Effects of amlodipine once or twice daily on circadian blood pressure profile, myocardial hypertrophy, and β-adrenergic signaling in transgenic hypertensive TGR(mREN2)27 rats

Journal of Cardiovascular Pharmacology

Volumn 31, Issue 5, 1998, Pages 661-668

  Witte, Klaus ^a   Schnecko, Anke ^a   Voll, Christian ^a   Schmidt, Thomas ^a   Lemmer, Björn ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Adenylyl cyclase; Amlodipine; Circadian rhythm; Hypertension; Myocardial hypertrophy; Transgenic rat

Indexed keywords

ADENYLATE CYCLASE; AMLODIPINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BETA ADRENERGIC STIMULATION; BLOOD PRESSURE REGULATION; CIRCADIAN RHYTHM; DOSE RESPONSE; DRUG EFFECT; DRUG RECEPTOR BINDING; HEART VENTRICLE HYPERTROPHY; HYPERTENSION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; SIGNAL TRANSDUCTION; TRANSGENIC ANIMAL;

ADENYLATE CYCLASE; AMLODIPINE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CARDIOMEGALY; CIRCADIAN RHYTHM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; HEART RATE; HYPERTENSION; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, BETA;

EID: 0031977415     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199805000-00003     Document Type: Article

References (33)

