Application of tumbling melt granulation (TMG) method to prepare controlled-release fine granules

Chemical and Pharmaceutical Bulletin

Volumn 46, Issue 3, 1998, Pages 534-536

  Maejima, Toru ^a   Kubo, Masashi ^a   Osawa, Takashi ^a   Nakajima, Kingo ^a   Kobayashi, Masao ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Centrifugal fluidizing granulator; Controlled release; Fine granule; Tumbling melt granulation; Wax

Indexed keywords

DILTIAZEM; ETHYL CELLULOSE; SUCROSE; TALC;

ARTICLE; CONTROLLED RELEASE FORMULATION; DEVICE; DRUG COATING; DRUG GRANULATION; DRUG SOLUBILITY; ELECTRON PROBE MICROANALYSIS; TECHNIQUE;

EID: 0031976821     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.46.534     Document Type: Article

References (7)

1. Akiyama Y., Yoshioka M., Horibe H., Hirai S., Kitamori N., Toguchi H., J. Controlled Release. 26, 1-10 (1993).
2. Fukumori Y., "Multiparticulate Oral Drug Delivery," ed. by Ghebre-Sellassie I., Marcel Dekker, New York, 1994, p. 79.
3. Deasy P. B., "Microencapsulation and Related Drug Processes," Marcel Dekker, New York. 1984, p. 161.
4. Maejima T., Osawa T., Nakajima K., Kobayashi M., Chem. Pharm. Bull., 45, 518-524 (1997); idem, ibid., 45, 904-910 (1997); idem, ibid., 45, 1332-1338 (1997); idem, ibid., 45, 1833-1839 (1997).
5. Maejima T., Osawa T., Nakajima K., Kobayashi M., Chem. Pharm. Bull., 45, 518-524 (1997); idem, ibid., 45, 904-910 (1997); idem, ibid., 45, 1332-1338 (1997); idem, ibid., 45, 1833-1839 (1997).
6. Maejima T., Osawa T., Nakajima K., Kobayashi M., Chem. Pharm. Bull., 45, 518-524 (1997); idem, ibid., 45, 904-910 (1997); idem, ibid., 45, 1332-1338 (1997); idem, ibid., 45, 1833-1839 (1997).
7. Maejima T., Osawa T., Nakajima K., Kobayashi M., Chem. Pharm. Bull., 45, 518-524 (1997); idem, ibid., 45, 904-910 (1997); idem, ibid., 45, 1332-1338 (1997); idem, ibid., 45, 1833-1839 (1997).