The effect of drug lipophilicity on P-glycoprotein-mediated colchicine efflux at the blood-brain barrier

International Journal of Clinical Pharmacology and Therapeutics

Volumn 36, Issue 2, 1998, Pages 84-86

  Khan, E U ^a   Reichel, A ^a   Begley, D J ^a   Roffey, S J ^b   Jezequel, S G ^b   Abbott, N J ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COLCHICINE; GLYCOPROTEIN P; MEMBRANE PROTEIN;

ANIMAL CELL; BLOOD BRAIN BARRIER; BRAIN CAPILLARY; CAPILLARY ENDOTHELIUM; CONFERENCE PAPER; CONTROLLED STUDY; DRUG POTENCY; DRUG UPTAKE; LIPOPHILICITY; MEMBRANE BINDING; NONHUMAN; PARTITION COEFFICIENT; RAT;

ANIMALS; BLOOD-BRAIN BARRIER; CELL LINE; COLCHICINE; CYCLOSPORINE; DIPYRIDAMOLE; LIPIDS; P-GLYCOPROTEIN; RATS; SOLUBILITY; VERAPAMIL; ZIDOVUDINE;

EID: 0031975846     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (11)

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