1. Mullins JJ, Peters J, Ganten D. Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 renin gene. Nature 1990;344:541-4.
2. Bachmann S, Peters J, Engler E, Ganten D, Mullins J. Transgenic rats carrying the mouse renin gene-morphological characterization of a low-renin hypertension model. Kidney Int 1992;41:24-36.
3. Springate JE, Feld LG, Ganten D. Renal function in hypertensive rats transgenic for mouse renin gene. Am J Physiol 1994;266:F731-7.
4. Villarreal FJ, Mackenna DA, Omens JH, Dillmann WH. Myocardial remodeling in hypertensive Ren-2 transgenic rats. Hypertension 1995;25:98-104.
5. Struijkerboudier HAJ, Vanessen H, Fazzi G, Demey JGR, Qiu HY, Levy BI. Disproportional arterial hypertrophy in hypertensive mRen-2 transgenic rats. Hypertension 1996;28:779-84.
6. Lemmer B, Mattes A, Böhm M, Ganten D. Circadian blood pressure variation in transgenic hypertensive rats. Hypertension 1993;22:97-101.
7. Middeke M, Schrader J. Nocturnal blood pressure in normotensive subjects and those with white coat, primary, and secondary hypertension. Br Med J 1994;308:630-2.
8. Verdecchia P, Schillaci G, Guerrieri M, et al. Circadian blood pressure changes and left ventricular hypertrophy in essential hypertension. Circulation 1990;81:528-36.
9. Kuwajima I, Suzuki Y, Shimosava T, Kanemaru A, Hoshino S, Kuramoto K. Diminished nocturnal decline in elderly hypertensive patients with left ventricular hypertrophy. Am Heart J 1992;67:1307-11.
10. Timio M, Venanzi S, Lolli S, et al. "Non-dipper" hypertensive patients and progressive renal insufficiency: a 3-year longitudinal study. Clin Nephrol 1995;43:382-7.
11. Nakamura K, Oita J, Yamaguchi T. Nocturnal blood pressure dip in stroke survivors: a pilot study. Stroke 1995;26:1373-8.
12. Böhm M, Moll M, Schmid B, et al. β-Adrenergic neuroeffector mechanisms in cardiac hypertrophy of renin transgenic rats. Hypertension 1994;24:653-62.
13. Witte K, Lemmer B. Signal transduction in animal models of normotension and hypertension. Ann N Y Acad Sci 1996;783:71-83.
14. Witte K, Zuther P, Lemmer B. Analysis of telemetric time series data for periodic components using DQ-FIT. Chronobiol Int 1997;14:561-74.
15. Lemmer B, Langer L, Ohm T, Bohl J. Beta-adrenoceptor density and subtype distribution in cerebellum and hippocampus from patients with Alzheimer's disease. Naunyn Schmiedebergs Arch Pharmacol 1993;347:214-9.
16. Lemmer B, Witte K. Circadian rhythm of the in vitro stimulation of adenylate cyclase in rat heart tissue. Eur J Pharmacol 1989;159:311-4.
17. Witte K, Schnecko A, Olbrich HG, Lemmer B. Efficiency of β-adrenoceptor subtype coupling to cardiac adenylyl cyclase in cardiomyopathic and control hamsters. Eur J Pharmacol 1995; 290:1-10.
18. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-75.
19. Mattes A, Witte K, Hohmann W, Lemmer B. PHARMFIT - a nonlinear fitting program for pharmacology. Chronobiol Int 1991;8:460-76.
20. Ackermann H. BiAS: Biometrische Analyse von Stichproben. Hochheim-Darmstadt: Epsilon-Verlag, 1997.
21. Moriguchi A, Brosnihan KB, Kumagai H, Ganten D, Ferrario CM. Mechanisms of hypertension in transgenic rats expressing the mouse Ren-2 gene. Am J Physiol 1994;266:R1273-9.
22. Böhm M, Lippoldt A, Wienen W, Ganten D, Bader M. Reduction of cardiac hypertrophy in TGR(mREN2)27 by angiotensin II receptor blockade. Mol Cell Biochem 1996;163/164:217-21.
23. Schricker S, Hamann M, Macher A, Krämer BK, Kaissling B, Kurtz A. Effect of amlodipine on renin secretion and renin gene expression in rats. Br J Pharmacol 1996;119:744-50.
24. Mattes A, Lemmer B. Effects of amlodipine on arcadian rhythms in blood pressure, heart rate, and motility: a telemetric study in rats. Chronobiol Int 1991;8:526-38.
25. Fujimura A, Shiga T, Ohashi K, Ebihara A. Chronopharmacology of amlodipine in rats. Life Sci 1993;53:595-602.
26. Dahlöf B. Regression of left ventricular hypertrophy - are there differences between antihypertensive agents? Cardiology 1992;81:307-15.
27. Liebson PR, Grandits GA, Dianzumba S, et al. for the Treatment of Hypertension Study Research Group. Comparison of five antihypertensive monotherapies and placebo for change in left ventricular mass in patients receiving nutritional-hygienic therapy in the treatment of mild hypertension study (TOMHS). Circulation 1995;91:698-706.
28. Arita M, Horinaka S, Frohlich ED. Biochemical components and myocardial performance after reversal of left ventricular hypertrophy in spontaneously hypertensive rats. J Hypertens 1993;11:951-9.
29. Patel VB, Siddiq T, Richardson PJ, Preedy VR. Protein synthesis in the hypertrophied heart of spontaneously hypertensive rats and a comparison of the effects of an ACE-inhibitor and a calcium channel antagonist. Cell Biochem Funct 1995;13:111-24.
30. 1 receptor antagonists, an ACE inhibitor and a calcium channel antagonist on cardiac gene expressions in hypertensive rats. Br J Pharmacol 1996;118:549-56.
31. Ohta K, Kim S, Wanibuchi H, Ganten D, Iwao H. Contribution of local renin-angiotensin system to cardiac hypertrophy, phenotypic modulation, and remodeling in TGR(mRen2)27 transgenic rats. Circulation 1996;94:785-91.
32. 1-receptor blockade [Abstract]. Naunyn Schmiedebergs Arch Pharmacol 1997:355(suppl):R100.
33. Mengden T, Binswanger B, Spühler T, Weisser B, Vetter W. The use of self-measured blood pressure determinations in assessing dynamics of drug compliance in a study with amlodipine once a day, morning versus evening. J Hypertens 1993;11:1403-11.