GB virus C (GBV-C) infection in patients with chronic hepatitis C. Influence on liver disease and on hepatitis virus behaviour: Effect of interferon alfa therapy

Journal of Medical Virology

Volumn 54, Issue 1, 1998, Pages 26-37

  Pawlotsky, Jean Michel ^a   Roudot Thoraval, Françoise ^a   Muerhoff, A Scott ^b   Pellerin, Muriel ^a   Germanidis, Georgios ^a   Desai, Suresh M ^b   Bastie, Anne ^a   Darthuy, Françoise ^a   Rémiré, Jocelyne ^a   Zafrani, Elie Serge ^a   Soussy, Claude James ^a   Mushahwar, Isa K ^b   Dhumeaux, Daniel ^a  

^a HENRI MONDOR HOSPITAL   (France)

^b ABBOTT LABORATORIES   (United States)

Author keywords

GB virus C; Genotypes; Hepatitis C virus; Interferon alfa

Indexed keywords

ALANINE AMINOTRANSFERASE; GAMMA GLUTAMYLTRANSFERASE; RECOMBINANT ALPHA2A INTERFERON;

ADULT; AGED; ARTICLE; CHRONIC HEPATITIS; FEMALE; FOLLOW UP; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HEPATITIS G VIRUS; HUMAN; IMMUNOTHERAPY; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; SINGLE STRAND CONFORMATION POLYMORPHISM; SUPERINFECTION; TREATMENT OUTCOME; VIRUS PATHOGENESIS; VIRUS REPLICATION; VIRUS TYPING;

ADULT; AGED; FEMALE; FLAVIVIRIDAE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HEPATITIS, VIRAL, HUMAN; HUMANS; INTERFERON-ALPHA; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; RNA, VIRAL; VIRUS REPLICATION;

GB VIRUS C/HEPATITIS G VIRUS; HEPATITIS C VIRUS; RNA VIRUSES;

EID: 0031975188     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9071(199801)54:1<26::AID-JMV5>3.0.CO;2-R     Document Type: Article

References (55)

