Platelets, neutrophils, and vasoconstriction after arterial injury by angioplasty in pigs: Effects of MK-886, a leukotriene biosynthesis inhibitor

British Journal of Pharmacology

Volumn 123, Issue 2, 1998, Pages 251-258

  Provost, Patrick ^a,c   Borgeat, Pierre ^b   Merhi, Yahye ^a  

^a MONTREAL HEART INSTITUTE   (Canada)

^b LAVAL UNIVERSITY   (Canada)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

5 lipoxygenase inhibitor; Arterial injury; Balloon angioplasty; Leukotrienes; MK 886; Neutrophil; Platelet; Thrombosis; Vasoconstriction

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; CALCIMYCIN; CHROMIUM 51; INDIUM 111; LEUKOTRIENE; LEUKOTRIENE B4; LIPOXYGENASE INHIBITOR; SUPEROXIDE; THROMBOXANE B2;

ANGIOGRAPHY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INJURY; ARTERY THROMBOSIS; ARTERY WALL; ARTICLE; BIOSYNTHESIS; BLOOD LEVEL; CAROTID ARTERY; CELL AGGREGATION; CELL FUNCTION; CELL INTERACTION; CONTROLLED STUDY; FEMALE; INFLAMMATION; MALE; NEUTROPHIL; NONHUMAN; PATHOPHYSIOLOGY; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PRIORITY JOURNAL; SWINE; THROMBOCYTE; THROMBOCYTE AGGREGATION; VASOCONSTRICTION; VASOMOTOR REFLEX;

ANIMALS; BALLOON DILATATION; BLOOD PLATELETS; CAROTID ARTERIES; CAROTID ARTERY INJURIES; FEMALE; INDOLES; LEUKOTRIENE B4; LEUKOTRIENES; LIPOXYGENASE INHIBITORS; MALE; NEUTROPHILS; PLATELET AGGREGATION; SUPEROXIDES; SWINE; THROMBOXANE B2; VASOCONSTRICTION;

EID: 0031974635     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701611     Document Type: Article

References (54)

