAL; VASODILATATION;

EID: 9344242922     PISSN: 08159319     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1746.1996.tb00285.x     Document Type: Article

References (34)

1. Sherwin RS, Joshi P, Hendler R, Felig PH, Conn HO. Hyperglucagonemia in Laennec's cirrhosis. The role of portal-systemic shunting. N. Engl. J. Med. 1974; 290: 239-42.
2. Marco J, Deigo J, Villanueva ML, Diaz-Fierros M, Valverde I, Segovia JM. Elevated plasma glucagon levels in cirrhosis of the liver. N. Engl. J. Med. 1973; 289: 1107-11.
3. Smith-Laing G, Orskov H, Gore MBR, Sherlock S. Hyperglucagonaemia in cirrhosis. Relationship to hepatocellular damage. Diabetologia 1980; 19: 103-8.
4. Kabadi UM, Eisenstein AB, Tucci J, Pellicone J. Hyperglucagonemia in hepatic cirrhosis: Its relation to hepatocellular dysfunction and normalization on recovery. Am. J. Gastroenterol. 1984; 79: 143-9.
5. Lewis FW, Adair O, Hossack KF, Everson GT, White JC, Rector WG. Plasma glucagon concentration in cirrhosis is related to liver function but not to portal-systemic shunting, systemic vascular resistance, or urinary sodium excretion. J. Lab. Clin. Med. 1991; 117: 67-75.
6. Sherwin RS, Fisher M, Bessoff J et al. Hyperglucagonemia in cirrhosis: Altered secretion and sensitivity to glucagon. Gastroenterology 1978; 74: 1224-8.
7. Greco AV, Crucitti F, Ghirlanda G et al. Insulin and glucagon concentrations in portal and peripheral veins in patients with hepatic cirrhosis. Diabetologia 1979; 17: 23-8.
8. Benoit JN, Zimmerman B, Preman AJ, Go VLW, Granger DN. Role of glucagon in splanchnic hyperemia of chronic portal hypertension. Am. J. Physiol. 1986; 251: G674-7.
9. Pizcueta MP, Casamitjana R, Bosch J, Rodés J. Decreased systemic vascular sensitivity to norepinephrine in portal hypertensive rats: Role of hyperglucagonism. Am. J. Physiol. 1990; 258: G191-5.
10. Mesh CL, Joh T, Korthuis RJ, Granger DN, Benoit JN. Intestinal vascular sensitivity to vasopressin in portal hypertensive rats. Gastroenterology 1991; 100: 916-21.
11. Silva G, Navasa M, Bosch J et al. Hemodynamic effects of glucagon in portal hypertension. Hepatology 1990; 11: 668-73.
12. Lee SS, Moreau R, Hadengue A, Cerini R, Koshy A, Lebrec D. Glucagon selectively increases splanchnic blood flow in patients with well-compensated cirrhosis. Hepatology 1988; 8: 1501-5.
13. Pugh RNH, Marray-Lyon M, Dawson JL, Pietroni MC, Williams R. Transection of the oesophagus for bleeding oesophageal varices. Br. J. Surg. 1973; 60: 646-9.
14. Lin HC, Tsai YT, Lee FY et al. Hemodynamic evaluation of octreotide in patients with hepatitis B-related cirrhosis. Gastroenterology 1992; 103: 229-34.
15. Garcia-Tsao G, Grace ND, Groszmann RJ et al. Short-term effects of propranolol on portal venous pressure. Hepatology 1986; 6: 101-6.
16. Groszmann RJ, Bosch J, Grace ND et al. Hemodynamic events in a prospective randomized trial of propranolol versus placebo in the prevention of a first variceal hemorrhage. Gastroenterology 1990; 99: 1401-7.
17. Bernardi M, Fornale L, Di Marco C et al. Hyperdynamic circulation of advanced cirrhosis: A re-appraisal based on posture-induced changes in hemodynamics. J. Hepatol. 1995; 22: 309-18.
18. Beppu K, Inokuchi K, Koyanagi N et al. Prediction of variceal hemorrhage by esophageal endoscopy. Gastrointest. Endosc. 1981; 27: 213-18.
19. Forrester JS, Ganz W, Diamond G, McHugh T, Chonette DW, Swan HJC. Thermodilution cardiac output determination with a single flow-directed catheter. Am. Heart J. 1972; 83: 306-11.
20. 131I]-orthoiodohippurate. Mayo Clin. Proc. 1971; 46: 524-31.
21. Gentilini P, Romanelli RG, La Villa G et al. Effects of low-dose captopril on renal hemodynamics and function in patients with cirrhosis of liver. Gastroenterology 1993; 104: 588-94.
22. Hsia HC, Lin HC, Tsai YT et al. The effects of chronic administration of indomethacin and misoprostol on renal function in cirrhotic patients with and without ascites. Scand. J. Gastroenterol. 1995; 30: 1194-9.
23. Lin RS, Lee FY, Lee SD et al. Endotoxemia in patients with chronic liver disease: Relationship to severity of liver disease, presence of esophageal varices, and hyperdynamic circulation. J. Hepatol. 1995; 22: 165-72.
24. Meng HC, Lin HC, Tsai YT et al. Relationships between the severity of cirrhosis and haemodynamic values in patients with cirrhosis. J. Gastroenterol. Hepatol. 1994; 9: 148-53.
25. Kravetz D, Arderiu M, Bosch J et al. Hyperglucagonemia and hyperkinetic circulation after portocaval shunt in the rat. Am. J. Physiol. 1987; 252: G257-61.
26. Schrier RW, Arroyo V, Bernardi M, Epstein M, Henriksen JH, Rodés J. Peripheral artery vasodilatation hypothesis: A proposal for the initiation of renal sodium and water retention in cirrhosis. Hepatology 1988; 5: 1151-7.
27. Lopez C, Jiménez W, Arroyo V et al. Temporal relationship between the decrease in arterial pressure and sodium retention in conscious spontaneously hypertensive rats with carbon tetrachloride-induced cirrhosis. Hepatology 1991; 13: 585-9.
28. Colombato LA, Albillos A, Groszmann RJ. Temporal relationship of peripheral vasodilatation, plasma volume expansion and the hyperdynamic circulatory state in portal-hypertensive rats. Hepatology 1991; 15: 323-8.
29. Albillos A, Colombato LA, Groszmann RJ. Vasodilatation and sodium retention in prehepatic portal hypertension. Gastroenterology 1992; 10: 931-5.
30. Bendtsen F, Schifter S, Henriksen JH. Increased circulating calcitonin gene-related peptide (CGRP) in cirrhosis. J. Hepatol. 1991; 12: 118-23.
31. Fernandez-Rodriguez CM, Prieto J, Quiroga J et al. Plasma levels of substance P in liver cirrhosis: Relationship to the activation of vaspressor systems and urinary sodium excretion. Hepatology 1995; 21: 35-40.
32. Guarner C, Soriano G, Such J et al. Systemic prostacyclin in cirrhotic patients. Relationship with portal hypertension and changes after intestinal decontamination. Gastroenterology 1992; 102: 303-9.
33. Claris J, Jiménez W, Ros J et al. Pathogenesis of arterial hypotension in cirrhotic rats with ascites: Role of endogenous nitric oxide. Hepatology 1992; 15: 343-9.
34. Lewis FW, Adair O, Rector WG. Arterial vasodilation is not the cause of increased cardiac output in cirrhosis. Gastroenterology 1992; 102: 1024-9.