1. Aikawa T, Sugai Y, Okamoto H (1996): Hepatitis G infection in drug abusers with chronic hepatitis C. New England Journal of Medicine 334:195-196.
2. Alter HJ (1994): Transfusion-transmitted hepatitis C and non-A, non-B, non-C. Vox Sanguinis 67:19-24.
3. Alter HJ (1996): The cloning and clinical implications of HGV and HGBV-C. New England Journal of Medicine 334:1536-1537.
4. Alter HJ, Nakatsuji Y, Melpolder J, Wages J, Wesley R, Shih WK, Kim JP (1997): The incidence of transfusion-associated hepatitis G virus infection and its relation to liver disease. New England Journal of Medicine 336:747-754.
5. Alter MJ, Margolis HS, Krawczynski K, Judson PN, Mares A, Alexander WJ, Hu PY, Miller JK, Gerber MA, Sampliner RE, Meeks EL, Beach MJ, for the Sentinel Counties Chronic non-A, non-B Hepatitis Study Team (1992): The natural history of community-acquired hepatitis C in the United States. New England Journal of Medicine 327:1899-1905.
6. Alter MJ, Gallagher M, Morris TT, Moyer LA, Meeks EL, Krawczynski K, Kim JP, Margolis HS, for the Sentinel Counties Counties Viral Hepatitis Study Team (1997): Acute non-A-E hepatitis in the United States and the role of hepatitis G virus infection. New England Journal of Medicine 336:741-746.
7. Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M (1989): Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244:359-362.
8. Crespo J, Lozano JL, Carte B, Rodrigo L, Rodriguez M, San Miguel G, Pons-Romero F (1995): Reciprocal inhibition of viral replication in patients with concomitant HBV and HCV infections. Journal of Hepatology 3 (suppl. 1):97.
9. Dawson GJ, Schlauder GG, Pilot-Matias TJ, Thiele D, Leary TP, Murphy P, Rosenblatt JE, Simons JN, Martinson PEA, Gutierrez RA, Lentino JR, Pachucki C, Muerhoff AS, Widell A, Tegtmeier G, Desai S, Mushahwar IK (1996): Prevalence studies of GB virus-C infection using reverse transcriptase-polymerase chain reaction. Journal of Medical Virology 50:97-103.
10. De Lamballerie X, Charrel RN, Dussol B (1996): Hepatitis GB virus C in patients on hemodialysis. New England Journal of Medicine 334:1549.
11. Desai SM, Simons JN, Muerhoff AS, Leary TP, Pilot-Matias TJ, Erker JC, Chalmers ML, Buijk SL, Schlauder GG, Dawson GJ, Mushahwar IK (1996): Molecular biology of GB viruses A, B and C. In Rizzetto M (ed): Abstract Volume of the IX Triennial International Symposium on Viral Hepatitis and Liver Disease. Rome: p 33.
12. Detmer J, Lagier R, Flynn J, Zayati C, Kolberg J, Collins M, Urdea M, Sanchez-Pescador R (1996): Accurate quantification of hepatitis C virus (HCV) RNA from all HCV genotypes by using branched DNA technology. Journal of Clinical Microbiology 34:901-907.
13. Enomoto N, Kurosaki M, Tanaka Y, Marumo F, Sato C (1994): Fluctuation of hepatitis C virus quasispecies in persistent infection and interferon treatment revealed by single-strand conformation polymorphism analysis. Journal of General Virology 75:1361-1369.
14. Erker JC, Simons JN, Muerhoff AS, Leary TP, Chalmers ML, Desai SM, Mushahwar IK (1996): Molecular cloning and characterization of a GB virus C isolate from a patient with non-A-E hepatitis. Journal of General Virology 77:2713-2720.
15. Felsenstein J (1989): PHYLIP-Phylogeny inference package. Cladistics 5:164-166.
16. Feucht HH, Zollner B, Polywka S, Laufs R (1996): Vertical transmission of hepatitis G. Lancet 347:61-66.
17. Fiordalisi G, Bettinardi A, Zanella I, Paraninfo G, Stellini R, Primi D (1996): Prevalence of the GBV-C virus in a group of Italian patients with acute and chronic hepatitis of unknown etiology. In Rizzetto M (ed): Abstract Volume of the IX Triennial International Symposium on Viral Hepatitis and Liver Disease. Rome: p 259.
18. Fiore M, Mitchell J, Doan T, Nelson R, Winter G, Grandone C, Zeng K, Haraden R, Smith J, Harris R (1988): The Abbott IMx automated benchtop immunochemistry analyzer system. Clinical Chemistry 34:1726-1732.
19. French Study Group for the Standardization of Hepatitis C Virus Polymerase Chain Reaction (1994): Improvement of hepatitis C virus RNA polymerase chain reaction through a multicenter quality control study. Journal of Virological Methods 49:79-88.
20. Hadziyannis SJ, Dawson GJ, Vrettou E, Gioustozi A, Schlauder G, Desai S (1996): Infection with the novel GB-C virus in multiply transfused patients and in various forms of chronic liver disease. Hepatology 22:218A.