1. BERMAN, C.L., YEO, E.L., WENCEL-DRAKE, J.D., FURIE, B.C., GINSBERG, M.H. & FURIE, B. (1986). A platelet a granule membrane protein that is associated with the plasma membrane after activation: characterization and subcellular localization of platelet activation-dependent granule-external membrane protein. J. Clin. Invest., 78, 130-137.
2. 2. J. Biol. Chem., 260, 6899-6906.
3. BORGEAT, P. & SAMUELSSON, B. (1979). Arachidonic acid metabolism in polymorphonuclear leukocytes: effects of ionophore A23187. Proc. Natl. Acad. Sci. U.S.A., 76, 2148-2152.
4. 4. Impact of aspirin therapy. Circulation, 86, 56-63.
5. CARRY, M., KORLEY, V., WILLERSON, J.T., WEIGELT, L., FORD-HUTCHINSON, A.W. & TAGARI, P. (1992). Increased urinary leukotriene excretion in patients with cardiac ischemia: in vivo evidence for 5-lipoxygenase activation. Circulation, 85, 230-236.
6. 4. Eur. J. Biochem., 173, 93-100.
7. DATTA, Y.H., ROMANO, M., JACOBSON, B.C., GOLAN, D.E., SERHAN, C.N. & EWENSTEIN, B.M. (1995). Peptido-leukotrienes are potent agonists of von Willebrand factor secretion and P-selectin surface expression in human umbilical endothelial cells. Circulation, 92, 3304-3311.
8. DE SERVI, S., MAZZONE, A., RICEVUTI, G., FIORAVANTI, A., BRAMUCCI, E., ANGOLI, L., STEPHANO, G. & SPECCHIA, G. (1990). Granulocyte activation after coronary angioplasty in humans. Circulation, 82, 140-146.
9. DIXON, R.A.F., DIEHL, R.E., OPAS, E., RANDS, E., VICKERS, P.J., EVANS, J.F., GILLARD, J.W. & MILLER, D.K. (1990). Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature, 343, 282-284.
10. DUNIEC, Z., ROBAK, J. & GRYGLEWSKI, R. (1983). Antioxidant properties of some chemicals vs their influence on cyclooxygenase and lipoxidase activities. Biochem. Pharmacol., 32, 2283-2286.
11. 4 synthesized by polymorphonuclear leukocytes. J. Biol. Chem., 261, 16466-16472.
12. 4 in inflammation. Immunology, 10, 1-12.
13. FORD-HUTCHINSON, A.W., BRAY, M.A., DOIG, M.V., SHIPLEY, M.E. & SMITH, M.J.H. (1980). Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes. Nature, 286, 264-265.
14. FUSTER, V., BADIMON, L., BADIMON, S.S. & CHESEBRO, J.H. (1992). The pathogenesis of coronary artery disease and the acute coronary syndromes. N. Engl. J. Med., 326, 310-318.
15. GILLARD, J., FORD-HUTCHINSON, A.W., CHAN, C., CHARLESON, S., DENIS, D., FOSTER, A., FORTIN, R., LEGER, S., MCFARLANE, C.S., MORTON, H., PIECHUTA, H., RIENDEAU, D., ROUZER, C.A., ROKACH, J., YOUNG, R., MACINTYRE, D.E., PETERSON, L., BACH, T., HERMANN, G., HOPPLE, S., HUMES, J., HUPE, L., LUELL, S., METZGER, J., MEURER, R., MILLER, D.K., OPAS, E. & PACHOLOK, S. (1989). L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2- dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor. Can. J. Physiol. Pharmacol., 67, 456-464.
16. GREENWALD, S.E., LETTS, L.G., NEWMAN, D.L. & PIPER, P.J. (1984). Actions of cysteinyl leukotrienes in coronary, femoral and carotid vessels of the pig. Eur. J. Pharmacol., 103, 107-114.
17. GROVES, P.H., LEWIS, M.J., CHEADLE, H.A. & PENNY, W.J. (1993). SIN-1 reduces platelet adhesion and platelet thrombus formation in a porcine model of balloon angioplasty. Circulation, 87, 590-597.
18. HENRY, R.L. (1965). Leukocytes and thrombosis. Thromb. Diath. Haemorrh., 13, 35-46.
19. HERAS, M., CHESEBRO, J.H., WEBSTER, M.W.I., MRUK, J.S., GRILL, D.E. & FUSTER, V. (1992). Antithrombotic efficacy of low-molecular-weight heparin in deep arterial injury. Arterioscler. Thromb., 12, 250-255.
20. HERAS, M., CHESEBRO, J.H., WEBSTER, M.W.I., MRUK, J.S., GRILL, D.E., PENNY, W.J., BOWIE, E.J., BADIMON, L. & FUSTER, V. (1990). Hirudin heparin, and placebo during deep arterial injury in the pig: the in vivo role of thrombin in platelet-mediated thrombosis. Circulation, 82, 1476-1484.
21. 2, and adenine nucleotides. J. Clin. Invest., 78, 539-544.
22. IKEDA, H., NAKAYAMA, H., ODA, T., KUWANO, K., YAMAGA, A., VENO, T., YOH, M., HIYAMATA, K., KAGO, Y. & TOSHIMA, H. (1994). Neutrophil activation after percutaneous transluminal coronary angioplasty. Am. Heart. J., 128, 1091-1098.
23. KORNECKI, E., EHRLICH, Y.H., DE MARS, D.D. & LENOX, R.H. (1986). Exposure of fibrinogen receptors in human platelets by surface proteolysis with elastase. J. Clin. Invent., 77, 750-756.
24. LAURINDO, F.R.M., DA LUZ, P.L., UINT, L., ROCHA, T.F., JAEGER, R.G. & LOPES, E.A. (1991). Evidence for superoxide radical-dependent coronary vasospasm after angioplasty in intact dogs. Circulation, 83, 1705-1715.
25. LETTS, L.G., CIRINO, M., YUSKO, P., FITZSIMMONS, B., FORD-HUTCHINSON, A.W. & ROKACH, J. (1985). Actions of synthetic leukotrienes on platelets and blood vessels in the anesthetised pig: the release of a platelet derived vasodilator. Prostaglandins, 29, 1049-1062.
26. LEWIS, R.A. & AUSTEN, K.F. (1984). The biologically active leukotrienes: biosynthesis, metabolism, receptors, functions, and pharmacology. J. Clin. Invest., 73, 889-897.
27. 4 synthesis in human polymorphonuclear leukocytes. J. Clin. Invest., 70, 1058-1065.
28. 4. J. Biol. Chem., 263, 174-181.
29. 4 cooperative synthesis. Thromb. Haemost., 72, 450-456.
