Assessment of glucosylifosfamide mustard biodistribution in rats with prostate adenocarcinomas by means of in vivo 31P NMR and in vitro uptake experiments

Magnetic Resonance in Medicine

Volumn 39, Issue 5, 1998, Pages 754-761

  Haberkorn, Uwe ^a   Krems, Boris ^a   Gerlach, Ludwig ^a   Bachert, Peter ^a   Morr, Iris ^a   Wiessler, Manfred ^a   Van Kaick, Gerhard ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

31P NMR spectroscopy; Chemotherapy; Prostate adenocarcinoma

Indexed keywords

CELL CULTURE; CHEMOTHERAPY; METABOLITES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHORUS; RATS; TUMORS; UROLOGY;

31P-NMR SPECTROSCOPY; DRUG ADMINISTRATION; NEGATIVELY CHARGED; PROSTATE ADENOCARCINOMAS; RADIOTRACER TECHNIQUES; SIGNAL INTENSITIES; STATISTICAL SIGNIFICANCE; TRANSPORT MECHANISM;

DRUG DOSAGE;

IFOSFAMIDE; MUSTARD GAS DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CANCER CHEMOTHERAPY; DEGLYCOSYLATION; DRUG DISTRIBUTION; DRUG UPTAKE; MALE; NONHUMAN; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PROSTATE ADENOCARCINOMA; RAT;

EID: 0031980730     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.1910390513     Document Type: Article

References (31)

1. I. Tamai, A. Tsuji, Carrier-mediated approaches for oral drug delivery. Adv. Drug Deliv. Rev. 20, 5-32 (1996).
2. T. Mizuma, K. Ohta, S. Awazu, The β-anomeric and glucose preferences of glucose transport carrier for intestinal active absorption of monosaccharide conjugates. Biochim. Biophys. Acta 1200, 117-122 (1994).
3. + /glucose cotransporter. Biochim. Biophys. Acta 1193, 151-154 (1994).
4. +/glucose cotransporter (SGLT1): analysis of interactions. J. Membr. Biol. 142, 161-170 (1994).
5. R. Polt, F. Porreca, L. Z. Szabo, E. J. Bilsky, P. Davis, T. J. Abbruscato, T. P. Davis, R. Horvath, H. I. Yamamura, V. J. Hruby, Glycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier. Proc. Natl. Acad. Sci. U S A 91, 7114-7118 (1994).
6. J. S. Flier, M. M. Mueckler, P. Usher, H. F. Lodish, Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes. Science 235, 1492-1495 (1987).
7. T. Yamamoto, Y. Seino, H. Fukumoto, G. Koh, H. Yano, N. Inagaki, Y. Yamada, K. Inoue, T. Manabe, H. Imura, Over-expression of facilitative glucose transporter genes in human cancer. Biochem. Biophys. Res. Comm. 170, 223-230 (1990).
8. U. Haberkorn, S. I. Ziegler, F. Oberdorfer, H. Trojan, D. Haag, P. Peschke, M. R. Berger, A. Altmann, G. van Kaick, FDG uptake, tumor proliferation and expression of glycolysis associated genes in animal tumor models. Nucl. Med. Biol. 21, 827-834 (1994).
9. N. Brock, Oxazaphosphorine cytostatics: past-present-future. Cancer Res. 49, 1-7 (1989).
10. N. E. Sladek, Metabolism of oxazaphosphorines. Pharmacol. Ther. 37, 301-355 (1988).
11. J. Pohl, B. Bertram, P. Hilgard, M.R. Nowrousian, J. Stüben, M. Wiessler, D-19575- a sugar-linked isophosphoramide mustard derivative exploiting transmembrane glucose transport. Cancer Chemother. Pharmacol. 35, 364-370 (1995).
12. 3H]-thymidine in various tissues of the rat. Cancer Chemother. Pharmacol. 38, 355-365 (1996).
13. 31P MRS, in "Proc., SMR, 2nd Annual Meeting, San Francisco, 1994," p. 1338.
14. 31P-MRS in rat tumours: increased uptake and cytotoxicity induced by carbogen breathing in GH3 prolactinomas. Br. J. Cancer 75, 62-68 (1997).
15. 31P NMR spectroscopy, in "Proc., SMR, 2nd Annual Meeting, San Francisco, 1994," p. 1317.
16. M. F. G. Schmidt, R. T. Schwarz, C. Scholtissek, Nucleoside-diphosphate derivatives of 2-deoxy-D-glucose in animal cells. Eur. J. Biochem. 49, 237-247 (1974).
17. 13C-NMR studies. Biochim. Biophys. Acta 1052, 255-263 (1990).
18. 31P NMR spectroscopy of a xenografted hypopharynx carcinoma: effects of tumor growth and treatment with cisplatin on the tumor phosphorus metabolism, histology and cytokinetics. NMR Biomed. 5, 127-136 (1992).
19. 31P magnetic resonance spectroscopy is sensitive to tumor hypoxia: perfusion and oxygenation of rat 9L gliosarcoma after treatment with BCNU. NMR Biomed. 4, 117-124 (1991).
20. 31P NMR study of the impact of dietary manipulation on tumor metabolism and response to methotrexate. NMR Biomed. 2, 12-18 (1989).
21. W. Negendank, Studies of human tumors by MRS: a review. NMR Biomed. 5, 303-324 (1992).
22. J. Ruiz-Caballo, J. S. Cohen, Phospholipid metabolites as indicators of cancer cell function. NMR Biomed. 5, 226-233 (1992).
23. 31P nuclear magnetic resonance spectroscopy in murine mammary adenocarcinomas. Cancer Res. 47, 3396-3401 (1987).
24. 31P magnetic spectroscopy for monitoring treatment response in breast cancer. Lancet I, 1326-1327 (1989).
25. 19F NMR. Br. J. Cancer 50, 113-117 (1984).
26. D. W. Tilsley, R. J. Harte, T. Jones, F. Brady, S. K. Luthra, G. Brown, P. M. Price, New techniques in the pharmacokinetic analysis of cancer drugs. IV. Positron emission tomography. Cancer Surv. 17, 425-442 (1993).
27. V. Gilard, M. C. Malet-Martino, M. deForni, U. Niemeyer, J. C. Ader, R. Martino, Determination of the urinary excretion of ifosfamide and its phosphorated metabolites by phosphorus-31 nuclear magnetic resonance spectroscopy. Cancer Chemother. Pharmacol. 31, 387-394 (1993).
28. 31P nuclear magnetic resonance spectroscopy. J. Pharmacol. Exp. Ther. 260, 1133-1144 (1992).
29. D. L. Baly, R. Horuk, The biology and biochemistry of the glucose transporter. Biochim. Biophys. Acta 947, 571-590 (1988).
30. +/glucose cotransporter. Annu. Rev. Physiol. 55, 575-589 (1993).
31. 31P NMR investigations of phosphoramide mustard: evaluation of pH control over the rate of intramolecular cyclization to an aziridinium ion and the hydrolysis of this reactive alkylator. J. Med. Chem. 22, 897-899 (1979).