21. Kolberg J, Sanchez-Pescador R, Detmer J, Collins M, Sheridan P, Neuwald P, Wilber J, Dailey P, Urdea M (1994): Branched DNA (bDNA) quantitation of hepatitis C viral RNA in patient sera. In Groupe Français d'Etudes Moléculaire des Hépatites (GEMHEP) (ed): "Hepatitis C Virus: New Diagnostic Tools." Paris: John Libbey Eurotext, pp 57-70.
22. Krawczynski K, Gallagher M, Speibring J, Wages J, Morris T, Chen S, Meeks E, Zou JC, Bradley D, Alter M, Foung S, Kim J, Margolis H (1996): Experimental HGV infection in primates. In Rizzetto M (ed): Abstract Volume of the IX Triennial International Symposium on Viral Hepatitis and Liver Disease. Rome: p 39.
23. Leary TP, Muerhoff AS, Simons JN, Pilot-Matias TJ, Erker JC, Chalmers ML, Montes CC, Buijk SL, Carinato ME, Dawson GJ, Desai SM, Mushahwar IK (1996a): Molecular diagnostic assays for the detection of GB virus infection. In Rizzetto M (ed): Abstract Volume of the IX Triennial International Symposium on Viral Hepatitis and Liver Disease. Rome: p 33.
24. Leary TP, Muerhoff AS, Simons JN, Pilot-Matias TJ, Erker JC, Chalmers ML, Schlauder GG, Dawson GJ, Desai SM, Mushahwar IK (1996b): Sequence and genomic organization of GBV-C: a novel member of the Flaviviridae associated with human non-A-E hepatitis. Journal of Medical Virology 48:60-67.
25. Leary TP, Muerhoff AS, Simons JN, Pilot-Matias TJ, Erker JC, Chalmers ML, Schlauder GG, Dawson GJ, Desai SM, Mushahwar IK (1996c): Consensus oligonucleotide primers for the detection of GB virus C in human cryptogenetic hepatitis. Journal of Virological Methods 56:119-121.
26. Liaw YF (1995): Role of hepatitis C virus in dual and triple hepatitis virus infection. Hepatology 22:1101-1108.
27. Linnen J, Wages J, Zhang-Keck ZY, Fry KE, Krawczynski K, Alter H, Koonin E, Gallagher M, Alter M, Hadziyannis S, Karayiannis P, Fung K, Nakatsuji Y, Shih JWK, Young L, Piatak M, Hoover C, Fernandez J, Chen S, Zou JC, Morris T, Hyams KC, Ismay S, Lifson JD, Hess G, Foung SKH, Thomas H, Bradley D, Margolis H, Kim JP (1996): Molecular cloning and disease association of hepatitis G virus: A transfusion-transmissible agent. Science 271:505-508.
28. Martell M, Esteban JI, Quer J, Genesca J, Weiner A, Esteban R, Guardia J, Gomez J (1992): Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: Quasispecies nature of HCV genome distribution. Journal of Virology 66:3225-3229.
29. Masuko K, Mitsui T, Iwano K, Yamazaki C, Okuda K, Meguro T, Murayama N, Inoue T, Tsuda F, Okamoto H, Miyakawa Y, Mayumi M (1996): Infection with hepatitis GB virus C in patients on maintenance hemodialysis. New England Journal of Medicine 334:1485-1490.
30. Muerhoff AS, Leary TP, Simons JN, Pilot-Matias TJ, Dawson GJ, Erker JC, Chalmers ML, Schlauder GG, Desai SM, Mushahwar IK (1995): Genomic organization of GBV-A and GBV-B: Two new members of the Flaviviridae associated with GB agent hepatitis. Journal of Virology 69:5621-5630.
31. Muerhoff AS, Simons JN, Erker JC, Chalmers MC, Desai SM, Mushahwar IK (1996a): Identification of conserved nucleotide sequences within the GB virus C 5′-untranslated region: Design of PCR primers for detection of viral RNA. Journal of Virological Methods 62:55-62.
32. Muerhoff AS, Simons JN, Leary TP, Erker JC, Chalmers ML, Pilot-Matias TJ, Dawson GJ, Desai SM, Mushahwar IK (1996b): Sequence heterogeneity within the 5′-terminal region of the hepatitis GB virus C genome and evidence for genotypes. Journal of Hepatology 25:379-384.
33. Mushahwar IK (1991): Recent progress on anti-HCV screening. Canada Disease Weekly Report 1755:41-43.
34. Orita M, Suzuki Y, Sekiya T, Hayashi K (1989): Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction. Genomics 5:874-879.
35. Pawlotsky JM, Fleury A, Choukroun V, Deforges L, Roudot-Thoraval F, Aumont P, Duval J, Dhumeaux D (1994): Significance of highly positive c22-3 "indeterminate" second-generation hepatitis C virus (HCV) recombinant immunoblot assay (RIBA) and resolution by third-generation HCV RIBA. Journal of Clinical Microbiology 32: 1357-1359.
36. Pawlotsky JM, Darthuy F, Rémiré J, Pellet C, Udin L, Stuyver L, Roudot-Thoraval F, Duvoux C, Douvin C, Mallat A, Mavier JP, Métreau JM, Duval J, Dhumeaux D (1995a): Significance of anti-hepatitis C virus core IgM antibodies in patients with chronic hepatitis C. Journal of Medical Virology 47:285-291.