30. MAUGERI, N., EVANGELISTA, V., PICCARDONI, P., DELL'ELBA, G., CELARDO, A., DE GAETANO, G. & CERLETTI, C. (1992). Transcellular metabolism of arachidonic acid: increased platelet thromboxane generation in the presence of activated polymorphonuclear leukocytes. Blood, 80, 447-451.
31. 4 and platelet-activating factor in human neutrophils. Br. J. Pharmacol., 111, 852-860.
32. 4 by transcellular biosynthesis. Proc. Natl. Acad. Sci. U.S.A., 83, 1349-1353.
33. MEHTA, P., MEHTA, J., LAWSON, D., KROP, I. & LETTS, L.G. (1986). Leukotrienes potentiate the effects of epinephrine and thrombin on human platelet aggregation. Thromb. Res., 41, 731-738.
34. MÉNARD, L., PILOTE, S., NACCACHE, P.H., LAVIOLETTE, M. & BORGEAT, P. (1990). Inhibitory effects of MK-886 on arachidonic acid metabolism in human phagocytes. Br. J. Pharmacol., 100, 15-20.
35. MERHI, Y., GUIDOIN, R., PROVOST, P., LEUNG, T.-K. & LAM, J.Y.T. (1995). Increase of neutrophil adhesion and vasoconstriction with platelet deposition after deep arterial injury by angioplasty. Am. Heart J., 129, 445-451.
36. MERHI, Y., L-LACOSTE, L. & LAM, J.Y.T. (1994). Neutrophil implications in platelet deposition and vascoconstriction after deep arterial injury by angioplasty in pigs. Circulation, 90, 997-1002.
37. MERHI, Y., PROVOST, P., GUIDOIN, R. & LATOUR, J.-G. (1997). Importance of platelets in neutrophil adhesion and vasoconstriction after deep carotid arterial injury by angioplasty in pigs. Arterioscler. Thromb. Vasc. Biol., 17, 1185-1191.
38. MERHI, Y., LAM, J.Y.T., L. LACOSTE, L., LATOUR, J.-G., GUIDOIN, R. & WATERS, D. (1993). Effects of thrombocytopenia and shear rate on neutrophil and platelet deposition on endothelial and medial arterial surfaces. Arterioscler. Thromb., 13, 951-957.
39. 4: a potent coronary artery vasoconstrictor associated with impaired ventricular contraction. Science, 217, 841-843.
40. MICKELSON, J.K., LAKKIS, N.M., VILLARREAL-LEVY, G., HUGHES, B.J. (1996). Leukocyte activation with platelet adhesion after coronary angioplasty: a mechanism for recurrent disease? J. Am. Coll. Cardiol., 28, 345-353.
41. 2 on coronary flow and myocardial function. Am. J. Physiol., 255, H153-H159.
42. 4 synthesis in polymorphonuclear leucocytes stimulated by physiological agonists. Br. J. Pharmacol., 103, 1909-1916.
43. PIETERSMA, A., KOFFLARD, M., DE WIT, E.A., STIJNEN, T., KOSTER, J.F., SERRUYS, P.W. & SLUITER, W. (1995). Late lumen loss after coronary angioplasty is associated with the activation status of circulating phoyocytes before treatment. Circulation, 91, 1320-1325.
44. PROVOST, P., LAM, J.Y.T., LACOSTE, L., MERHI, Y. & WATERS, D. (1994). Endothelium-derived nitric oxide attenuates neutrophil adhesion to endothelium under arterial flow conditions. Arterioscler. Thromb., 14, 331-335.
45. PROVOST, P. & MERHI, Y. (1996). BW755C, a dual lipoxygenase/ cyclooxygenase inhibitor, reduces mural platelet and neutrophil deposition and vasoconstriction after angioplasty injury in pigs. J. Pharmacol. Exp. Ther., 277, 17-21.
46. PROVOST, P., TREMBLAY, J. & MERHI, Y. (1997). The antiadhesive and antithrombotic effects of the nitric oxide donor SIN-1 are combined with a decreased vasoconstriction in a porcine model of balloon angioplasty. Arterioscler. Thromb. Vasc. Biol., 17, 1802-1806.
47. REID, G.K., KARGMAN, S., VICKERS, P.J., MANCINI, J.A., LEVEILLÉ, C., ETHIER, D., MILLER, D.K., GILLARD, J.W., DIXON, R.A.F. & EVANS, J.F. (1990). Correlation between expression of 5-lipoxygenase-activating protein, 5-lipoxygenase, and cellular leukotriene synthesis. J. Biol. Chem., 265, 19818-19823.
48. ROUZER, C.A., FORD-HUTCHINSON, A.W., MORTON, H.E. & GILLARD, J.W. (1990). MK886, a potent and specific leukotriene biosynthesis inhibitor blocks and reverses the membrane association of 5-lipoxygenase in ionophore-challenged leukocytes. J. Biol. Chem., 265, 1436-1442.
49. SAMUELSSON, B. (1983). Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. Science, 220, 568-575.
50. SELAK, M.A., CHIGNARD, M. & SMITH, J.B. (1988). Cathepsin G is a strong platelet agonist released by neutrophils. Biochem. J., 251, 293-299.
51. SNYDER, F. (1990). Platelet-activating factor and related acetylated lipids as potent biologically active cellular mediators. Am. J. Physiol., 259, C697-C708.
52. STEELE, P.M., CHESEBRO, J.H., STANSON, A.W., HOLMES JR D.R., DEWANJEE, M.K., BADIMON, L. & FUSTER, V. (1985). Balloon angioplasty: natural history of the pathophysiological response to injury in a pig model. Circ. Res., 57, 105-112.
53. SURETTE, M.E., ODEIMAT, A., PALMANTIER, R., MARLEAU, S., POUBELLE, P.E. & BORGEAT, P. (1994). Reverse-phase high-performance liquid chromatography analysis of arachidonic acid metabolites in plasma after stimulation of whole blood ex vivo. Anal. Biochem., 216, 392-400.
54. YEO, E., SHEPPARD, J.-A.I. & FEUERSTEIN, I.A. (1994). Role of P-selectin and leukocyte activation in polymorphonuclear cell adhesion to surface adherent activated platelets under physiologic shear conditions (an injury vessel wall model). Blood, 83, 2498-2507.