37. Pawlotsky JM, Tsakiris L, Roudot-Thoraval F, Pellet C, Stuyver L, Duval J, Dhumeaux D (1995b): Relationship between hepatitis C virus genotypes and sources of infection in patients with chronic hepatitis C. Journal of Infectious Diseases 171:1607-1610.
38. Pawlotsky JM, Bastie A, Pellet C, Darthuy F, Rémiré J, Duval J, Dhumeaux D (1996a): Did the second-generation "branched DNA" assay improve quantification of HCV RNA in patients with chronic hepatitis C? In Rizzetto M (ed): Abstract Volume of the IX Triennial International Symposium on Viral Hepatitis and Liver Disease. Rome: p 237.
39. Pawlotsky JM, Germanidis G, Huraux C, Naudin G, Harvey T, Estrangin E, Desai S, Muerhoff AS, Bastie A, Rémiré J, Darthuy F, Mushahwar I, Duval J, Dhumeaux D, Roudot-Thoraval F (1996b): Mother-to-infant transmission of GB virus C (GBV-C) and HCV in HCV-infected pregnant women. Hepatology 24:225A.
40. Pawlotsky JM, Roudot-Thoraval F, Bastie A, Darthuy F, Rémiré J, Métreau JM, Zafrani ES, Duval J, Dhumeaux D (1996c): Factors affecting treatment responses to interferon-α in chronic hepatitis C. Journal of Infectious Diseases 174:1-7.
41. Reyes GR, Purdy MA, Kim JP, Luk KC, Young LM, Fry KE, Bradley DW (1990): Isolation of a cDNA from the virus responsible for enterically-transmitted non-A, non-B hepatitis. Science 247:1335-1339.
42. Schlauder GG, Mushahwar IK (1994): Detection of hepatitis C and E viruses by the polymerase chain reaction. Journal of Virological Methods 47:243-253.
43. Schlauder GG, Pilot-Matias TJ, Gabriel GS, Simons JN, Muerhoff AS, Dawson GJ, Mushahwar IK (1995): Origin of GB-hepatitis viruses. Lancet 346:447.
44. Schmidt B, Korn K, Fleckenstein B (1996): Molecular evidence for transmission of hepatitis G virus by blood transfusion. Lancet 347: 909.
45. Simons JN, Leary TP, Dawson GJ, Pilot-Matias TJ, Muerhoff AS, Schlauder GG, Desai SM, Mushahwar IK (1995a): Isolation of novel virus-like sequences associated with human hepatitis. Nature Medicine 1:564-569.
46. Simons JN, Pilot-Matias TJ, Leary TP, Dawson GJ, Desai SM, Schlauder GG, Muerhoff AS, Erker JC, Buijk SL, Chalmers ML, Sant CL, Mushahwar IK (1995b): Identification of two flavivirus-like genomes in the GB hepatitis agent. Proceedings of the National Academy of Sciences of the United States of America 92: 3401-3405.
47. Simons JN, Desai SM, Schultz DE, Lemon SM, Mushahwar IK (1996): Translation initiation in GB viruses A and C: Evidence for internal ribosome entry and implications on genome organization. Journal of Virology 70:6126-6135.
48. Stark K, Bienzle U, Hess G, Engel AM, Hegenscheid B, Schlüter V (1996): Detection of the hepatitis G virus genome among injecting drug users, homosexual and bisexual men, and blood donors. Journal of Infectious Diseases 174:1320-1323.
49. Stuyver L, Rossau R, Wyseur A, Duhamel M, Vanderborght B, Van Heuverswyn H, Maertens G (1993): Typing of hepatitis C virus isolates and characterization of new subtypes using a line probe assay. Journal of General Virology 74:1093-1102.
50. Tacke M, Kiyosawa K, Stark K, Schlueter V, Ofenloch-Haehnle B, Hess G, Engel AM (1997): Detection of antibodies to a putative hepatitis G virus envelope protein. Lancet 349:318-320.
51. Tanaka E, Alter HJ, Nakatsuji Y, Shih WK, Kim JP, Matsumoto A, Kobayashi M, Kiyosawa K (1996): Effect of hepatitis G virus infection on chronic hepatitis C. Annals of Internal Medicine 125: 740-743.
52. Weiner AJ, Geyseb HM, Christopherson C, Hall JE, Mason TJ, Saracco G, Bonino F, Crawford K, Marion CD, Crawford KA, Brunetto M, Barr PJ, Miyamura T, McHutchison J, Houghton M (1992): Evidence for immune selection of hepatitis C virus (HCV) putative envelope glycoprotein variants: Potential role in chronic HCV infections. Proceedings of the National Academy of Sciences of the United States of America 89:3468-3472.
53. Yoshiba M, Okamoto H, Mishiro S (1995): Detection of the GBV-C hepatitis virus genome in serum from patients with fulminant hepatitis of unknown aetiology. Lancet 346:1131-1132.
54. Zarski JP, Bohn B, Bastie A, Baud M, Pawlotsky JM, Tran Van Nhieu J, Buffet C, Dhumeaux D (1995): What are epidemiological, biochemical, virological and histologic characteristics of chronic hepatitis B-C? Hepatology 22:265A.
55. Zuckerman AJ (1996): Alphabet of hepatitis viruses. Lancet 347:558-559.